JP4361545B2 - ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 - Google Patents
ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 Download PDFInfo
- Publication number
- JP4361545B2 JP4361545B2 JP2006128058A JP2006128058A JP4361545B2 JP 4361545 B2 JP4361545 B2 JP 4361545B2 JP 2006128058 A JP2006128058 A JP 2006128058A JP 2006128058 A JP2006128058 A JP 2006128058A JP 4361545 B2 JP4361545 B2 JP 4361545B2
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- human
- seq
- antibodies
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67946605P | 2005-05-09 | 2005-05-09 | |
| US73843405P | 2005-11-21 | 2005-11-21 | |
| US74891905P | 2005-12-08 | 2005-12-08 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009086400A Division JP5028700B2 (ja) | 2005-05-09 | 2009-03-31 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006340714A JP2006340714A (ja) | 2006-12-21 |
| JP2006340714A5 JP2006340714A5 (Direct) | 2009-05-14 |
| JP4361545B2 true JP4361545B2 (ja) | 2009-11-11 |
Family
ID=37396674
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006128058A Active JP4361545B2 (ja) | 2005-05-09 | 2006-05-02 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2009086400A Active JP5028700B2 (ja) | 2005-05-09 | 2009-03-31 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2012106662A Active JP5872377B2 (ja) | 2005-05-09 | 2012-05-08 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2014010140A Pending JP2014077015A (ja) | 2005-05-09 | 2014-01-23 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2015213586A Active JP6185971B2 (ja) | 2005-05-09 | 2015-10-30 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2016220640A Pending JP2017052784A (ja) | 2005-05-09 | 2016-11-11 | Programmed Death 1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2019018345A Active JP6975733B2 (ja) | 2005-05-09 | 2019-02-05 | Programmed Death 1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2021149019A Active JP7443302B2 (ja) | 2005-05-09 | 2021-09-14 | Programmed Death 1(PD-1)に対するヒトモノクローナル抗体および抗PD-1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2023205124A Pending JP2024023539A (ja) | 2005-05-09 | 2023-12-05 | Programmed Death 1(PD-1)に対するヒトモノクローナル抗体および抗PD-1抗体単独または他の免疫療法と併用した癌治療方法 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009086400A Active JP5028700B2 (ja) | 2005-05-09 | 2009-03-31 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2012106662A Active JP5872377B2 (ja) | 2005-05-09 | 2012-05-08 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2014010140A Pending JP2014077015A (ja) | 2005-05-09 | 2014-01-23 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2015213586A Active JP6185971B2 (ja) | 2005-05-09 | 2015-10-30 | ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2016220640A Pending JP2017052784A (ja) | 2005-05-09 | 2016-11-11 | Programmed Death 1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2019018345A Active JP6975733B2 (ja) | 2005-05-09 | 2019-02-05 | Programmed Death 1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2021149019A Active JP7443302B2 (ja) | 2005-05-09 | 2021-09-14 | Programmed Death 1(PD-1)に対するヒトモノクローナル抗体および抗PD-1抗体単独または他の免疫療法と併用した癌治療方法 |
| JP2023205124A Pending JP2024023539A (ja) | 2005-05-09 | 2023-12-05 | Programmed Death 1(PD-1)に対するヒトモノクローナル抗体および抗PD-1抗体単独または他の免疫療法と併用した癌治療方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (10) | US8008449B2 (Direct) |
| EP (6) | EP2439273B1 (Direct) |
| JP (9) | JP4361545B2 (Direct) |
| KR (3) | KR101498834B1 (Direct) |
| CN (5) | CN105315373B (Direct) |
| AU (1) | AU2006244885B2 (Direct) |
| BE (1) | BE2015C074I2 (Direct) |
| BR (1) | BRPI0610235B8 (Direct) |
| CA (3) | CA2970873C (Direct) |
| CY (2) | CY2015057I1 (Direct) |
| DK (2) | DK2161336T4 (Direct) |
| ES (2) | ES2427646T5 (Direct) |
| FR (1) | FR15C0087I2 (Direct) |
| HU (2) | HUE044719T2 (Direct) |
| IL (2) | IL187108A (Direct) |
| LT (2) | LT2439273T (Direct) |
| LU (1) | LU92904I2 (Direct) |
| MX (1) | MX2007013978A (Direct) |
| NL (1) | NL300782I2 (Direct) |
| NO (6) | NO341219B1 (Direct) |
| NZ (1) | NZ563193A (Direct) |
| PL (2) | PL2439273T3 (Direct) |
| PT (2) | PT2439273T (Direct) |
| RU (4) | RU2494107C2 (Direct) |
| SI (2) | SI2439273T1 (Direct) |
| TW (1) | TWI379898B (Direct) |
| WO (1) | WO2006121168A1 (Direct) |
Families Citing this family (2199)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| CN1652820A (zh) * | 2002-04-12 | 2005-08-10 | 梅达雷克斯公司 | 使用ctla-4抗体的治疗方法 |
| SI2206517T1 (sl) | 2002-07-03 | 2023-12-29 | Ono Pharmaceutical Co., Ltd. | Imunopotencirni sestavki,ki obsegajo protitelesa proti PD-L1 |
| ES2357505T3 (es) | 2002-09-11 | 2011-04-27 | Genentech, Inc. | Composición y procedimientos novedosos para el tratamiento de enfermedades inmunorelacionadas. |
| DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| PL2439273T3 (pl) | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Ludzkie przeciwciała monoklonalne przeciwko białku programowanej śmierci komórki 1(pd-1) oraz metody leczenia nowotworów z wykorzystaniem przeciwciał anty-pd-1 samodzielnie lub w połączeniu z innymi immunoterapeutykami |
| MY153424A (en) | 2005-05-10 | 2015-02-13 | Incyte Corp | Modulators of indoleamine 2,3-dioxygenase and methods of using the same |
| KR101804078B1 (ko) | 2005-06-08 | 2017-12-01 | 다나-파버 캔서 인스티튜트 인크. | 예정 세포사 1(pd-1) 경로를 억제함으로써 지속 감염 및 암을 치료하기 위한 방법 및 조성물 |
| HRP20080053A2 (hr) | 2005-07-01 | 2009-08-31 | Medarex | Ljudska monoklonska protutijela na ligand 1 za programiranu smrt stanice (pd-l1) |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| WO2007067959A2 (en) | 2005-12-07 | 2007-06-14 | Medarex, Inc. | Ctla-4 antibody dosage escalation regimens |
| EP2889309B1 (en) | 2006-03-03 | 2017-12-27 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of pd-1 or pd-l1 |
| CA2663521A1 (en) * | 2006-09-20 | 2008-07-17 | The Johns Hopkins University | Combinatorial therapy of cancer and infectious diseases with anti-b7-h1 antibodies |
| AU2013200388B2 (en) * | 2006-12-27 | 2014-10-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of infections and tumors |
| NZ600281A (en) * | 2006-12-27 | 2013-03-28 | Harvard College | Compositions and methods for the treatment of infections and tumors |
| WO2008100562A2 (en) * | 2007-02-14 | 2008-08-21 | Medical College Of Georgia Research Institute, Inc. | Indoleamine 2,3-dioxygenase, pd-1/pd-l pathways, and ctla4 pathways in the activation of regulatory t cells |
| KR101580937B1 (ko) | 2007-06-01 | 2015-12-31 | 유니버시티 오브 매릴랜드, 발티모어 | 면역글로불린 불변영역 Fc 수용체 결합제 |
| AU2014201367B2 (en) * | 2007-06-18 | 2016-01-28 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
| WO2008156712A1 (en) * | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| US20090028857A1 (en) * | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
| EP2195347A1 (en) | 2007-08-17 | 2010-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating and diagnosing hematologic malignancies |
| WO2009067812A1 (en) | 2007-11-28 | 2009-06-04 | Universite De Montreal | Pd-1 modulation and uses thereof |
| EP3153526B1 (en) | 2008-01-31 | 2020-09-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| SI2279412T1 (sl) | 2008-04-09 | 2017-10-30 | Genentech, Inc., | Novi sestavki in postopki za zdravljenje imunsko povezanih bolezni |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| ES2741730T3 (es) | 2008-05-19 | 2020-02-12 | Advaxis Inc | Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico |
| JP5945096B2 (ja) * | 2008-07-04 | 2016-07-05 | 小野薬品工業株式会社 | 抗ヒトpd−1抗体の癌に対する治療効果を最適化するための判定マーカーの使用 |
| ME03065B (me) * | 2008-07-08 | 2019-01-20 | Incyte Holdings Corp | 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze |
| WO2010014784A2 (en) | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| RS54233B1 (sr) | 2008-08-25 | 2015-12-31 | Amplimmune Inc. | Kompozicije pd-1 antagonista i postupci za njihovu primenu |
| EP2662383A1 (en) * | 2008-08-25 | 2013-11-13 | Amplimmune, Inc. | PD-I antagonists and methods for treating infectious disease |
| EP2342228B1 (en) | 2008-09-12 | 2017-09-06 | Oxford University Innovation Limited | Pd-1 specific antibodies and uses thereof |
| CA2736829C (en) * | 2008-09-12 | 2018-02-27 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
| MX2011003195A (es) * | 2008-09-26 | 2011-08-12 | Dana Farber Cancer Inst Inc | Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. |
| SG2014010573A (en) * | 2008-11-12 | 2014-04-28 | Merck Sharp & Dohme | ßGI-IGG INTRON FOR ENHANCED ANTI-IGF1 R EXPRESSION |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| EP2356446A4 (en) * | 2008-11-14 | 2014-03-19 | Brigham & Womens Hospital | Therapeutic and diagnostic methods related to cancer stem cells |
| SI2370593T1 (sl) | 2008-11-28 | 2016-08-31 | Emory University | Postopek za določanje učinkovitosti antagonista pd-1 |
| FI4209510T3 (fi) | 2008-12-09 | 2024-03-22 | Hoffmann La Roche | Anti-PD-L1-vasta-aineita ja niiden käyttö T-solutoiminnan tehostamiseksi |
| JP5844159B2 (ja) * | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | Pd−1抗体およびpd−l1抗体ならびにその使用 |
| PE20120923A1 (es) | 2009-03-30 | 2012-08-27 | Eisai Randd Man Co Ltd | Composiciones farmaceuticas comprendiendo liposomas que contiene eribulina o una sal del mismo |
| WO2010148501A1 (en) | 2009-06-26 | 2010-12-29 | Soricimed Biopharma Inc. | Soricidin derived peptides and methods for the detection of trpv-6 cancers and drug delivery |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| TH121482A (th) | 2009-08-19 | 2013-02-28 | นางสาวปัณณพัฒน์ เหลืองธาตุทอง | องค์ประกอบทางเภสัชกรรมที่ประกอบด้วยอนุพันธ์ของควิโนลีน |
| WO2011041613A2 (en) | 2009-09-30 | 2011-04-07 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for the treatment of cancer |
| ES2895226T3 (es) | 2009-10-16 | 2022-02-18 | Mereo Biopharma 5 Inc | Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| US8993731B2 (en) | 2010-03-11 | 2015-03-31 | Ucb Biopharma Sprl | PD-1 antibody |
| TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20110288545A1 (en) * | 2010-04-22 | 2011-11-24 | Old Dominion University Research Foundation | Method and Device for Ablation of Cancer and Resistance to New Cancer Growth |
| BR122021014039B1 (pt) | 2010-05-14 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Método de identificação de neoantígenos específicos de tumor |
| US20130064831A1 (en) * | 2010-05-17 | 2013-03-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| EP3543257A1 (en) | 2010-07-28 | 2019-09-25 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| HRP20220796T1 (hr) | 2010-10-01 | 2022-10-14 | ModernaTX, Inc. | Ribonukleinske kiseline koje sadrže n1-metil-pseudouracil i njihove uporabe |
| CN103282048B (zh) | 2010-10-01 | 2017-05-17 | 宾夕法尼亚大学理事会 | 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途 |
| EP2625292B1 (en) | 2010-10-07 | 2018-12-05 | The General Hospital Corporation | Biomarkers of cancer |
| EP2655409A4 (en) | 2010-12-22 | 2015-07-01 | Univ Leland Stanford Junior | SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2 |
| EP2683400A4 (en) | 2011-03-11 | 2014-09-17 | Advaxis | ADJUVANZIA ON LISTERIA BASE |
| AU2012236479B2 (en) | 2011-03-31 | 2016-10-20 | Merck Sharp & Dohme Llc | Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| MX338353B (es) | 2011-04-20 | 2016-04-13 | Medimmune Llc | Anticuerpos y otras moleculas que se unen a b7 - h1 y pd - 1. |
| SI3892295T1 (sl) | 2011-05-24 | 2023-09-29 | BioNTech SE | Individualizirana cepiva proti raku |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| WO2012166899A2 (en) | 2011-06-03 | 2012-12-06 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| CN103796680A (zh) * | 2011-06-21 | 2014-05-14 | 约翰霍普金斯大学 | 用于增强针对赘生物的基于免疫的治疗的聚焦放射 |
| WO2013013188A1 (en) | 2011-07-21 | 2013-01-24 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
| PE20190262A1 (es) * | 2011-08-01 | 2019-02-25 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek |
| ES2893855T3 (es) * | 2011-08-11 | 2022-02-10 | Ono Pharmaceutical Co | Agente terapéutico para enfermedades autoinmunes que comprende agonista de PD-1 |
| KR102004559B1 (ko) | 2011-08-30 | 2019-07-26 | 아스텍스 파마수티컬스, 인크. | 데시타빈 유도체 제제 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES2707580T3 (es) | 2011-09-23 | 2019-04-04 | Oncomed Pharm Inc | Agentes de unión a VEGF/DLL4 y usos de los mismos |
| SI3682905T1 (sl) | 2011-10-03 | 2022-04-29 | Modernatx, Inc. | Modificirani nukleozidi, nukleotidi in nukleinske kisline ter njihove uporabe |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| US11951157B2 (en) | 2011-10-11 | 2024-04-09 | Universitat Zurich | Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody |
| EP2766035B1 (en) | 2011-10-11 | 2018-03-28 | Universität Zürich Prorektorat MNW | Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy |
| TW201329078A (zh) | 2011-11-29 | 2013-07-16 | Ono Pharmaceutical Co | 嘌呤酮衍生物鹽酸鹽 |
| MX2014007233A (es) | 2011-12-16 | 2015-02-04 | Moderna Therapeutics Inc | Composiciones de nucleosidos, nucleotidos y acidos nucleicos modificados. |
| KR101968370B1 (ko) | 2011-12-28 | 2019-04-11 | 갈렉틴 테라퓨틱스, 인크. | 인간 질환의 치료를 위한 신규 탄수화물 약물의 조성물 |
| WO2013112986A1 (en) * | 2012-01-27 | 2013-08-01 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
| WO2013116656A1 (en) * | 2012-02-03 | 2013-08-08 | Emory University | Immunostimulatory compositions, particles, and uses related thereto |
| ES2615268T3 (es) | 2012-02-13 | 2017-06-06 | Bristol-Myers Squibb Company | Compuestos de enediino, conjugados de los mismos y usos y métodos para ello |
| JP6152120B2 (ja) | 2012-02-15 | 2017-06-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Fc受容体に基づくアフィニティークロマトグラフィー |
| CN104411327A (zh) | 2012-03-12 | 2015-03-11 | 阿德瓦希斯公司 | 李斯特菌疫苗治疗以后的抑制细胞功能抑制 |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| HK1207306A1 (en) | 2012-04-02 | 2016-01-29 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| PL2836234T3 (pl) | 2012-04-12 | 2020-02-28 | Yale University | Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych |
| WO2013169693A1 (en) | 2012-05-09 | 2013-11-14 | Bristol-Myers Squibb Company | Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody |
| CA2873402C (en) * | 2012-05-15 | 2023-10-24 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| KR102129636B1 (ko) * | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
| EP3495367B1 (en) | 2012-06-13 | 2020-09-30 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| AR091649A1 (es) * | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| EP2872646B1 (en) * | 2012-07-12 | 2017-08-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes |
| CN103566377A (zh) | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| JP6403166B2 (ja) * | 2012-08-03 | 2018-10-10 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | 単一抗原抗pd−l1およびpd−l2二重結合抗体およびその使用方法 |
| US10131712B2 (en) * | 2012-08-14 | 2018-11-20 | Ibc Pharmaceuticals, Inc. | Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors |
| US20150231241A1 (en) | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| CA2874864C (en) * | 2012-08-14 | 2023-02-21 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| CN104718223A (zh) | 2012-08-20 | 2015-06-17 | 格利克尼克股份有限公司 | 具有抗原结合和多价FCγ受体结合活性的分子 |
| JP6457940B2 (ja) | 2012-08-30 | 2019-01-23 | アムジエン・インコーポレーテツド | 単純ヘルペスウイルスおよび免疫チェックポイント阻害薬を使用して、メラノーマを治療するための方法 |
| KR102207767B1 (ko) | 2012-09-17 | 2021-01-26 | 갈렉틴 테라퓨틱스, 인크. | 암 치료에서의 특이적 면역요법을 강화하는 방법 |
| WO2014047085A2 (en) * | 2012-09-20 | 2014-03-27 | Rongfu Wang | Prostate-specific tumor antigen and uses thereof |
| PL2904011T3 (pl) * | 2012-10-02 | 2018-01-31 | Bristol Myers Squibb Co | Połączenie przeciwciał anty-kir i przeciwciał anty-pd-1 w leczeniu raka |
| EP2906241B1 (en) * | 2012-10-12 | 2020-01-08 | The Brigham and Women's Hospital, Inc. | Enhancement of the immune response |
| USRE50065E1 (en) | 2012-10-17 | 2024-07-30 | 10X Genomics Sweden Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| US10047164B2 (en) * | 2012-10-19 | 2018-08-14 | Opsona Therapeutics Limited | Methods and compositions for the treatment of pancreatic cancer |
| US9234035B2 (en) | 2012-10-22 | 2016-01-12 | Fountain Biopharma Inc. | Antibodies to interleukin-6 |
| ES2949394T3 (es) | 2012-11-05 | 2023-09-28 | Found Medicine Inc | Moléculas de fusión novedosas y usos de las mismas |
| RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
| US10155031B2 (en) | 2012-11-28 | 2018-12-18 | Biontech Rna Pharmaceuticals Gmbh | Individualized vaccines for cancer |
| JP2016500251A (ja) | 2012-12-03 | 2016-01-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 免疫調節Fc融合タンパク質の抗癌活性の増強 |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| AU2014207342C1 (en) | 2013-01-18 | 2019-04-04 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| CN103965363B (zh) * | 2013-02-06 | 2021-01-15 | 上海白泽生物科技有限公司 | 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途 |
| US20150377891A1 (en) | 2013-02-07 | 2015-12-31 | (Institute National De La Santé Et De La Rechere Médicale) | Methods for Predicting the Survival Time of Patients Suffering from Diffuse Large B-Cell Lymphomas |
| SI2956173T1 (sl) | 2013-02-14 | 2017-06-30 | Bristol-Myers Squibb Company | Spojine tubulizina, postopki pridobivanja in uporaba |
| UY35340A (es) | 2013-02-20 | 2014-09-30 | Novartis Ag | Marcaje efectivo de leucemia humana usando células diseñadas con un receptor quimérico de antígeno anti-cd123 |
| JP6647868B2 (ja) | 2013-02-20 | 2020-02-14 | ノバルティス アーゲー | ヒト化抗EGFRvIIIキメラ抗原受容体を用いたがんの処置 |
| SG11201506052PA (en) | 2013-02-22 | 2015-09-29 | Curevac Gmbh | Combination of vaccination and inhibition of the pd-1 pathway |
| DK3292873T3 (da) | 2013-02-22 | 2019-06-03 | Curevac Ag | Kombination af vaccination og hæmning af PD-1-vejen |
| CN113699114A (zh) * | 2013-02-26 | 2021-11-26 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| PL2961388T3 (pl) | 2013-03-01 | 2019-10-31 | Astex Pharmaceuticals Inc | Kombinacje lekowe |
| US9066979B2 (en) | 2013-03-06 | 2015-06-30 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
| ES2644022T3 (es) | 2013-03-14 | 2017-11-27 | Bristol-Myers Squibb Company | Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso |
| CN105209919B (zh) | 2013-03-15 | 2019-03-05 | 豪夫迈·罗氏有限公司 | 治疗pd-1和pd-l1相关疾患的生物标志物和方法 |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
| EP2981821B2 (en) | 2013-04-02 | 2021-11-03 | Merck Sharp & Dohme Corp. | Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue |
| CN107252485A (zh) * | 2013-04-03 | 2017-10-17 | Ibc药品公司 | 用于诱导对疾病的免疫应答的组合疗法 |
| HK1220155A1 (zh) | 2013-04-09 | 2017-04-28 | Boston Biomedical, Inc. | 治疗癌症的方法 |
| JP2016516772A (ja) | 2013-04-09 | 2016-06-09 | リクスト・バイオテクノロジー,インコーポレイテッド | オキサシクロヘプタン及びオキサビシクロヘプテンの配合物 |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Fgfr抑制剤としての二環式複素環 |
| EP2992017B1 (en) * | 2013-05-02 | 2020-11-18 | AnaptysBio, Inc. | Antibodies directed against programmed death-1 (pd-1) |
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| CN103242448B (zh) * | 2013-05-27 | 2015-01-14 | 郑州大学 | 一种全人源化抗pd-1单克隆抗体及其制备方法和应用 |
| WO2014194293A1 (en) | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
| WO2014193898A1 (en) * | 2013-05-31 | 2014-12-04 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
| EP3004169B1 (en) * | 2013-05-31 | 2023-03-22 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind pd-1 |
| WO2014209804A1 (en) * | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
| CN104250302B (zh) * | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| JP6636920B2 (ja) | 2013-07-16 | 2020-01-29 | ジェネンテック, インコーポレイテッド | Pd−1軸結合アンタゴニスト及びtigit阻害剤を使用するがんの治療方法 |
| WO2015016718A1 (en) | 2013-08-02 | 2015-02-05 | Bionovion Holding B.V. | Combining cd27 agonists and immune checkpoint inhibition for immune stimulation |
| EA031080B1 (ru) | 2013-08-08 | 2018-11-30 | Ситюн Фарма | МОДУЛОКИНЫ НА ОСНОВЕ ДОМЕНА SUSHI IL-15 И IL-15Rα |
| KR102861895B1 (ko) | 2013-08-08 | 2025-09-22 | 싸이튠 파마 | 병용 약학 조성물 |
| US9777013B2 (en) | 2013-08-14 | 2017-10-03 | William Marsh Rice University | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| AU2014309199B2 (en) | 2013-08-20 | 2018-04-19 | Merck Sharp & Dohme Llc | Treating cancer with a combination of a PD-1 antagonist and dinaciclib |
| BR112016004889B1 (pt) | 2013-09-06 | 2023-10-03 | Aurigene Discovery Technologies Limited | Derivados de 1,2,4-oxadiazol como imunomoduladores |
| CU24345B1 (es) | 2013-09-06 | 2018-05-08 | Aurigene Discovery Tech Ltd | Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores |
| EA201891818A3 (ru) | 2013-09-06 | 2019-03-29 | Ауриген Дискавери Текнолоджиз Лимитед | Способ получения соединений, используемых при получении циклических пептидомиметических соединений |
| WO2015036394A1 (en) * | 2013-09-10 | 2015-03-19 | Medimmune Limited | Antibodies against pd-1 and uses thereof |
| KR102100419B1 (ko) * | 2013-09-13 | 2020-04-14 | 베이진 스위찰랜드 게엠베하 | 항-pd1 항체 및 이의 치료 및 진단 용도 |
| JP6595458B2 (ja) | 2013-09-20 | 2019-10-23 | ブリストル−マイヤーズ スクイブ カンパニー | 腫瘍を処置するための抗lag−3抗体と抗pd−1抗体との組合せ |
| EP3049445A4 (en) | 2013-09-24 | 2017-10-25 | Medicenna Therapeutics, Inc. | Interleukin-2 fusion proteins and uses thereof |
| EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| CN104558177B (zh) * | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
| CN104560884A (zh) * | 2013-10-25 | 2015-04-29 | 苏州思坦维生物技术有限责任公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及分泌它的杂交瘤细胞系与用途 |
| WO2015066535A1 (en) | 2013-11-01 | 2015-05-07 | Yale University | Modular particles for immunotherapy |
| WO2015066413A1 (en) | 2013-11-01 | 2015-05-07 | Novartis Ag | Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections |
| EP4461372A3 (en) * | 2013-11-05 | 2025-01-22 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| HK1222803A1 (zh) | 2013-11-07 | 2017-07-14 | 豪夫迈.罗氏有限公司 | 抗cd20抗体与btk抑制剂的组合疗法 |
| WO2015070060A1 (en) * | 2013-11-11 | 2015-05-14 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| MX2016006316A (es) | 2013-11-13 | 2016-07-26 | Novartis Ag | Inhibidores de mtor para potenciar la respuesta inmunitaria. |
| DK3071697T3 (da) | 2013-11-22 | 2020-01-27 | Dnatrix Inc | Adenovirus der udtrykker immuncelle-stimulatorisk(e) receptor agonist(er) |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| ES2808684T3 (es) * | 2013-11-25 | 2021-03-01 | Famewave Ltd | Composiciones que incluyen anticuerpos anti-ceacam1 y anti-pd para terapia de cáncer |
| US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| AU2014360318B2 (en) | 2013-12-05 | 2019-10-31 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (RF-EMB) |
| US10241115B2 (en) | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| DK3081576T3 (da) | 2013-12-12 | 2019-10-21 | Shanghai hengrui pharmaceutical co ltd | Pd-1-antistof, antigenbindende fragment deraf og medicinsk anvendelse deraf |
| US20160304969A1 (en) | 2013-12-17 | 2016-10-20 | Merck Sharp & Dohme Corp. | Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists |
| US9067998B1 (en) * | 2014-07-15 | 2015-06-30 | Kymab Limited | Targeting PD-1 variants for treatment of cancer |
| EP3083690A1 (en) | 2013-12-17 | 2016-10-26 | F.Hoffmann-La Roche Ag | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
| SG10202002334PA (en) | 2013-12-17 | 2020-05-28 | Genentech Inc | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
| EP3527587A1 (en) | 2013-12-17 | 2019-08-21 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists |
| AU2014366047B2 (en) | 2013-12-19 | 2021-03-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| AU2014368449C1 (en) | 2013-12-20 | 2021-05-06 | Intervet International B.V. | Canine antibodies with modified CH2-CH3 sequences |
| JP7060324B2 (ja) * | 2013-12-20 | 2022-04-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | ネオ抗原ワクチンによる併用療法 |
| CA3156357A1 (en) | 2014-01-06 | 2015-07-09 | The Trustees Of The University Of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
| JP2017502068A (ja) | 2014-01-10 | 2017-01-19 | シャンハイ バーディー バイオテック インコーポレイテッド | Her2陽性腫瘍を処置するための化合物及び組成物 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| EP3096782A4 (en) * | 2014-01-21 | 2017-07-26 | Medlmmune, LLC | Compositions and methods for modulating and redirecting immune responses |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| TW201613635A (en) | 2014-02-04 | 2016-04-16 | Pfizer | Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer |
| EP3102605B1 (en) | 2014-02-04 | 2018-11-14 | Pfizer Inc | Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer |
| PH12020550847A1 (en) | 2014-02-04 | 2022-05-11 | Incyte Corp | Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer |
| LT3134123T (lt) * | 2014-02-21 | 2021-04-12 | Nektar Therapeutics (India) Pvt. Ltd. | Il-2rbeta atžvilgiu selektyvūs agonistai derinyje su anti-ctla-4 antikūnu arba anti-pd-1 antikūnu |
| EP3338801A1 (en) * | 2014-02-21 | 2018-06-27 | Idac Theranostics, Inc. | Therapeutic agent for solid cancer |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| EP3572430A3 (en) * | 2014-03-05 | 2020-02-12 | Bristol-Myers Squibb Company | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| WO2015135558A1 (en) | 2014-03-12 | 2015-09-17 | Curevac Gmbh | Combination of vaccination and ox40 agonists |
| JP6903432B2 (ja) | 2014-03-12 | 2021-07-14 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | Cnsの疾患および傷害を処置するために全身性調節性t細胞のレベルまたは活性を低下させること |
| TWI898718B (zh) | 2014-03-14 | 2025-09-21 | 瑞士商諾華公司 | 針對lag-3之抗體分子及其用途 |
| US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| PL3122745T3 (pl) | 2014-03-24 | 2019-08-30 | Novartis Ag | Monobaktamowe związki organiczne do leczenia zakażeń bakteryjnych |
| CA2944456C (en) * | 2014-03-31 | 2023-10-31 | The Johns Hopkins University | Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-ctla-4 and/or anti-pd-1 antibodies to treat solid tumor malignancies |
| CR20160500A (es) | 2014-03-31 | 2016-12-14 | Genentech Inc | Anticuerpos anti-ox40 y métodos de uso |
| MA39817A (fr) | 2014-03-31 | 2017-02-08 | Hoffmann La Roche | Thérapie combinatoires comprenant des agents anti-angiogenèse et des agonistes se liant à ox40 |
| CN104974253A (zh) * | 2014-04-01 | 2015-10-14 | 上海中信国健药业股份有限公司 | 抗ctla-4/pd-1双特异性抗体、其制备方法及应用 |
| US9987258B2 (en) | 2014-04-06 | 2018-06-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Histone deacetylase as a modulator of PDL1 expression and activity |
| DK3888674T3 (da) | 2014-04-07 | 2024-07-08 | Novartis Ag | Behandling af cancer ved anvendelse af anti-cd19-kimær antigenreceptor |
| EP3154350B1 (en) | 2014-04-10 | 2024-03-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
| JP6592505B2 (ja) | 2014-04-24 | 2019-10-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン−2のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト |
| CN105031630A (zh) * | 2014-04-28 | 2015-11-11 | 四川大学 | 同时分泌pd-1中和抗体和gm-csf因子的肿瘤细胞疫苗及其制备方法 |
| HRP20202030T1 (hr) | 2014-04-30 | 2021-02-19 | Fujifilm Corporation | Liposomska kompozicija i postupak za njeno dobivanje |
| NZ725459A (en) * | 2014-05-13 | 2023-04-28 | Bavarian Nordic As | Combination therapy for treating cancer with a recombinant poxvirus expressing a tumor antigen and an immune checkpoint molecule antagonist or agonist |
| DK3142689T3 (da) * | 2014-05-13 | 2021-02-15 | Bavarian Nordic As | Kombinationsbehandling til behandling af cancer med en koppevirus, som udtrykker et tumorantigen, og et monoklonalt antistof mod tim-3 |
| KR20250153873A (ko) * | 2014-05-15 | 2025-10-27 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 사용한 폐암의 치료 |
