EA201690492A1 - Проникающие в клетку конъюгаты и способы их применения - Google Patents

Проникающие в клетку конъюгаты и способы их применения

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Publication number
EA201690492A1
EA201690492A1 EA201690492A EA201690492A EA201690492A1 EA 201690492 A1 EA201690492 A1 EA 201690492A1 EA 201690492 A EA201690492 A EA 201690492A EA 201690492 A EA201690492 A EA 201690492A EA 201690492 A1 EA201690492 A1 EA 201690492A1
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Eurasian Patent Office
Prior art keywords
conjugates
thiophosphate
cellulating
methods
application
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EA201690492A
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English (en)
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Линь Ли
Джон Эрнест Шивели
Петр Марек Свидерски
Андреас Херрманн
Хуа Юй
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Сити Оф Хоуп
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Publication of EA201690492A1 publication Critical patent/EA201690492A1/ru

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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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Abstract

В настоящем документе предложены приникающие в клетку конъюгаты. Конъюгаты содержат не проникающий в клетку белок, присоединенный к тиофосфатной нуклеиновой кислоте или остову тиофосфатного полимера, при этом тиофосфатная нуклеиновая кислота или остов тиофосфатного полимера повышают внутриклеточную доставку не проникающего в клетку белка. Также предложены композиции и наборы, содержащие конъюгаты.
EA201690492A 2013-08-29 2014-08-29 Проникающие в клетку конъюгаты и способы их применения EA201690492A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361871729P 2013-08-29 2013-08-29
US201461939993P 2014-02-14 2014-02-14
PCT/US2014/053549 WO2015031837A1 (en) 2013-08-29 2014-08-29 Cell penetrating conjugates and methods of use thereof

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Publication Number Publication Date
EA201690492A1 true EA201690492A1 (ru) 2016-08-31

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US (2) US10967070B2 (ru)
EP (1) EP3038639B1 (ru)
JP (3) JP6736464B2 (ru)
KR (2) KR102522346B1 (ru)
CN (2) CN111437395A (ru)
AU (3) AU2014312031A1 (ru)
CA (1) CA2922698C (ru)
EA (1) EA201690492A1 (ru)
IL (1) IL244296A0 (ru)
MX (2) MX2016002643A (ru)
PH (1) PH12016500395A1 (ru)
SG (1) SG11201601443PA (ru)
WO (1) WO2015031837A1 (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017116710A (ru) 2014-10-23 2018-11-23 Сингх Биотекнолоджи, Ллк Однодоменные антитела, направленные против внутриклеточных антигенов
US20170267784A1 (en) 2014-10-23 2017-09-21 Singh Molecular Medicine, Llc Single domain antibodies directed against intracellular antigens
SG11201705413WA (en) * 2015-01-16 2017-08-30 Hope City Cell penetrating antibodies
TW201718024A (zh) * 2015-08-06 2017-06-01 世代好公司 治療性細胞內化結合物
EP3331543A4 (en) * 2015-08-06 2019-03-20 City of Hope CONJUGATES OF CELL PENETRATION FORMED OF PROTEIN AND ANTIBODIES AND METHODS OF USE
CN108473574A (zh) * 2015-10-20 2018-08-31 索伦托治疗有限公司 细胞内递送化合物
TWI746473B (zh) 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 針對細胞內抗原之單域抗體
TW201733621A (zh) * 2015-12-10 2017-10-01 世代好公司 細胞穿透性之花青耦合抗體
KR20180059091A (ko) 2016-11-25 2018-06-04 김정수 소비자 패션선호도 기반의 가상 피팅 방법, 그 시스템 및 시스템의 작동을 제어하기 위한 제어방법
EP3565601A2 (en) * 2017-01-04 2019-11-13 Sorrento Therapeutics Cell internalizing compounds
CN110770345A (zh) 2017-04-14 2020-02-07 托尔奈公司 免疫调节多核苷酸、抗体缀合物及其使用方法
US11607457B2 (en) * 2017-07-13 2023-03-21 City Of Hope Anti-cancer phosphorothioate-coupled peptide conjugates and methods of using the same
EP3651807B1 (en) * 2017-07-13 2023-11-01 City of Hope Phosphorothioate-conjugated peptides and methods of using the same
JP7130274B2 (ja) 2017-12-22 2022-09-05 ロフィバイオ インコーポレイテッド 細胞内浸透能を有する抗ｓｔａｔ３二重特異性抗体およびこれを含む薬学的組成物
KR20190076354A (ko) * 2017-12-22 2019-07-02 주식회사 로피바이오 세포 내 침투능을 갖는 항 stat3 이중특이 항체를 포함하는, 염증성 질환 치료용 약학적 조성물
EP3805400A4 (en) 2018-06-04 2022-06-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule showing changed half-life in cytoplasm
US20220125891A1 (en) 2018-06-06 2022-04-28 Osaka University Method for treating and/or preventing regnase-1-related disease
WO2021237160A2 (en) * 2020-05-22 2021-11-25 City Of Hope Phosphorothioate nucleic acid conjugates including dna editing enzymes
US20230277612A1 (en) * 2020-06-24 2023-09-07 Sapreme Technologies B.V. Saponin derivatives for use in medicine
US20240115726A1 (en) * 2020-06-24 2024-04-11 Sapreme Technologies B.V. Hydrazone-based saponin derivatives
WO2024091824A1 (en) 2022-10-26 2024-05-02 Ada Forsyth Institute, Inc. Differentiation and reprogramming of chondrocyte
WO2024129459A1 (en) 2022-12-16 2024-06-20 University Of Rochester Repairmen! of barrier dysfunction in esophagus

