JP2001527386A - 異種抗体を産生し得るトランスジェニック非ヒト動物 - Google Patents
異種抗体を産生し得るトランスジェニック非ヒト動物Info
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- JP2001527386A JP2001527386A JP52568798A JP52568798A JP2001527386A JP 2001527386 A JP2001527386 A JP 2001527386A JP 52568798 A JP52568798 A JP 52568798A JP 52568798 A JP52568798 A JP 52568798A JP 2001527386 A JP2001527386 A JP 2001527386A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ヒト重鎖トランスジーンおよびヒト軽鎖トランスジーンを含むゲノムを有す るトランスジェニックマウスから入手したB細胞を含むハイブリドーマであって 、該B細胞は、ハイブリドーマを生成するのに適した不死化細胞に融合されてお り、ここで、該ハイブリドーマは、インターロイキン−8に特異的に結合する検 出可能な量の免疫グロブリンを産生する、ハイブリドーマ。 2.前記免疫グロブリンがGROαに特異的に結合する、請求項1に記載のハイブ リドーマ。 3.前記免疫グロブリンが、ヒトインターロイキン−8への結合についての少な くとも2×109M-1の親和定数(Ka)を有する、請求項1に記載のハイブリドーマ 。 4.前記親和定数が、少なくとも2×1010M-1である、請求項1に記載のハイブ リドーマ。 5.前記免疫グロブリンが、1F8、2D11、2F9、2G1、3E5、5E7、5F10、5H8、2C6 、2D6、3A1、4D4、7C5、および10A6からなる群から選択される、請求項3に記載 のハイブリドーマ。 6.請求項3に記載のハイブリドーマによって産生される実質的に純粋な免疫グ ロブリンを含む組成物。 7.実質的に純粋なヒトモノクローナル抗体を含む組成物であって、ここで該抗 体が、ヒトインターロイキン−8への結合についての少なくとも2×109M-1の親 和定数(Ka)を有し、そして該免疫グロブリンが、 (1)ヒトVL遺伝子セグメントおよびヒトJLセグメントによってコードされる ポリペプチド配列に実質的に同一であるポリペプチド配列を有する軽鎖可変領域 、 および(2)CL遺伝子セグメントによってコードされるポリペプチド配列に実質 的に同一であるポリペプチド配列を有する軽鎖定常領域、から構成されるヒト配 列軽鎖;ならびに (1)ヒトVH遺伝子セグメント、必要に応じてD領域、およびヒトJHセグメン トによってコードされるポリペプチド配列に実質的に同一であるポリペプチド配 列を有する重鎖可変領域、および(2)ヒトCH遺伝子セグメントによってコード されるポリペプチド配列に実質的に同一であるポリペプチド配列を有する定常領 域、から構成されるヒト配列重鎖、 からなる、組成物。 8.前記ヒトモノクローナル抗体がGROαに特異的に結合する、請求項7に記載 の組成物。 9.患者の血管系からの好中球の流出を防止する方法であって、ヒトインターロ イキン−8への結合についての少なくとも2×109M-1の親和定数(Ka)を有する ヒトモノクローナル抗体の有効量を投与する工程を包含する、方法。 10.再灌流傷害を処置する方法であって、ヒトインターロイキン−8への結合 についての少なくとも2×109M-1の親和定数(Ka)を有するヒトモノクローナル 抗体の治療有効用量を患者に投与する工程を包含する、方法。 11.霊長類におけるTヘルパー細胞依存性免疫応答を抑制する方法であって、 ヒトCD-4への結合についての少なくとも2×109M-1の親和定数(Ka)を有するヒ トモノクローナル抗体の治療有効用量を投与する工程を包含する、方法。 12.前記霊長類がチンパンジーである、請求項11に記載の方法。 13.前記抗体が、VH4-34セグメント、JH5セグメント、配列VINWFDPを含む重鎖 CDR3領域、VkL19セグメント、Jk2セグメント、および配列QQANSFPYTを含む軽鎖C D3領域を含む、請求項11に記載の方法。 14.前記抗体が6G5である、請求項13に記載の方法。 15.前記抗体が、VH5-51セグメント、JH2セグメント、配列PANWNWYFVLを含む 重鎖CDR3領域、VkL18セグメント、Jk4セグメント、および配列QQFISYPQLTを含む 軽鎖CD3領域を含む、請求項11に記載の方法。 16.前記抗体が1G2である、請求項15に記載の方法。
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US08/758,417 | 1996-12-02 | ||
US08/758,417 US6300129B1 (en) | 1990-08-29 | 1996-12-02 | Transgenic non-human animals for producing heterologous antibodies |
PCT/US1997/021803 WO1998024884A1 (en) | 1996-12-02 | 1997-12-01 | Transgenic non-human animals capable of producing heterologous antibodies |
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JP (2) | JP2001527386A (ja) |
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JP2009532034A (ja) * | 2006-03-31 | 2009-09-10 | メダレックス インコーポレーティッド | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
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WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
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WO1996002647A1 (en) * | 1994-07-19 | 1996-02-01 | Beth Israel Hospital | Antibodies that bind a conformationally altered cd4 molecule induced upon human immunodefficiency virus binding |
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CA2219486A1 (en) * | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
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1996
- 1996-12-02 US US08/758,417 patent/US6300129B1/en not_active Expired - Lifetime
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- 1997-12-01 AU AU56881/98A patent/AU747370B2/en not_active Expired
- 1997-12-01 EP EP97953058A patent/EP0942959A4/en not_active Withdrawn
- 1997-12-01 WO PCT/US1997/021803 patent/WO1998024884A1/en active IP Right Grant
- 1997-12-01 CA CA002274105A patent/CA2274105A1/en not_active Abandoned
- 1997-12-01 JP JP52568798A patent/JP2001527386A/ja not_active Ceased
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2008
- 2008-09-18 JP JP2008239776A patent/JP2009045066A/ja active Pending
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US8383796B2 (en) | 2005-07-01 | 2013-02-26 | Medarex, Inc. | Nucleic acids encoding monoclonal antibodies to programmed death ligand 1 (PD-L1) |
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US9102725B2 (en) | 2005-07-01 | 2015-08-11 | E. R. Squibb & Sons, L. L. C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
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US20160075782A1 (en) | 2005-07-01 | 2016-03-17 | E.R. Squibb & Sons, L. L. C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
US9580505B2 (en) | 2005-07-01 | 2017-02-28 | E.R. Squibb & Sons, L. L. C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
US9580507B2 (en) | 2005-07-01 | 2017-02-28 | E.R. Squibb & Sons, L. L. C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
JP2018027952A (ja) * | 2005-07-01 | 2018-02-22 | イー・アール・スクイブ・アンド・サンズ・リミテッド・ | プログラム死リガンド1(pd−l1)に対するヒトモノクローナル抗体 |
JP2009532034A (ja) * | 2006-03-31 | 2009-09-10 | メダレックス インコーポレーティッド | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
JP2010513529A (ja) * | 2006-12-22 | 2010-04-30 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ヒトil−12を結合するヒト抗体及び製造方法 |
Also Published As
Publication number | Publication date |
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JP2009045066A (ja) | 2009-03-05 |
AU5688198A (en) | 1998-06-29 |
EP0942959A1 (en) | 1999-09-22 |
AU747370B2 (en) | 2002-05-16 |
EP0942959A4 (en) | 2005-04-13 |
WO1998024884A1 (en) | 1998-06-11 |
CA2274105A1 (en) | 1998-06-11 |
US6300129B1 (en) | 2001-10-09 |
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