| CA2949961C (en) | 2014-05-23 | 2023-09-19 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of cancer |
| AU2015265607A1 (en) | 2014-05-28 | 2016-11-17 | Idenix Pharmaceuticals Llc | Nucleoside derivatives for the treatment of cancer |
| SG11201609721WA (en) | 2014-05-28 | 2016-12-29 | Agenus Inc | Anti-gitr antibodies and methods of use thereof |
| KR102204937B1 (ko) | 2014-06-06 | 2021-01-18 | 브리스톨-마이어스 스큅 컴퍼니 | 글루코코르티코이드-유도 종양 괴사 인자 수용체 (gitr)에 대한 항체 및 그의 용도 |
| SG11201609638RA (en) | 2014-06-19 | 2016-12-29 | Regeneron Pharma | Non-human animals having a humanized programmed cell death 1 gene |
| US10301624B2 (en) | 2014-06-25 | 2019-05-28 | The General Hospital Corporation | Targeting human satellite II (HSATII) |
| TWI693232B (zh) * | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| US10544225B2 (en) | 2014-07-03 | 2020-01-28 | Beigene, Ltd. | Anti-PD-L1 antibodies and their use as therapeutics and diagnostics |
| JP6789124B2 (ja) * | 2014-07-03 | 2020-11-25 | イエール ユニバーシティ | 腫瘍形成を抑制するディコップ2(Dickkopf2)(Dkk2)阻害 |
| KR102462743B1 (ko) | 2014-07-09 | 2022-11-02 | 버디 바이오파마슈티칼즈, 인크. | 종양 치료용 항-pd-l1 조합 |
| WO2016007876A1 (en) | 2014-07-10 | 2016-01-14 | Biothera, Inc. | Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment |
| EP3166974A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Anti-pd-l1 antibodies and diagnostic uses thereof |
| BR112017000672A2 (pt) | 2014-07-15 | 2017-11-14 | Genentech Inc | composições para tratamento de câncer utilizando antagonistas de ligação de eixo pd-1 e inibidores de mek |
| AU2015289922A1 (en) * | 2014-07-15 | 2017-02-16 | The Johns Hopkins University | Suppression of myeloid derived suppressor cells and immune checkpoint blockade |
| WO2016009017A1 (en) | 2014-07-16 | 2016-01-21 | Institut Gustave-Roussy | Combination of oncolytic virus with immune checkpoint modulators |
| CA2954841A1 (en) | 2014-07-16 | 2016-01-21 | Transgene Sa | Oncolytic virus for expression of immune checkpoint modulators |
| SG10201913696YA (en) | 2014-07-18 | 2020-03-30 | Advaxis Inc | Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer |
| CN112481283A (zh) | 2014-07-21 | 2021-03-12 | 诺华股份有限公司 | 使用cd33嵌合抗原受体治疗癌症 |
| EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| EP3171892B1 (en) * | 2014-07-22 | 2021-11-24 | Apollomics Inc. | Anti-pd-1 antibodies |
| CN105330740B (zh) * | 2014-07-30 | 2018-08-17 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| EP3660042B1 (en) | 2014-07-31 | 2023-01-11 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
| CN105296433B (zh) * | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
| ES2987034T3 (es) | 2014-08-05 | 2024-11-13 | Apollomics Inc | Anticuerpos anti-PD-L1 |
| DK3177644T3 (da) * | 2014-08-05 | 2021-01-11 | MabQuest SA | Immunologiske reagenser, som binder til PD-1 |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| WO2016020836A1 (en) | 2014-08-06 | 2016-02-11 | Novartis Ag | Quinolone derivatives as antibacterials |
| TW201618775A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | Btk抑制劑、pi3k抑制劑、jak-2抑制劑、pd-1抑制劑及/或pd-l1抑制劑之治療組合物 |
| US20170224777A1 (en) | 2014-08-12 | 2017-08-10 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| JP6654187B2 (ja) | 2014-08-12 | 2020-02-26 | アリゲーター・バイオサイエンス・アーベー | 抗cd40抗体を用いた併用療法 |
| AU2015301753B2 (en) | 2014-08-12 | 2021-04-08 | Massachusetts Institute Of Technology | Synergistic tumor treatment with IL-2 and integrin-binding-Fc-fusion protein |
| AU2015301460B2 (en) | 2014-08-14 | 2021-04-08 | Novartis Ag | Treatment of cancer using GFR alpha-4 chimeric antigen receptor |
| DK3183268T3 (da) | 2014-08-19 | 2020-05-11 | Univ Pennsylvania | Behandling af cancer ved anvendelse af en cd123-kimær antigenreceptor |
| EP3232199B1 (en) | 2014-08-19 | 2022-05-04 | National University Corporation Okayama University | Combination of immunosuppressive factor blocking agent and biguanide antidiabetic drug for use in a method of preventing progression of, treating and/or preventing cancer |
| EP3185866A1 (en) | 2014-08-25 | 2017-07-05 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| KR102512940B1 (ko) | 2014-08-28 | 2023-03-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고순도의 퀴놀린 유도체 및 이를 제조하는 방법 |
| WO2016030455A1 (en) * | 2014-08-28 | 2016-03-03 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer |
| HRP20190881T1 (hr) | 2014-08-28 | 2019-07-12 | Halozyme, Inc. | Kombinacijska terapija s hijaluronan-razgrađujućim enzimom i inhibitorom imunološke kontrolne točke |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| US9535074B2 (en) | 2014-09-08 | 2017-01-03 | Merck Sharp & Dohme Corp. | Immunoassay for soluble PD-L1 |
| WO2016040313A2 (en) * | 2014-09-08 | 2016-03-17 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer |
| WO2016040892A1 (en) | 2014-09-13 | 2016-03-17 | Novartis Ag | Combination therapies |
| PT3799885T (pt) * | 2014-09-16 | 2025-10-31 | Innate Pharma | Neutralização de vias inibidoras em linfócitos |
| EP3194443B1 (en) | 2014-09-17 | 2021-07-14 | Novartis AG | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| RS60349B8 (sr) | 2014-09-23 | 2022-10-31 | Hoffmann La Roche | Postupak upotrebe anti-cd79b imunokonjugata |
| WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
| CN107074952B (zh) | 2014-09-30 | 2021-04-09 | 英特维特国际股份有限公司 | 结合犬pd-l1的pd-l1抗体 |
| AU2015327868A1 (en) | 2014-10-03 | 2017-04-20 | Novartis Ag | Combination therapies |
| AU2015330898B2 (en) | 2014-10-08 | 2022-03-10 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| WO2016057898A1 (en) | 2014-10-10 | 2016-04-14 | Idera Pharmaceuticals, Inc. | Treatment of cancer using tlr9 agonist with checkpoint inhibitors |
| DK3204417T3 (da) | 2014-10-10 | 2020-10-12 | Innate Pharma | Cd73-blokering |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| ES2753391T3 (es) | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
| CN107001478B (zh) | 2014-10-14 | 2022-01-11 | 诺华股份有限公司 | 针对pd-l1的抗体分子及其用途 |
| WO2016059602A2 (en) * | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
| EP3206688A4 (en) * | 2014-10-16 | 2018-06-13 | Epizyme, Inc. | Method for treating cancer |
| CA2962451C (en) * | 2014-10-21 | 2023-01-17 | Sciclone Pharmaceuticals, Inc. | Treatment of cancer with immune stimulators |
| GB201419084D0 (en) * | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
| BR112017008914A2 (pt) | 2014-10-29 | 2018-01-16 | Five Prime Therapeutics, Inc. | método para tratar câncer, composição e uso da composição |
| CN107530419B (zh) * | 2014-10-31 | 2021-05-18 | 昂考梅德药品有限公司 | 治疗疾病的组合疗法 |
| KR20170074246A (ko) | 2014-11-03 | 2017-06-29 | 제넨테크, 인크. | Ox40 효능제 치료의 효능 예측 및 평가용 방법 및 바이오마커 |
| MX2017005750A (es) | 2014-11-03 | 2017-12-15 | Genentech Inc | Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso. |
| JP7305300B2 (ja) | 2014-11-05 | 2023-07-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 併用免疫療法 |
| AR102521A1 (es) | 2014-11-06 | 2017-03-08 | Hoffmann La Roche | Variantes de región fc con unión de fcrn modificada y métodos de utilización |
| ES2875338T3 (es) * | 2014-11-06 | 2021-11-10 | Hibercell Inc | Métodos de beta-glucano y composiciones que afectan al microentorno tumoral |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| US10822414B2 (en) * | 2014-11-11 | 2020-11-03 | Sutro Biopharma, Inc. | Anti-PD-1 antibodies, compositions comprising anti-PD-1 antibodies and methods of using anti-PD-1 antibodies |
| CN113694193A (zh) | 2014-11-13 | 2021-11-26 | 约翰·霍普金斯大学 | 检查点阻断和微卫星不稳定性 |
| BR112017009813A2 (pt) | 2014-11-14 | 2017-12-26 | Novartis Ag | conjugados de anticorpo fármaco |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| SG10201807625PA (en) | 2014-11-17 | 2018-10-30 | Genentech Inc | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| LT3221355T (lt) | 2014-11-20 | 2020-12-28 | F. Hoffmann-La Roche Ag | Kombinuotoji t ląsteles aktyvinančių bispecifinių antigeną surišančių molekulių cd3 bei folato receptoriaus 1 (folr1) ir pd-1 ašą surišančių antagonistų terapija |
| WO2016081854A1 (en) | 2014-11-20 | 2016-05-26 | Promega Corporation | Systems and methods for assessing modulators of immune checkpoints |
| KR20230125855A (ko) | 2014-11-21 | 2023-08-29 | 브리스톨-마이어스 스큅 컴퍼니 | Cd73에 대항한 항체 및 그의 용도 |
| PL3221346T3 (pl) | 2014-11-21 | 2021-03-08 | Bristol-Myers Squibb Company | Przeciwciała ze zmodyfikowanym regionem stałym łańcucha ciężkiego |
| CA2968961A1 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Methods and compositions for 18f-radiolabeling of biologics |
| EP3224277B1 (en) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| US9763922B2 (en) | 2014-11-27 | 2017-09-19 | Genentech, Inc. | Therapeutic compounds and uses thereof |
| US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| KR102597989B1 (ko) | 2014-12-04 | 2023-11-02 | 얀센 바이오테크 인코포레이티드 | 급성 골수성 백혈병을 치료하기 위한 항-cd38 항체 |
| EA201791049A1 (ru) | 2014-12-04 | 2017-10-31 | Бристол-Майерс Сквибб Компани | Комбинация анти-cs1 и анти-pd1 антител для лечения рака (миеломы) |
| EP3226688B1 (en) | 2014-12-05 | 2020-07-01 | Merck Sharp & Dohme Corp. | Tricyclic compounds as inhibitors of mutant idh enzymes |
| EP3226689B1 (en) | 2014-12-05 | 2020-01-15 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
| EP3226690B1 (en) | 2014-12-05 | 2020-05-20 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
| WO2016090300A1 (en) | 2014-12-05 | 2016-06-09 | Genentech, Inc. | Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists |
| WO2016089610A1 (en) | 2014-12-06 | 2016-06-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bispecific antibody for cancer immunotherapy |
| WO2016094273A1 (en) | 2014-12-08 | 2016-06-16 | Dana-Farber Cancer Institute, Inc. | Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents |
| AU2015360736A1 (en) | 2014-12-09 | 2017-06-01 | Merck Sharp & Dohme Corp. | System and methods for deriving gene signature biomarkers of response to PD-1 antagonists |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
| DK3233843T3 (da) | 2014-12-16 | 2019-11-18 | Novartis Ag | Isoxazol-hydraxamsyreforbindelser som LPXC-hæmmere |
| MA40948A (fr) | 2014-12-18 | 2017-10-25 | Amgen Inc | Formulation de virus de l'herpès simplex congelée stable |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
| US10975442B2 (en) | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| EP4636401A2 (en) | 2014-12-19 | 2025-10-22 | The Broad Institute, Inc. | Methods for profiling the t-cell-receptor repertoire |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| CA3175979A1 (en) | 2014-12-22 | 2016-06-30 | Pd-1 Acquisition Group, Llc | Anti-pd-1 antibodies |
| US11639385B2 (en) | 2014-12-22 | 2023-05-02 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
| WO2016106160A1 (en) * | 2014-12-22 | 2016-06-30 | Enumeral Biomedical Holdings, Inc. | Methods for screening therapeutic compounds |
| MA40662B1 (fr) | 2014-12-23 | 2020-12-31 | Bristol Myers Squibb Co | Anticorps contre tigit |
| ME03077B (me) | 2014-12-23 | 2019-01-20 | 4D Pharma Res Ltd | Pirinski polipepтid i imunska modulacija |
| CN104479020B (zh) * | 2014-12-26 | 2019-08-02 | 上海复宏汉霖生物技术股份有限公司 | 一种抗pd-1人源抗体 |
| GB201500319D0 (en) * | 2015-01-09 | 2015-02-25 | Agency Science Tech & Res | Anti-PD-L1 antibodies |
| AU2016206808A1 (en) | 2015-01-14 | 2017-08-31 | Bristol-Myers Squibb Company | Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using |
| AU2016209337A1 (en) * | 2015-01-20 | 2017-07-13 | Immunexcite, Inc. | Compositions and methods for cancer immunotherapy |
| MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| JP6723249B2 (ja) | 2015-01-30 | 2020-07-15 | アールエフイーエムビー ホールディングス リミテッド ライアビリティ カンパニー | 軟部組織を切除するためのシステムおよび方法 |
| HK1247861A1 (zh) | 2015-01-30 | 2018-10-05 | President And Fellows Of Harvard College | 用於癌症治疗的肿瘤周围和肿瘤内部材料 |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10983128B2 (en) | 2015-02-05 | 2021-04-20 | Bristol-Myers Squibb Company | CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy |
| US20180244779A1 (en) * | 2015-02-06 | 2018-08-30 | Kadmon Corporation Llc | Immunomodulatory agents |
| WO2016128912A1 (en) | 2015-02-12 | 2016-08-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor, and/or a pd-l1 inhibitor |
| WO2016130839A1 (en) * | 2015-02-12 | 2016-08-18 | Beyondspring Pharmaceuticals, Inc. | Use of plinabulin in combination with immune checkpoint inhibitors |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| WO2016128542A1 (en) * | 2015-02-13 | 2016-08-18 | Transgene Sa | Immunotherapeutic vaccine and antibody combination therapy |
| EP3259269B9 (en) | 2015-02-20 | 2020-03-04 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| PT3263106T (pt) | 2015-02-25 | 2024-01-12 | Eisai R&D Man Co Ltd | Método para suprimir o amargor do derivado de quinolina |
| KR20170132171A (ko) | 2015-02-26 | 2017-12-01 | 메르크 파텐트 게엠베하 | 암 치료를 위한 pd1 / pdl1 저해제 |
| AR103726A1 (es) * | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
| CA2978226C (en) | 2015-03-04 | 2025-02-18 | Eisai R&D Management Co., Ltd. | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER |
| US10945990B2 (en) * | 2015-03-04 | 2021-03-16 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and eribulin for treating cancer |
| WO2016144635A1 (en) | 2015-03-06 | 2016-09-15 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a ras mutation |
| JP6904570B2 (ja) | 2015-03-06 | 2021-07-21 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | 脳腫瘍の治療方法 |
| NZ734650A (en) | 2015-03-10 | 2023-07-28 | Aurigene Oncology Ltd | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
| JP6692826B2 (ja) | 2015-03-10 | 2020-05-13 | アドゥロ バイオテック,インク. | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達の活性化のための組成物及び方法 |
| EP3067062A1 (en) * | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| LT3274370T (lt) | 2015-03-23 | 2020-02-10 | Bayer Pharma Aktiengesellschaft | Antikūnai prieš ceacam6 ir jų panaudojimas |
| EP3286311B1 (en) * | 2015-03-26 | 2021-05-05 | OncoSec Medical Incorporated | Method for the treatment of malignancies |
| US11933786B2 (en) | 2015-03-30 | 2024-03-19 | Stcube, Inc. | Antibodies specific to glycosylated PD-L1 and methods of use thereof |
| JP6936784B2 (ja) | 2015-03-30 | 2021-09-22 | エスティーキューブ,インコーポレイテッド | グリコシル化pd−l1に特異的な抗体およびその使用方法 |
| MA41866A (fr) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
| DK3277321T3 (da) | 2015-04-01 | 2024-09-02 | Anaptysbio Inc | Antistoffer, der er rettet mod T-celle-immunglobulin og mucin-protein 3 (TIM-3) |
| CN116327915A (zh) | 2015-04-03 | 2023-06-27 | 佐马技术有限公司 | 使用TGF-β抑制剂和PD-1抑制剂治疗癌症 |
| EP3277325B1 (en) | 2015-04-03 | 2020-10-28 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Combination immunotherapy for cancer |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| WO2016164480A1 (en) | 2015-04-07 | 2016-10-13 | Genentech, Inc. | Antigen binding complex having agonistic activity and methods of use |
| EP3280795B1 (en) | 2015-04-07 | 2021-03-24 | Novartis AG | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
| WO2016163489A1 (ja) | 2015-04-07 | 2016-10-13 | 日本電気株式会社 | 医薬 |
| CN119925616A (zh) | 2015-04-08 | 2025-05-06 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法 |
| CN114681608A (zh) | 2015-04-13 | 2022-07-01 | 戊瑞治疗有限公司 | 癌症组合疗法 |
| CN108473957B (zh) | 2015-04-17 | 2024-07-16 | 诺华股份有限公司 | 改善嵌合抗原受体表达细胞的功效和扩增的方法 |
| IL289600B2 (en) | 2015-04-17 | 2025-09-01 | Bristol Myers Squibb Co | Compositions comprising a combination of an anti–pd–1 antibody and another antibody |
| US11326211B2 (en) | 2015-04-17 | 2022-05-10 | Merck Sharp & Dohme Corp. | Blood-based biomarkers of tumor sensitivity to PD-1 antagonists |
| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| EP3288980B1 (en) | 2015-04-28 | 2021-03-10 | Bristol-Myers Squibb Company | Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody |
| WO2016176503A1 (en) | 2015-04-28 | 2016-11-03 | Bristol-Myers Squibb Company | Treatment of pd-l1-negative melanoma using an anti-pd-1 antibody and an anti-ctla-4 antibody |
| JP6810396B2 (ja) | 2015-04-30 | 2021-01-06 | 国立大学法人京都大学 | Pd−l1(cd274)の異常を指標としたpd−1/pd−l1阻害剤の治療効果予測方法 |
| KR20250107283A (ko) | 2015-05-06 | 2025-07-11 | 스니프르 테크놀로지스 리미티드 | 미생물 개체군 변경 및 미생물군 변형 |
| MX2017014381A (es) | 2015-05-12 | 2018-03-02 | Genentech Inc | Metodos terapeuticos y diagnosticos para cancer. |
| CN104987421A (zh) * | 2015-05-13 | 2015-10-21 | 北京比洋生物技术有限公司 | 抗ctla-4和pd-1的双重可变结构域免疫球蛋白 |
| EP3527574B1 (en) | 2015-05-18 | 2022-04-06 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs having increased bioavailability |
| TW202523682A (zh) | 2015-05-20 | 2025-06-16 | 美商博德研究所有限公司 | 共有之gata3相關之腫瘤特異性新抗原 |
| UA124143C2 (uk) | 2015-05-20 | 2021-07-28 | Янссен Байотек, Інк. | Антитіла до cd38 для лікування амілоїдозу, викликаного відкладеннями легких ланцюгів імуноглобулінів, і інших cd38-позитивних злоякісних гематологічних новоутворень |
| IL293719B2 (en) | 2015-05-21 | 2023-07-01 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
| US10881733B2 (en) * | 2015-05-22 | 2021-01-05 | Translational Drug Development, Llc | Benzamide and active compound compositions and methods of use |
| CN104931690A (zh) * | 2015-05-22 | 2015-09-23 | 华中科技大学同济医学院附属协和医院 | 一种pd-1抗体检测试剂盒及其应用 |
| EP3303361A1 (en) | 2015-05-27 | 2018-04-11 | Idenix Pharmaceuticals LLC | Nucleotides for the treatment of cancer |
| US20160347836A1 (en) * | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of hodgkin's lymphoma using an anti-pd-1 antibody |
| US20180155429A1 (en) | 2015-05-28 | 2018-06-07 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| PL3303396T3 (pl) | 2015-05-29 | 2023-03-06 | Bristol-Myers Squibb Company | Przeciwciała przeciwko ox40 i ich zastosowanie |
| JP6893608B2 (ja) | 2015-05-29 | 2021-06-23 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | がんの処置のためのPD−1アンタゴニストとCpG−C型オリゴヌクレオチドの併用 |
| WO2016196389A1 (en) | 2015-05-29 | 2016-12-08 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
| HK1248773A1 (zh) | 2015-05-29 | 2018-10-19 | 豪夫迈‧罗氏有限公司 | 用於癌症的治疗和诊断方法 |
| PL3303394T3 (pl) | 2015-05-29 | 2020-11-16 | Agenus Inc. | Przeciwciała anty-ctla-4 i sposoby ich zastosowania |
| CN115554399A (zh) | 2015-05-31 | 2023-01-03 | 源生公司 | 用于免疫疗法的组合组合物 |
| EP3303401B1 (en) * | 2015-06-01 | 2024-10-16 | The University of Chicago | Treatment of cancer by manipulation of commensal microflora |
| CA2988126A1 (en) | 2015-06-03 | 2016-12-08 | Boston Biomedical, Inc. | Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer |
| US10995140B2 (en) | 2015-06-05 | 2021-05-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | GM-CSF/CD40L vaccine and checkpoint inhibitor combination therapy |
| JP2018521019A (ja) | 2015-06-08 | 2018-08-02 | ジェネンテック, インコーポレイテッド | 抗ox40抗体を使用して癌を治療する方法 |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| WO2016201425A1 (en) | 2015-06-12 | 2016-12-15 | Bristol-Myers Squibb Company | Treatment of cancer by combined blockade of the pd-1 and cxcr4 signaling pathways |
| TWI870335B (zh) | 2015-06-12 | 2025-01-21 | 美商宏觀基因股份有限公司 | 變異的嵌合4d5抗體及其與抗pd-1抗體聯合用於治療癌症的應用 |
| WO2016197974A1 (en) * | 2015-06-12 | 2016-12-15 | Yen-Ta Lu | Methods and antibodies for modulation of immunoresponse |
| PE20180243A1 (es) | 2015-06-15 | 2018-01-31 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| PL3307288T3 (pl) | 2015-06-15 | 2019-12-31 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| HUE046770T2 (hu) | 2015-06-15 | 2020-03-30 | 4D Pharma Res Ltd | Baktériumtörzseket tartalmazó készítmények |
| US10869924B2 (en) | 2015-06-16 | 2020-12-22 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
| JP6757959B2 (ja) | 2015-06-16 | 2020-09-23 | 株式会社 PRISM BioLab | 抗がん剤 |
| MX388166B (es) | 2015-06-17 | 2025-03-19 | Genentech Inc | Metodos para tratar canceres de mama metastasicos o localmente avanzados con antagonistas de union al eje de pd-1 y taxanos |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| CN114133448A (zh) | 2015-06-23 | 2022-03-04 | 纪念斯隆-凯特琳癌症中心 | 新型pd-1免疫调节剂 |
| EP4385569A3 (en) | 2015-06-24 | 2024-09-25 | Janssen Biotech, Inc. | Immune modulation and treatment of solid tumors with antibodies that specifically bind cd38 |
| CA2990015A1 (en) | 2015-06-29 | 2017-01-05 | The Rockefeller University | Antibodies to cd40 with enhanced agonist activity |
| EA035888B1 (ru) | 2015-06-29 | 2020-08-27 | Бристол-Майерс Сквибб Компани | Режимы дозирования иммунотерапевтических средств и их комбинаций |
| EP3316874A4 (en) | 2015-06-30 | 2019-03-06 | The Trustees Of The University Of Pennsylvania | TOPICAL AND INJECTABLE RESIQUIMOD COMPOSITIONS FOR THE TREATMENT OF NEOPLASTIC GUM DISEASES |
| MX2018000216A (es) | 2015-07-02 | 2018-05-22 | Celgene Corp | Terapia de combinacion para el tratamiento de canceres hematologicos y tumores solidos. |
| EP3316685A4 (en) | 2015-07-02 | 2019-03-13 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized Pharmaceutical Compositions |
| GB201511790D0 (en) | 2015-07-06 | 2015-08-19 | Iomet Pharma Ltd | Pharmaceutical compound |
| CN113735834B (zh) | 2015-07-13 | 2023-06-13 | 大连万春布林医药有限公司 | 普那布林组合物 |
| KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
| RS61532B1 (sr) * | 2015-07-14 | 2021-04-29 | Bristol Myers Squibb Co | Postupak lečenja kancera primenom inhibitora imunološke kontrolne tačke; antitelo koje se vezuje za receptor programirane smrti-1 (pd-1) ili ligand programirane smrti-1 (pd-l1) |
| AU2016291817A1 (en) | 2015-07-16 | 2018-02-22 | Biolinerx Ltd. | Compositions and methods for treating cancer |
| WO2017011831A1 (en) | 2015-07-16 | 2017-01-19 | Bioxcel Corporation | A novel approach for treatment of cancer using immunomodulation |
| JP7146632B2 (ja) | 2015-07-21 | 2022-10-04 | ノバルティス アーゲー | 免疫細胞の有効性および増大を改善する方法 |
| KR102690998B1 (ko) * | 2015-07-22 | 2024-07-31 | 이나터리 | 항-TfR 항체 및 증식성 및 염증성 장애의 치료에서의 그의 용도 |
| KR102794242B1 (ko) | 2015-07-24 | 2025-04-11 | 글리크닉 인코포레이티드 | 향상된 상보체 결합을 갖는 규칙적으로 다형체화된 면역글로불린 fc 조성물을 생성하기 위한 인간 단백질 단편의 융합 단백질 |
| CN106699888B (zh) * | 2015-07-28 | 2020-11-06 | 上海昀怡健康科技发展有限公司 | 一种pd-1抗体及其制备方法和应用 |
| EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| SI3317301T1 (sl) | 2015-07-29 | 2021-10-29 | Novartis Ag | Kombinirane terapije, ki obsegajo molekule protitelesa na LAG-3 |
| EP4378957A3 (en) | 2015-07-29 | 2024-08-07 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| HK1247850A1 (zh) | 2015-07-29 | 2018-10-05 | Novartis Ag | Pd-1 拮抗剂与egfr 抑制剂的组合 |
| BR112018000212A2 (pt) | 2015-07-29 | 2018-09-04 | Novartis Ag | uso combinado de anticorpos anti pd-1 e anti m-csf no tratamento de câncer |
| CR20220194A (es) | 2015-07-30 | 2022-06-16 | Macrogenics Inc | Moléculas de unión a pd-1 y métodos de uso de las mismas |
| JP2018522044A (ja) | 2015-08-04 | 2018-08-09 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 併用治療ならびにその使用およびその方法 |
| US20180222989A1 (en) * | 2015-08-04 | 2018-08-09 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
| EP3331917A1 (en) | 2015-08-04 | 2018-06-13 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
| BR112018000366A2 (pt) | 2015-08-07 | 2018-09-11 | Pieris Pharmaceuticals Gmbh | polipeptídeo de fusão, muteína de lipocalina, molécula de ácido nucleico, célula hospedeira, métodos de produção de um polipeptídeo de fusão, para inibir simultaneamente os pontos de controle imunes, para aumentar a atividade celular de linfócitos antitumorais e para interferir com a ligação do lag-3 humano e uso do polipeptídeo de fusão |
| WO2017025871A1 (en) | 2015-08-07 | 2017-02-16 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy comprising anti ctla-4 antibodies |
| WO2017024465A1 (en) * | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| MX392711B (es) * | 2015-08-11 | 2025-03-24 | Wuxi Biologics Ireland Ltd | Anticuerpos anti-pd-1 novedosos. |
| WO2017024515A1 (en) * | 2015-08-11 | 2017-02-16 | Wuxi Biologics (Cayman) Inc. | Novel anti-pd-1 antibodies |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| UA123701C2 (uk) | 2015-08-13 | 2021-05-19 | Мерк Шарп І Доум Корп. | Циклічні динуклеотидні сполуки як агоністи sting |
| US12220398B2 (en) | 2015-08-20 | 2025-02-11 | Eisai R&D Management Co., Ltd. | Tumor therapeutic agent |
| JP6791951B2 (ja) | 2015-08-27 | 2020-11-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 肺ガンを患っている患者の生存時間を予測するための方法 |
| CA2993432A1 (en) | 2015-09-01 | 2017-03-09 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
| CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
| CN108025069B (zh) | 2015-09-03 | 2021-11-12 | 小野药品工业株式会社 | 使用变应素-1拮抗剂的癌症免疫增强剂 |
| CN108348571B (zh) | 2015-09-03 | 2022-03-22 | 艾瑞朗医疗公司 | 拟肽大环化合物及其用途 |
| JP6980649B2 (ja) | 2015-09-14 | 2021-12-15 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | イソキノリノン誘導体の固体形態、それを製造する方法、それを含む組成物、及びそれを使用する方法 |
| MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
| US11124569B2 (en) * | 2015-09-18 | 2021-09-21 | Dana-Farber Cancer Institute, Inc. | Methods of reducing liver PD-1-expressing CD8+ T cells using PD-1 Fc fusion proteins that bind Fc receptors |
| CN109071644B (zh) | 2015-09-23 | 2023-09-19 | 昂考梅德药品有限公司 | 治疗癌症的方法和组合物 |
| KR102279524B1 (ko) | 2015-09-25 | 2021-07-20 | 제넨테크, 인크. | 항-tigit 항체 및 이의 이용 방법 |
| MX395336B (es) * | 2015-09-28 | 2025-03-25 | Suzhou Suncadia Biopharmaceuticals Co Ltd | Preparacion farmaceutica de anticuerpo anti-pd-1 estable y aplicacion del mismo en medicina. |
| US10954300B2 (en) * | 2015-09-28 | 2021-03-23 | The Trustees Of Columbia University In The City Of New York | Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma |
| US10947598B2 (en) | 2015-09-29 | 2021-03-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for determining the metabolic status of lymphomas |
| WO2017055324A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cells of monocytic origin in a tissue sample |
| WO2017058859A1 (en) * | 2015-09-29 | 2017-04-06 | Celgene Corporation | Pd-1 binding proteins and methods of use thereof |
| WO2017055327A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of endothelial cells in a tissue sample |
| WO2017055319A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of b cells in a tissue sample |
| WO2017055321A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of fibroblasts in a tissue sample |
| WO2017055322A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of neutrophils in a tissue sample |
| WO2017055320A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample |
| WO2017055325A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of nk cells in a tissue sample |
| WO2017055326A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
| RU2722451C1 (ru) * | 2015-09-29 | 2020-06-01 | Шанхай Чжанцзян Биотекнолоджи Ко., Лтд. | Pd-1 антитела и их применение. |
| US20190048089A1 (en) | 2015-09-30 | 2019-02-14 | Janssen Biotech, Inc. | Antagonistic Antibodies Specifically Binding Human CD40 and Methods of Use |
| JP2018529719A (ja) | 2015-09-30 | 2018-10-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Alk陰性がんを処置するためのpd−1系結合アンタゴニストおよびalk阻害剤の組合せ |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| EP3355875B1 (en) | 2015-10-01 | 2021-09-29 | Gilead Sciences, Inc. | Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers |
| WO2017055443A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-pd1 antibodies and methods of use |
| US12030942B2 (en) | 2015-10-02 | 2024-07-09 | Les Laboratoires Servier | Anti-PD-1 antibodies and compositions |
