US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US4309989A
(en)
|
1976-02-09 |
1982-01-12 |
The Curators Of The University Of Missouri |
Topical application of medication by ultrasound with coupling agent
|
FR2374910A1
(fr)
|
1976-10-23 |
1978-07-21 |
Choay Sa |
Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
GB2097032B
(en)
|
1981-04-22 |
1984-09-19 |
Teron International Urban Dev |
A combined ceiling air and services distribution system mechanical chasse and structural roof member
|
US4818542A
(en)
|
1983-11-14 |
1989-04-04 |
The University Of Kentucky Research Foundation |
Porous microspheres for drug delivery and methods for making same
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
SE448277B
(sv)
|
1985-04-12 |
1987-02-09 |
Draco Ab |
Indikeringsanordning vid en doseringsanordning for lekemedel
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
US5576195A
(en)
|
1985-11-01 |
1996-11-19 |
Xoma Corporation |
Vectors with pectate lyase signal sequence
|
SE453566B
(sv)
|
1986-03-07 |
1988-02-15 |
Draco Ab |
Anordning vid pulverinhalatorer
|
US4767402A
(en)
|
1986-07-08 |
1988-08-30 |
Massachusetts Institute Of Technology |
Ultrasound enhancement of transdermal drug delivery
|
EP0318512B1
(fr)
|
1986-08-18 |
1998-06-17 |
Emisphere Technologies, Inc. |
Systemes de distribution pour agents pharmacologiques
|
US4704692A
(en)
|
1986-09-02 |
1987-11-03 |
Ladner Robert C |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
EP0279582A3
(fr)
|
1987-02-17 |
1989-10-18 |
Pharming B.V. |
Séquences d'ADN pour diriger des protéines vers les glandes mammaires afin d'être sécrétées efficacement
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
US4939666A
(en)
|
1987-09-02 |
1990-07-03 |
Genex Corporation |
Incremental macromolecule construction methods
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
US5266491A
(en)
|
1989-03-14 |
1993-11-30 |
Mochida Pharmaceutical Co., Ltd. |
DNA fragment and expression plasmid containing the DNA fragment
|
DE3909708A1
(de)
|
1989-03-23 |
1990-09-27 |
Boehringer Mannheim Gmbh |
Verfahren zur herstellung bispezifischer antikoerper
|
CA2062795A1
(fr)
|
1989-06-29 |
1990-12-30 |
Michael W. Fanger |
Reactifs bispecifiques pour le traitement du sida
|
JP3127158B2
(ja)
|
1989-10-05 |
2001-01-22 |
オプテイン,インコーポレイティド |
新規の遺伝子及びポリペチドの無細胞合成並びに単離
|
US5580575A
(en)
|
1989-12-22 |
1996-12-03 |
Imarx Pharmaceutical Corp. |
Therapeutic drug delivery systems
|
DK0463151T3
(da)
|
1990-01-12 |
1996-07-01 |
Cell Genesys Inc |
Frembringelse af xenogene antistoffer
|
TW212184B
(fr)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
AU8081491A
(en)
|
1990-06-01 |
1991-12-31 |
Cetus Corporation |
Compositions and methods for identifying biologically active molecules
|
US5723286A
(en)
|
1990-06-20 |
1998-03-03 |
Affymax Technologies N.V. |
Peptide library and screening systems
|
WO1992000373A1
(fr)
|
1990-06-29 |
1992-01-09 |
Biosource Genetics Corporation |
Production de melanines a l'aide de microorganismes transformes
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
DE69133476T2
(de)
|
1990-08-29 |
2006-01-05 |
GenPharm International, Inc., Palo Alto |
Transgene Mäuse fähig zur Produktion heterologer Antikörper
|
WO1992005258A1
(fr)
|
1990-09-20 |
1992-04-02 |
La Trobe University |
Gene encodant une enzyme de l'orge
|
DE69128253T2
(de)
|
1990-10-29 |
1998-06-18 |
Chiron Corp |
Bispezifische antikörper, verfahren zu ihrer herstellung und deren verwendungen
|
US5582996A
(en)
|
1990-12-04 |
1996-12-10 |
The Wistar Institute Of Anatomy & Biology |
Bifunctional antibodies and method of preparing same
|
CA2104698A1
(fr)
|
1991-02-21 |
1992-08-22 |
John J. Toole |
Aptameres specifiques de biomolecules et methodes de production
|
US5404871A
(en)
|
1991-03-05 |
1995-04-11 |
Aradigm |
Delivery of aerosol medications for inspiration
|
CA2106079C
(fr)
|
1991-03-15 |
2000-04-25 |
Robert C. Thompson |
Pegylation de polypeptides
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
CA2444415A1
(fr)
|
1991-07-02 |
1993-01-21 |
Nektar Therapeutics |
Methode et instrument pour la delivrance de medicaments en aerosol
|
US5270170A
(en)
|
1991-10-16 |
1993-12-14 |
Affymax Technologies N.V. |
Peptide library and screening method
|
WO1993008829A1
(fr)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions induisant la destruction de cellules infectees par l'hiv
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
ES2227512T3
(es)
|
1991-12-02 |
2005-04-01 |
Medical Research Council |
Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago.