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
KR20030097604A (ko) 1992-07-13 2003-12-31 유카리언, 인코포레이티드 세포의 세포내 구획으로 지질화된 면역글로불린을전달하기 위한 조성물, 지질화된 단백질 및 지질화된 항체
PT651805E (pt) 1992-07-17 2007-02-28 Dana Farber Cancer Inst Inc Método de ligação intracelular de moléculas-alvo
US6210671B1 (en) 1992-12-01 2001-04-03 Protein Design Labs, Inc. Humanized antibodies reactive with L-selectin
WO1995002422A1 (en) 1993-07-12 1995-01-26 Weltman Joel K Method for conjugating nucleotides and nucleosides to disulfide-, maleimide-, and thiol-containing compounds
AU1925195A (en) 1994-02-22 1995-09-04 Dana-Farber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
WO1998008859A1 (en) * 1996-08-27 1998-03-05 University Of Utah Research Foundation Bioconjugates and delivery of bioactive agents
WO2000032634A1 (en) 1998-12-01 2000-06-08 Protein Design Labs, Inc. Humanized antibodies to gamma-interferon
US6903077B1 (en) 1999-01-04 2005-06-07 University Of Vermont And State Agricultural College Methods and products for delivering nucleic acids
DE60040755D1 (de) 1999-12-01 2008-12-18 Novartis Vaccines & Diagnostic Hervorrufen von antikörpern spezifisch für hepatitis c virus (hcv)
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
US20030158109A1 (en) 2000-11-13 2003-08-21 Klaus Giese Metastatic breast and colon cancer regulated genes
CA2464472C (en) 2001-10-22 2014-01-07 The Scripps Research Institute Antibody targeting compounds
US20050042632A1 (en) 2002-02-13 2005-02-24 Sirna Therapeutics, Inc. Antibodies having specificity for nucleic acids
US20040147027A1 (en) * 2003-01-28 2004-07-29 Troy Carol M. Complex for facilitating delivery of dsRNA into a cell and uses thereof
US20060222657A1 (en) 2003-06-20 2006-10-05 Dowdy Steven F Polypeptide transduction and fusogenic peptides
WO2005024033A2 (en) * 2003-09-11 2005-03-17 Universitätsklinikum Schleswig-Holstein Campus Lübeck Nucleotide sequences promoting the trans-membrane transport of nucleic acids
WO2005082935A1 (en) 2004-02-26 2005-09-09 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Stamp modulation of glucocorticoid-responsive gene expression
US7714119B2 (en) 2004-07-13 2010-05-11 Biosante Pharmaceuticals, Inc. AAV vector compositions and methods for enhanced expression of immunoglobulins using the same
CA2633063A1 (en) * 2005-12-16 2007-06-21 Diatos Cell penetrating peptide conjugates for delivering of nucleic acids intocells
US20070225213A1 (en) 2006-03-23 2007-09-27 Kosak Matthew K Nucleic acid carriers for delivery of therapeutic agents
PL2446904T3 (pl) * 2006-05-30 2015-10-30 Genentech Inc Przeciwciała anty-CD22, ich immunokoniugaty oraz ich zastosowania
US20090093425A1 (en) * 2006-07-12 2009-04-09 The Regents Of The University Of California Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
WO2009008725A2 (en) * 2007-07-12 2009-01-15 Prosensa Technologies B.V. Molecules for targeting compounds to various selected organs, tissues or tumor cells
US20110129421A1 (en) 2007-07-17 2011-06-02 The General Hospital Corporation Matrix metalloprotease targeting nucleic acids
CN102317303A (zh) * 2007-07-31 2012-01-11 约翰·霍普金斯大学 用于肿瘤或感染性疾病的免疫预防或免疫治疗的多肽-核酸偶联物
US20110218334A1 (en) * 2008-07-11 2011-09-08 Alnylam Pharmaceuticals, Inc. PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS
JP5635512B2 (ja) * 2008-09-16 2014-12-03 カリエム・アーメド 遺伝子調節化合物の改良された送達のための化学的に修飾された細胞透過性ペプチド
US20100190691A1 (en) * 2009-01-27 2010-07-29 Trojan Technologies, Ltd Delivery of nucleic acids using cell-penetrating peptides
DK3903829T3 (da) 2009-02-13 2023-06-26 Immunomedics Inc Immunkonjugater med en intracellulær spaltelig binding
US8552167B2 (en) * 2009-10-20 2013-10-08 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Multifunctional aptamer-nucleic acid nanostructures for tumor-targeted killing
NZ586074A (en) * 2010-06-10 2013-07-26 Auckland Uniservices Ltd LCLRP peptides, constructs and uses thereof
US20120122795A1 (en) 2010-08-09 2012-05-17 University Of Southern California Accelerated extension of axons
US9045750B2 (en) 2011-03-18 2015-06-02 Yuelong Ma Humanized lewis-Y specific antibody-based delivery of dicer substrate siRNA (D-siRNA) against STAT3
JP6178785B2 (ja) * 2011-04-01 2017-08-09 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ 細胞浸透性抗ｄｎａ抗体およびｄｎａ修復を阻害するためのその使用
DK2751270T3 (en) 2011-08-29 2018-10-29 Ionis Pharmaceuticals Inc OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE

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