| HRP20221041T1 (hr) * | 2015-10-02 | 2022-11-11 | Symphogen A/S | Anti-pd-1 antitijela i sastavi |
| AU2016329126B2 (en) | 2015-10-02 | 2023-04-13 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for PD1 and TIM3 |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| JP7320944B2 (ja) | 2015-10-08 | 2023-08-04 | マクロジェニクス,インコーポレーテッド | B7‐h3に特異的に結合する分子及びpd‐1に特異的に結合する分子 |
| WO2017062708A1 (en) * | 2015-10-09 | 2017-04-13 | Virginia Commonwealth University | T cell delivery of mda-7/il-24 to improve therapeutic eradication of cancer and generate protective antitumor immunity |
| WO2017060397A1 (en) | 2015-10-09 | 2017-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of subjects suffering from melanoma metastases |
| EP3362475B1 (en) | 2015-10-12 | 2023-08-30 | Innate Pharma | Cd73 blocking agents |
| WO2017066414A1 (en) * | 2015-10-14 | 2017-04-20 | Endocyte, Inc. | Drug delivery conjugates for use in combination therapy |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| WO2017070110A1 (en) | 2015-10-19 | 2017-04-27 | Cold Genesys, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
| US10149887B2 (en) * | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
| CN105238762A (zh) * | 2015-10-26 | 2016-01-13 | 无锡傲锐东源生物科技有限公司 | 抗pd-1蛋白单克隆抗体杂交瘤细胞及其产生的抗pd-1单克隆抗体和应用 |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| CN106632674B (zh) * | 2015-10-30 | 2018-11-16 | 泽达生物医药有限公司 | 一种抗pd-1单克隆抗体、其药物组合物及其用途 |
| US11594135B2 (en) | 2015-11-02 | 2023-02-28 | Memgen, Inc. | Methods of CD40 activation and immune checkpoint blockade |
| WO2017079117A1 (en) | 2015-11-02 | 2017-05-11 | Five Prime Therapeutics, Inc. | Cd80 extracellular domain polypeptides and their use in cancer treatment |
| TWI800341B (zh) | 2015-11-03 | 2023-04-21 | 美商健生生物科技公司 | 抗cd38抗體之皮下調配物及其用途 |
| EA201891093A1 (ru) | 2015-11-03 | 2018-10-31 | Янссен Байотек, Инк. | Антитела, специфически связывающие pd-1, и их применение |
| US11020430B2 (en) * | 2015-11-04 | 2021-06-01 | Emory University | Immune cells with DNMT3A gene modifications and methods related thereto |
| US11684656B2 (en) * | 2015-11-04 | 2023-06-27 | Taipei Veterans General Hospital | Combination therapy for malignant diseases |
| US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| JP2018532810A (ja) | 2015-11-07 | 2018-11-08 | マルチビア インコーポレイテッド | がんの処置のための腫瘍抑制因子遺伝子治療および免疫チェックポイント治療を含む組成物 |
| AU2016352572B2 (en) * | 2015-11-12 | 2023-10-19 | Hookipa Biotech Gmbh | Arenavirus particles as cancer vaccines |
| US11072657B2 (en) | 2015-11-18 | 2021-07-27 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-PD-1 antibody and an anti-CTLA-4 antibody |
| CN106699889A (zh) * | 2015-11-18 | 2017-05-24 | 礼进生物医药科技(上海)有限公司 | 抗pd-1抗体及其治疗用途 |
| EP3377107B1 (en) | 2015-11-19 | 2020-08-12 | H. Hoffnabb-La Roche Ag | Methods of treating cancer using b-raf inhibitors and immune checkpoint inhibitors |
| AU2016356780A1 (en) | 2015-11-19 | 2018-06-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| KR101914245B1 (ko) | 2015-11-20 | 2018-11-02 | 4디 파마 리서치 리미티드 | 박테리아성 균주를 함유한 조성물 |
| EP3380523A1 (en) | 2015-11-23 | 2018-10-03 | Five Prime Therapeutics, Inc. | Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment |
| JP2019505476A (ja) | 2015-12-01 | 2019-02-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 組合せ処置およびその方法 |
| KR102809728B1 (ko) | 2015-12-02 | 2025-05-21 | 주식회사 에스티큐브 | 글리코실화된 pd-1에 대해 특이적인 항체 및 이의 사용 방법 |
| CN108883173B (zh) | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | 抗体和其使用方法 |
| HK1250032A1 (zh) | 2015-12-03 | 2018-11-23 | Glaxosmithkline Intellectual Property Development Limited | 作为sting调节剂的环状嘌呤二核苷酸 |
| WO2017098421A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Benzothiadiazine compounds |
| US10590169B2 (en) * | 2015-12-09 | 2020-03-17 | Virogin Biotech Canada Ltd | Compositions and methods for inhibiting CD279 interactions |
| EP3178848A1 (en) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
| IL257696B2 (en) | 2015-12-09 | 2024-11-01 | Hoffmann La Roche | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
| EA201891178A1 (ru) | 2015-12-14 | 2019-01-31 | Макродженикс, Инк. | Биспецифичные молекулы, обладающие иммунореактивностью в отношении pd-1 и ctla-4, и способы их применения |
| SG11201804969PA (en) * | 2015-12-15 | 2018-07-30 | Oncoimmune Inc | Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof |
| WO2017106062A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Novel compounds as indoleamine 2,3-dioxygenase inhibitors |
| US10392442B2 (en) | 2015-12-17 | 2019-08-27 | Bristol-Myers Squibb Company | Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment |
| EP3389712B1 (en) | 2015-12-17 | 2024-04-10 | Novartis AG | Antibody molecules to pd-1 and uses thereof |
| GB201522309D0 (en) | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| HK1258204A1 (zh) | 2015-12-18 | 2019-11-08 | Novartis Ag | 靶向cd32b的抗体及其使用方法 |
| WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| DK3390451T3 (da) | 2015-12-18 | 2025-03-17 | Intervet Int Bv | Kaniniserede humane antistoffer mod il-4r-alpha hos mennesker og hunde |
| BR112018012524A2 (pt) | 2015-12-21 | 2018-12-11 | Bristol Myers Squibb Co | anticorpos variantes para conjugação sítio-específica |
| US11413340B2 (en) | 2015-12-22 | 2022-08-16 | Novartis Ag | Mesothelin chimeric antigen receptor (CAR) and antibody against PD-L1 inhibitor for combined use in anticancer therapy |
| EP3828171A1 (en) | 2015-12-22 | 2021-06-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SMT202300304T1 (it) | 2015-12-22 | 2023-11-13 | Regeneron Pharma | Combinazione di anticorpi anti-pd-1 e anticorpi bispecifici anti-cd20/anti-cd3 per il trattamento del cancro |
| RS63135B1 (sr) | 2015-12-23 | 2022-05-31 | Modernatx Inc | Postupci upotrebe polinukleotida koji kodiraju ox40 ligand |
| WO2017112954A1 (en) * | 2015-12-23 | 2017-06-29 | Moonshot Pharma Llc | Methods for inducing an immune response by promoting premature termination codon read-through |
| CN105669864B (zh) * | 2015-12-23 | 2018-10-16 | 杭州尚健生物技术有限公司 | 抗人程序性死亡受体1抗体及其制备方法和用途 |
| EP3400443B1 (en) | 2016-01-04 | 2020-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pd-1 and tim-3 as a measure for cd8+ cells in predicting and treating renal cell carcinoma |
| CN115554406A (zh) | 2016-01-07 | 2023-01-03 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| JP7071922B2 (ja) | 2016-01-08 | 2022-05-19 | セルジーン コーポレイション | 2-(4-クロロフェニル)-n-((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-5-イル)メチル)-2,2-ジフルオロアセトアミドの固体形態、ならびにそれらの薬学的組成物及び使用 |
| TWI717448B (zh) | 2016-01-08 | 2021-02-01 | 美商西建公司 | 抗增生化合物,及其醫藥組合物及用途 |
| US10052315B2 (en) | 2016-01-08 | 2018-08-21 | Celgene Corporation | Formulations of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| MA43859A (fr) | 2016-01-11 | 2018-11-21 | Novartis Ag | Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion |
| ES2839408T3 (es) | 2016-01-13 | 2021-07-05 | Acerta Pharma Bv | Combinaciones terapéuticas de un antifolato y un inhibidor de BTK |
| CN109069628A (zh) | 2016-01-14 | 2018-12-21 | Bps生物科学有限公司 | 抗pd-1抗体及其用途 |
| KR20250099278A (ko) | 2016-01-15 | 2025-07-01 | 알에프이엠비 홀딩스, 엘엘씨 | 암의 면역학적 치료 |
| PL3405495T3 (pl) | 2016-01-21 | 2021-10-11 | Innate Pharma | Neutralizacja szlaków inhibitorowych w limfocytach |
| US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| JOP20170013B1 (ar) | 2016-01-22 | 2021-08-17 | Merck Sharp & Dohme | أجسام xi مضادة لعامل مضاد للتجلط |
| CA3012075A1 (en) | 2016-01-22 | 2017-07-27 | MabQuest SA | Immunological reagents |
| KR20180101584A (ko) * | 2016-01-27 | 2018-09-12 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합을 사용하는 폐암의 치료 |
| EP4035681A1 (en) | 2016-01-28 | 2022-08-03 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical composition for the treatment of cancer |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| EP3407912B1 (en) | 2016-01-28 | 2022-05-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for enhancing the potency of the immune checkpoint inhibitors |
| CA3013554A1 (en) | 2016-02-05 | 2017-08-10 | Orionis Biosciences Nv | Targeted therapeutic agents and uses thereof |
| AU2017217426B2 (en) * | 2016-02-08 | 2022-12-01 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| RU2018131123A (ru) | 2016-02-17 | 2020-03-17 | Новартис Аг | Антитела к tgf-бета2 |
| BR112018016842A2 (pt) | 2016-02-19 | 2018-12-26 | Novartis Ag | compostos de piridona tetracíclica como antivirais |
| EP3416690A4 (en) | 2016-02-19 | 2020-02-19 | City of Hope | BISPECIFIC APTAMER |
| MX2018010295A (es) | 2016-02-26 | 2019-06-06 | Inst Nat Sante Rech Med | Anticuerpos que tienen especificidad para atenuador de linfocitos b y t (btla) y usos de los mismos. |
| JP2019509282A (ja) | 2016-02-29 | 2019-04-04 | ファウンデーション・メディシン・インコーポレイテッド | 癌の治療方法 |
| KR102500659B1 (ko) | 2016-02-29 | 2023-02-16 | 제넨테크, 인크. | 암에 대한 치료 및 진단 방법 |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| WO2017152085A1 (en) | 2016-03-04 | 2017-09-08 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US20200281973A1 (en) | 2016-03-04 | 2020-09-10 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| HUE044051T2 (hu) | 2016-03-04 | 2019-09-30 | 4D Pharma Plc | Zsigeri túlérzékenység kezelésére szolgáló, Blautia baktériumtörzset tartalmazó készítmény |
| SG10201601719RA (en) | 2016-03-04 | 2017-10-30 | Agency Science Tech & Res | Anti-LAG-3 Antibodies |
| US20170252417A1 (en) | 2016-03-07 | 2017-09-07 | Massachusetts Institute Of Technology | Protein-chaperoned t-cell vaccines |
| JP7270379B2 (ja) | 2016-03-08 | 2023-05-10 | イナート・ファルマ・ソシエテ・アノニム | Siglec中和抗体 |
| WO2017153952A1 (en) | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
| PL3426271T3 (pl) | 2016-03-10 | 2025-11-24 | Cg Oncology, Inc. | Sposoby leczenia guzów litych terapią skojarzoną |
| EP3426299A4 (en) * | 2016-03-11 | 2019-10-16 | University of Louisville Research Foundation, Inc. | METHOD AND COMPOSITIONS FOR TREATMENT OF TUMORS |
| WO2017160599A1 (en) | 2016-03-14 | 2017-09-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of cd300b antagonists to treat sepsis and septic shock |
| PL3430054T3 (pl) | 2016-03-15 | 2022-05-23 | Chugai Seiyaku Kabushiki Kaisha | Sposoby leczenia nowotworów z zastosowaniem antagonistów wiązania z osią PD-1 i przeciwciał anty-GPC3 |
| EP3429693B1 (en) | 2016-03-15 | 2023-08-23 | Mersana Therapeutics, Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
| WO2017165412A2 (en) | 2016-03-21 | 2017-09-28 | Dana-Farber Cancer Institute, Inc. | T-cell exhaustion state-specific gene expression regulators and uses thereof |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| US10894823B2 (en) * | 2016-03-24 | 2021-01-19 | Gensun Biopharma Inc. | Trispecific inhibitors for cancer treatment |
| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| DK3433257T3 (da) | 2016-03-24 | 2024-01-02 | Novartis Ag | Alkynylnukleosidanaloger som hæmmere af human rhinovirus |
| EP3436481B1 (en) | 2016-03-29 | 2021-06-30 | Stcube, Inc. | Dual function antibodies specific to glycosylated pd-l1 and methods of use thereof |
| KR102584300B1 (ko) | 2016-03-29 | 2023-10-05 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
| US12059474B2 (en) | 2016-03-29 | 2024-08-13 | Stcube & Co., Inc. | Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins |
| CN109195990A (zh) | 2016-03-30 | 2019-01-11 | Musc研究发展基金会 | 通过靶向糖蛋白a重复优势蛋白(garp)治疗和诊断癌症以及单独或联合提供有效免疫疗法的方法 |
| EP3436829A1 (en) | 2016-03-30 | 2019-02-06 | Centre Léon-Bérard | Lymphocytes expressing cd73 in cancerous patient dictates therapy |
| AU2017240074B2 (en) | 2016-03-31 | 2020-01-02 | Jiangsu Yahong Meditech Co., Ltd. | Combinational uses of Nitroxoline and its analogues with chemotherapies and immunotherapies in the treatment of cancers |
| CN107286242B (zh) | 2016-04-01 | 2019-03-22 | 中山康方生物医药有限公司 | 抗pd-1的单克隆抗体 |
| EP3225253A1 (en) | 2016-04-01 | 2017-10-04 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| US11209441B2 (en) | 2016-04-05 | 2021-12-28 | Bristol-Myers Squibb Company | Cytokine profiling analysis |
| US10975287B2 (en) | 2016-04-07 | 2021-04-13 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| PE20181920A1 (es) | 2016-04-07 | 2018-12-11 | Glaxosmithkline Ip Dev Ltd | Amidas heterociclicas utiles como moduladores de proteinas |
| US20170306050A1 (en) | 2016-04-08 | 2017-10-26 | Gilead Sciences, Inc. | Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases |
| KR102466763B1 (ko) | 2016-04-13 | 2022-11-11 | 오리맵스 리미티드 | 항- psma 항체 및 이의 용도 |
| IL262359B (en) | 2016-04-13 | 2022-09-01 | Vivia Biotech Sl | In vitro bite-activated T cells |
| MX2018012493A (es) | 2016-04-15 | 2019-06-06 | Genentech Inc | Métodos para controlar y tratar el cáncer. |
| JP7503887B2 (ja) * | 2016-04-15 | 2024-06-21 | ジェネンテック, インコーポレイテッド | がんを監視及び治療するための方法 |
| SG11201808821WA (en) | 2016-04-18 | 2018-11-29 | Celldex Therapeutics Inc | Agonistic antibodies that bind human cd40 and uses thereof |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| EP3449921B1 (en) | 2016-04-28 | 2023-05-31 | Eisai R&D Management Co., Ltd. | Eribulin for inhibiting tumor growth |
| ES2913073T3 (es) | 2016-04-29 | 2022-05-31 | Icahn School Med Mount Sinai | Direccionamiento del sistema inmunitario innato para inducir tolerancia a largo plazo y resolver la acumulación de macrófagos en aterosclerosis |
| EP4029950A1 (en) | 2016-04-29 | 2022-07-20 | Board of Regents, The University of Texas System | Targeted measure of transcriptional activity related to hormone receptors |
| US20190298824A1 (en) | 2016-05-04 | 2019-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Albumin-binding immunomodulatory compositions and methods of use thereof |
| WO2017191545A1 (en) | 2016-05-05 | 2017-11-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| CN120350015A (zh) * | 2016-05-05 | 2025-07-22 | 宾夕法尼亚大学理事会 | 靶向检查点分子的dna单克隆抗体 |
| AR108377A1 (es) | 2016-05-06 | 2018-08-15 | Medimmune Llc | Proteínas de unión biespecíficas y sus usos |
| SG10201603721TA (en) | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
| EP3454909A1 (en) | 2016-05-10 | 2019-03-20 | Bristol-Myers Squibb Company | Antibody-drug conjugates of tubulysin analogs with enhanced stability |
| TWI808055B (zh) * | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| TWI755395B (zh) | 2016-05-13 | 2022-02-21 | 美商再生元醫藥公司 | 抗-pd-1抗體與輻射治療癌症之組合 |
| EP3454887B1 (en) | 2016-05-13 | 2021-01-20 | Orionis Biosciences BV | Targeted mutant interferon-beta and uses thereof |
| EP3243832A1 (en) * | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
| CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
| HRP20221135T8 (hr) | 2016-05-18 | 2023-02-03 | Modernatx, Inc. | KOMBINACIJE mRNK KOJE KODIRAJU IMUNOMODULIRAJUĆE POLIPEPTIDE I NJIHOVE UPOTREBE |
| HRP20230050T1 (hr) | 2016-05-18 | 2023-03-03 | Modernatx, Inc. | Polinukleotidi koji kodiraju interleukin-12 (il12) i njihova upotreba |
| AU2017268399B2 (en) | 2016-05-18 | 2023-01-12 | Modernatx, Inc. | mRNA combination therapy for the treatment of cancer |
| WO2017201432A2 (en) | 2016-05-19 | 2017-11-23 | Jounaidi Youssef | Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| CN105968200B (zh) | 2016-05-20 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-l1人源化单克隆抗体及其应用 |
| IL263110B (en) | 2016-05-20 | 2022-07-01 | Lilly Co Eli | Combined treatment of notch and pd-1 or pd-l1 inhibitors |
| EP4019019B1 (en) | 2016-05-20 | 2024-02-07 | Biohaven Pharmaceutical Holding Company Ltd. | Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers |
| CN109476663B (zh) | 2016-05-24 | 2021-11-09 | 基因泰克公司 | 用于治疗癌症的吡唑并吡啶衍生物 |
| EP4067347B1 (en) | 2016-05-24 | 2024-06-19 | Genentech, Inc. | Heterocyclic inhibitors of cbp/ep300 for the treatment of cancer |
| CN106008714B (zh) * | 2016-05-24 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
| WO2017202962A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
| KR20240103039A (ko) | 2016-05-25 | 2024-07-03 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 암 치료 방법 및 조성물 |
| MY195089A (en) | 2016-05-27 | 2023-01-10 | Agenus Inc | Anti-Tim-3 Antibodies and Methods of use thereof |
| US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
| KR102397783B1 (ko) | 2016-06-01 | 2022-05-12 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-l1 결합 폴리펩티드에 의한 pet 영상화 |
| SI3464368T1 (sl) | 2016-06-02 | 2023-10-30 | Bristol-Myers Squibb Company | Uporaba protitelesa anti-pd-1 v kombinaciji s protitelesom anti-cd30 pri zdravljenju limfoma |
| LT3463436T (lt) | 2016-06-02 | 2024-01-25 | Ultimovacs Asa | Vakcina derinyje su imuninės patikros taško slopikliu, skirta vėžiui gydyti |
| HRP20230864T1 (hr) | 2016-06-02 | 2023-11-10 | Bristol-Myers Squibb Company | Pd-1 blokada nivolumabom kod refraktornog hodgkinovog limfoma |
| WO2017210624A1 (en) | 2016-06-03 | 2017-12-07 | Bristol-Myers Squibb Company | Anti-pd-1 antibody for use in a method of treating a tumor |
| ES2897964T3 (es) | 2016-06-03 | 2022-03-03 | Bristol Myers Squibb Co | Uso del anticuerpo anti-PD-1 en el tratamiento de pacientes con cáncer colorrectal |
| JP2019517498A (ja) | 2016-06-03 | 2019-06-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 再発性小細胞肺癌の処置方法において使用するための抗pd−1抗体 |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| CN118304304A (zh) | 2016-06-06 | 2024-07-09 | 大连万春布林医药有限公司 | 用于减少中性粒细胞减少症的组合物和方法 |
| WO2017214182A1 (en) * | 2016-06-07 | 2017-12-14 | The United States Of America. As Represented By The Secretary, Department Of Health & Human Services | Fully human antibody targeting pdi for cancer immunotherapy |
| WO2017214321A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| AU2017279027A1 (en) | 2016-06-08 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
| RU2018145734A (ru) | 2016-06-08 | 2020-07-14 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Химические соединения в качестве ингибиторов atf4 пути |
| WO2017218435A1 (en) * | 2016-06-13 | 2017-12-21 | Askgene Pharma Inc. | PD-L1 Specific Monoclonal Antibodies for Disease Treatment and Diagnosis |
| CN116425879A (zh) | 2016-06-14 | 2023-07-14 | 默沙东有限责任公司 | 抗-凝血因子xi抗体 |
| CA3026356A1 (en) | 2016-06-14 | 2017-12-21 | Novartis Ag | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |
| WO2017216685A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | Pentacyclic pyridone compounds as antivirals |
| EP3471762A4 (en) * | 2016-06-16 | 2020-03-11 | The Board of Trustees of the Leland Stanford Junior University | HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES DIRECTED AGAINST CD81 |
| WO2017216686A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals |
| MD3472167T2 (ro) | 2016-06-20 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| EP3471754A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 antibodies |
| MX391135B (es) | 2016-06-24 | 2025-03-21 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
| EP3481393B1 (en) | 2016-07-05 | 2021-04-14 | Beigene, Ltd. | Combination of a pd-1 antagonist and a raf inhibitor for treating cancer |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| CN109641968B (zh) * | 2016-07-06 | 2023-10-20 | 百时美施贵宝公司 | Tim-4拮抗剂和pd-1拮抗剂的组合及其使用方法 |
| WO2018009894A1 (en) | 2016-07-07 | 2018-01-11 | Iovance Biotherapeutics, Inc. | Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof |
| WO2018011166A2 (en) | 2016-07-12 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
| RU2656181C1 (ru) * | 2016-07-13 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Анти-pd-1-антитела, способ их получения и способ применения |
| TW201821093A (zh) | 2016-07-13 | 2018-06-16 | 英商4D製藥有限公司 | 包含細菌菌株之組合物 |
| EP3484516A4 (en) | 2016-07-14 | 2020-03-18 | Fred Hutchinson Cancer Research Center | MULTIPLE CONSTRUCTIONS OF BI-SPECIFIC LINK AREAS HAVING A DIFFERENT EPITOPE LINK TO TREAT CANCER |
| EP4512829A3 (en) | 2016-07-14 | 2025-06-11 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| GB2567093A (en) | 2016-07-15 | 2019-04-03 | Viracta Therapeutics Inc | Histone deacetylase inhibitors for use in immunotherapy |
| US11746152B2 (en) | 2016-07-20 | 2023-09-05 | Stcube, Inc. | Methods of cancer treatment and therapy using a combination of antibodies that bind glycosylated PD-L1 |
| US11365252B2 (en) | 2016-07-20 | 2022-06-21 | University Of Utah Research Foundation | CD229 CAR T cells and methods of use thereof |
| KR20190028540A (ko) | 2016-07-20 | 2019-03-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Perk 억제제로서의 이소퀴놀린 유도체 |
| NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
| JP2019525934A (ja) | 2016-07-29 | 2019-09-12 | イーライ リリー アンド カンパニー | 癌の治療に使用するためのメレスチニブおよび抗pd−l1または抗pd−1阻害剤を用いた組み合わせ治療 |
| EP4549467A3 (en) | 2016-08-01 | 2025-07-23 | ImmunoGenesis, Inc. | Administration of hypoxia activated prodrugs in combination with immune modulatory agents for treating cancer |
| JP2019528311A (ja) | 2016-08-03 | 2019-10-10 | ネクストキュア インコーポレイテッド | Lairシグナル伝達を調節するための組成物及び方法 |
| WO2018025221A1 (en) | 2016-08-04 | 2018-02-08 | Glaxosmithkline Intellectual Property Development Limited | Anti-icos and anti-pd-1 antibody combination therapy |
| WO2018026248A1 (ko) * | 2016-08-05 | 2018-02-08 | 주식회사 와이바이오로직스 | 프로그램화된 세포 사멸 단백질(pd-1)에 대한 신규 항체 및 이의 용도 |
| CN109963871A (zh) | 2016-08-05 | 2019-07-02 | 豪夫迈·罗氏有限公司 | 具有激动活性的多价及多表位抗体以及使用方法 |
| UA125395C2 (uk) * | 2016-08-05 | 2022-03-02 | І-Байолоджікс Інк. | Антитіло проти білка-1 запрограмованої клітинної смерті (pd-1) і його застосування |
| JP7250674B2 (ja) | 2016-08-08 | 2023-04-03 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | がんの治療及び診断方法 |
| WO2018027524A1 (en) | 2016-08-09 | 2018-02-15 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibody formulation |
| BR112019002529A2 (pt) * | 2016-08-09 | 2019-05-28 | Kymab Limited | anticorpo isolado, composição, método para modular o equilíbrio de células t, método para tratar uma doença ou afecção tratável com terapia, método para tratar câncer, combinação de anticorpo igg1, anticorpo anti-icos, mamífero não humano transgênico, e método para produzir um anticorpo |
| AU2017311585A1 (en) | 2016-08-12 | 2019-02-28 | Genentech, Inc. | Combination therapy with a MEK inhibitor, a PD-1 axis inhibitor, and a VEGF inhibitor |
| WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
| CN109790534A (zh) * | 2016-08-15 | 2019-05-21 | 国立大学法人北海道大学 | 抗pd-1抗体 |
| ES2902179T3 (es) | 2016-08-19 | 2022-03-25 | Bristol Myers Squibb Co | Compuestos de seco-ciclopropapirroloindol, conjugados de anticuerpo-fármaco de los mismos y métodos de elaboración y uso |
| ES2971881T3 (es) | 2016-08-19 | 2024-06-10 | Beigene Switzerland Gmbh | Combinación de zanubrutinib con un anticuerpo anti-cd20 o anti-pd-1 para su uso en el tratamiento del cáncer |
| MA45999A (fr) | 2016-08-22 | 2019-06-26 | Arbutus Biopharma Corp | Anticorps anti-pd-1, ou leurs fragments, pour le traitement de l'hépatite b |
| CN106977602B (zh) | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
| EP3858365B1 (en) | 2016-09-01 | 2024-01-31 | Chimera Bioengineering Inc. | Gold optimized car t-cells |
| WO2018049008A1 (en) | 2016-09-07 | 2018-03-15 | Trustees Of Tufts College | Dash inhibitors, and uses related thereto |
| WO2018048975A1 (en) | 2016-09-09 | 2018-03-15 | Bristol-Myers Squibb Company | Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment |
| US20190247399A1 (en) | 2016-09-09 | 2019-08-15 | Tg Therapeutics, Inc. | Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers |
| TW201811788A (zh) | 2016-09-09 | 2018-04-01 | 瑞士商諾華公司 | 作為抗病毒劑之多環吡啶酮化合物 |
| WO2018046736A1 (en) | 2016-09-12 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from cancer |
| WO2018046738A1 (en) | 2016-09-12 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from cancer |
| AU2017327360A1 (en) * | 2016-09-13 | 2019-03-28 | North Carolina State University | Platelet compositions and methods for the delivery of therapeutic agents |
| US9914783B1 (en) | 2016-09-14 | 2018-03-13 | Abbvie Biotherapeutics Inc. | Anti-PD-1 antibodies and their uses |
| WO2018053434A1 (en) | 2016-09-16 | 2018-03-22 | The Johns Hopkins University | Protein nanocages with enhanced mucus penetration for targeted tissue and intracellular delivery |
| CN109923126B (zh) | 2016-09-16 | 2022-06-03 | 上海复宏汉霖生物技术股份有限公司 | 抗-pd-1抗体 |
| EP3515943A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS |
| WO2018053463A1 (en) | 2016-09-19 | 2018-03-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells for genetic engineering of immune cells |
| WO2018053405A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
| RS66679B1 (sr) * | 2016-09-21 | 2025-05-30 | Cstone Pharmaceuticals | Monoklonska antitela za programiranu smrt 1 (pd-1) |
| EP4360714A3 (en) | 2016-09-21 | 2024-07-24 | Nextcure, Inc. | Antibodies for siglec-15 and methods of use thereof |
| EP3515478B1 (en) | 2016-09-21 | 2024-02-28 | Nextcure, Inc. | Antibodies for siglec-15 and methods of use thereof |
| WO2018057585A1 (en) | 2016-09-21 | 2018-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptor (car) that targets chemokine receptor ccr4 and its use |
| CN114456269A (zh) * | 2016-09-21 | 2022-05-10 | 基石药业(苏州)有限公司 | 一种新的pd-1单克隆抗体 |
| US20200016177A1 (en) | 2016-09-22 | 2020-01-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof |
| CA3036564A1 (en) | 2016-09-23 | 2018-03-29 | Elstar Therapeutics, Inc. | Multispecific antibody molecules comprising lambda and kappa light chains |
| CN109844536B (zh) | 2016-09-26 | 2023-04-14 | 豪夫迈·罗氏有限公司 | 预测对pd-1轴抑制剂的响应 |
| MX2019003447A (es) | 2016-09-27 | 2019-08-29 | Univ Texas | Metodos para mejorar la terapia de bloqueo del punto de control inmune mediante la modulacion del microbioma. |
| JP2019537619A (ja) | 2016-09-27 | 2019-12-26 | オンコロジー、インコーポレイテッド | β2−糖タンパク質1のレベルに基づいて、バビツキシマブで癌を治療するための方法、およびそのためのアッセイ |
| JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| MX2019003603A (es) | 2016-09-29 | 2019-08-01 | Genentech Inc | Terapia de combinacion con un inhibidor de mek, un inhibidor del eje pd-1 y un taxano. |
| MA46452B1 (fr) | 2016-10-04 | 2021-10-29 | Merck Sharp & Dohme | Composés de benzo[b]thiophéne en tant qu'agonistes de sting |
| IL265759B2 (en) | 2016-10-06 | 2025-10-01 | Genentech Inc | Therapeutic and diagnostic methods for cancer |
| WO2018065938A1 (en) | 2016-10-06 | 2018-04-12 | Pfizer Inc. | Dosing regimen of avelumab for the treatment of cancer |
| MY200337A (en) | 2016-10-07 | 2023-12-20 | Novartis Ag | Nucleic acid molecules encoding chimeric antigen receptors comprising a cd20 binding domain |
| TWI764943B (zh) * | 2016-10-10 | 2022-05-21 | 大陸商蘇州盛迪亞生物醫藥有限公司 | 一種抗pd-1抗體和vegfr抑制劑聯合在製備治療癌症的藥物中的用途 |
| CN110022907A (zh) | 2016-10-10 | 2019-07-16 | 国家生物技术研究所公司 | 非细胞毒性的修饰细胞及其用途 |
| US11291718B2 (en) | 2016-10-11 | 2022-04-05 | Cytlimic Inc. | Method for treating cancer by administering a toll-like receptor agonist and LAG-3 IgG fusion protein |
| WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
| BR112019007365A2 (pt) | 2016-10-12 | 2019-07-09 | Board Of Regents, The University Of Texas System | métodos e composições para imunoterapia com tusc2 |
| WO2018071576A1 (en) | 2016-10-14 | 2018-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Treatment of tumors by inhibition of cd300f |
| US20190263927A1 (en) | 2016-10-14 | 2019-08-29 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and eribulin for treating urothelial cancer |
| WO2018073753A1 (en) | 2016-10-18 | 2018-04-26 | Novartis Ag | Fused tetracyclic pyridone compounds as antivirals |