|
DE4207475A1
(de)
|
1992-03-10 |
1993-09-16 |
Goldwell Ag |
Mittel zum blondieren von menschlichen haaren und verfahren zu dessen herstellung
|
AU4829593A
(en)
|
1992-09-23 |
1994-04-12 |
Fisons Plc |
Inhalation device
|
AU5322494A
(en)
|
1992-10-02 |
1994-04-26 |
Trustees Of Dartmouth College |
Bispecific reagents for redirected targeting of low density lipoprotein
|
NZ257056A
(en)
|
1992-10-19 |
1996-08-27 |
Dura Pharma Inc |
Dry powder inhaler: housing with mixing chamber and impeller
|
US5643252A
(en)
|
1992-10-28 |
1997-07-01 |
Venisect, Inc. |
Laser perforator
|
WO1994012520A1
(fr)
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Segment de liaison pour polypeptides fusionnes lies
|
US5849695A
(en)
|
1993-01-13 |
1998-12-15 |
The Regents Of The University Of California |
Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals
|
DK0680451T3
(da)
|
1993-01-19 |
1999-07-19 |
Glaxo Group Ltd |
Aerosoldispenser samt fremgangsmåde ved dens fremstilling
|
ATE453709T1
(de)
|
1993-02-12 |
2010-01-15 |
Univ Leland Stanford Junior |
Regulierte transkription von zielgerichteten genen und andere biologische ereignisse
|
US5770428A
(en)
|
1993-02-17 |
1998-06-23 |
Wisconsin Alumni Research Foundation |
Chimeric retrovial expression vectors and particles containing a simple retroviral long terminal repeat, BLV or HIV coding regions and cis-acting regulatory sequences, and an RNA translational enhancer with internal ribsome entry site
|
AU6819494A
(en)
|
1993-04-26 |
1994-11-21 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5514670A
(en)
|
1993-08-13 |
1996-05-07 |
Pharmos Corporation |
Submicron emulsions for delivery of peptides
|
US5625825A
(en)
|
1993-10-21 |
1997-04-29 |
Lsi Logic Corporation |
Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
|
DE4337197C1
(de)
|
1993-10-30 |
1994-08-25 |
Biotest Pharma Gmbh |
Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore
|
US5814599A
(en)
|
1995-08-04 |
1998-09-29 |
Massachusetts Insitiute Of Technology |
Transdermal delivery of encapsulated drugs
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
PT749325E
(pt)
|
1994-03-07 |
2002-11-29 |
Medarex Inc |
Mpleculas biespecificas possuindo utilidades clinicas
|
US5763733A
(en)
|
1994-10-13 |
1998-06-09 |
Enzon, Inc. |
Antigen-binding fusion proteins
|
US5549551A
(en)
|
1994-12-22 |
1996-08-27 |
Advanced Cardiovascular Systems, Inc. |
Adjustable length balloon catheter
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US6037453A
(en)
|
1995-03-15 |
2000-03-14 |
Genentech, Inc. |
Immunoglobulin variants
|
US5656730A
(en)
|
1995-04-07 |
1997-08-12 |
Enzon, Inc. |
Stabilized monomeric protein compositions
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
WO1996034096A1
(fr)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Anticorps humains derives de xeno-souris immunisees
|
US5730723A
(en)
|
1995-10-10 |
1998-03-24 |
Visionary Medical Products Corporation, Inc. |
Gas pressured needle-less injection device and method
|
GB9526100D0
(en)
|
1995-12-20 |