| WO2018075447A1 (en) | 2016-10-19 | 2018-04-26 | The Trustees Of Columbia University In The City Of New York | Combination of braf inhibitor, talimogene laherparepvec, and immune checkpoint inhibitor for use in the treatment cancer (melanoma) |
| WO2018075842A1 (en) | 2016-10-20 | 2018-04-26 | Bristol-Myers Squibb Company | Condensed benzodiazepine derivatives and conjugates made therefrom |
| EP3529264B1 (en) | 2016-10-24 | 2022-03-09 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
| CA3041678A1 (en) | 2016-10-26 | 2018-05-03 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| WO2018081621A1 (en) | 2016-10-28 | 2018-05-03 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
| US11555076B2 (en) | 2016-10-29 | 2023-01-17 | Genentech, Inc. | Anti-MIC antibodies and methods of use |
| WO2018080812A1 (en) * | 2016-10-30 | 2018-05-03 | Henlix, Inc. | Anti-pd-l1 antibodies and variants |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| US11155624B2 (en) | 2016-11-01 | 2021-10-26 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (PD-1) |
| BR112019008861A2 (pt) | 2016-11-01 | 2019-07-09 | Tesaro, Inc. | anticorpos direcionados contra imunoglobulina de células t e proteína de mucina 3 (tim-3) |
| CA3041183A1 (en) | 2016-11-02 | 2018-05-11 | Engmab Sarl | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
| JP7086066B2 (ja) | 2016-11-02 | 2022-06-17 | ジョンス セラピューティクス, インコーポレイテッド | Pd-1に対する抗体及びその使用 |
| WO2018083087A2 (en) | 2016-11-02 | 2018-05-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Binding proteins |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| US11117968B2 (en) * | 2016-11-03 | 2021-09-14 | Bristol-Myers Squibb Company | Activatable anti-CTLA-4 antibodies and uses thereof |
| US10342785B2 (en) | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| EP3535280B1 (en) | 2016-11-07 | 2022-03-16 | Bristol-Myers Squibb Company | Immunomodulators |
| CN118480125A (zh) * | 2016-11-08 | 2024-08-13 | 齐鲁皮吉特湾生物治疗有限公司 | 抗pd1和抗ctla4抗体 |
| WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
| EP3538112A4 (en) | 2016-11-09 | 2020-09-02 | Musc Foundation for Research Development | CD38-NAD + REGULATED METABOLIC AXIS IN ANTITUMOR IMMUNOTHERAPY |
| WO2018087391A1 (en) | 2016-11-14 | 2018-05-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for modulating stem cells proliferation or differentiation |
| AU2017361081B2 (en) | 2016-11-15 | 2024-12-19 | Genentech, Inc. | Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies |
| EP3541930A1 (en) | 2016-11-17 | 2019-09-25 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| CN117599061A (zh) | 2016-11-17 | 2024-02-27 | 得克萨斯州大学系统董事会 | 具有针对携带egfr或her2外显子20突变之癌细胞的抗肿瘤活性的化合物 |
| CA3043141A1 (en) | 2016-11-18 | 2018-05-24 | Symphogen A/S | Anti-pd-1 antibodies and compositions |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| CN110177571B (zh) * | 2016-11-18 | 2024-05-24 | 加利福尼亚大学董事会 | 工程化抗体及其用途 |
| EP3541825A1 (en) | 2016-11-21 | 2019-09-25 | Idenix Pharmaceuticals LLC. | Cyclic phosphate substituted nucleoside derivatives for the treatment of liver diseases |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| CA3039316A1 (en) | 2016-11-28 | 2018-05-31 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand binding activity |
| WO2018102427A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| WO2018102536A1 (en) | 2016-11-30 | 2018-06-07 | Oncomed Pharmaceuticals, Inc. | Methods for treatment of cancer comprising tigit-binding agents |
| TW201825119A (zh) | 2016-11-30 | 2018-07-16 | 日商協和醱酵麒麟有限公司 | 使用抗ccr4抗體及抗pd-1抗體治療癌症之方法 |
| EP3548068A1 (en) | 2016-12-01 | 2019-10-09 | GlaxoSmithKline Intellectual Property Development Limited | Combination therapy |
| MY191926A (en) | 2016-12-01 | 2022-07-18 | Regeneron Pharma | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
| CA3045241A1 (en) | 2016-12-01 | 2018-06-07 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| AU2017368332A1 (en) | 2016-12-03 | 2019-06-13 | Juno Therapeutics, Inc. | Methods for modulation of CAR-T cells |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| AU2017373945B2 (en) * | 2016-12-07 | 2025-01-23 | Agenus Inc. | Antibodies and methods of use thereof |
| HUE065144T2 (hu) | 2016-12-07 | 2024-05-28 | Agenus Inc | Anti-CTLA-4 antitestek és azok felhasználásának módszerei |
| CN110234647B (zh) | 2016-12-08 | 2023-05-23 | 利克斯特生物技术公司 | 用于调节免疫应答的氧杂双环庚烷 |
| WO2018107082A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent fc compounds |
| EP3551647A4 (en) | 2016-12-09 | 2021-01-13 | Gliknik Inc. | MANUFACTURING OPTIMIZATION OF GL-2045, MULTIMERIZING STRADOMER |
| KR20190095921A (ko) | 2016-12-12 | 2019-08-16 | 제넨테크, 인크. | 항-pd-l1 항체 및 안티안드로겐을 사용하여 암을 치료하는 방법 |
| WO2018111902A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| US11273155B2 (en) | 2016-12-12 | 2022-03-15 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
| WO2018112266A1 (en) | 2016-12-14 | 2018-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13 superkine: immune cell targeting constructs and methods of use thereof |
| WO2018112360A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating cancer |
| WO2018112364A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating melanoma |
| MA47130B1 (fr) * | 2016-12-21 | 2025-05-30 | Cephalon, Inc. | Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations |
| ES2918974T3 (es) | 2016-12-22 | 2022-07-21 | Incyte Corp | Compuestos heteroaromaticos biciclicos como inmunomoduladores |
| EA201991528A1 (ru) | 2016-12-22 | 2020-01-16 | Эмджен Инк. | БЕНЗИЗОТИАЗОЛЬНЫЕ, ИЗОТИАЗОЛО[3,4-b]ПИРИДИНОВЫЕ, ХИНАЗОЛИНОВЫЕ, ФТАЛАЗИНОВЫЕ, ПИРИДО[2,3-d]ПИРИДАЗИНОВЫЕ И ПИРИДО[2,3-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ G12C KRAS ДЛЯ ЛЕЧЕНИЯ РАКА ЛЕГКОГО, РАКА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ ИЛИ КОЛОРЕКТАЛЬНОГО РАКА |
| BR112019012993A2 (pt) | 2016-12-22 | 2019-12-03 | Incyte Corporation | derivados de benzo-oxazol como imunomoduladores |
| CN106519034B (zh) * | 2016-12-22 | 2020-09-18 | 鲁南制药集团股份有限公司 | 抗pd-1抗体及其用途 |
| CN110366564B (zh) | 2016-12-23 | 2023-07-07 | 瑞美德生物医药科技有限公司 | 使用与程序性死亡1(pd-1)结合的抗体的免疫疗法 |
| CA3047508A1 (en) | 2016-12-23 | 2018-06-28 | Virttu Biologics Limited | Treatment of cancer |
| RU2761873C2 (ru) * | 2016-12-23 | 2021-12-13 | Кэйо Юниверсити | Композиции и способы для индукции cd8+ t-клеток |
| WO2018122249A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
| WO2018122245A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
| US12162932B2 (en) | 2017-01-05 | 2024-12-10 | Netris Pharma | Combined treatment with Netrin-1 interfering drug and immune checkpoint inhibitors drugs |
| US11357841B2 (en) | 2017-01-06 | 2022-06-14 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| CA3049435A1 (en) | 2017-01-09 | 2018-07-12 | Scott Grindrod | Selective histone deacetylase inhibitors for the treatment of human disease |
| AU2018206481B2 (en) | 2017-01-09 | 2025-02-27 | Tesaro, Inc. | Methods of treating cancer with anti-PD-1 antibodies |
| US11613785B2 (en) | 2017-01-09 | 2023-03-28 | Onkosxcel Therapeutics, Llc | Predictive and diagnostic methods for prostate cancer |
| TWI793094B (zh) | 2017-01-09 | 2023-02-21 | 美商提薩羅有限公司 | 用抗tim-3抗體治療癌症之方法 |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| EP3568466A4 (en) | 2017-01-10 | 2020-07-15 | The General Hospital Corporation | TARGETED T CELLS WITH CYTOTOXICITY TO IMMUNOSUPPRESSIVE CELLS |
| CA3049016A1 (en) | 2017-01-13 | 2018-07-19 | Agenus Inc. | T cell receptors that bind to ny-eso-1 and methods of use thereof |
| WO2018134279A1 (en) | 2017-01-18 | 2018-07-26 | Pieris Pharmaceuticals Gmbh | Novel fusion polypeptides specific for lag-3 and pd-1 |
| US20200237874A1 (en) | 2017-01-20 | 2020-07-30 | Novartis Ag | Combination therapy for the treatment of cancer |
| US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| CN108341871A (zh) * | 2017-01-24 | 2018-07-31 | 三生国健药业(上海)股份有限公司 | 抗pd-1单克隆抗体及其制备方法和应用 |
| US11555038B2 (en) | 2017-01-25 | 2023-01-17 | Beigene, Ltd. | Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| EP3573979A1 (en) | 2017-01-27 | 2019-12-04 | Celgene Corporation | 3-(1-oxo-4-((4-((3-oxomorpholino) methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione and isotopologues thereof |
| SG11201907023UA (en) | 2017-02-01 | 2019-08-27 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
| JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
| EP3577138A1 (en) | 2017-02-06 | 2019-12-11 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| IL268346B2 (en) | 2017-02-06 | 2024-08-01 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
| US10906985B2 (en) | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| WO2018146128A1 (en) | 2017-02-07 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Detection of kit polymorphism for predicting the response to checkpoint blockade cancer immunotherapy |
| WO2018146148A1 (en) | 2017-02-07 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for predicting the response to checkpoint blockade cancer immunotherapy |
| US12303505B2 (en) | 2017-02-08 | 2025-05-20 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
| SI3579874T1 (sl) | 2017-02-10 | 2021-11-30 | Novartis Ag | 1-(4-amino-5-bromo-6-(1 h-pirazol-1-yl)pyrimidin-2-il)-1 h-pirazol-4-ol in njegova uporaba v zdravljenju raka |
| WO2018150326A1 (en) | 2017-02-15 | 2018-08-23 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| WO2018151820A1 (en) | 2017-02-16 | 2018-08-23 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| IL268479B2 (en) | 2017-02-21 | 2024-06-01 | Regeneron Pharma | Anti-PD-1 antibodies for the treatment of lung cancer |
| US12077590B2 (en) | 2017-02-22 | 2024-09-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bispecific antibody for cancer immunotherapy |
| WO2018156434A1 (en) | 2017-02-22 | 2018-08-30 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Tim3-binding chimeric antigen receptors |
| US11693007B2 (en) | 2017-02-24 | 2023-07-04 | Board Of Regents, The University Of Texas System | Assay for detection of early stage pancreatic cancer |
| US11815435B2 (en) | 2017-02-24 | 2023-11-14 | Hibercell, Inc. | Beta glucan immunopharmacodynamics |
| EP3585437B1 (en) | 2017-02-24 | 2022-12-21 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib with anti-pd-1 antibody |
| BR112019017628A2 (pt) | 2017-02-24 | 2020-07-07 | Macrogenics, Inc. | molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição |
| CN110573504A (zh) | 2017-02-27 | 2019-12-13 | 葛兰素史克知识产权开发有限公司 | 作为激酶抑制剂的杂环酰胺 |
| AU2018223349A1 (en) | 2017-02-27 | 2019-08-29 | Bristol-Myers Squibb | Dosing schedule for a combination of ceritinib and an anti-PD-1 antibody molecule |
| EP3366703B1 (en) | 2017-02-28 | 2019-04-03 | Ralf Kleef | Immune checkpoint therapy with hyperthermia |
| MX2019009660A (es) | 2017-02-28 | 2019-10-02 | Bristol Myers Squibb Co | Uso de anticuerpos antigeno 4 del linfocito t (ctla-4) con citotoxicidad celular dependiente de anticuerpos (adcc) mejorada para mejorar la respuesta inmune a una vacuna. |
| US20180271996A1 (en) | 2017-02-28 | 2018-09-27 | Mersana Therapeutics, Inc. | Combination therapies of her2-targeted antibody-drug conjugates |
| PE20200735A1 (es) | 2017-02-28 | 2020-07-23 | Sanofi Sa | Arn terapeutico |
| CN110546277B (zh) | 2017-03-01 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| EP3589652B1 (en) * | 2017-03-04 | 2024-12-25 | Xiangtan Tenghua Bioscience | Recombinant antibodies to programmed death 1 (pd-1) and uses therefor |
| EP3592868B1 (en) | 2017-03-06 | 2022-11-23 | Novartis AG | Methods of treatment of cancer with reduced ubb expression |
| EP3596469A1 (en) | 2017-03-12 | 2020-01-22 | Yeda Research and Development Co., Ltd. | Methods of diagnosing and prognosing cancer |
| WO2018167780A1 (en) | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of prognosing and treating cancer |
| WO2018170168A1 (en) | 2017-03-15 | 2018-09-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| JP2020510050A (ja) | 2017-03-15 | 2020-04-02 | アムジエン・インコーポレーテツド | がんを治療するための、腫瘍溶解性ウイルスの単独又はチェックポイント阻害剤との組み合わせでの使用 |
| JP7165717B2 (ja) | 2017-03-15 | 2022-11-04 | パンディオン・オペレーションズ・インコーポレイテッド | 標的免疫寛容 |
| AU2018235092B2 (en) | 2017-03-16 | 2024-09-19 | Innate Pharma | Compositions and methods for treating cancer |
| EP3600427A1 (en) | 2017-03-24 | 2020-02-05 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and compositions for treating melanoma |
| CN108623686A (zh) | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | 抗ox40抗体及其用途 |
| JP7346302B2 (ja) | 2017-03-28 | 2023-09-19 | オハイオ・ステイト・イノベーション・ファウンデーション | ヒトpd-1ペプチドワクチン及びその使用法 |
| EP3601338A4 (en) * | 2017-03-29 | 2020-12-16 | Celgene Corporation | FORMULATIONS INCLUDING PROTEINS BINDING PD-1 AND THEIR PREPARATION METHODS |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| WO2018183608A1 (en) | 2017-03-31 | 2018-10-04 | Five Prime Therapeutics, Inc. | Combination therapy for cancer using anti-gitr antibodies |
| MX2019010958A (es) | 2017-03-31 | 2019-10-17 | Bristol Myers Squibb Co | Metodos de tratamiento de tumores. |
| RU2734900C1 (ru) | 2017-03-31 | 2020-10-26 | Фуджифилм Корпорэйшн | Липосомальная композиция и фармацевтическая композиция |
| CA3053226A1 (en) | 2017-03-31 | 2018-10-04 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| WO2018187227A1 (en) | 2017-04-03 | 2018-10-11 | Concologie, Inc. | Methods for treating cancer using ps-targeting antibodies with immuno-oncology agents |
| PL3606946T3 (pl) | 2017-04-03 | 2022-11-28 | F. Hoffmann-La Roche Ag | Immunokoniugaty przeciwciała anty-PD-1 ze zmutowaną IL-2 lub z IL-15 |
| WO2018187356A2 (en) | 2017-04-03 | 2018-10-11 | Neon Therapeutics, Inc. | Protein antigens and uses thereof |
| UA128451C2 (uk) | 2017-04-05 | 2024-07-17 | Ф. Хоффманн-Ля Рош Аг | Біспецифічне антитіло, яке специфічно зв'язується з pd1 і lag3 |
| US20200101079A1 (en) | 2017-04-05 | 2020-04-02 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| KR20220083863A (ko) | 2017-04-05 | 2022-06-20 | 심포젠 에이/에스 | Pd-1, tim-3 및 lag-3을 표적화하는 조합 요법 |
| US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| MX2019012187A (es) | 2017-04-13 | 2019-11-25 | Hoffmann La Roche | Un inmunoconjugado de interleuquina-2, un agonista de cd40 y opcionalmente un antagonista de union al eje pd-1 para uso en metodos para tratar cancer. |
| BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc | anticorpos anti-cd137 e métodos de uso dos mesmos |
| MX2019012192A (es) | 2017-04-14 | 2020-01-21 | Genentech Inc | Métodos de diagnóstico y terapéuticos para el cáncer. |
| US12460208B2 (en) | 2017-04-18 | 2025-11-04 | Parr Biotechnology Co., Ltd. | Immunomodulatory polynucleotides and uses thereof |
| US11738009B2 (en) | 2017-04-18 | 2023-08-29 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| CN108728444A (zh) | 2017-04-18 | 2018-11-02 | 长春华普生物技术股份有限公司 | 免疫调节性多核苷酸及其应用 |
| CN110709422B (zh) | 2017-04-19 | 2023-12-26 | 马伦戈治疗公司 | 多特异性分子及其用途 |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| CN106939049B (zh) | 2017-04-20 | 2019-10-01 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用 |
| WO2018195552A1 (en) | 2017-04-21 | 2018-10-25 | Sillajen, Inc. | Oncolytic vaccinia virus and checkpoint inhibitor combination therapy |
| EP3615070A1 (en) | 2017-04-26 | 2020-03-04 | Bristol-Myers Squibb Company | Methods of antibody production that minimize disulfide bond reduction |
| AR111419A1 (es) | 2017-04-27 | 2019-07-10 | Novartis Ag | Compuestos fusionados de indazol piridona como antivirales |
| CN108794467A (zh) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| EP4063859A1 (en) | 2017-04-28 | 2022-09-28 | Merck Sharp & Dohme Corp. | Biomarkers for cancer therapeutics |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| CA3059769A1 (en) | 2017-04-28 | 2018-11-01 | Elstar Therapeutics, Inc. | Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| WO2018201056A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| JP2020517913A (ja) | 2017-04-28 | 2020-06-18 | ファイブ プライム セラピューティクス, インコーポレイテッド | Cd80細胞外ドメインポリペプチドによる治療方法 |
| US11427636B2 (en) * | 2017-05-01 | 2022-08-30 | The Children's Medical Center Corporation | Methods and compositions relating to anti-PD1 antibody reagents |
| US11021537B2 (en) | 2017-05-01 | 2021-06-01 | Agenus Inc. | Anti-TIGIT antibodies and methods of use thereof |
| SG11201909955XA (en) | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| MX2019013034A (es) * | 2017-05-02 | 2020-02-05 | Merck Sharp & Dohme | Formulaciones estables de anticuerpos anti-ctla4 solos y en combinacion con anticuerpos contra el receptor de muerte programasa 1 (pd-1) y metodos para su uso. |
| UY37718A (es) | 2017-05-05 | 2018-11-30 | Novartis Ag | 2-quinolinonas triciclicas como agentes antibacteriales |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| KR102376863B1 (ko) | 2017-05-12 | 2022-03-21 | 하푼 테라퓨틱스, 인크. | 메소텔린 결합 단백질 |
| EP3621624B1 (en) | 2017-05-12 | 2023-08-30 | Merck Sharp & Dohme LLC | Cyclic di-nucleotide compounds as sting agonists |
| KR20200006115A (ko) | 2017-05-16 | 2020-01-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-gitr 효능제 항체에 의한 암의 치료 |
| CN110831597A (zh) | 2017-05-16 | 2020-02-21 | 卫材R&D管理有限公司 | 肝细胞癌的治疗 |
| US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
| WO2018213731A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
| CN116478289A (zh) * | 2017-05-19 | 2023-07-25 | 上海药明生物技术有限公司 | 一种新的ctla-4单克隆抗体 |
| AR111760A1 (es) | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
| WO2018209701A1 (en) | 2017-05-19 | 2018-11-22 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4) |
| RS61872B1 (sr) | 2017-05-22 | 2021-06-30 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| CN108948206B (zh) * | 2017-05-23 | 2022-08-23 | 赵磊 | 一种抗egfr/pd-1双靶向抗体、其制备方法及用途 |
| CA3064435A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| BR112019024556A2 (pt) | 2017-05-24 | 2020-06-23 | Novartis Ag | Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer |
| EP3630162A1 (en) | 2017-05-24 | 2020-04-08 | Novartis AG | Antibody-cytokine engrafted proteins and methods of use |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| MX2019013132A (es) | 2017-05-25 | 2020-01-27 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas. |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CN111108123A (zh) | 2017-05-29 | 2020-05-05 | 加马玛布斯制药公司 | 癌症相关的免疫抑制抑制剂 |
| HUE065242T2 (hu) | 2017-05-30 | 2024-05-28 | Bristol Myers Squibb Co | LAG-3-pozitív tumorok kezelése |
| KR102721137B1 (ko) | 2017-05-30 | 2024-10-25 | 브리스톨-마이어스 스큅 컴퍼니 | 항-lag-3 항체 또는 항-lag-3 항체 및 항-pd-1 또는 항-pd-l1 항체를 포함하는 조성물 |
| AU2018277559A1 (en) | 2017-05-30 | 2019-10-17 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-LAG-3 antibody, a PD-1 pathway inhibitor, and an immunotherapeutic agent |
| AU2018277545B2 (en) | 2017-05-31 | 2025-05-15 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
| JOP20190279A1 (ar) | 2017-05-31 | 2019-11-28 | Novartis Ag | الصور البلورية من 5-برومو -2، 6-داي (1h-بيرازول -1-يل) بيريميدين -4- أمين وأملاح جديدة |
| EP3630836A1 (en) | 2017-05-31 | 2020-04-08 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| US20200181274A1 (en) | 2017-06-01 | 2020-06-11 | Novartis Ag | Bispecific antibodies that bind cd 123 cd3 |
| US11168144B2 (en) | 2017-06-01 | 2021-11-09 | Cytomx Therapeutics, Inc. | Activatable anti-PDL1 antibodies, and methods of use thereof |
| WO2018223004A1 (en) | 2017-06-01 | 2018-12-06 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 |
| EP3630840A1 (en) | 2017-06-01 | 2020-04-08 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-pd-1 antibody |
| WO2018220169A1 (en) | 2017-06-02 | 2018-12-06 | Boehringer Ingelheim International Gmbh | Anti-cancer combination therapy |
| EP3630126A4 (en) | 2017-06-02 | 2021-03-17 | The Penn State Research Foundation | CERAMIDE NANOLIPOSOMES, COMPOSITIONS AND METHODS OF USE FOR IMMUNOTHERAPY |
| MX2019014268A (es) | 2017-06-02 | 2020-08-03 | Juno Therapeutics Inc | Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva. |
| US11819517B2 (en) | 2017-06-05 | 2023-11-21 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| US11542331B2 (en) | 2017-06-06 | 2023-01-03 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to BTN1A1 or BTN1A1-ligands |
| WO2018225093A1 (en) | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| JP2020522555A (ja) | 2017-06-09 | 2020-07-30 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 組み合わせ療法 |
| JP7657023B2 (ja) | 2017-06-09 | 2025-04-04 | プロビデンス ヘルス アンド サービシーズ-オレゴン | がんの処置のための腫瘍反応性ヒトt細胞の同定のためのcd39およびcd103の使用 |
| HRP20202033T1 (hr) | 2017-06-14 | 2021-02-19 | 4D Pharma Research Limited | Sastavi koji sadrže bakterijske sojeve |
| DK3600363T3 (da) | 2017-06-14 | 2021-01-25 | 4D Pharma Res Ltd | Sammensætninger omfattende bakteriestammer |
| LT3600364T (lt) | 2017-06-14 | 2020-10-26 | 4D Pharma Research Limited | Kompozicijos, apimančios bakterinį kamieną iš megasphaera genties, ir jų panaudojimas |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| EP3641814A4 (en) | 2017-06-19 | 2021-06-23 | Medicenna Therapeutics Inc. | USES AND METHODS FOR IL-2 SUPERAGONISTS AND AGONISTS AND FUSIONS THEREOF |
| EP3641739A1 (en) | 2017-06-20 | 2020-04-29 | Institut Curie | Inhibitor of suv39h1 histone methyltransferase for use in cancer combination therapy |
| EP3641752A4 (en) | 2017-06-22 | 2021-03-17 | Moonshot Pharma LLC | CANCER TREATMENT METHODS USING COMPOSITIONS INCLUDING AMLEXANOX AND IMMUNOMODULATORS |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| KR20200021087A (ko) | 2017-06-22 | 2020-02-27 | 노파르티스 아게 | Cd73에 대한 항체 분자 및 이의 용도 |
| EP3641772B1 (en) | 2017-06-22 | 2023-08-02 | Celgene Corporation | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| KR102735038B1 (ko) | 2017-06-23 | 2024-11-28 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-1의 길항제로서 작용하는 면역조정제 |
| WO2018232725A1 (en) | 2017-06-23 | 2018-12-27 | Birdie Biopharmaceuticals, Inc. | Pharmaceutical compositions |
| JP7601635B2 (ja) * | 2017-06-25 | 2024-12-17 | システィミューン, インク. | 抗pd-1抗体とその作製及び使用方法 |
| CN116535508A (zh) * | 2017-06-25 | 2023-08-04 | 西雅图免疫公司 | 抗pd-l1抗体及其制备和使用方法 |
| WO2019001417A1 (en) | 2017-06-26 | 2019-01-03 | Beigene, Ltd. | IMMUNOTHERAPY FOR HEPATOCELLULAR CARCINOMA |
| JP2020525483A (ja) | 2017-06-27 | 2020-08-27 | ノバルティス アーゲー | 抗tim−3抗体のための投与レジメンおよびその使用 |
| AU2018291081B2 (en) | 2017-06-27 | 2025-02-20 | Neuracle Science Co., Ltd. | Use of anti-FAM19A5 antibodies for treating cancers |
| AU2018291032A1 (en) | 2017-06-29 | 2020-01-16 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| HUE061356T2 (hu) | 2017-06-30 | 2023-06-28 | Celgene Corp | 2-(4-klórfenil)-N-((2-(2,6-dioxopiperidin-3-il)-1-oxoizoindolin-5-il)metil)-2,2--difluoracetamidot tartalmazó készítmények és eljárások ezek alkalmazására |
| JP7158677B2 (ja) * | 2017-06-30 | 2022-10-24 | 小野薬品工業株式会社 | 溶血性レンサ球菌の菌体を含む製剤との併用療法 |
| US20200140383A1 (en) | 2017-07-03 | 2020-05-07 | Glaxosmithkline Intellectual Property Development Limited | 2-(4-chlorophenoxy)-n-((1 -(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases |
| US20210145771A1 (en) | 2017-07-03 | 2021-05-20 | Glaxosmithkline Intellectual Property Development Limited | N-(3-(2-(4-chlorophenoxy)acetamido)bicyclo[1.1.1] pentan-1-yl)-2-cyclobutane-1- carboxamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases |
| US11732043B2 (en) * | 2017-07-06 | 2023-08-22 | Merus N.V. | Antibodies that modulate a biological activity expressed by a cell |
| EA202090003A1 (ru) | 2017-07-06 | 2020-06-18 | Мерус Н.В. | Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка |
| BR112020000227A2 (pt) | 2017-07-06 | 2020-09-29 | Merus N.V. | anticorpos biespecíficos anti pd1-anti tim3 |
| SG11201911838UA (en) | 2017-07-07 | 2020-01-30 | H Lee Moffitt Cancer Center And Research Institute Inc | Chimeric antigen receptors with mutated cd28 costimulatory domains |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| AU2018298676A1 (en) | 2017-07-10 | 2019-12-19 | Innate Pharma | Siglec-9-neutralizing antibodies |
| US10357489B2 (en) | 2017-07-10 | 2019-07-23 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| US11293066B2 (en) | 2017-07-18 | 2022-04-05 | Institut Gustave Roussy | Method for assessing the response to PD-1/PDL-1 targeting drugs |
| IL319798A (en) | 2017-07-20 | 2025-05-01 | Novartis Ag | ANTI-LAG-3 Antibody Dosage Regimens and Their Uses |
| MX2020000604A (es) | 2017-07-21 | 2020-09-10 | Genentech Inc | Métodos terapéuticos y de diagnóstico para el cáncer. |
| US11926664B2 (en) | 2017-07-25 | 2024-03-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for modulating monocytopoiesis |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| WO2019021208A1 (en) | 2017-07-27 | 2019-01-31 | Glaxosmithkline Intellectual Property Development Limited | USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS |
| KR20200033930A (ko) | 2017-07-28 | 2020-03-30 | 브리스톨-마이어스 스큅 컴퍼니 | 체크포인트 억제제에 대한 예측성 말초 혈액 바이오마커 |
| SG11202000932XA (en) | 2017-08-03 | 2020-02-27 | Otsuka Pharma Co Ltd | Drug compound and purification methods thereof |
| ES2975221T3 (es) | 2017-08-03 | 2024-07-04 | Amgen Inc | Muteínas de interleucina-21 y métodos de tratamiento |
| CA3071537A1 (en) | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | Combinations of pd-1 antagonists and benzo[b]thiophene sting agonists for cancer treatment |
| EP3661498A4 (en) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme Corp. | BENZO [B] THIOPHEN STING ANTAGONISTS FOR CANCER TREATMENT |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| JP7250764B2 (ja) | 2017-08-18 | 2023-04-03 | コセラ バイオサイエンス, インコーポレイテッド | Tg02の多形形態 |
| WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| CN107383174B (zh) * | 2017-08-21 | 2019-01-18 | 生工生物工程(上海)股份有限公司 | 一种能与pd-1特异性结合的肿瘤抑制肽及其用途 |
| CA3078605A1 (en) | 2017-08-28 | 2019-03-07 | Bristol-Myers Squibb Company | Tim-3 antagonists for the treatment and diagnosis of cancers |
| JP7387585B2 (ja) | 2017-09-04 | 2023-11-28 | アジェナス インコーポレイテッド | 混合系統白血病(mll)特異的ホスホペプチドに結合するt細胞受容体およびその使用方法 |
| CN111133005B (zh) | 2017-09-07 | 2024-09-03 | 奥古斯塔大学研究所公司 | 程序性细胞死亡蛋白1抗体 |
| UY37866A (es) | 2017-09-07 | 2019-03-29 | Glaxosmithkline Ip Dev Ltd | Nuevos compuestos derivados de benzoimidazol sustituidos que reducen la proteína myc (c-myc) en las células e inhiben la histona acetiltransferasa de p300/cbp. |
| EP3679040B1 (en) | 2017-09-08 | 2022-08-03 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| WO2019053617A1 (en) | 2017-09-12 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | CHEMICAL COMPOUNDS |
| US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
| AU2018334171A1 (en) | 2017-09-13 | 2020-03-05 | Bristol-Myers Squibb Company | Combination anti-CSF1R and anti-PD-1 antibody combination therapy for pancreatic cancer |
| WO2019057744A1 (en) | 2017-09-19 | 2019-03-28 | Institut Curie | AROMATIC HYDROCARBON RECEPTOR AGONIST FOR USE IN ASSOCIATION TREATMENT AGAINST CANCER |
| EP3684413A1 (en) | 2017-09-20 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent |
| CN111148534A (zh) * | 2017-09-29 | 2020-05-12 | 勃林格殷格翰国际有限公司 | 抗igf和抗pd-1抗癌组合疗法 |
| US11351163B2 (en) | 2017-09-29 | 2022-06-07 | Bristol-Myers Squibb Company | Compositions and methods of treating cancer |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| JP7257393B2 (ja) | 2017-10-03 | 2023-04-13 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| CN111417630B (zh) | 2017-10-05 | 2023-06-06 | 葛兰素史克知识产权开发有限公司 | 干扰素基因刺激因子(sting)的调节剂 |
| JP2020536106A (ja) | 2017-10-05 | 2020-12-10 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Hivの処置に有用なインターフェロン遺伝子の刺激物質(sting)の調節物質 |
| EP3692068B1 (en) | 2017-10-06 | 2022-12-07 | Innate Pharma | Restoration of t cell activity via the cd39/cd73 axis |
| WO2019072566A1 (en) | 2017-10-10 | 2019-04-18 | Biotest Ag | COMBINATION OF ANTI-IL10 AND ANTI-PD1 ANTIBODIES FOR THE TREATMENT OF CANCER |
| US11136300B2 (en) | 2017-10-11 | 2021-10-05 | Aurigene Discovery Technologies Limited | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
| CN111433222B (zh) | 2017-10-12 | 2025-01-28 | 得克萨斯大学体系董事会 | 用于免疫疗法的t细胞受体 |
| HUE068484T2 (hu) | 2017-10-13 | 2025-01-28 | Harpoon Therapeutics Inc | Trispecifikus proteinek és eljárások felhasználásra |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| WO2019075468A1 (en) | 2017-10-15 | 2019-04-18 | Bristol-Myers Squibb Company | TUMOR TREATMENT METHODS |
| EP4488366A3 (en) | 2017-10-18 | 2025-03-12 | Vivia Biotech, S.L. | Bite-activated car-t cells |
| WO2019083971A1 (en) | 2017-10-23 | 2019-05-02 | Children's Medical Center Corporation | METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY |
| WO2019081983A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | CD32B TARGETING ANTIBODIES AND METHODS OF USE |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| KR20200079293A (ko) | 2017-10-31 | 2020-07-02 | 얀센 바이오테크 인코포레이티드 | 고위험 다발성 골수종을 치료하는 방법 |
| JP2021501801A (ja) | 2017-11-01 | 2021-01-21 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 癌の処置に用いるための免疫刺激アゴニスト抗体 |
| MX2020004243A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Receptores de anticuerpos y de antigenos quimericos especificos para el antigeno de maduracion de celulas b. |
| PL3703750T3 (pl) | 2017-11-01 | 2025-04-07 | Juno Therapeutics, Inc. | Chimeryczne receptory antygenowe specyficzne dla antygenu dojrzewania komórek b i kodujące polinukleotydy |
| EP3703692B1 (en) | 2017-11-01 | 2025-07-23 | Merck Sharp & Dohme LLC | Novel substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| JP7159007B2 (ja) | 2017-11-01 | 2022-10-24 | 小野薬品工業株式会社 | 脳腫瘍の治療のための医薬 |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| JP7378394B2 (ja) | 2017-11-03 | 2023-11-13 | オーリジーン オンコロジー リミテッド | Tim-3およびpd-1経路の二重阻害剤 |
| ES2984919T3 (es) | 2017-11-06 | 2024-10-31 | Hoffmann La Roche | Procedimientos diagnósticos y terapéuticos para el cáncer |
| CA3081748A1 (en) | 2017-11-06 | 2019-05-09 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| CA3081675A1 (en) | 2017-11-06 | 2019-05-09 | Aurigene Discovery Technologies Limited | Conjoint therapies for immunomodulation |
| EP3707165A4 (en) | 2017-11-07 | 2021-09-08 | The Board of Regents of The University of Texas System | LILRB4 TARGETING WITH CAR-T OR CAR-NK CELLS IN THE TREATMENT OF CANCER |
| EP3706803A4 (en) | 2017-11-08 | 2021-08-04 | Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. | CONJUGATES BASED ON A BIOMOLECULE AND THEIR USE |
| ES2939112T3 (es) | 2017-11-10 | 2023-04-19 | Armo Biosciences Inc | Composiciones y métodos de uso de interleucina-10 en combinación con inhibidores de vías de puntos de control inmunitario |
| WO2019099294A1 (en) | 2017-11-14 | 2019-05-23 | Merck Sharp & Dohme Corp. | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| KR102718287B1 (ko) | 2017-11-14 | 2024-10-16 | 머크 샤프 앤드 돔 엘엘씨 | 인돌아민 2,3-디옥시게나제 (ido) 억제제로서의 신규 치환된 비아릴 화합물 |
| TWI698238B (zh) | 2017-11-14 | 2020-07-11 | 美商輝瑞股份有限公司 | Ezh2抑制劑組合治療 |
| WO2019096136A1 (zh) * | 2017-11-14 | 2019-05-23 | 拜西欧斯(北京)生物技术有限公司 | 抗pd-1抗体及其制备方法和应用 |
| KR20200089286A (ko) | 2017-11-16 | 2020-07-24 | 노파르티스 아게 | 조합 요법 |
| WO2019097479A1 (en) | 2017-11-17 | 2019-05-23 | Novartis Ag | Novel dihydroisoxazole compounds and their use for the treatment of hepatitis b |
| JP7194481B2 (ja) | 2017-11-17 | 2022-12-22 | メルク・シャープ・アンド・ドーム・エルエルシー | 免疫グロブリン様転写産物3(ilt3)に特異的な抗体およびその使用 |
| TW202446951A (zh) | 2017-11-17 | 2024-12-01 | 美商艾歐凡斯生物治療公司 | 來自細針抽吸物及小活體組織切片之腫瘤浸潤淋巴細胞(til)擴增 |
| AU2018371212B2 (en) | 2017-11-24 | 2025-04-17 | Assistance Publique - Hôpitaux De Paris | Methods and compositions for treating cancers |
| WO2019104289A1 (en) | 2017-11-27 | 2019-05-31 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| CA3083259A1 (en) | 2017-11-28 | 2019-06-06 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide including antigen-binding domain and carrying section |
| MX2020005160A (es) | 2017-11-28 | 2020-08-20 | Chugai Pharmaceutical Co Ltd | Molecula de union a ligando que tiene actividad de union a ligando ajustable. |
| WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
| RU2020121458A (ru) | 2017-11-30 | 2021-12-30 | Новартис Аг | Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения |
| WO2019104716A1 (en) * | 2017-12-01 | 2019-06-06 | Adagene Inc. | Methods for using cd137 ligand as biomarker for treatment with anti-cd137 antibody |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US20200377571A1 (en) | 2017-12-08 | 2020-12-03 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
| US11946094B2 (en) | 2017-12-10 | 2024-04-02 | Augusta University Research Institute, Inc. | Combination therapies and methods of use thereof |
| US12006356B2 (en) | 2017-12-15 | 2024-06-11 | Juno Therapeutics, Inc. | Anti-CCT5 binding molecules and chimeric antigen receptors comprising the same |
| US11793867B2 (en) | 2017-12-18 | 2023-10-24 | Biontech Us Inc. | Neoantigens and uses thereof |
| MX2020006372A (es) | 2017-12-19 | 2020-09-03 | Univ Rockefeller | Variantes de dominio de fc de igg humana con funcion efectora mejorada. |
| JP2021507906A (ja) | 2017-12-20 | 2021-02-25 | ノバルティス アーゲー | 抗ウイルス剤としての融合三環式ピラゾロ−ジヒドロピラジニル−ピリドン化合物 |
| WO2019125974A1 (en) | 2017-12-20 | 2019-06-27 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| TW201929908A (zh) | 2017-12-21 | 2019-08-01 | 美商梅爾莎納醫療公司 | 吡咯并苯并二氮呯抗體共軛物 |
| WO2019129137A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| CN115925943A (zh) * | 2017-12-27 | 2023-04-07 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| US11306149B2 (en) | 2017-12-27 | 2022-04-19 | Bristol-Myers Squibb Company | Anti-CD40 antibodies and uses thereof |
| EP3731848A4 (en) | 2017-12-28 | 2021-12-15 | The General Hospital Corporation | TARGETING OF THE CBM-SIGNALOSOME COMPLEX FOR INDUCING REGULATORY T-CELLS TO CITIZE INFLAMMATION OF THE TUMOR MICRO-ENVIRONMENT |
| JP2021508477A (ja) | 2017-12-29 | 2021-03-11 | オンコラス, インコーポレイテッド | 治療用ポリペプチドの腫瘍溶解性ウイルス送達 |
| WO2019134946A1 (en) | 2018-01-04 | 2019-07-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma resistant |
| US11324774B2 (en) | 2018-01-05 | 2022-05-10 | Augusta University Research Institute, Inc. | Compositions of oral alkaline salts and metabolic acid inducers and uses thereof |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| CA3087771A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| BR112020013910A2 (pt) | 2018-01-08 | 2020-12-01 | H. Lee Moffitt Cancer Center And Research Institute Inc. | composições e métodos para alvejamento de cânceres que expressam cd99 |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| AU2019207635A1 (en) | 2018-01-09 | 2020-08-06 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Compositions and methods for targeting CLEC12A-expressing cancers |
| CN112004537A (zh) | 2018-01-09 | 2020-11-27 | 穿梭药业公司 | 用于治疗人疾病的选择性组蛋白去乙酰化酶抑制剂 |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| JOP20200172A1 (ar) * | 2018-01-12 | 2020-07-12 | Amgen Inc | الأجسام المضادة لـ pd-1 وطرق العلاج |
| AU2019207812A1 (en) | 2018-01-12 | 2020-07-23 | Bristol-Myers Squibb Company | Combination therapy with anti-IL-8 antibodies and anti-PD-1 antibodies for treating cancer |
| US12129297B2 (en) | 2018-01-12 | 2024-10-29 | Bristol-Myers Squibb Company | Antibodies against TIM3 and uses thereof |
| CN111868091A (zh) | 2018-01-16 | 2020-10-30 | 百时美施贵宝公司 | 用抗tim3抗体治疗癌症的方法 |
| US20210038559A1 (en) | 2018-01-22 | 2021-02-11 | Thomas Richard Gadek | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| KR20200112904A (ko) | 2018-01-22 | 2020-10-05 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하는 조성물 및 방법 |
| US12286478B2 (en) | 2018-01-23 | 2025-04-29 | Nextcure, Inc. | B7-H4 antibodies and methods of use thereof |
| BR112020014960A2 (pt) | 2018-01-24 | 2020-12-22 | Beyondspring Pharmaceuticals, Inc. | Composição e método para redução de trombocitopenia |
| WO2019148089A1 (en) | 2018-01-26 | 2019-08-01 | Orionis Biosciences Inc. | Xcr1 binding agents and uses thereof |
| AU2019212719B2 (en) | 2018-01-26 | 2024-12-05 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| MA51673B1 (fr) | 2018-01-26 | 2025-10-31 | Exelixis, Inc. | Composés pour le traitement des troubles dépendants de kinases |
| EP3743417A1 (en) | 2018-01-26 | 2020-12-02 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| CA3090249A1 (en) | 2018-01-31 | 2019-08-08 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| EP3746117A1 (en) | 2018-01-31 | 2020-12-09 | Celgene Corporation | Combination therapy using adoptive cell therapy and checkpoint inhibitor |
| CN108314734B (zh) * | 2018-01-31 | 2021-11-05 | 中国药科大学 | 抗pd-1单克隆抗体及其应用 |
| WO2019149716A1 (en) | 2018-01-31 | 2019-08-08 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising an antigen-binding site binding to lag3 |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| CN117643587A (zh) | 2018-02-05 | 2024-03-05 | 深圳市原力生命科学有限公司 | 用于治疗癌症的杂二环羧酸 |
| CN118754990A (zh) | 2018-02-05 | 2024-10-11 | 奥里尼斯生物科学公司股份有限公司 | 成纤维细胞结合剂及其用途 |
| WO2019157087A1 (en) | 2018-02-06 | 2019-08-15 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
| US20200405806A1 (en) | 2018-02-08 | 2020-12-31 | Bristol-Myers Squibb Company | Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors |
| TWI804572B (zh) | 2018-02-09 | 2023-06-11 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| JP2021512638A (ja) | 2018-02-09 | 2021-05-20 | 学校法人慶應義塾 | Cd8+t細胞の誘導のための組成物および方法 |
| NL2020422B1 (en) | 2018-02-12 | 2019-08-19 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Methods for Predicting Treatment Outcome and/or for Selecting a Subject Suitable for Immune Checkpoint Therapy. |
| SI3752501T1 (sl) | 2018-02-13 | 2023-08-31 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| US20200399383A1 (en) | 2018-02-13 | 2020-12-24 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| MX2020008445A (es) | 2018-02-13 | 2020-09-28 | Merck Sharp & Dohme | Metodos para tratar el cancer con anticuerpos anti-pd-1. |
| KR20200119845A (ko) * | 2018-02-13 | 2020-10-20 | 머크 샤프 앤드 돔 코포레이션 | 항 pd-1 항체 및 항 ctla4 항체를 사용한 암의 치료 방법 |
| JP7350756B2 (ja) | 2018-02-14 | 2023-09-26 | アバ セラピューティクス アーゲー | 抗ヒトpd-l2抗体 |
| EP3756012A1 (en) | 2018-02-21 | 2020-12-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sk1 as biomarker for predicting response to immunecheckpoint inhibitors |
| US12090142B2 (en) | 2018-02-22 | 2024-09-17 | Board Of Regents, The University Of Texas System | Combination therapy for the treatment of cancer |
| CR20230030A (es) | 2018-02-27 | 2023-03-10 | Incyte Corp | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b (divisional 2020-0441) |
| EP3759110A1 (en) | 2018-02-28 | 2021-01-06 | Novartis AG | Indole-2-carbonyl compounds and their use for the treatment of hepatitis b |
| WO2019169229A1 (en) | 2018-03-01 | 2019-09-06 | Nextcure, Inc. | Klrg1 binding compositions and methods of use thereof |
| AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
| CA3090620A1 (en) | 2018-03-06 | 2019-09-12 | Institut Curie | Inhibitor of setdb1 histone methyltransferase for use in cancer combination therapy |
| IL277095B2 (en) | 2018-03-07 | 2025-10-01 | Pfizer | Preparations containing anti-PD-1 antibody |
| GB201803746D0 (en) * | 2018-03-08 | 2018-04-25 | Ultrahuman Eight Ltd | PD1 binding agents |
| GB201803745D0 (en) | 2018-03-08 | 2018-04-25 | Ultrahuman Eight Ltd | PD1 binding agents |
| BR112020018585A8 (pt) | 2018-03-12 | 2022-12-06 | Inst Nat Sante Rech Med | Uso de mimeticos de restrição calórica para potencializar a quimioimunoterapia para o tratamento de câncer |
| CN108434452A (zh) * | 2018-03-13 | 2018-08-24 | 安徽瀚海博兴生物技术有限公司 | 一种将pd-1抗体和jmjd6联合用于制备抗癌药物的应用 |
| US12215116B2 (en) | 2018-03-13 | 2025-02-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| WO2019177011A1 (ja) * | 2018-03-13 | 2019-09-19 | 国立大学法人大阪大学 | 腫瘍免疫賦活剤 |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3765516A2 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| CA3092635A1 (en) | 2018-03-14 | 2019-09-19 | Surface Oncology, Inc. | Antibodies that bind cd39 and uses thereof |
| CN110272490B (zh) * | 2018-03-14 | 2021-05-14 | 上海开拓者生物医药有限公司 | 靶向ctla-4抗体、其制备方法和用途 |
| KR20200135986A (ko) | 2018-03-19 | 2020-12-04 | 멀티비르 인코포레이티드 | 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물 |
| EP3768719A4 (en) * | 2018-03-19 | 2022-04-27 | Abeome Corporation | HIGH AFFINITY NEUTRALIZING ANTIBODIES AGAINST PROGRAMMED DEATH LIGAND 1 (PD-L1) AND THEIR USE |
| JP7482031B2 (ja) * | 2018-03-20 | 2024-05-13 | ウーシー バイオロジクス アイルランド リミテッド | 新規の抗pd-1抗体 |
| US12173069B2 (en) | 2018-03-21 | 2024-12-24 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic pH |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體-藥物共軛物的組合治療癌症之方法 |
| KR20250160366A (ko) | 2018-03-22 | 2025-11-12 | 서피스 온콜로지, 엘엘씨 | 항-il-27 항체 및 이의 용도 |
| CN111886256B (zh) | 2018-03-23 | 2025-01-10 | 百时美施贵宝公司 | 抗mica和/或micb抗体及其用途 |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| SG11202009504YA (en) | 2018-03-25 | 2020-10-29 | Snipr Biome Aps | Treating & preventing microbial infections |
| BR112020019251A2 (pt) | 2018-03-27 | 2021-01-12 | Board Of Regents, The University Of Texas System | Compostos com atividade anti-tumor contra células de câncer com mutações de her2 exon 19 |
| MA52667B1 (fr) | 2018-03-29 | 2024-07-31 | Iovance Biotherapeutics, Inc. | Procédés de production de lymphocytes infiltrant les tumeurs et leurs utilisations en immunothérapie |
| WO2019185792A1 (en) | 2018-03-29 | 2019-10-03 | Philogen S.P.A | Cancer treatment using immunoconjugates and immune check-point inhibitors |
| MX2020007842A (es) * | 2018-03-29 | 2020-09-25 | I Mab Biopharma Us Ltd | Anticuerpos anti-pd-l1 y usos de los mismos. |
| CN108588030B (zh) * | 2018-03-30 | 2020-07-14 | 四川迈克生物新材料技术有限公司 | 抗人IgM单克隆抗体、其杂交瘤细胞株及应用 |
| DK4212529T3 (da) | 2018-03-30 | 2025-04-07 | Incyte Corp | Heterocykliske forbindelser som immunmodulatorer |
| EP3774911A1 (en) | 2018-03-30 | 2021-02-17 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN111971277B (zh) | 2018-04-03 | 2023-06-06 | 默沙东有限责任公司 | 作为sting激动剂的苯并噻吩及相关化合物 |
| WO2019195063A1 (en) | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
| KR20200140315A (ko) | 2018-04-04 | 2020-12-15 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cd27 항체 및 그의 용도 |
| WO2019193541A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| WO2019193540A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Heteroaryl derivatives of formula (i) as atf4 inhibitors |
| BR112020020826A2 (pt) | 2018-04-12 | 2021-01-19 | Bristol-Myers Squibb Company | Terapia de combinação anticâncer com anticorpo antagonista de cd73 e anticorpo antagonista do eixo pd-1/pd-l1 |
| US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
| KR20200143689A (ko) * | 2018-04-15 | 2020-12-24 | 살루브리스 (청두) 바이오테크 코., 리미티드 | Pd-1 결합 항체 및 그의 용도 |
| KR102558418B1 (ko) | 2018-04-15 | 2023-07-24 | 임비라 컴퍼니 리미티드 | Pd-1에 결합하는 항체 및 그 용도 |
| EP3782618A4 (en) | 2018-04-16 | 2022-01-26 | OnQuality Pharmaceuticals China Ltd. | METHODS OF PREVENTING OR TREATMENT OF SIDE EFFECTS OF CANCER THERAPY |
| SG11202010153WA (en) | 2018-04-17 | 2020-11-27 | Tempest Therapeutics Inc | Bicyclic carboxamides and methods of use thereof |
| TWI851572B (zh) | 2018-04-18 | 2024-08-11 | 美商山可爾股份有限公司 | IL-15/IL-15Rα異二聚體Fc融合蛋白及其用途 |
| JP2021521784A (ja) | 2018-04-18 | 2021-08-30 | ゼンコア インコーポレイテッド | IL−15/IL−15RaFc融合タンパク質とPD−1抗原結合ドメインを含むPD−1標的化ヘテロダイマー融合タンパク質およびそれらの使用 |
| ES3035911T3 (en) | 2018-04-19 | 2025-09-11 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| US10907161B2 (en) | 2018-04-19 | 2021-02-02 | Checkmate Pharmaceuticals, Inc. | Synthetic RIG-I-like receptor agonists |
| US11542505B1 (en) | 2018-04-20 | 2023-01-03 | Merck Sharp & Dohme Llc | Substituted RIG-I agonists: compositions and methods thereof |
| US11485741B2 (en) | 2018-04-24 | 2022-11-01 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (TLR7) agonists |
| WO2019207030A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer |
| CA3096909A1 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
| WO2019207942A1 (ja) * | 2018-04-27 | 2019-10-31 | OTA Takayo | 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー |
| US20210047405A1 (en) | 2018-04-27 | 2021-02-18 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| MA52533A (fr) | 2018-04-27 | 2021-03-03 | Iovance Biotherapeutics Inc | Procédé en circuit fermé pour l'amplification et l'edition de gènes de lymphocytes d'infiltration des tumeurs et leurs utilisations en immunothérapie |
| US12048745B2 (en) | 2018-05-01 | 2024-07-30 | Augusta University Research Institute, Inc. | Methods for detecting and reversing immune therapy resistance |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP3788079A4 (en) | 2018-05-03 | 2022-12-21 | Shanghai Epimab Biotherapeutics Co., Ltd. | High affinity antibodies to pd-1 and lag-3 and bispecific binding proteins made therefrom |
| EP3788053B1 (en) | 2018-05-04 | 2024-07-10 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| JP7568512B2 (ja) | 2018-05-04 | 2024-10-16 | インサイト・コーポレイション | Fgfr阻害剤の塩 |
| CN112352052A (zh) | 2018-05-04 | 2021-02-09 | 托利斯有限公司 | 激活上皮细胞和髓样细胞的tlr3配体 |
| AU2019262589B2 (en) | 2018-05-04 | 2022-07-07 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| US20210246208A1 (en) | 2018-05-04 | 2021-08-12 | Merck Patent Gmbh | Combined inhibition of pd-1/pd-l1, tgfb and dna-pk for the treatment of cancer |
| SMT202400507T1 (it) | 2018-05-04 | 2025-01-14 | Incyte Corp | Forme solide di un inibitore di fgfr e procedimenti per preparare le stesse |
| KR102882368B1 (ko) * | 2018-05-07 | 2025-11-07 | 젠맵 에이/에스 | 항-pd-1 항체와 항-조직 인자 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법 |
| AU2019266203A1 (en) | 2018-05-07 | 2020-11-26 | Genmab A/S | Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| EP3790886B1 (en) | 2018-05-10 | 2024-06-26 | Amgen Inc. | Kras g12c inhibitors for the treatment of cancer |
| RS64188B1 (sr) | 2018-05-11 | 2023-06-30 | Incyte Corp | Tetrahidro-imidazo[4,5-c]piridin derivati kao pd-l1 imunomodulatori |
| IL291430B2 (en) | 2018-05-14 | 2024-04-01 | Gilead Sciences Inc | Mcl-1 inhibitors |
| CA3100376A1 (en) | 2018-05-15 | 2019-11-21 | Duke University | Systems and methods for genetic manipulation of akkermansia species |
| EP3793607A1 (en) | 2018-05-15 | 2021-03-24 | MedImmune Limited | Treatment of cancer |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| CN112236455B (zh) * | 2018-05-17 | 2023-05-16 | 南京维立志博生物科技有限公司 | 结合pd-1的抗体及其用途 |
| JP7391046B2 (ja) | 2018-05-18 | 2023-12-04 | インサイト・コーポレイション | A2a/a2b阻害剤としての縮合ピリミジン誘導体 |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| CN112492874A (zh) | 2018-05-23 | 2021-03-12 | 细胞基因公司 | 治疗多发性骨髓瘤以及生物标志物对于4-(4-(4-(((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苄基)哌嗪-1-基)-3-氟苄腈的用途 |
| DK3796912T5 (da) | 2018-05-23 | 2024-08-19 | Celgene Corp | Antiproliferative forbindelser og bispecifikt antistof mod bcma og cd3 til kombineret anvendelse |
| KR20210015923A (ko) | 2018-05-29 | 2021-02-10 | 브리스톨-마이어스 스큅 컴퍼니 | 전구약물 및 접합체에 사용하기 위한 변형된 자기-희생 모이어티 및 사용 및 제조 방법 |
| TWI869346B (zh) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法 |
| EP3801766A1 (en) | 2018-05-31 | 2021-04-14 | Novartis AG | Hepatitis b antibodies |
| US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| US12331068B2 (en) | 2018-05-31 | 2025-06-17 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting CD73 |
| WO2019231870A1 (en) | 2018-05-31 | 2019-12-05 | Merck Sharp & Dohme Corp. | Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| CA3102097A1 (en) | 2018-06-01 | 2019-12-05 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof |
| IL317554A (en) | 2018-06-01 | 2025-02-01 | Novartis Ag | Anti-BCMA binding molecules and their uses |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| EP3818085A4 (en) | 2018-06-01 | 2022-03-09 | Tayu Huaxia Biotech Medical Group Co., Ltd. | COMPOSITIONS AND THEIR USES FOR TREATING A DISEASE OR CONDITION |
| AU2019278998B2 (en) | 2018-06-01 | 2023-11-09 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| JP7346466B2 (ja) * | 2018-06-01 | 2023-09-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スプライシング調節薬の使用方法 |
| CN112512578A (zh) | 2018-06-01 | 2021-03-16 | 诺华股份有限公司 | 结合cd123和cd3的双特异性抗体的给药 |
| MX2020013122A (es) | 2018-06-03 | 2021-04-13 | Lamkap Bio Beta Ltd | Anticuerpos biespecificos contra anticuerpos biespecíficos que se unen al antígeno carcinoembrionario humano (ceacam5) y grupo de diferenciación (cd47). |
| MX2020012204A (es) | 2018-06-11 | 2021-03-31 | Amgen Inc | Inhibidores de kras g12c para tratar el cáncer. |
| US20210230289A1 (en) | 2018-06-12 | 2021-07-29 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
| MA51848A (fr) | 2018-06-12 | 2021-04-21 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
| MX2020013443A (es) | 2018-06-13 | 2021-02-26 | Novartis Ag | Receptores de antigeno quimerico de bcma y usos de los mismos. |
| EP3806848A2 (en) | 2018-06-15 | 2021-04-21 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
| US11377503B2 (en) | 2018-06-18 | 2022-07-05 | Innate Pharma | Antibodies that bind human CD39 and inhibit ATPase activity of a soluble extracellular domain human CD39 polypeptide |
| AU2019290127B2 (en) | 2018-06-19 | 2025-03-20 | Biontech Us Inc. | Neoantigens and uses thereof |
| EP3810189A1 (en) | 2018-06-19 | 2021-04-28 | Armo Biosciences, Inc. | Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy |
| CA3104467A1 (en) | 2018-06-20 | 2019-12-26 | Incyte Corporation | Anti-pd-1 antibodies and uses thereof |
| FI3811931T3 (fi) | 2018-06-20 | 2024-09-12 | Fujifilm Corp | Liposomikoostumukseen kapseloidun lääkkeen ja immuunitarkistuspisteinhibiittorin sisältävä yhdistelmälääkitys |
| TWI874322B (zh) | 2018-06-20 | 2025-03-01 | 日商富士軟片股份有限公司 | 包含內含吉西他濱之脂質體組成物及免疫檢查點抑制劑之組合醫藥 |
| EP3810615A4 (en) | 2018-06-20 | 2022-03-30 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
| TWI890661B (zh) | 2018-06-21 | 2025-07-21 | 美商再生元醫藥公司 | 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法 |
| MA52968A (fr) | 2018-06-23 | 2021-04-28 | Hoffmann La Roche | Méthodes de traitement du cancer du poumon à l'aide d'un antagoniste de liaison à l'axe pd-1, d'un agent de platine et d'un inhibiteur de la topoisomérase ii |
| WO2020005068A2 (en) | 2018-06-29 | 2020-01-02 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Gene signatures and method for predicting response to pd-1 antagonists and ctla-4 antagonists, and combination thereof |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| UA128332C2 (uk) | 2018-07-05 | 2024-06-12 | Інсайт Корпорейшн | Похідні конденсованих піразинів як інгібітори a2a/a2b |
| CN112424167A (zh) | 2018-07-09 | 2021-02-26 | 葛兰素史密斯克莱知识产权发展有限公司 | 化学化合物 |
| TWI819024B (zh) | 2018-07-09 | 2023-10-21 | 美商戊瑞治療有限公司 | 結合至ilt4的抗體 |
| CA3105750A1 (en) * | 2018-07-09 | 2020-01-16 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| JOP20210001A1 (ar) | 2018-07-10 | 2021-01-05 | Novartis Ag | مشتقات 3-(5- هيدروكسي -1- أوكسو أيزو إندولين -2- يل) بيبريدين -2، 6- دايون واستخدامها لمعالجة أمراض مرتبطة ببروتين ذات أصبع الزنك من عائلة (ikaros 2 (ikzf2 |
| EP3820902A2 (en) | 2018-07-11 | 2021-05-19 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
| US12398181B2 (en) | 2018-07-11 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Methods and compositions for delivery of agents across the blood-brain barrier |
| MX2021000165A (es) | 2018-07-11 | 2021-05-28 | Actym Therapeutics Inc | Cepas bacterianas inmunoestimuladoras modificadas y usos de las mismas. |
| EP3820898B1 (en) | 2018-07-12 | 2025-09-03 | invoX Pharma Limited | Antibody molecules that bind cd137 and ox40 |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| BR112020026746A2 (pt) | 2018-07-13 | 2021-03-30 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
| WO2020014583A1 (en) | 2018-07-13 | 2020-01-16 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a mehtod of treating a cancer or a solid tumor |
| CA3104147A1 (en) | 2018-07-18 | 2020-01-23 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent |
| CN113861295B (zh) * | 2018-07-20 | 2024-05-24 | 厦门大学 | 抗pd-1抗体及其用途 |
| US20210301020A1 (en) | 2018-07-24 | 2021-09-30 | Amgen Inc. | Combination of lilrb1/2 pathway inhibitors and pd-1 pathway inhibitors |
| CN112534052B (zh) | 2018-07-25 | 2024-09-20 | 奥美药业有限公司 | 全新il-21前药及使用方法 |
| AU2019309849A1 (en) | 2018-07-26 | 2021-03-18 | Bristol-Myers Squibb Company | LAG-3 combination therapy for the treatment of cancer |
| WO2020021061A1 (en) | 2018-07-26 | 2020-01-30 | Pieris Pharmaceuticals Gmbh | Humanized anti-pd-1 antibodies and uses thereof |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| CN112703011A (zh) | 2018-08-06 | 2021-04-23 | 国家医疗保健研究所 | 用于治疗癌症的方法和组合物 |
| WO2020030571A1 (en) | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combinations of a pd-1 antibody and a tlr4 modulator and uses thereof |
| WO2020031107A1 (en) | 2018-08-08 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
| US20210317461A1 (en) | 2018-08-09 | 2021-10-14 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| CN113307872B (zh) * | 2018-08-11 | 2022-12-06 | 广东天科雅生物医药科技有限公司 | 一种工程化核酸、t细胞及其应用和产生方法 |
| EP4249511A3 (en) * | 2018-08-21 | 2024-01-10 | I-Mab Biopharma (Hangzhou) Co., Ltd. | Anti-pd-l1/anti-lag3 bispecific antibodies and uses thereof |
| EP3843849A1 (en) | 2018-08-27 | 2021-07-07 | Pieris Pharmaceuticals GmbH | Combination therapies comprising cd137/her2 bispecific agents and pd-1 axis inhibitors and uses thereof |
| CN120775968A (zh) * | 2018-08-28 | 2025-10-14 | 10X基因组学股份有限公司 | 用于生物样品中转座酶介导的空间标记和分析基因组dna的方法 |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| WO2020044252A1 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Dosage regimes for anti-m-csf antibodies and uses thereof |
| US20210340279A1 (en) | 2018-08-31 | 2021-11-04 | Yale University | Compositions and methods of using cell-penetrating antibodies in combination with immune checkpoint modulators |
| TW202031273A (zh) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療 |
| CN112805267B (zh) | 2018-09-03 | 2024-03-08 | 豪夫迈·罗氏有限公司 | 用作tead调节剂的甲酰胺和磺酰胺衍生物 |
| WO2020048942A1 (en) | 2018-09-04 | 2020-03-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses |
| WO2020049534A1 (en) | 2018-09-07 | 2020-03-12 | Novartis Ag | Sting agonist and combination therapy thereof for the treatment of cancer |
| BR112021004287A2 (pt) | 2018-09-07 | 2021-08-03 | Pfizer Inc. | anticorpos anti-avss8 e composições e usos dos mesmos |
| WO2020053742A2 (en) | 2018-09-10 | 2020-03-19 | Novartis Ag | Anti-hla-hbv peptide antibodies |
| CN113164466B (zh) | 2018-09-11 | 2025-07-08 | 柯瑞斯公司 | 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗 |
| CA3112326A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| CA3111066A1 (en) | 2018-09-13 | 2020-03-19 | Merck Sharp & Dohme Corp. | Combination therapy of a pd-1 antagonist and lag3 antagonist for treating patients with non-microsatellite instability-high or proficient mismatch repair colorectal cancer |