1996-02-21 |
Intersurgical Ltd |
Nebulizer
|
KR19990077014A
(ko)
|
1996-01-03 |
1999-10-25 |
그레이엄 브레레톤 |
흡입 장치
|
DE19624387C2
(de)
|
1996-06-19 |
1999-08-19 |
Hatz Motoren |
Kaltstartvorrichtung
|
EP0826695B1
(fr)
|
1996-09-03 |
2001-12-12 |
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH |
Destruction de cellules tumorales contaminantes dans un transplant de cellules souches avec des anticorps bispecifiques
|
JP4215172B2
(ja)
|
1996-12-03 |
2009-01-28 |
アムジェン フレモント インク. |
複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
|
US5879681A
(en)
|
1997-02-07 |
1999-03-09 |
Emisphere Technolgies Inc. |
Compounds and compositions for delivering active agents
|
US5921447A
(en)
|
1997-02-13 |
1999-07-13 |
Glaxo Wellcome Inc. |
Flow-through metered aerosol dispensing apparatus and method of use thereof
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
IL120943A
(en)
|
1997-05-29 |
2004-03-28 |
Univ Ben Gurion |
A system for administering drugs through the skin
|
BR9812693A
(pt)
|
1997-09-29 |
2000-08-22 |
Inhale Therapeutic Syst |
Uso de um agente bioativo, processo para formar uma microestrutura perfurada, microestrutura perfurada, processo para aumentar a dispersibilidade de um pó, pó de microestrutura perfurada, pó tendo dispersibilidade aumentada, sistema de inalação para a administração pulmonar de um agente bioativo a um paciente, e, processo para a liberação pulmonar de um ou mais agentes bioativos
|
DE69942021D1
(de)
|
1998-04-20 |
2010-04-01 |
Glycart Biotechnology Ag |
Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität
|
PL220113B1
(pl)
|
1999-01-15 |
2015-08-31 |
Genentech Inc |
Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc
|
US6309663B1
(en)
|
1999-08-17 |
2001-10-30 |
Lipocine Inc. |
Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
|
WO2002079255A1
(fr)
|
2001-04-02 |
2002-10-10 |
Idec Pharmaceuticals Corporation |
Anticorps recombinants co-exprimes avec gntiii
|
CA2838062C
(fr)
|
2001-08-03 |
2015-12-22 |
Roche Glycart Ag |
Variants de glycosylation d'anticorps presentant une cytotoxicite cellulaire accrue dependante des anticorps
|
SI3219328T1
(sl)
|
2005-12-29 |
2020-10-30 |
Janssen Biotech, Inc. |
Človeška protitelesa proti-IL-23, sestavki, postopki in uporabe
|
US9803010B2
(en)
*
|
2012-06-27 |
2017-10-31 |
Merck Sharp & Dohme Corp. |
Crystalline anti-human IL-23p19 antibodies
|
CA2955460A1
(fr)
|
2014-07-17 |
2016-01-21 |
Protagonist Therapeutics, Inc. |
Peptides inhibiteurs par voie orale du recepteur de l'interleukine-23 et leur utilisation dans le traitement des maladies inflammatoires de l'intestin
|
US20170291942A1
(en)
*
|
2016-04-07 |
2017-10-12 |
Janssen Biotech, Inc. |
Treatment of Depression Using Agents that Block Binding of IL-6 to IL-6 Receptor
|
US11326182B2
(en)
*
|
2016-04-29 |
2022-05-10 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
MX2019003703A
(es)
*
|
2016-09-30 |
2020-08-13 |
Janssen Biotech Inc |
Método seguro y eficaz para tratar la psoriasis con el anticuerpo específico anti-il23.
|