| US20220073638A1 (en) | 2018-09-19 | 2022-03-10 | INSERM (Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical composition for the treatment of cancers resistant to immune checkpoint therapy |
| CN113544144A (zh) | 2018-09-19 | 2021-10-22 | 高山免疫科学股份有限公司 | 变体cd80融合蛋白和相关构建体的方法和用途 |
| MX2021003214A (es) | 2018-09-19 | 2021-05-12 | Genentech Inc | Metodos terapeuticos y de diagnostico para el cancer de vejiga. |
| SG11202101787XA (en) | 2018-09-20 | 2021-04-29 | Iovance Biotherapeutics Inc | Expansion of tils from cryopreserved tumor samples |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP4249917A3 (en) | 2018-09-21 | 2023-11-08 | F. Hoffmann-La Roche AG | Diagnostic methods for triple-negative breast cancer |
| IL314988A (en) | 2018-09-25 | 2024-10-01 | Harpoon Therapeutics Inc | Dll3 binding proteins and methods of use |
| CN113164777B (zh) | 2018-09-27 | 2024-12-13 | 马伦戈治疗公司 | Csf1r/ccr2多特异性抗体 |
| US20220047633A1 (en) | 2018-09-28 | 2022-02-17 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
| CN112771071A (zh) | 2018-09-28 | 2021-05-07 | 麻省理工学院 | 胶原蛋白定位的免疫调节分子及其方法 |
| US20210347851A1 (en) | 2018-09-28 | 2021-11-11 | Novartis Ag | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
| CA3113379A1 (en) | 2018-09-29 | 2020-04-02 | Novartis Ag | Process of manufacture of a compound for inhibiting the activity of shp2 |
| EP3861987A4 (en) | 2018-10-01 | 2021-09-15 | FUJIFILM Corporation | COMBINATION DRUG CONTAINING A LIPOSOME COMPOSITION ENCAPSULATING A DRUG AND A PLATINUM PREPARATION |
| EP3860578A1 (en) | 2018-10-01 | 2021-08-11 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of inhibitors of stress granule formation for targeting the regulation of immune responses |
| KR102884523B1 (ko) | 2018-10-03 | 2025-11-10 | 젠코어 인코포레이티드 | IL-12 이종이량체 Fc-융합 단백질 |
| KR20210072059A (ko) | 2018-10-09 | 2021-06-16 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하기 위한 항-MerTK 항체 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| TWI855000B (zh) | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Sting促效化合物 |
| WO2020077276A2 (en) | 2018-10-12 | 2020-04-16 | Xencor, Inc. | Pd-1 targeted il-15/il-15ralpha fc fusion proteins and uses in combination therapies thereof |
| EP3868784A4 (en) | 2018-10-15 | 2022-07-27 | Industry-Academic Cooperation Foundation, Yonsei University | ANTIBODIES WITH INCREASED PRODUCTIVITY AND METHODS FOR THEIR PRODUCTION |
| WO2020079581A1 (en) | 2018-10-16 | 2020-04-23 | Novartis Ag | Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy |
| CN113164600A (zh) | 2018-10-17 | 2021-07-23 | 百欧林纳克斯有限公司 | 转移性胰脏腺癌的治疗 |
| WO2020081381A1 (en) | 2018-10-17 | 2020-04-23 | Merck Sharp & Dohme Corp. | Novel arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors |
| US20210340240A1 (en) | 2018-10-18 | 2021-11-04 | INSERM (Institut National de la Santé et de la Recherche Médicale | Combination of a big-h3 antagonist and an immune checkpoint inhibitor for the treatment of solid tumor |
| MX2021004348A (es) | 2018-10-18 | 2021-05-28 | Genentech Inc | Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide. |
| CN113286611A (zh) | 2018-10-19 | 2021-08-20 | 百时美施贵宝公司 | 用于黑色素瘤的组合疗法 |
| BR112021007517A2 (pt) | 2018-10-22 | 2021-10-26 | Glaxosmithkline Intellectual Property Development Limited | Dosagem |
| US12479917B2 (en) | 2018-10-23 | 2025-11-25 | Bristol-Myers Squibb Company | Methods of treating NSCLC comprising administering platinum doublet chemotherapy followed by an anti-PD-1 antibody and an anti-CTLA-4 antibody |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| AU2019369340A1 (en) | 2018-10-29 | 2021-05-20 | Mersana Therapeutics, Inc. | Cysteine engineered antibody-drug conjugates with peptide-containing linkers |
| US11564995B2 (en) | 2018-10-29 | 2023-01-31 | Wisconsin Alumni Research Foundation | Peptide-nanoparticle conjugates |
| KR20210084552A (ko) | 2018-10-29 | 2021-07-07 | 위스콘신 얼럼나이 리서어치 화운데이션 | 향상된 암 면역요법을 위한 면역관문 억제제와 복합체화된 덴드리틱 폴리머 |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法 |
| WO2020092736A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2020089811A1 (en) | 2018-10-31 | 2020-05-07 | Novartis Ag | Dc-sign antibody drug conjugates |
| WO2020092839A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| MX2021005024A (es) | 2018-11-01 | 2021-07-21 | Juno Therapeutics Inc | Metodos de tratamiento que utilizan receptores de antigenos quimericos especificos para antigeno de maduracion de celulas b. |
| AU2019374103A1 (en) | 2018-11-01 | 2021-05-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) |
| WO2020092183A1 (en) | 2018-11-01 | 2020-05-07 | Merck Sharp & Dohme Corp. | Novel substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors |
| AU2019377422A1 (en) | 2018-11-05 | 2021-05-27 | Iovance Biotherapeutics, Inc. | Treatment of NSCLC patients refractory for anti-PD-1 antibody |
| SG11202104615VA (en) | 2018-11-05 | 2021-06-29 | Iovance Biotherapeutics Inc | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| KR20210099573A (ko) | 2018-11-05 | 2021-08-12 | 이오반스 바이오테라퓨틱스, 인크. | 개선된 종양 반응성 t-세포의 선택 |
| WO2020096871A1 (en) | 2018-11-06 | 2020-05-14 | Merck Sharp & Dohme Corp. | Novel substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors |
| BR112021008873A8 (pt) | 2018-11-07 | 2023-04-11 | Merck Sharp & Dohme | Formulação |
| WO2020097350A1 (en) | 2018-11-08 | 2020-05-14 | Orionis Biosciences, Inc. | Modulation of dendritic cell lineages |
| US20220001026A1 (en) | 2018-11-08 | 2022-01-06 | Modernatx, Inc. | Use of mrna encoding ox40l to treat cancer in human patients |
| EP3876955A4 (en) | 2018-11-09 | 2022-08-24 | Pierian Biosciences, LLC | METHODS AND COMPOSITIONS FOR DETERMINING THE COMPOSITION OF A TUMOR MICROENVIRONMENT |
| CN112996814B (zh) | 2018-11-14 | 2025-01-03 | 拜耳公司 | 用于治疗癌症的抗ceacam6和抗pd-1或抗pd-l1抗体的药物组合 |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| CN113038939A (zh) | 2018-11-14 | 2021-06-25 | 瑞泽恩制药公司 | 损害内施用pd-1抑制剂用于治疗皮肤癌 |
| MY205758A (en) | 2018-11-16 | 2024-11-12 | Bristol Myers Squibb Co | Anti-nkg2a antibodies and uses thereof |
| CA3119341A1 (en) | 2018-11-16 | 2020-05-22 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
| SG11202105084VA (en) | 2018-11-16 | 2021-06-29 | Juno Therapeutics Inc | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の重要な中間体の改良合成法 |
| JP2022507495A (ja) | 2018-11-16 | 2022-01-18 | アーキュール・インコーポレイテッド | 癌治療のための医薬の組合せ |
| MX2021005700A (es) | 2018-11-19 | 2021-07-07 | Amgen Inc | Inhibidores de kras g12c y metodos de uso de los mismos. |
| JP7630832B2 (ja) | 2018-11-19 | 2025-02-18 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Carおよびtcr形質導入用のモジュール式ポリシストロニックベクター |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| EP3883610A4 (en) | 2018-11-20 | 2022-11-02 | Cornell University | MACROCYCLIC COMPLEXES OF RADIONUCLIDES AND THEIR USE IN CANCER RADIATION THERAPY |
| CN113015530A (zh) | 2018-11-20 | 2021-06-22 | 默沙东公司 | 取代的氨基三唑并嘧啶和氨基三唑并吡嗪腺苷受体拮抗剂、药物组合物及其用途 |
| US12414952B2 (en) | 2018-11-20 | 2025-09-16 | Merck Sharp & Dohme Llc | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| US20230183379A1 (en) | 2018-11-20 | 2023-06-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Bispecific antibody targeting transferrin receptor 1 and soluble antigen |
| WO2020104479A1 (en) | 2018-11-20 | 2020-05-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers and resistant cancers with anti transferrin receptor 1 antibodies |
| WO2020109328A1 (en) | 2018-11-26 | 2020-06-04 | Debiopharm International S.A. | Combination treatment of hiv infections |
| WO2020111018A1 (ja) | 2018-11-27 | 2020-06-04 | 小野薬品工業株式会社 | 免疫チェックポイント阻害薬およびfolfirinox療法との併用によるがん治療 |
| JP7672702B2 (ja) | 2018-11-28 | 2025-05-08 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 機能および抑制性環境に対する抵抗性を増強するための免疫細胞のマルチプレックスゲノム編集 |
| US20220018828A1 (en) | 2018-11-28 | 2022-01-20 | Inserm (Institut National De La Santé Et La Recherche Médicale | Methods and kit for assaying lytic potential of immune effector cells |
| US12264134B2 (en) | 2018-11-28 | 2025-04-01 | Merck Sharp & Dohme Llc | Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors |
| EP3887397A1 (en) | 2018-11-28 | 2021-10-06 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| MX2021006393A (es) | 2018-11-29 | 2021-10-13 | Univ Texas | Metodos para expansion ex vivo de celulas exterminadoras naturales y uso de las mismas. |
| WO2020109570A1 (en) | 2018-11-30 | 2020-06-04 | Gbg Forschungs Gmbh | Method for predicting the response to cancer immunotherapy in cancer patients |
| BR112021010427B1 (pt) | 2018-11-30 | 2022-09-27 | Merck Sharp & Dohme Corp | Compostos derivados de amino triazolo quinazolina substituídos na posição 9 como antagonistas de receptores de adenosina, suas composições farmacêuticas e seus usos |
| FI3886875T3 (fi) | 2018-11-30 | 2024-07-23 | Juno Therapeutics Inc | Adoptiivista soluterapiaa käyttäviä hoitomenetelmiä |
| AR117206A1 (es) | 2018-11-30 | 2021-07-21 | Glaxosmithkline Ip Dev Ltd | Derivados de octahidropirrolo[2,1-b][1,3]tiazepin-7-carboxamido útiles en la terapia para el vih y para el tratamiento del cáncer |
| DK3886914T3 (da) | 2018-11-30 | 2023-07-03 | Bristol Myers Squibb Co | Antistof omfattende en glutaminholdig letkæde-c-terminal forlængelse, konjugater deraf og fremgangsmåder samt anvendelser |
| SG11202105689XA (en) | 2018-12-03 | 2021-06-29 | Agensys Inc | Pharmaceutical compositions comprising anti-191p4d12 antibody drug conjugates and methods of use thereof |
| JP2022511029A (ja) | 2018-12-04 | 2022-01-28 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | がんの処置のための薬剤としての使用のためのcdk9インヒビターおよびその多形 |
| CA3121265A1 (en) | 2018-12-05 | 2020-06-11 | Genentech, Inc. | Diagnostic methods and compositions for cancer immunotherapy |
| WO2020115262A1 (en) | 2018-12-07 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes |
| WO2020115261A1 (en) | 2018-12-07 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| EP3894401A2 (en) | 2018-12-11 | 2021-10-20 | Theravance Biopharma R&D IP, LLC | Naphthyridine and quinoline derivatives useful as alk5 inhibitors |
| WO2020120592A1 (en) | 2018-12-12 | 2020-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating melanoma |
| WO2020123425A2 (en) | 2018-12-12 | 2020-06-18 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
| AU2019399474A1 (en) | 2018-12-13 | 2021-06-03 | Surface Oncology, LLC | Anti-IL-27 antibodies and uses thereof |
| GB201820547D0 (en) | 2018-12-17 | 2019-01-30 | Oxford Univ Innovation | Modified antibodies |
| WO2020131885A1 (en) * | 2018-12-17 | 2020-06-25 | Eamonn Hobbs | In situ therapeutic cancer vaccine creation system and method |
| WO2020127059A1 (en) | 2018-12-17 | 2020-06-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sulconazole as a furin inhibitor |
| US12240867B2 (en) | 2018-12-18 | 2025-03-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| EP3898699A1 (en) | 2018-12-19 | 2021-10-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers by immuno-modulation using antibodies against cathespin-d |
| WO2020126808A1 (en) | 2018-12-19 | 2020-06-25 | Bayer Aktiengesellschaft | Pharmaceutical combination of anti ceacam6 and tim3 antibodies |
| EP3898616B1 (en) | 2018-12-20 | 2024-10-02 | Amgen Inc. | Heteroaryl amides useful as kif18a inhibitors |
| KR20210106437A (ko) | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
| MX2021007157A (es) | 2018-12-20 | 2021-08-16 | Amgen Inc | Heteroarilamidas utiles como inhibidores de kif18a. |
| JP7686559B2 (ja) | 2018-12-20 | 2025-06-02 | アムジエン・インコーポレーテツド | Kif18a阻害剤 |
| WO2020132646A1 (en) | 2018-12-20 | 2020-06-25 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
| AR117490A1 (es) | 2018-12-20 | 2021-08-11 | Amgen Inc | Inhibidores de kif18a |
| CN113166762B (zh) | 2018-12-21 | 2025-01-14 | 瓦莱里奥治疗公司 | 新的偶联核酸分子及其用途 |
| SG11202106251UA (en) | 2018-12-21 | 2021-07-29 | Ose Immunotherapeutics | Bifunctional anti-pd-1/sirpa molecule |
| KR20210106531A (ko) | 2018-12-21 | 2021-08-30 | 에임 이뮤노테크 인코포레이티드 | 암 치료를 위한 조성물 및 방법 |
| BR112021012037A2 (pt) | 2018-12-21 | 2021-11-03 | Ose Immunotherapeutics | Molécula anti-pd-1/il-7 bifuncional |
| CN111349162A (zh) * | 2018-12-21 | 2020-06-30 | 神州细胞工程有限公司 | 人源化抗pd-1抗体及其用途 |
| SG11202106629PA (en) | 2018-12-21 | 2021-07-29 | Novartis Ag | Antibodies to pmel17 and conjugates thereof |
| WO2020127885A1 (en) | 2018-12-21 | 2020-06-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for treating cancers and resistant cancers |
| EP3902833A2 (en) | 2018-12-26 | 2021-11-03 | City of Hope | Activatable masked anti-ctla4 binding proteins |
| AU2019412489A1 (en) | 2018-12-26 | 2021-06-10 | Innate Pharma | Leucocyte immunoglobulin-like receptor 2 neutralizing antibodies |
| MX2021007692A (es) * | 2018-12-27 | 2021-09-30 | Gigagen Inc | Proteinas de union anti-pd-1 y metodos de uso de las mismas. |
| AR117547A1 (es) | 2018-12-27 | 2021-08-11 | Amgen Inc | Formulaciones de virus liofilizadas |
| CA3125476A1 (en) | 2019-01-03 | 2020-07-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer |
| CN113597425A (zh) | 2019-01-09 | 2021-11-02 | 细胞基因公司 | 包含(s)-4-(4-(4-(((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苯甲基)哌嗪-1-基)-3-氟苯甲腈及其盐的固体形式,以及包含它们的组合物和它们的使用方法 |
| CA3126067A1 (en) | 2019-01-09 | 2020-07-16 | Celgene Corporation | Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
| SG11202107413YA (en) | 2019-01-09 | 2021-08-30 | Celgene Corp | Antiproliferative compounds and second active agents for use in treating multiple myeloma |
| CN111423510B (zh) | 2019-01-10 | 2024-02-06 | 迈威(上海)生物科技股份有限公司 | 重组抗人pd-1抗体及其应用 |
| MX2021008434A (es) | 2019-01-14 | 2021-09-23 | Genentech Inc | Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn. |
| WO2020148338A1 (en) | 2019-01-15 | 2020-07-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mutated interleukin-34 (il-34) polypeptides and uses thereof in therapy |
| AU2020209766B2 (en) | 2019-01-17 | 2025-08-28 | Georgia Tech Research Corporation | Drug delivery systems containing oxidized cholesterols |
| WO2020150639A1 (en) | 2019-01-18 | 2020-07-23 | Dracen Pharmaceuticals, Inc. | Combinaton therapy with a don prodrug and an immune checkpoint inhibitor |
| AU2020210614A1 (en) | 2019-01-21 | 2021-08-26 | Sanofi | Therapeutic RNA and anti-PD1 antibodies for advanced stage solid tumor cancers |
| US11235032B2 (en) | 2019-01-23 | 2022-02-01 | Massachusetts Institute Of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| US12263234B2 (en) | 2019-01-23 | 2025-04-01 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-PD-L1 diabodies and the use thereof |
| TWI894135B (zh) | 2019-01-25 | 2025-08-21 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
| MA54863A (fr) | 2019-01-29 | 2021-12-08 | Juno Therapeutics Inc | Anticorps et récepteurs antigéniques chimériques spécifiques du récepteur orphelin-1 de type récepteur à tyrosine kinase (ror1) |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US20220107323A1 (en) | 2019-01-30 | 2022-04-07 | Inserm(Institut National De La Santé Et De La Recherche Médicale) | Methods and compositions for identifying whether a subject suffering from a cancer will achieve a response with an immune-checkpoint inhibitor |
| CN120058944A (zh) | 2019-01-30 | 2025-05-30 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CA3128064A1 (en) | 2019-02-01 | 2020-08-06 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments for cancer comprising belantamab mafodotin and an anti ox40 antibody and uses and methods thereof |
| TWI843799B (zh) | 2019-02-03 | 2024-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗pd-1抗體、其抗原結合片段及醫藥用途 |
| US20220117911A1 (en) | 2019-02-04 | 2022-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for modulating blood-brain barrier |
| JP2022519649A (ja) | 2019-02-08 | 2022-03-24 | ジェネンテック, インコーポレイテッド | がんの診断および治療方法 |
| EP3924351B1 (en) | 2019-02-12 | 2025-05-21 | Sumitomo Pharma America, Inc. | Crystalline form of the hydrochloride salt of 2-((1r,4r)-4-((3-(3-(trifluoromethyl)phenyl) imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol |
| TW202045172A (zh) | 2019-02-12 | 2020-12-16 | 瑞士商諾華公司 | 包含tno155和pd-1抑制劑之藥物組合 |
| EP3924520A1 (en) | 2019-02-13 | 2021-12-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for selecting a cancer treatment in a subject suffering from cancer |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| WO2020168244A1 (en) | 2019-02-15 | 2020-08-20 | Incelldx, Inc. | Assaying bladder-associated samples, identifying and treating bladder-associated neoplasia, and kits for use therein |
| SG11202108702XA (en) | 2019-02-15 | 2021-09-29 | Incyte Corp | Cyclin-dependent kinase 2 biomarkers and uses thereof |
| EP3924054B1 (en) | 2019-02-15 | 2025-04-02 | Novartis AG | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| EA202192029A1 (ru) | 2019-02-15 | 2021-10-27 | Новартис Аг | Замещенные производные 3-(1-оксоизоиндолин-2-ил)пиперидин-2,6-диона и варианты их применения |
| WO2020169472A2 (en) | 2019-02-18 | 2020-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of inducing phenotypic changes in macrophages |
| PT3927370T (pt) | 2019-02-19 | 2024-06-03 | Turnstone Biologics Corp | Métodos para produção de células t autólogas para tratar cancros e composições destas |
| GB2599228B (en) | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| CA3131700A1 (en) | 2019-02-27 | 2020-09-03 | Ionis Pharmaceuticals, Inc. | Modulators of malat1 expression |
| US20220259313A1 (en) | 2019-02-28 | 2022-08-18 | Regeneron Pharmaceuticals, Inc. | Administration of a pd-1 inhibitor for for treating skin cancer |
| CN113767100A (zh) | 2019-03-01 | 2021-12-07 | 锐新医药公司 | 双环杂芳基化合物及其用途 |
| KR20210146288A (ko) | 2019-03-01 | 2021-12-03 | 레볼루션 메디슨즈, 인크. | 이환식 헤테로사이클릴 화합물 및 이의 용도 |
| MX2021010458A (es) | 2019-03-05 | 2021-09-21 | Amgen Inc | Uso de virus oncoliticos para el tratamiento del cancer. |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| SG11202109003QA (en) | 2019-03-06 | 2021-09-29 | Regeneron Pharma | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US12358986B2 (en) | 2019-03-13 | 2025-07-15 | Merck Sharp & Dohme Llc | Anti-cancer combination therapies comprising CTLA-4 and PD-1 blocking agents |
| CA3130446A1 (en) | 2019-03-14 | 2020-09-17 | Genentech, Inc. | Treatment of cancer with her2xcd3 bispecific antibodies in combination with anti-her2 mab |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| EP3942024A4 (en) | 2019-03-18 | 2023-03-22 | The Regents of the University of California | ENHANCEMENT OF T LYMPHOCYTE ACTIVATION BY OSCILLATORY FORCES AND MODIFIED ANTIGEN-PRESENTING CELLS |
| MX2021011320A (es) | 2019-03-19 | 2021-12-10 | Fundacio Privada Inst Dinvestigacio Oncològica De Vall Hebron | Terapia de combinacion con omomyc y un anticuerpo que se une a pd-1 o a ctla-4 para el tratamiento del cancer. |
| WO2020191326A1 (en) | 2019-03-20 | 2020-09-24 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (aml) with venetoclax failure |
| KR20210141621A (ko) | 2019-03-22 | 2021-11-23 | 스미토모 다이니폰 파마 온콜로지, 인크. | Pkm2 조정제를 포함하는 조성물 및 그를 사용한 치료 방법 |
| CN114269763A (zh) | 2019-03-26 | 2022-04-01 | 美国密歇根州立大学试剂中心 | Stat3的小分子降解剂 |
| WO2020198676A1 (en) | 2019-03-28 | 2020-10-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
| EP3946625A1 (en) | 2019-03-28 | 2022-02-09 | Bristol-Myers Squibb Company | Methods of treating tumor |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US20220185831A1 (en) | 2019-03-29 | 2022-06-16 | The Regents Of The University Of Michigan | Stat3 protein degraders |
| CN118388628A (zh) | 2019-03-29 | 2024-07-26 | 居里研究所 | 具有经修饰的生物活性的白介素-2变体 |
| TW202102543A (zh) | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
| BR112021019328A2 (pt) | 2019-03-29 | 2021-11-30 | Myst Therapeutics Llc | Métodos ex vivo para produzir um produto terapêutico de célula t e composições e métodos relacionados |
| CN113631910A (zh) | 2019-03-29 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 细胞表面蛋白质相互作用的调节剂及其相关方法和组合物 |
| US20200318200A1 (en) | 2019-04-02 | 2020-10-08 | The Brigham And Women's Hospital, Inc. | Methods for Identifying Progression of a Primary Melanoma |
| US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP3946450A1 (en) | 2019-04-03 | 2022-02-09 | TargImmune Therapeutics AG | Immunotherapy for the treatment of cancer |
| US12281109B2 (en) | 2019-04-04 | 2025-04-22 | Merck Sharp & Dohme Llc | Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes |
| EP3952850A1 (en) | 2019-04-09 | 2022-02-16 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer |
| KR20210151808A (ko) | 2019-04-11 | 2021-12-14 | 바이엘 악티엔게젤샤프트 | 항-ildr2 항체 및 pd-1 길항제의 조합물 |
| CA3134080A1 (en) | 2019-04-12 | 2020-10-15 | Vascular Biogenics Ltd. | Methods of anti-tumor therapy |
| CN110095612B (zh) * | 2019-04-12 | 2022-05-10 | 河北仁博科技有限公司 | 一种基于spr快速筛选单克隆抗体的方法 |
| US20220220480A1 (en) | 2019-04-17 | 2022-07-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders |
| WO2020215037A1 (en) | 2019-04-18 | 2020-10-22 | The Regents Of The University Of Michigan | Combination with checkpoint inhibitors to treat cancer |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| WO2020214957A1 (en) | 2019-04-19 | 2020-10-22 | Tcrcure Biopharma Corp. | Anti-pd-1 antibodies and uses thereof |
| CN114364703A (zh) | 2019-04-19 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 抗mertk抗体及它们的使用方法 |
| KR20220002959A (ko) | 2019-04-23 | 2022-01-07 | 이나뜨 파르마 에스.에이. | Cd73 차단 항체 |
| WO2020223233A1 (en) | 2019-04-30 | 2020-11-05 | Genentech, Inc. | Prognostic and therapeutic methods for colorectal cancer |
| US20220220565A1 (en) | 2019-04-30 | 2022-07-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| CN110402892A (zh) * | 2019-04-30 | 2019-11-05 | 梁廷波 | 选择性敲除胰腺上皮细胞程序性死亡配体1分子的自发胰腺癌小鼠模型的建立方法 |
| WO2020223639A1 (en) | 2019-05-01 | 2020-11-05 | Sensei Biotherapeutics, Inc. | Combination therapies for cancer |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| WO2020225552A1 (en) | 2019-05-06 | 2020-11-12 | Medimmune Limited | Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer |
| AU2019444218A1 (en) | 2019-05-07 | 2021-11-25 | Immunicom, Inc. | Increasing responses to checkpoint inhibitors by extracorporeal apheresis |
| CN114144514B (zh) | 2019-05-09 | 2025-11-25 | 富士胶片细胞动力公司 | 产生肝细胞的方法 |
| CN120939219A (zh) | 2019-05-13 | 2025-11-14 | 瑞泽恩制药公司 | 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合 |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| CN114302875A (zh) | 2019-05-16 | 2022-04-08 | 斯汀塞拉股份有限公司 | 氧代吖啶基乙酸衍生物及使用方法 |
| WO2020232378A1 (en) | 2019-05-16 | 2020-11-19 | Silicon Swat, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
| CN114096240A (zh) | 2019-05-17 | 2022-02-25 | 癌症预防制药股份有限公司 | 用于治疗家族性腺瘤性息肉病的方法 |
| IL266728B (en) | 2019-05-19 | 2020-11-30 | Yeda Res & Dev | Identification of recurrent mutant neopeptides |
| US11739146B2 (en) | 2019-05-20 | 2023-08-29 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
| CA3225293A1 (en) | 2019-05-21 | 2020-11-26 | Amgen Inc. | Solid state forms |
| CN113874036A (zh) | 2019-05-24 | 2021-12-31 | 辉瑞公司 | 使用cdk抑制剂的联合治疗 |
| CN114174537A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 细胞定位特征和组合疗法 |
| CN114174538A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 适合于免疫肿瘤学疗法的多肿瘤基因特征 |
| KR20220016155A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법 |
| EP3976111A4 (en) | 2019-06-03 | 2023-07-05 | The University of Chicago | Methods and compositions for treating cancer with collagen binding drug carriers |
| AU2020286523A1 (en) | 2019-06-03 | 2022-02-03 | The University Of Chicago | Methods and compositions for treating cancer with cancer-targeted adjuvants |
| US11246906B2 (en) | 2019-06-11 | 2022-02-15 | Alkermes Pharma Ireland Limited | Compositions and methods for subcutaneous administration of cancer immunotherapy |
| EP3983084A1 (en) | 2019-06-12 | 2022-04-20 | Vanderbilt University | Amino acid transport inhibitors and the uses thereof |
| US11845801B2 (en) | 2019-06-12 | 2023-12-19 | AskGene Pharma, Inc. | IL-15 prodrugs and methods of use thereof |
| JP2022536728A (ja) | 2019-06-12 | 2022-08-18 | ヴァンダービルト ユニバーシティー | アミノ酸輸送阻害剤としてのジベンジルアミン類 |
| US20220251604A1 (en) | 2019-06-14 | 2022-08-11 | Tilt Biotherapeutics Oy | Oncolytic adenovirus and checkpoint inhibitor combination therapy |
| WO2020255009A2 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody |
| CA3143680A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
| MX2021015651A (es) | 2019-06-26 | 2022-06-14 | Glaxosmithkline Ip Dev Ltd | Proteinas de union a la proteina accesoria del receptor de interleucina-1 (il1rap). |
| EP3990491A1 (en) | 2019-06-26 | 2022-05-04 | Massachusetts Institute of Technology | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
| EP3990635A1 (en) | 2019-06-27 | 2022-05-04 | Rigontec GmbH | Design method for optimized rig-i ligands |
| WO2020264437A1 (en) | 2019-06-27 | 2020-12-30 | The George Washington University | Hdac6-activated macrophages, compositions, and uses thereof |
| MX2021015433A (es) | 2019-07-02 | 2022-06-08 | Hutchinson Fred Cancer Res | Vectores ad35 recombinantes y mejoras de la terapia génica relacionadas. |
| MX2022000164A (es) | 2019-07-03 | 2022-04-01 | Sumitomo Pharma Oncology Inc | Inhibidores de tirosina cinasa no receptora 1 (tnk1) y usos de los mismos. |
| TWI889320B (zh) | 2019-07-05 | 2025-07-01 | 日商小野藥品工業股份有限公司 | 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療 |
| EP3997126A4 (en) * | 2019-07-09 | 2024-01-24 | Zydus Lifesciences Limited | ANTIBODIES AGAINST THE HUMAN PROGRAMMED DEATH RECEPTOR PD-1 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| BR112022000713A2 (pt) | 2019-07-16 | 2022-03-22 | Univ Michigan Regents | Imidazopirimidinas como inibidores de eed e o uso das mesmas |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| EP4004548B1 (en) | 2019-07-29 | 2026-01-14 | Yeda Research and Development Co. Ltd | Methods of treating and diagnosing lung cancer |
| MX2022001407A (es) | 2019-08-02 | 2022-04-27 | Mersana Therapeutics Inc | Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer. |
| MX2022001295A (es) | 2019-08-02 | 2022-02-22 | Amgen Inc | Inhibidores de kif18a. |
| ES3051918T3 (en) | 2019-08-02 | 2025-12-30 | Amgen Inc | Kif18a inhibitors |
| WO2021023108A1 (zh) * | 2019-08-02 | 2021-02-11 | 正大天晴康方(上海)生物医药科技有限公司 | 一种抗pd-1抗体及其医药用途 |
| JP2022542437A (ja) | 2019-08-02 | 2022-10-03 | ランティオペプ ベスローテン ヴェンノーツハップ | 癌の処置に用いるアンジオテンシン2型(at2)受容体アゴニスト |
| EP4007756B1 (en) | 2019-08-02 | 2025-12-24 | Amgen Inc. | Kif18a inhibitors |
| MX2022001302A (es) | 2019-08-02 | 2022-03-02 | Amgen Inc | Inhibidores de kif18a. |
| CN114206386A (zh) | 2019-08-05 | 2022-03-18 | 小野药品工业株式会社 | 免疫检查点抑制剂的有效性判定生物标记 |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
| EP4013788A1 (en) | 2019-08-12 | 2022-06-22 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells |
| EP4013750A1 (en) | 2019-08-14 | 2022-06-22 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| GB201912107D0 (en) | 2019-08-22 | 2019-10-09 | Amazentis Sa | Combination |
| AU2020336381A1 (en) | 2019-08-27 | 2022-03-03 | The Regents Of The University Of Michigan | Cereblon E3 ligase inhibitors |
| KR20220053007A (ko) | 2019-08-30 | 2022-04-28 | 아게누스 인코포레이티드 | 항-cd96 항체 및 이의 사용 방법 |
| WO2021043961A1 (en) | 2019-09-06 | 2021-03-11 | Glaxosmithkline Intellectual Property Development Limited | Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy |
| WO2021048292A1 (en) | 2019-09-11 | 2021-03-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| US12121565B2 (en) | 2019-09-13 | 2024-10-22 | Duke University | Methods of treatment of specific cancers with NLRP3 inhibitors and anti-PD1/PD-L1 antibodies |
| CN114450024A (zh) | 2019-09-16 | 2022-05-06 | 表面肿瘤学公司 | 抗cd39抗体组合物和方法 |
| WO2021055306A1 (en) | 2019-09-16 | 2021-03-25 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
| BR112022004791A2 (pt) | 2019-09-17 | 2022-06-21 | Bial R&D Invest S A | Carboxamidas de imidazol substituídas e seu uso no tratamento de distúrbios médicos |
| EP4031535A1 (en) | 2019-09-17 | 2022-07-27 | Bial-R&D Investments, S.A. | Substituted n-heterocyclic carboxamides as acid ceramidase inhibitors and their use as medicaments |
| EP4031540A1 (en) | 2019-09-17 | 2022-07-27 | Bial-R&D Investments, S.A. | Substituted, saturated and unsaturated n-heterocyclic carboxamides and related compounds for their use in the treatment of medical disorders |
| US12441807B2 (en) | 2019-09-18 | 2025-10-14 | Lamkap Bio Alpha AG | Bispecific antibodies against CEACAM5 and CD3 |
| MX2022003192A (es) | 2019-09-18 | 2022-04-11 | Novartis Ag | Proteinas de fusion nkg2d y sus usos. |
| TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
| EP4031578A1 (en) | 2019-09-18 | 2022-07-27 | Novartis AG | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| CN115023267A (zh) | 2019-09-19 | 2022-09-06 | 密歇根大学董事会 | 螺环雄激素受体蛋白质降解剂 |
| JP7650867B2 (ja) | 2019-09-19 | 2025-03-25 | ブリストル-マイヤーズ スクイブ カンパニー | 酸性pHでVISTAと結合する抗体 |
| CN110467675B (zh) * | 2019-09-19 | 2020-08-14 | 合源生物科技(天津)有限公司 | 一种ctla-4单克隆抗体6f1及其用于抗肿瘤的用途 |
| EP4031873A1 (en) | 2019-09-22 | 2022-07-27 | Bristol-Myers Squibb Company | Quantitative spatial profiling for lag-3 antagonist therapy |
| KR20220091480A (ko) | 2019-09-24 | 2022-06-30 | 미라티 테라퓨틱스, 인크. | 병용 요법 |
| JP2022549854A (ja) | 2019-09-25 | 2022-11-29 | サーフィス オンコロジー インコーポレイテッド | 抗il-27抗体及びその使用 |
| MX2022003487A (es) | 2019-09-25 | 2022-04-25 | Bristol Myers Squibb Co | Biomarcador compuesto para terapia de cancer. |
| WO2021062122A1 (en) | 2019-09-25 | 2021-04-01 | Seagen Inc. | Combination anti-cd30 adc, anti-pd-1 and chemotherapeutic for treatment of hematopoietic cancers |
| TW202535873A (zh) | 2019-09-26 | 2025-09-16 | 瑞士商諾華公司 | 抗病毒吡唑并吡啶酮化合物 |
| KR20220070011A (ko) | 2019-09-27 | 2022-05-27 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 항원 결합 단백질 |
| CN114401997B (zh) | 2019-09-28 | 2025-05-16 | 奥美药业有限公司 | 细胞因子前药和双前药 |
| EP4037773A1 (en) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| AU2020358726A1 (en) | 2019-10-01 | 2022-04-07 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| EP3800201A1 (en) | 2019-10-01 | 2021-04-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd28h stimulation enhances nk cell killing activities |
| WO2021064180A1 (en) | 2019-10-03 | 2021-04-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for modulating macrophages polarization |
| CN115916233A (zh) | 2019-10-03 | 2023-04-04 | Xencor股份有限公司 | 靶向IL-12异源二聚体Fc融合蛋白 |
| US20220363776A1 (en) | 2019-10-04 | 2022-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of ovarian cancer, breast cancer or pancreatic cancer |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| CR20220170A (es) | 2019-10-11 | 2022-10-10 | Incyte Corp | Aminas bicíclicas como inhibidoras de la cdk2 |
| GB201914747D0 (en) | 2019-10-11 | 2019-11-27 | Ultrahuman Eight Ltd | PD1 and vegfr2 dual-binding agents |
| KR20220100879A (ko) | 2019-10-14 | 2022-07-18 | 인사이트 코포레이션 | Fgfr 저해제로서의 이환식 헤테로사이클 |
| US12380963B2 (en) | 2019-10-14 | 2025-08-05 | The Medical College Of Wisconsin, Inc. | Gene expression signature of hyperprogressive disease (HPD) in patients after anti-PD-1 immunotherapy |
| EP4045047A1 (en) | 2019-10-15 | 2022-08-24 | Amgen Inc. | Combination therapy of kras inhibitor and shp2 inhibitor for treatment of cancers |
| WO2021074683A1 (en) | 2019-10-16 | 2021-04-22 | Avacta Life Sciences Limited | Bispecific anti-pd-l1 and anti-fcrn polypeptides |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021074391A1 (en) | 2019-10-17 | 2021-04-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing nasal intestinal type adenocarcinomas |
| MX2022004766A (es) | 2019-10-21 | 2022-05-16 | Novartis Ag | Terapias combinadas con venetoclax e inhibidores de tim-3. |
| TW202128191A (zh) | 2019-10-21 | 2021-08-01 | 瑞士商諾華公司 | Tim-3抑制劑及其用途 |
| EP4048304A1 (en) | 2019-10-22 | 2022-08-31 | Institut Curie | Immunotherapy targeting tumor neoantigenic peptides |
| US20220378817A1 (en) | 2019-10-23 | 2022-12-01 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
| AU2020369569A1 (en) | 2019-10-24 | 2022-04-14 | Amgen Inc. | Pyridopyrimidine derivatives useful as KRAS G12C and KRAS G12D inhibitors in the treatment of cancer |
| US11459389B2 (en) | 2019-10-24 | 2022-10-04 | Massachusetts Institute Of Technology | Monoclonal antibodies that bind human CD161 |
| WO2021081378A1 (en) | 2019-10-25 | 2021-04-29 | Iovance Biotherapeutics, Inc. | Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JPWO2021079958A1 (Direct) | 2019-10-25 | 2021-04-29 | ||
| NL2024108B1 (en) | 2019-10-26 | 2021-07-19 | Vitroscan B V | Methods and apparatus for measuring immune-cell mediated anti-tumoroid responses |
| AU2020373913B2 (en) | 2019-10-28 | 2024-04-18 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof |
| US20220409724A1 (en) | 2019-10-29 | 2022-12-29 | Eisai R&D Management Co., Ltd. | Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer |
| US20240122938A1 (en) | 2019-10-29 | 2024-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating uveal melanoma |
| US20220380765A1 (en) | 2019-11-02 | 2022-12-01 | Board Of Regents, The University Of Texas System | Targeting nonsense-mediated decay to activate p53 pathway for the treatment of cancer |
| CR20220243A (es) | 2019-11-04 | 2022-08-04 | Revolution Medicines Inc | Inhibidores de ras |
| EP4054719A1 (en) | 2019-11-04 | 2022-09-14 | Revolution Medicines, Inc. | Ras inhibitors |
| EP4055153A4 (en) | 2019-11-04 | 2024-02-14 | Duke University | TREATMENT OF PRIMARY AND METASTASIC CANCER |
| BR112022008534A2 (pt) | 2019-11-04 | 2022-08-09 | Revolution Medicines Inc | Compostos, composição farmacêutica, conjugado e métodos para tratar câncer e para tratar um distúrbio relacionado à proteína ras |
| US12502398B2 (en) | 2019-11-04 | 2025-12-23 | Astrazeneca Ab | Combination therapy for treating cancer |
| KR20220092578A (ko) | 2019-11-05 | 2022-07-01 | 브리스톨-마이어스 스큅 컴퍼니 | M-단백질 검정 및 이의 용도 |
| CA3157196A1 (en) | 2019-11-05 | 2021-05-14 | Celgene Corporation | Combination therapy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide |
| WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| EP4055388A1 (en) | 2019-11-06 | 2022-09-14 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
| WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| AU2020378280A1 (en) | 2019-11-07 | 2022-04-07 | Feng Biosciences, Ltd. | Classification of tumor microenvironments |
| KR20220100903A (ko) | 2019-11-08 | 2022-07-18 | 레볼루션 메디슨즈, 인크. | 이환식 헤테로아릴 화합물 및 이의 용도 |
| US20220411499A1 (en) | 2019-11-08 | 2022-12-29 | Bristol-Myers Squibb Company | LAG-3 Antagonist Therapy for Melanoma |
| CA3160131A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| EP4058593A4 (en) | 2019-11-12 | 2023-11-15 | Foundation Medicine, Inc. | METHODS FOR DETECTING A FUSION GENE ENCODING A NEO-ANTIGEN |
| CA3155989A1 (en) | 2019-11-13 | 2021-05-20 | Jason Robert ZBIEG | Therapeutic compounds and methods of use |
| JP2023501528A (ja) | 2019-11-14 | 2023-01-18 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の改善された合成 |
| CA3161156A1 (en) | 2019-11-14 | 2021-05-20 | Amgen Inc. | Improved synthesis of kras g12c inhibitor compound |
| EP4058465A1 (en) | 2019-11-14 | 2022-09-21 | Cohbar Inc. | Cxcr4 antagonist peptides |
| WO2021098757A1 (en) * | 2019-11-21 | 2021-05-27 | Beigene, Ltd. | Methods of cancer treatment using anti-ox40 antibodies in combination with anti-tigit antibodies |
| US20230000864A1 (en) | 2019-11-22 | 2023-01-05 | Sumitomo Pharma Oncology, Inc. | Solid dose pharmaceutical composition |
| EP3824954A1 (en) | 2019-11-22 | 2021-05-26 | Centre National de la Recherche Scientifique | Device, apparatus and method for minibeam radiation therapy |
| AU2020385400A1 (en) | 2019-11-22 | 2022-06-09 | Theravance Biopharma R&D Ip, Llc | Substituted 1,5-naphthyridines or quinolines as ALK5 inhibitors |
| CN113179631B (zh) * | 2019-11-25 | 2024-08-30 | 中国科学院理化技术研究所杭州研究院 | 通过临近使能反应疗法开发的共价蛋白质药物 |
| JP2023503161A (ja) | 2019-11-26 | 2023-01-26 | ノバルティス アーゲー | Cd19及びcd22キメラ抗原受容体及びその使用 |
| US20210154281A1 (en) | 2019-11-26 | 2021-05-27 | Massachusetts Institute Of Technology | Cell-based cancer vaccines and cancer therapies |
| CA3162703A1 (en) | 2019-11-27 | 2021-06-03 | Myst Therapeutics, Llc | Method of producing tumor-reactive t cell composition using modulatory agents |
| WO2021108683A1 (en) | 2019-11-27 | 2021-06-03 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| US20220401540A1 (en) | 2019-11-27 | 2022-12-22 | Cytlimic Inc. | Pharmaceutical composition |
| CN110927389B (zh) * | 2019-11-29 | 2021-07-16 | 中国科学院苏州生物医学工程技术研究所 | 一种癌症生物标志物、用途 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| EP4069695A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| EP4289951A3 (en) | 2019-12-04 | 2024-03-13 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| JP7720840B2 (ja) | 2019-12-04 | 2025-08-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| EP4069683A1 (en) | 2019-12-06 | 2022-10-12 | Mersana Therapeutics, Inc. | Dimeric compounds as sting agonists |
| US11897950B2 (en) | 2019-12-06 | 2024-02-13 | Augusta University Research Institute, Inc. | Osteopontin monoclonal antibodies |
| WO2021119105A1 (en) | 2019-12-09 | 2021-06-17 | Seagen Inc. | Combination therapy with liv1-adc and pd-1 antagonist |
| EP4073236A1 (en) | 2019-12-11 | 2022-10-19 | Iovance Biotherapeutics, Inc. | Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same |
| GB201918230D0 (en) | 2019-12-11 | 2020-01-22 | Prec Therapeutics Ltd | Antibodies and their uses |
| US20230028414A1 (en) | 2019-12-16 | 2023-01-26 | Amgen Inc. | Dosing regimen of kras g12c inhibitor |
| KR20220128622A (ko) | 2019-12-16 | 2022-09-21 | 바이엘 악티엔게젤샤프트 | Ahr-억제제 및 pd1-억제제 항체의 조합물 및 암 치료에서의 그의 용도 |
| JP2023509359A (ja) | 2019-12-17 | 2023-03-08 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | 鉄依存性細胞分解の誘導物質との併用抗癌療法 |
| AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Boehringer Ingelheim International Gmbh | Bifunctional molecules comprising an IL-7 variant |
| EP4076443B1 (en) | 2019-12-17 | 2025-09-10 | Merck Sharp & Dohme LLC | Substituted 1,3,8-triazaspiro[4,5]decane-2,4-dione compound as indoleamine 2,3-dioxygenase (ido) and/or tryptophan 2,3-dioxygenase (tdo) inhibitors |
| JP7662644B2 (ja) | 2019-12-18 | 2025-04-15 | シーティーエックスティー・ピーティーワイ・リミテッド | 化合物 |
| CA3164754A1 (en) | 2019-12-19 | 2021-06-24 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and vaccine compositions to treat cancers |
| KR20220118481A (ko) | 2019-12-19 | 2022-08-25 | 브리스톨-마이어스 스큅 컴퍼니 | Dgk 억제제 및 체크포인트 길항제의 조합물 |
| JP2023506958A (ja) | 2019-12-20 | 2023-02-20 | ノバルティス アーゲー | 骨髄線維症および骨髄異形成症候群を処置するための、デシタビンまたは抗pd-1抗体スパルタリズマブを伴うかまたは伴わない抗tim-3抗体mbg453および抗tgf-ベータ抗体nis793の組合せ |
| CN113004408B (zh) * | 2019-12-20 | 2022-07-01 | 广东菲鹏制药股份有限公司 | 抗人程序死亡因子-1单克隆抗体 |
| CN113024670A (zh) * | 2019-12-25 | 2021-06-25 | 百奥泰生物制药股份有限公司 | Ctla-4抗体及其制备方法 |
| CN113045655A (zh) | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| TW202135824A (zh) | 2020-01-03 | 2021-10-01 | 美商英塞特公司 | 包含a2a/a2b及pd-1/pd-l1抑制劑之組合療法 |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| JP2023509516A (ja) | 2020-01-07 | 2023-03-08 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | がん治療のための改良型ヒトメチルチオアデノシン/アデノシン枯渇酵素変種 |
| WO2021141751A1 (en) | 2020-01-07 | 2021-07-15 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CA3163703A1 (en) | 2020-01-07 | 2021-07-15 | Steve Kelsey | Shp2 inhibitor dosing and methods of treating cancer |
| KR20220127847A (ko) | 2020-01-10 | 2022-09-20 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 뇌암을 치료하기 위해 혈액-뇌 장벽을 통해 면역요법제를 전달하기 위한 방법 및 조성물 |
| WO2021142237A1 (en) | 2020-01-10 | 2021-07-15 | Clovis Oncology, Inc. | Methods for administering lucitanib and combinations thereof |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021144426A1 (en) | 2020-01-17 | 2021-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| JP2023510393A (ja) | 2020-01-17 | 2023-03-13 | ノバルティス アーゲー | 骨髄異形成症候群または慢性骨髄単球性白血病の処置に使用するためのtim-3阻害剤と低メチル化剤とを含む組合せ |
| EP4096698A1 (en) | 2020-01-28 | 2022-12-07 | Genentech, Inc. | Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of cancer |
| CN115038466A (zh) | 2020-01-28 | 2022-09-09 | 葛兰素史密斯克莱知识产权发展有限公司 | 联合治疗及其用途和方法 |
| WO2021152005A1 (en) | 2020-01-28 | 2021-08-05 | Universite De Strasbourg | Antisense oligonucleotide targeting linc00518 for treating melanoma |
| CA3166133A1 (en) | 2020-01-29 | 2021-08-05 | John Heymach | Use of egfr/her2 tyrosine kinase inhibitors and/or her2/her3 antibodies for the treatment of cancers with nrg1 fusions |
| KR20220133238A (ko) | 2020-01-29 | 2022-10-04 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Nrg1 융합체가 있는 암의 치료를 위한 포지오티닙의 용도 |
| JP2023516885A (ja) | 2020-01-29 | 2023-04-21 | コーセプト セラピューティクス, インコーポレイテッド | 選択的グルココルチコイド受容体モジュレーター(sgrm)及び抗体チェックポイント阻害剤による副腎皮質がん腫の処置 |
| IL295093A (en) | 2020-01-30 | 2022-09-01 | Ona Therapeutics S L | Combination therapy for treatment of cancer and cancer metastasis |
| WO2021152400A1 (en) | 2020-01-30 | 2021-08-05 | Gnubiotics Sciences Sa | Compositions comprising pig stomach mucins and uses thereof |
| TW202142257A (zh) | 2020-01-31 | 2021-11-16 | 美商建南德克公司 | 用pd-1軸結合拮抗劑及rna疫苗誘導新抗原決定基特異性t細胞之方法 |
| EP4100126A1 (en) | 2020-02-05 | 2022-12-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for discontinuing a treatment with a tyrosine kinase inhibitor (tki) |
| JP2023514152A (ja) | 2020-02-06 | 2023-04-05 | ブリストル-マイヤーズ スクイブ カンパニー | Il-10およびその使用 |
| CN113244385A (zh) * | 2020-02-07 | 2021-08-13 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗恶性肿瘤中的用途 |
| US20230106973A1 (en) | 2020-02-17 | 2023-04-06 | Board Of Regents, The University Of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| EP4110818A1 (en) | 2020-02-26 | 2023-01-04 | Biograph 55, Inc. | C19 c38 bispecific antibodies |
| US20230086675A1 (en) | 2020-02-27 | 2023-03-23 | H. Lee Moffitt Cancer Center And Research Institute, Inc | Tumor-infiltrating lymphocytes with enhanced tumor reactivity |
| AU2021226903A1 (en) | 2020-02-27 | 2022-10-20 | Turnstone Biologics Corp. | Methods for ex vivo enrichment and expansion of tumor reactive T cells and related compositions thereof |
| CN115279374A (zh) | 2020-02-28 | 2022-11-01 | 诺华股份有限公司 | 包含达拉菲尼、erk抑制剂和raf抑制剂的三重药物组合 |
| WO2021171264A1 (en) | 2020-02-28 | 2021-09-02 | Novartis Ag | Dosing of a bispecific antibody that binds cd123 and cd3 |
| WO2021170777A1 (en) | 2020-02-28 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, prognosing and managing treatment of breast cancer |
| MX2022010936A (es) | 2020-03-05 | 2022-11-16 | Neotx Therapeutics Ltd | ³métodos y composiciones para el tratamiento del cáncer con células inmunológicas. |
| JP2023516724A (ja) | 2020-03-06 | 2023-04-20 | オーエヌエー セラピューティクス エセ.エレ. | 抗cd36抗体及び癌を治療するためのそれらの使用 |
| BR112022017637A2 (pt) | 2020-03-06 | 2022-11-08 | Celgene Quanticel Res Inc | Métodos de tratamento do câncer de pulmão de células pequenas e/ou câncer de pulmão de células não pequenas |
| WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
| US20230114276A1 (en) | 2020-03-06 | 2023-04-13 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Modulating anti-tumor immunity |
| US12214036B2 (en) | 2020-03-06 | 2025-02-04 | Incyte Corporation | Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors |
| WO2021183318A2 (en) | 2020-03-09 | 2021-09-16 | President And Fellows Of Harvard College | Methods and compositions relating to improved combination therapies |
| EP3878446A1 (en) | 2020-03-09 | 2021-09-15 | Universite De Geneve | Hsd11b1 inhibitors for use in immunotherapy and uses thereof |
| US20230140384A1 (en) | 2020-03-09 | 2023-05-04 | Bristol-Myers Squibb Company | Antibodies to cd40 with enhanced agonist activity |
| US12404332B2 (en) * | 2020-03-13 | 2025-09-02 | Research Development Foundation | Methods for diagnosing and treating cancers |
| EP4121453A2 (en) | 2020-03-20 | 2023-01-25 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| PE20230821A1 (es) | 2020-03-23 | 2023-05-19 | Bristol Myers Squibb Co | Anticuerpos anti-ccr8 para el tratamiento del cancer |
| AU2021242305A1 (en) * | 2020-03-26 | 2022-10-20 | Cureimmune Therapeutics Inc. | Anti-PD-1 antibodies and methods of use |
| WO2021195481A1 (en) | 2020-03-26 | 2021-09-30 | The Regents Of The University Of Michigan | Small molecule stat protein degraders |
| CN115916963A (zh) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途 |
| EP4126824A1 (en) | 2020-03-31 | 2023-02-08 | Theravance Biopharma R&D IP, LLC | Substituted pyrimidines and methods of use |
| BR122022020762A2 (pt) | 2020-04-02 | 2023-04-11 | Mersana Therapeutics, Inc | Conjugados de anticorpo-fármaco compreendendo agonistas de sting, seu uso e composição |
| WO2021202959A1 (en) | 2020-04-03 | 2021-10-07 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
| WO2021205444A1 (en) | 2020-04-06 | 2021-10-14 | Yeda Research And Development Co. Ltd. | Methods of diagnosing cancer and predicting responsiveness to therapy |
| CN115916223A (zh) | 2020-04-10 | 2023-04-04 | 朱诺治疗学股份有限公司 | 与用靶向b细胞成熟抗原的嵌合抗原受体工程化的细胞疗法相关的方法和用途 |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| WO2021205631A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | Sting作動化合物 |
| WO2021209357A1 (en) | 2020-04-14 | 2021-10-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer involving anti-icos and anti-pd1 antibodies, optionally further involving anti-tim3 antibodies |
| EP4136112A1 (en) | 2020-04-14 | 2023-02-22 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
| EP4135844A1 (en) | 2020-04-16 | 2023-02-22 | Incyte Corporation | Fused tricyclic kras inhibitors |
| US20230149560A1 (en) | 2020-04-20 | 2023-05-18 | Massachusetts Institute Of Technology | Lipid compositions for delivery of sting agonist compounds and uses thereof |
| US11834485B2 (en) | 2020-04-21 | 2023-12-05 | Regeneron Pharmaceuticals, Inc. | IL-2 variants with reduced binding to IL-2 receptor alpha and uses thereof |
| CN115427036A (zh) | 2020-04-21 | 2022-12-02 | 诺华股份有限公司 | 用于治疗由csf-1r调节的疾病的给药方案 |
| CR20220530A (es) | 2020-04-22 | 2022-12-15 | Merck Sharp & Dohme Llc | CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 ß¿c Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO. |
| US12159700B2 (en) | 2020-04-22 | 2024-12-03 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| TW202206100A (zh) | 2020-04-27 | 2022-02-16 | 美商西健公司 | 癌症之治療 |
| EP4143345A1 (en) | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
| US20230181756A1 (en) | 2020-04-30 | 2023-06-15 | Novartis Ag | Ccr7 antibody drug conjugates for treating cancer |
| WO2021224186A1 (en) | 2020-05-04 | 2021-11-11 | Institut Curie | New pyridine derivatives as radiosensitizers |
| JP2023524108A (ja) | 2020-05-04 | 2023-06-08 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 改良された腫瘍反応性t細胞の選択 |
| AU2021266969A1 (en) * | 2020-05-04 | 2022-12-08 | Beyondspring Pharmaceuticals, Inc. | Triple combination therapy for enhancing cancer cell killing in cancers with low immunogenicity |
| EP4146697A1 (en) | 2020-05-05 | 2023-03-15 | Regeneron Pharmaceuticals, Inc. | Car comprising cd28 zeta and cd3 zeta |
| WO2021226206A2 (en) | 2020-05-05 | 2021-11-11 | Teon Therapeutics, Inc. | Cannabinoid receptor type 2 (cb2) modulators and uses thereof |
| WO2021224215A1 (en) | 2020-05-05 | 2021-11-11 | F. Hoffmann-La Roche Ag | Predicting response to pd-1 axis inhibitors |
| EP4146644A1 (en) | 2020-05-06 | 2023-03-15 | Merck Sharp & Dohme LLC | Il4i1 inhibitors and methods of use |
| US20230258645A1 (en) | 2020-05-07 | 2023-08-17 | Institut Curie | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| CA3178260A1 (en) | 2020-05-13 | 2021-11-18 | Massachusetts Institute Of Technology | Compositions of polymeric microdevices and their use in cancer immunotherapy |
| WO2021231526A1 (en) | 2020-05-13 | 2021-11-18 | Incyte Corporation | Fused pyrimidine compounds as kras inhibitors |
| WO2021231732A1 (en) | 2020-05-15 | 2021-11-18 | Bristol-Myers Squibb Company | Antibodies to garp |
| PH12022553153A1 (en) | 2020-05-19 | 2024-02-26 | Boehringer Ingelheim Int | Binding molecules for the treatment of cancer |
| WO2021234110A1 (en) | 2020-05-20 | 2021-11-25 | Institut Curie | Single domain antibodies and their use in cancer therapies |
| TW202208418A (zh) | 2020-05-21 | 2022-03-01 | 美國德州系統大學評議委員會 | 具有vgll1特異性之t細胞受體及其用途 |
| HUE069403T2 (hu) | 2020-05-26 | 2025-03-28 | Boehringer Ingelheim Int | Anti-PD-1 antitestek |
| CN115666724A (zh) | 2020-05-26 | 2023-01-31 | 瑞泽恩制药公司 | 通过施用pd-1抑制剂抗体西米普利单抗来治疗宫颈癌的方法 |
| MX2022014943A (es) | 2020-05-26 | 2023-03-08 | Inst Nat Sante Rech Med | Polipéptidos de coronavirus 2 causante del síndrome respiratorio agudo severo (sars-cov-2) y usos de los mismos para propositos de vacuna. |
| AU2021278935A1 (en) | 2020-05-26 | 2022-12-08 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| EP4157319A1 (en) | 2020-05-28 | 2023-04-05 | Modernatx, Inc. | Use of mrnas encoding ox40l, il-23 and il-36gamma for treating cancer |
| EP4157923A2 (en) | 2020-05-29 | 2023-04-05 | President And Fellows Of Harvard College | Living cells engineered with polyphenol-functionalized biologically active nanocomplexes |
| WO2021247836A1 (en) | 2020-06-03 | 2021-12-09 | Board Of Regents, The University Of Texas System | Methods for targeting shp-2 to overcome resistance |
| CN115916231A (zh) | 2020-06-03 | 2023-04-04 | 勃林格殷格翰国际有限公司 | 编码CD80胞外域Fc融合蛋白的重组弹状病毒 |
| US11767353B2 (en) | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
| TW202214623A (zh) | 2020-06-10 | 2022-04-16 | 美商施萬生物製藥研發 Ip有限責任公司 | 結晶型alk5抑制劑及其用途 |
| WO2021252920A1 (en) | 2020-06-11 | 2021-12-16 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| EP4165415A1 (en) | 2020-06-12 | 2023-04-19 | Genentech, Inc. | Methods and compositions for cancer immunotherapy |
| IL299039A (en) | 2020-06-16 | 2023-02-01 | Genentech Inc | Methods and preparations for the treatment of triple-negative breast cancer |
| TW202214253A (zh) | 2020-06-18 | 2022-04-16 | 美商銳新醫藥公司 | 延遲、預防及治療對ras抑制劑之後天抗性之方法 |
| AU2021291011A1 (en) | 2020-06-19 | 2023-01-05 | F. Hoffmann-La Roche Ag | Antibodies binding to CD3 and CD19 |
| TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
| IL298262A (en) | 2020-06-23 | 2023-01-01 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| US20230293530A1 (en) | 2020-06-24 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
| WO2021260443A1 (en) | 2020-06-24 | 2021-12-30 | Bayer Aktiengesellschaft | Combinations of 2,3-dihydroimidazo[1,2-c]quinazolines |
| US20230235077A1 (en) | 2020-06-24 | 2023-07-27 | The General Hospital Corporation | Materials and methods of treating cancer |
| MX2022015891A (es) | 2020-06-25 | 2023-01-24 | Celgene Corp | Metodos para tratar cancer con terapias combinadas. |
| CN116209459A (zh) | 2020-06-26 | 2023-06-02 | 美国安进公司 | Il-10突变蛋白及其融合蛋白 |
| CA3183034A1 (en) * | 2020-06-26 | 2021-12-30 | Heyue Zhou | Anti-pd1 antibodies and uses thereof |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| EP4172621A1 (en) | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| AU2021302958A1 (en) | 2020-06-30 | 2023-02-16 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| WO2022002874A1 (en) | 2020-06-30 | 2022-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| RS66027B1 (sr) | 2020-07-07 | 2024-11-29 | Celgene Corp | Farmaceutske kompozicije koje sadrže (s)-4-(4-(4-(((2-(2,6-dioksopiperidin-3-il)-1-oksoizoindolin-4-il)oksi)m etil)benzil)piperazin-1-il)-3-fluorbenzonitril i metode njihove upotrebe |
| KR20230035576A (ko) | 2020-07-07 | 2023-03-14 | 비온테크 에스이 | Hpv 양성 암 치료용 rna |
| WO2022009157A1 (en) | 2020-07-10 | 2022-01-13 | Novartis Ag | Lhc165 and spartalizumab combinations for treating solid tumors |
| US20230257365A1 (en) | 2020-07-10 | 2023-08-17 | The Regents Of The University Of Michigan | Small molecule androgen receptor protein degraders |
| WO2022011205A1 (en) | 2020-07-10 | 2022-01-13 | The Regents Of The University Of Michigan | Androgen receptor protein degraders |
| US20240294641A1 (en) * | 2020-07-13 | 2024-09-05 | The Children's Medical Center Corporation | Novel anti-pd1 antibodies for inhibiting t-cell activity |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Tigit及cd112r阻斷 |
| US11787775B2 (en) | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
| JP2023536086A (ja) * | 2020-07-27 | 2023-08-23 | マクロジェニクス,インコーポレーテッド | Pd‐1×ctla‐4二重特異性分子の使用のための方法 |
| WO2022023379A1 (en) | 2020-07-28 | 2022-02-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for preventing and treating a cancer |
| TW202221031A (zh) | 2020-07-30 | 2022-06-01 | 英商阿法克塔生命科學有限公司 | 血清半衰期延長之pd-l1抑制多肽 |
| EP4188440A2 (en) * | 2020-07-30 | 2023-06-07 | Tiziana Life Sciences PLC | Cd-3 antibodies for the treatment of coronavirus |
| CN116134027B (zh) | 2020-08-03 | 2025-01-24 | 诺华股份有限公司 | 杂芳基取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| JP7767391B2 (ja) | 2020-08-05 | 2025-11-11 | シンセカイン インコーポレイテッド | IL10Ra結合分子および使用方法 |
| CA3190430A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il10rb binding molecules and methods of use |
| AU2021321525A1 (en) | 2020-08-05 | 2023-03-30 | Synthekine, Inc. | IL10 receptor binding molecules and methods of use |
| WO2022031869A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Gp130 binding molecules and methods of use |
| WO2022032040A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il2rb/il2rg synthetic cytokines |
| WO2022036146A1 (en) | 2020-08-12 | 2022-02-17 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| WO2022036079A1 (en) | 2020-08-13 | 2022-02-17 | Bristol-Myers Squibb Company | Methods of redirecting of il-2 to target cells of interest |
| CN111944052B (zh) * | 2020-08-26 | 2022-02-11 | 中国药科大学 | 抗TNF-α/PD-1双特异性抗体及其应用 |
| WO2022046833A1 (en) | 2020-08-26 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer by administering a pd-1 inhibitor |
| WO2022047046A1 (en) | 2020-08-26 | 2022-03-03 | Marengo Therapeutics, Inc. | Methods of detecting trbc1 or trbc2 |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| AU2021331476A1 (en) | 2020-08-28 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
| CN111808196B (zh) * | 2020-08-31 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | 抗pd-1抗体及其用途 |
| CN116438199A (zh) | 2020-08-31 | 2023-07-14 | 百时美施贵宝公司 | 细胞定位特征和免疫疗法 |
| KR20230060531A (ko) * | 2020-08-31 | 2023-05-04 | 바이오션, 인코포레이티드 | Pd-1에 결합하는 항체 및 이의 용도 |
| US20230265196A1 (en) | 2020-09-02 | 2023-08-24 | Pharmabcine Inc. | Combination Therapy of a PD-1 Antagonist and an Antagonist for VEGFR-2 for Treating Patients with Cancer |
| EP4208261A1 (en) | 2020-09-03 | 2023-07-12 | Revolution Medicines, Inc. | Use of sos1 inhibitors to treat malignancies with shp2 mutations |
| WO2022051448A1 (en) | 2020-09-03 | 2022-03-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer pain by administering a pd-1 inhibitor |
| TW202227126A (zh) | 2020-09-14 | 2022-07-16 | 德商百靈佳殷格翰國際股份有限公司 | 異源初免加強疫苗 |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| US20230372294A1 (en) | 2020-10-02 | 2023-11-23 | Dracen Pharmaceuticals, Inc. | Lyophilized composition comprising (s)-isopropyl 2-((s)-2-acetamido-3-(1h-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate for subcutaneous administration and the use thereof |
| JP2023544164A (ja) | 2020-10-02 | 2023-10-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | サイトカイン放出症候群の低減を伴うがんを治療するための抗体の組合せ |
| US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
| US20230374064A1 (en) | 2020-10-05 | 2023-11-23 | Bristol-Myers Squibb Company | Methods for concentrating proteins |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| EP4225330A1 (en) | 2020-10-06 | 2023-08-16 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022076596A1 (en) | 2020-10-06 | 2022-04-14 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
| CN116348142A (zh) | 2020-10-08 | 2023-06-27 | 塔尔格免疫治疗有限公司 | 用于治疗癌症的免疫疗法 |
| US20230377684A1 (en) | 2020-10-09 | 2023-11-23 | Worldwide Innovative Network | Novel prediction method and gene signatures for the treatment of cancer |
| WO2022073515A1 (zh) * | 2020-10-11 | 2022-04-14 | 百奥泰生物制药股份有限公司 | 抗pd-1抗体在联合用药中的应用 |
| CA3173768A1 (en) | 2020-10-13 | 2022-04-21 | Brian Furmanski | Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer |
| EP4229090A1 (en) | 2020-10-16 | 2023-08-23 | Université d'Aix-Marseille | Anti-gpc4 single domain antibodies |
| EP4232453A1 (en) | 2020-10-20 | 2023-08-30 | Institut Curie | Metallic trans-(n-heterocyclic carbene)-amine-platinum complexes and uses thereof for treating cancer |
| JP2023545566A (ja) | 2020-10-20 | 2023-10-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Pd-1軸結合アンタゴニストとlrrk2阻害剤との併用療法 |
| AR123855A1 (es) | 2020-10-20 | 2023-01-18 | Genentech Inc | Anticuerpos anti-mertk conjugados con peg y métodos de uso |
| EP4232019A1 (en) | 2020-10-23 | 2023-08-30 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
| WO2022084531A1 (en) | 2020-10-23 | 2022-04-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating glioma |
| WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
| EP4209216A4 (en) | 2020-10-28 | 2024-10-02 | Eisai R&D Management Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF TUMORS |
| KR20230098279A (ko) | 2020-10-28 | 2023-07-03 | 이케나 온콜로지, 인코포레이티드 | Pdx 억제제 또는 독소루비신과 ahr 억제제의 조합 |
| TW202432189A (zh) | 2020-11-04 | 2024-08-16 | 美商建南德克公司 | 以抗 cd20/抗 cd3 雙特異性抗體和抗 cd79b 抗體藥物結合物治療的給藥方法 |
| JP2023548522A (ja) | 2020-11-04 | 2023-11-17 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫チェックポイント阻害剤と抗体-アマトキシンコンジュゲートの組合せを含む癌治療に使用するための組成物 |
| KR20230100732A (ko) | 2020-11-04 | 2023-07-05 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이성 항체의 피하 투여 |
| JP7402381B2 (ja) | 2020-11-04 | 2023-12-20 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体による処置のための投与 |
| KR20230104220A (ko) | 2020-11-05 | 2023-07-07 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Egfr 항원을 표적화하는 조작된 t 세포 수용체 및 사용 방법 |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
| EP4240739A1 (en) | 2020-11-06 | 2023-09-13 | Incyte Corporation | Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof |
| CA3199095A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
| CA3200974A1 (en) | 2020-11-08 | 2022-05-12 | Seagen Inc. | Combination therapy |
| US20240010739A1 (en) | 2020-11-12 | 2024-01-11 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Antibodies conjugated or fused to the receptor-binding domain of the sars-cov-2 spike protein and uses thereof for vaccine purposes |
| IL302728A (en) | 2020-11-13 | 2023-07-01 | Catamaran Bio Inc | Genetically modified natural killer cells and methods of use thereof |
| WO2022102731A1 (ja) | 2020-11-13 | 2022-05-19 | 小野薬品工業株式会社 | Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療 |
| EP4244391A1 (en) | 2020-11-16 | 2023-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating uveal melanoma |
| US20230416838A1 (en) | 2020-11-16 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating uveal melanoma |
| WO2022101463A1 (en) | 2020-11-16 | 2022-05-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of the last c-terminal residues m31/41 of zikv m ectodomain for triggering apoptotic cell death |
| KR20230110274A (ko) | 2020-11-17 | 2023-07-21 | 씨젠 인크. | 투카티닙 및 항-pd-1/항-pd-l1 항체의 조합으로 암을 치료하는 방법 |
| JP2023550402A (ja) | 2020-11-18 | 2023-12-01 | アンスティテュ・クリー | ビグアニジンの二量体及びその治療的使用 |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| AU2021388155A1 (en) | 2020-11-25 | 2023-06-15 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| TWI877433B (zh) | 2020-11-30 | 2025-03-21 | 大陸商杭州阿諾生物醫藥科技有限公司 | 用於治療pik3ca突變癌症的組合療法 |
| WO2022119830A1 (en) | 2020-12-02 | 2022-06-09 | Genentech, Inc. | Methods and compositions for neoadjuvant and adjuvant urothelial carcinoma therapy |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| PH12023500013A1 (en) | 2020-12-04 | 2024-03-11 | Tidal Therapeutics Inc | Ionizable cationic lipids and lipi nanoparticles, and methods of synthesis and use thereof |
| US20240050432A1 (en) | 2020-12-08 | 2024-02-15 | Infinity Pharmaceuticals, Inc. | Eganelisib for use in the treatment of pd-l1 negative cancer |
| TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk﹘5抑制劑和彼之用途 |
| WO2022130206A1 (en) | 2020-12-16 | 2022-06-23 | Pfizer Inc. | TGFβr1 INHIBITOR COMBINATION THERAPIES |
| JP2023554097A (ja) | 2020-12-17 | 2023-12-26 | オーエスイー・イミュノセラピューティクス | 二機能性抗pd1/il-7分子 |
| IL301701A (en) | 2020-12-18 | 2023-05-01 | Lamkap Bio Beta Ag | Bispecific antiodies against ceacam5 and cd47 |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性rna |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| AR124449A1 (es) | 2020-12-22 | 2023-03-29 | Qilu Regor Therapeutics Inc | Inhibidores de sos1 y usos de los mismos |
| RS66849B1 (sr) | 2020-12-28 | 2025-06-30 | Bristol Myers Squibb Co | Kompozicije antitela i postupci njihove upotrebe |
| EP4267172A1 (en) | 2020-12-28 | 2023-11-01 | Bristol-Myers Squibb Company | Subcutaneous administration of pd1/pd-l1 antibodies |
| CA3207066A1 (en) | 2020-12-29 | 2022-07-07 | Incyte Corporation | Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies |
| WO2022147196A2 (en) | 2020-12-31 | 2022-07-07 | Iovance Biotherapeutics, Inc. | Devices and processes for automated production of tumor infiltrating lymphocytes |
| WO2022148781A1 (en) | 2021-01-05 | 2022-07-14 | Institut Curie | Combination of mcoln activators and immune checkpoint inhibitors |
| EP4274658A1 (en) | 2021-01-06 | 2023-11-15 | F. Hoffmann-La Roche AG | Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody |
| WO2022150557A1 (en) | 2021-01-08 | 2022-07-14 | Bristol-Myers Squibb Company | Combination therapy using an anti-fucosyl-gm1 antibody |
| CA3204162A1 (en) | 2021-01-11 | 2022-07-14 | Robert Kastelein | Compositions and methods related to receptor pairing |
| WO2022152862A1 (en) | 2021-01-14 | 2022-07-21 | Institut Curie | Her2 single domain antibodies variants and cars thereof |
| US20240076355A1 (en) | 2021-01-14 | 2024-03-07 | AskGene Pharma, Inc. | Interferon Prodrugs and Methods of Making and Using the Same |
| US20240299568A1 (en) | 2021-01-19 | 2024-09-12 | William Marsh Rice University | Bone-specific delivery of polypeptides |
| US12397055B2 (en) | 2021-01-22 | 2025-08-26 | Mendus B.V. | Methods of tumor vaccination |
| KR20230150295A (ko) | 2021-01-29 | 2023-10-30 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키나제 억제제를 이용한 암의 치료 방법 |
| WO2022162569A1 (en) | 2021-01-29 | 2022-08-04 | Novartis Ag | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
| US20240423972A1 (en) | 2021-02-01 | 2024-12-26 | Yale University | Chemotherapeutic bioadhesive particles with immunostimulatory molecules for cancer treatment |
| MX2023009100A (es) | 2021-02-03 | 2023-09-25 | Mozart Therapeutics Inc | Agentes aglutinantes y métodos para usar los mismos. |
| CN114452403A (zh) | 2021-02-10 | 2022-05-10 | 同润生物医药(上海)有限公司 | 一种含有双功能免疫检查点/TGFβ抑制剂的药物组合 |
| EP4291243A1 (en) | 2021-02-12 | 2023-12-20 | Synthorx, Inc. | Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof |
| CN117337304A (zh) * | 2021-02-18 | 2024-01-02 | 齐鲁普吉湾生物治疗公司 | 抗pd1抗体和抗ctla4抗体的联合 |
| EP4296283A4 (en) | 2021-02-19 | 2025-03-05 | SHAPERON Inc. | SINGLE DOMAIN ANTIBODIES AGAINST PD-L1 AND USE THEREOF |
| CN116917322A (zh) | 2021-02-19 | 2023-10-20 | 沙裴隆有限公司 | 针对pd-l1及cd47的双特异性单域抗体及其用途 |
| MX2023010067A (es) | 2021-03-02 | 2023-09-06 | Glaxosmithkline Ip Dev Ltd | Piridinas sustituidas como inhibidores de dnmt1. |
| WO2022187419A1 (en) | 2021-03-03 | 2022-09-09 | The Regents Of The University Of Michigan | Small molecule degraders of androgen receptor |
| US20240166647A1 (en) | 2021-03-03 | 2024-05-23 | The Regents Of The University Of Michigan | Cereblon Ligands |
| WO2022187741A2 (en) | 2021-03-05 | 2022-09-09 | Iovance Biotherapeutics, Inc. | Tumor storage and cell culture compositions |
| EP4301780A1 (en) | 2021-03-05 | 2024-01-10 | Leadartis, S.L. | Trimeric polypeptides and uses thereof in the treatment of cancer |
| WO2022189618A1 (en) | 2021-03-12 | 2022-09-15 | Institut Curie | Nitrogen-containing heterocycles as radiosensitizers |
| CA3212351A1 (en) | 2021-03-12 | 2022-09-15 | Mendus B.V. | Methods of vaccination and use of cd47 blockade |
| WO2022194908A1 (en) | 2021-03-17 | 2022-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| CN117321418A (zh) | 2021-03-18 | 2023-12-29 | 诺华股份有限公司 | 癌症生物标志物及其使用方法 |
| AR125130A1 (es) | 2021-03-19 | 2023-06-14 | Heidelberg Pharma Res Gmbh | Conjugados de amatoxina y anticuerpo específicos de linfocitos b |
| WO2022198101A1 (en) | 2021-03-19 | 2022-09-22 | Trained Therapeutix Discovery, Inc. | Compounds for regulating trained immunity, and their methods of use |
| MX2023011007A (es) | 2021-03-23 | 2023-12-07 | Regeneron Pharma | Metodos para tratar el cancer en pacientes inmunosuprimidos o inmunocomprometidos mediante la administracion de un inhibidor de pd-1. |
| IL306090A (en) | 2021-03-25 | 2023-11-01 | Oncxerna Therapeutics Inc | Targeted cancer treatments |
| TW202304506A (zh) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | 涉及抗claudin 18.2抗體的組合治療以治療癌症 |
| WO2022212400A1 (en) | 2021-03-29 | 2022-10-06 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
| US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| EP4314060A1 (en) | 2021-03-31 | 2024-02-07 | GlaxoSmithKline Intellectual Property Development Limited | Antigen binding proteins and combinations thereof |
| AU2022248913A1 (en) * | 2021-03-31 | 2023-11-02 | Incyte Corporation | Novel pd-1 binding domains |
| EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| BR112023020832A2 (pt) | 2021-04-08 | 2023-12-19 | Marengo Therapeutics Inc | Moléculas multifuncionais ligadas a tcr e seus usos |
| US20240279225A1 (en) | 2021-04-08 | 2024-08-22 | Board Of Regents, The University Of Texas System | Compounds and methods for theranostic targeting of parp activity |
| TW202305009A (zh) | 2021-04-08 | 2023-02-01 | 美商默沙東有限責任公司 | 以皮下投予抗pd1抗體治療癌症之方法 |
| EP4319739A2 (en) | 2021-04-08 | 2024-02-14 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds |
| US20240182571A1 (en) | 2021-04-09 | 2024-06-06 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
| EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| EP4319728A1 (en) | 2021-04-09 | 2024-02-14 | Genentech, Inc. | Combination therapy with a raf inhibitor and a pd-1 axis inhibitor |
| US20240197723A1 (en) | 2021-04-09 | 2024-06-20 | Beyondspring Pharmaceuticals, Inc. | Therapeutic compositions and methods for treating tumors |
| AU2022254727A1 (en) | 2021-04-09 | 2023-10-12 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
| IL307519A (en) | 2021-04-09 | 2023-12-01 | Celldex Therapeutics Inc | Antibodies against ILT4, anti-ILT4\PD-L1 bispecific antibody and their uses |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| PE20240327A1 (es) | 2021-04-13 | 2024-02-22 | Nuvalent Inc | Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr |
| WO2022219080A1 (en) | 2021-04-14 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method to improve nk cells cytotoxicity |
| CA3235132A1 (en) | 2021-04-16 | 2022-10-20 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
| AU2022262600A1 (en) | 2021-04-20 | 2023-10-05 | Seagen Inc. | Modulation of antibody-dependent cellular cytotoxicity |
| EP4326903A1 (en) | 2021-04-23 | 2024-02-28 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating cell senescence accumulation related disease |
| US12472148B2 (en) | 2021-04-26 | 2025-11-18 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| EP4329780B1 (en) | 2021-04-29 | 2025-11-26 | Yeda Research and Development Co. Ltd | T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same |
| WO2022227015A1 (en) | 2021-04-30 | 2022-11-03 | Merck Sharp & Dohme Corp. | Il4i1 inhibitors and methods of use |
| WO2022232503A1 (en) | 2021-04-30 | 2022-11-03 | Genentech, Inc. | Therapeutic and diagnostic methods and compositions for cancer |
| CA3213632A1 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| AU2022270116A1 (en) | 2021-05-05 | 2023-12-21 | Revolution Medicines, Inc. | Ras inhibitors |
| EP4334324A1 (en) | 2021-05-05 | 2024-03-13 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| US12252497B2 (en) | 2021-05-05 | 2025-03-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2022236134A1 (en) | 2021-05-07 | 2022-11-10 | Surface Oncology, Inc. | Anti-il-27 antibodies and uses thereof |
| WO2022238386A1 (en) | 2021-05-10 | 2022-11-17 | Institut Curie | Methods for the treatment of cancer, inflammatory diseases and autoimmune diseases |
| JP2024519029A (ja) | 2021-05-17 | 2024-05-08 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Pd-1遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用 |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| JP2024518641A (ja) | 2021-05-21 | 2024-05-01 | 天津立博美華基因科技有限責任公司 | 医薬物組合せ及びその使用 |
| CN113030475B (zh) * | 2021-05-25 | 2021-08-10 | 泛肽生物科技(浙江)有限公司 | 一种基于细胞线粒体质量评估的t细胞pd-1检测方法 |
| WO2022251359A1 (en) | 2021-05-26 | 2022-12-01 | Theravance Biopharma R&D Ip, Llc | Bicyclic inhibitors of alk5 and methods of use |
| BR112023024775A2 (pt) | 2021-05-26 | 2024-02-15 | Ct Inmunologia Molecular | Uso de uma composição terapêutica, e, método de estratificação de pacientes |
| AU2022280511A1 (en) | 2021-05-28 | 2023-12-14 | Nippon Kayaku Kabushiki Kaisha | Combined use of ubenimex and immune checkpoint inhibitor |
| TW202307210A (zh) | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Cd19和cd22嵌合抗原受體及其用途 |
| TW202313117A (zh) | 2021-06-03 | 2023-04-01 | 美商欣爍克斯公司 | 包含il-2接合物及西妥昔單抗(cetuximab)之頭頸癌組合療法 |
| GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
| EP4351595A1 (en) | 2021-06-07 | 2024-04-17 | Providence Health & Services - Oregon | Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| US12428420B2 (en) | 2021-06-09 | 2025-09-30 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| KR20240019111A (ko) | 2021-06-10 | 2024-02-14 | 오노 야꾸힝 고교 가부시키가이샤 | Cd47 저해 물질, 면역 체크포인트 저해 물질 및 표준 요법의 병용에 의한 암 치료법 |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| JP2024522234A (ja) | 2021-06-18 | 2024-06-11 | アリゲーター・バイオサイエンス・アーベー | 新規な併用療法及びその使用 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| JP2024525475A (ja) | 2021-06-29 | 2024-07-12 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | タノトランスミッションを促進するように操作された免疫細胞及びその使用 |
| MX2023015416A (es) | 2021-07-02 | 2024-04-30 | Genentech Inc | Procedimientos y composiciones para tratar el cancer. |
| US20240316005A1 (en) | 2021-07-05 | 2024-09-26 | Institut National de la Santé et de la Recherche Médicale | Gene signatures for predicting survival time in patients suffering from renal cell carcinoma |
| TW202317565A (zh) | 2021-07-07 | 2023-05-01 | 美商英塞特公司 | 作為kras抑制劑的三環化合物 |
| KR20240046323A9 (ko) | 2021-07-13 | 2025-10-01 | 비온테크 에스이 | 암에 대한 병용 요법에 있어서 cd40 및 cd137에 대한 다중특이 결합제 |
| CA3224841A1 (en) | 2021-07-14 | 2023-01-19 | Zhenwu Li | Tricyclic compounds as inhibitors of kras |
| EP4370139A4 (en) | 2021-07-14 | 2025-10-15 | Synthekine Inc | METHODS AND COMPOSITIONS FOR USE IN CELL THERAPY FOR NEOPLASTIC DISEASE |
| AU2022314735A1 (en) | 2021-07-19 | 2024-02-22 | Regeneron Pharmaceuticals, Inc. | Combination of checkpoint inhibitors and an oncolytic virus for treating cancer |
| JP2024529451A (ja) | 2021-07-28 | 2024-08-06 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | がんを治療するための方法及び組成物 |
| WO2023010094A2 (en) | 2021-07-28 | 2023-02-02 | Genentech, Inc. | Methods and compositions for treating cancer |
| EP4377348A1 (en) | 2021-07-30 | 2024-06-05 | Seagen Inc. | Treatment for cancer |
| EP4377344A1 (en) | 2021-07-30 | 2024-06-05 | Ona Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
| EP4380980A1 (en) | 2021-08-03 | 2024-06-12 | F. Hoffmann-La Roche AG | Bispecific antibodies and methods of use |
| WO2023015198A1 (en) | 2021-08-04 | 2023-02-09 | Genentech, Inc. | Il15/il15r alpha heterodimeric fc-fusion proteins for the expansion of nk cells in the treatment of solid tumours |
| IL310550A (en) | 2021-08-04 | 2024-03-01 | Univ Colorado Regents | LAT-activating chimeric antigen receptor T cells and methods of using them |
| EP4380682A1 (en) | 2021-08-05 | 2024-06-12 | Institut Curie | Scanning dynamic device for minibeams production |
| AU2022332285A1 (en) | 2021-08-23 | 2024-02-15 | Immunitas Therapeutics, Inc. | Anti-cd161 antibodies and uses thereof |
| WO2023034290A1 (en) | 2021-08-31 | 2023-03-09 | Incyte Corporation | Naphthyridine compounds as inhibitors of kras |
| TW202325306A (zh) | 2021-09-02 | 2023-07-01 | 美商天恩治療有限公司 | 改良免疫細胞之生長及功能的方法 |
| JP2024534186A (ja) | 2021-09-02 | 2024-09-18 | ドイチェス クレブスフォルシュンクスツェントルム スチフトゥング デス エッフェントリヒェン レヒツ | 副作用が低減された抗cecam6抗体 |
| JP2024532931A (ja) | 2021-09-08 | 2024-09-10 | レドナ・セラピューティクス,インコーポレーテッド | Papd5及び/またはpapd7を阻害する4-オキソ-1,4-ジヒドロキノリン-3-カルボン酸誘導体 |
| WO2023039583A1 (en) * | 2021-09-10 | 2023-03-16 | Trustees Of Tufts College | Anti-pd-1 immunoglobulin polypeptides and uses thereof |
| CN118139986A (zh) | 2021-09-13 | 2024-06-04 | 植物抗体公司 | 用于重组蛋白生产的经遗传修饰的生物体 |
| EP4401715A1 (en) | 2021-09-17 | 2024-07-24 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
| US12030883B2 (en) | 2021-09-21 | 2024-07-09 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of KRAS |
| WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
| US12030884B2 (en) | 2021-10-01 | 2024-07-09 | Incyte Corporation | Pyrazoloquinoline KRAS inhibitors |
| WO2023057882A1 (en) | 2021-10-05 | 2023-04-13 | Pfizer Inc. | Combinations of azalactam compounds with a pd-1 axis binding antagonist for the treatment of cancer |
| WO2023060136A1 (en) | 2021-10-05 | 2023-04-13 | Cytovia Therapeutics, Llc | Natural killer cells and methods of use thereof |
| WO2023057534A1 (en) | 2021-10-06 | 2023-04-13 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| WO2023064857A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
| AR127408A1 (es) | 2021-10-20 | 2024-01-17 | Takeda Pharmaceuticals Co | Composiciones dirigidas a bcma y métodos de uso de las mismas |
| EP4419545A4 (en) | 2021-10-20 | 2025-10-22 | Synthekine Inc | HETERODIMERIC FC CYTOKINES AND THEIR USES |
| US20240409934A1 (en) | 2021-10-25 | 2024-12-12 | Board Of Regents, The University Of Texas System | Foxo1-targeted therapy for the treatment of cancer |
| CA3234821A1 (en) | 2021-10-28 | 2023-05-04 | Suman Kumar VODNALA | Methods for culturing immune cells |
| AU2022375806A1 (en) | 2021-10-29 | 2023-12-14 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| WO2023078900A1 (en) | 2021-11-03 | 2023-05-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating triple negative breast cancer (tnbc) |
| WO2023081730A1 (en) | 2021-11-03 | 2023-05-11 | Teon Therapeutics, Inc. | 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer |
| WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
| WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
| AU2022386323A1 (en) | 2021-11-09 | 2024-05-16 | Sensei Biotherapeutics, Inc. | Anti-vista antibodies and uses thereof |
| TW202319073A (zh) | 2021-11-12 | 2023-05-16 | 瑞士商諾華公司 | 用於治療肺癌的組合療法 |
| WO2023083379A1 (zh) | 2021-11-15 | 2023-05-19 | 中国科学院生物物理研究所 | 一种以白介素15为活性成份的融合蛋白构建体及其应用 |
| EP4433504A1 (en) | 2021-11-17 | 2024-09-25 | Institut National de la Santé et de la Recherche Médicale | Universal sarbecovirus vaccines |
| WO2023089032A1 (en) | 2021-11-19 | 2023-05-25 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
| US20230226040A1 (en) | 2021-11-22 | 2023-07-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a kras inhibitor |
| WO2023097211A1 (en) | 2021-11-24 | 2023-06-01 | The University Of Southern California | Methods for enhancing immune checkpoint inhibitor therapy |
| WO2023097195A1 (en) | 2021-11-24 | 2023-06-01 | Genentech, Inc. | Therapeutic indazole compounds and methods of use in the treatment of cancer |
| EP4436969A2 (en) | 2021-11-24 | 2024-10-02 | Genentech, Inc. | Bicyclic therapeutic compounds and methods of use in the treatment of cancer |
| WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
| TW202329937A (zh) | 2021-12-03 | 2023-08-01 | 美商英塞特公司 | 雙環胺ck12抑制劑 |
| TW202328438A (zh) | 2021-12-08 | 2023-07-16 | 新加坡商泰莎治療有限公司 | 淋巴瘤之治療 |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| EP4448761A1 (en) | 2021-12-16 | 2024-10-23 | Valerio Therapeutics | New conjugated nucleic acid molecules and their uses |
| TW202340214A (zh) | 2021-12-17 | 2023-10-16 | 美商健臻公司 | 做為shp2抑制劑之吡唑并吡𠯤化合物 |
| EP4452327A1 (en) | 2021-12-20 | 2024-10-30 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab |
| WO2023118165A1 (en) | 2021-12-21 | 2023-06-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| US20230192722A1 (en) | 2021-12-22 | 2023-06-22 | Incyte Corporation | Salts and solid forms of an fgfr inhibitor and processes of preparing thereof |
| WO2023129438A1 (en) | 2021-12-28 | 2023-07-06 | Wisconsin Alumni Research Foundation | Hydrogel compositions for use for depletion of tumor associated macrophages |
| JP2025501238A (ja) | 2021-12-30 | 2025-01-17 | ネオイミューンテック, インコーポレイテッド | Il-7タンパク質とvegfアンタゴニストの併用による腫瘍の治療方法 |
| MX2024008055A (es) | 2022-01-07 | 2024-09-06 | Regeneron Pharma | Métodos para tratar el cáncer ovarico recurrente con anticuerpos biespecificos anti-muc16 x anti-cd3 solos o en combinación con anticuerpos anti-pd-1. |
| CN118765285A (zh) | 2022-01-26 | 2024-10-11 | 百时美施贵宝公司 | 用于肝细胞癌的组合疗法 |
| EP4470565A1 (en) | 2022-01-28 | 2024-12-04 | OnQuality Pharmaceuticals China Ltd. | Method for preventing or treating disease or disorder associated with antineoplastic agent |
| CN118984837A (zh) | 2022-01-28 | 2024-11-19 | 乔治穆内公司 | 作为pd-1激动剂的程序性细胞死亡蛋白1的抗体 |
| EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| WO2023154799A1 (en) | 2022-02-14 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy for treating cancer |
| TWI864587B (zh) | 2022-02-14 | 2024-12-01 | 美商基利科學股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| US12052261B2 (en) | 2022-02-15 | 2024-07-30 | Bank Of America Corporation | System and method for authenticating the receiving end of data transmission via LiFi and holochain network |
| US12074641B2 (en) | 2022-02-15 | 2024-08-27 | Bank Of America Corporation | System and method for secured data transmission using LiFi and holochain network |
| EP4479141A1 (en) | 2022-02-17 | 2024-12-25 | Regeneron Pharmaceuticals, Inc. | Combinations of checkpoint inhibitors and oncolytic virus for treating cancer |
| CN118715226A (zh) | 2022-02-21 | 2024-09-27 | 上海岸阔医药科技有限公司 | 化合物及其用途 |
| US20230277669A1 (en) | 2022-02-24 | 2023-09-07 | Amazentis Sa | Uses of urolithins |
| WO2023164638A1 (en) | 2022-02-25 | 2023-08-31 | Bristol-Myers Squibb Company | Combination therapy for colorectal carcinoma |
| WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| JP2025512710A (ja) | 2022-03-07 | 2025-04-22 | インサイト・コーポレイション | Cdk2阻害剤の固体形態、塩、ならびに調製プロセス |
| EP4490146A1 (en) | 2022-03-07 | 2025-01-15 | Amgen Inc. | A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile |
| EP4489780A1 (en) | 2022-03-07 | 2025-01-15 | Mabxience Research, S.L. | Stable formulations for antibodies |
| KR20250004645A (ko) | 2022-03-08 | 2025-01-08 | 알렌티스 테라퓨틱스 아게 | T 세포 가용성을 증가시키기 위한 항-클라우딘-1 항체의 사용 |
| EP4489755A1 (en) | 2022-03-08 | 2025-01-15 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
| US20250188182A1 (en) | 2022-03-10 | 2025-06-12 | Genexine, Inc. | Triple combination drug dosing therapy for head and neck cancer treatment |
| JPWO2023176881A1 (Direct) | 2022-03-16 | 2023-09-21 | ||
| JP2025509567A (ja) | 2022-03-17 | 2025-04-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 再発性類上皮肉腫を、二重特異性抗MUC16x 抗CD3抗体単独で、または抗PD-1抗体と組み合わせて治療する方法 |
| JP2025509749A (ja) | 2022-03-18 | 2025-04-11 | ブリストル-マイヤーズ スクイブ カンパニー | ポリペプチドの単離方法 |
| JP2025510795A (ja) | 2022-03-24 | 2025-04-15 | アンスティテュ・クリー | 神経膠芽腫における腫瘍転位因子由来のネオ抗原ペプチドを標的化する免疫療法 |
| WO2023187024A1 (en) | 2022-03-31 | 2023-10-05 | Institut Curie | Modified rela protein for inducing interferon expression and engineered immune cells with improved interferon expression |
| CN115028726B (zh) * | 2022-03-31 | 2024-01-09 | 浙江特瑞思药业股份有限公司 | 一种抗pd-1纳米抗体及其应用 |
| WO2023192478A1 (en) | 2022-04-01 | 2023-10-05 | Bristol-Myers Squibb Company | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
| IL315770A (en) | 2022-04-01 | 2024-11-01 | Genentech Inc | Dosage for treatment with bispecific anti-FCRH5/anti-CD3 antibodies |
| EP4504220A1 (en) | 2022-04-06 | 2025-02-12 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| US20250222106A1 (en) | 2022-04-07 | 2025-07-10 | Institut Curie | Myeloid cells modified by chimeric antigen receptor with cd40 and uses thereof for anti-cancer therapy |
| WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
| US20250241949A1 (en) | 2022-04-07 | 2025-07-31 | Institut Curie | Myeloid cells modified by chimeric antigen receptor and uses thereof for anti-cancer therapy |
| WO2023196988A1 (en) | 2022-04-07 | 2023-10-12 | Modernatx, Inc. | Methods of use of mrnas encoding il-12 |
| CN119731651A (zh) | 2022-04-08 | 2025-03-28 | 百时美施贵宝公司 | 三级淋巴结构的机器学习标识、分类和量化 |
| TWI882313B (zh) | 2022-04-13 | 2025-05-01 | 美商建南德克公司 | 治療性蛋白質之醫藥組成物及使用方法 |
| JP7579481B2 (ja) | 2022-04-13 | 2024-11-07 | ジェネンテック, インコーポレイテッド | モスネツズマブの医薬組成物および使用方法 |
| EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| JP2025515324A (ja) | 2022-04-28 | 2025-05-14 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | がんを処置するためのキメラ抗原受容体改変調節性t細胞 |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| AU2022458320A1 (en) | 2022-05-11 | 2024-11-28 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| IL316628A (en) | 2022-05-12 | 2024-12-01 | Genmab As | Binding agents capable of binding to CD27 in combination therapy |
| US20250304714A1 (en) | 2022-05-16 | 2025-10-02 | Regeneron Pharmaceuticals, Inc. | Methods of Treating Metastatic Castration-Resistant Prostate Cancer with Bispecific Anti-PSMA x Anti-CD3 Antibodies Alone or in Combination with Anti-PD-1 Antibodies |
| CN119213032A (zh) | 2022-05-19 | 2024-12-27 | 沙裴隆有限公司 | 一种针对pd-l1和cd47的双特异性人源化单域抗体及其用途 |
| CA3256230A1 (en) | 2022-05-24 | 2023-11-30 | Daiichi Sankyo Company, Limited | DOSAGE REGIMEN OF AN ANTI-CDH6 ANTIBODY-DRUG CONJUGATE |
| CA3257280A1 (en) | 2022-05-25 | 2023-11-30 | Msd International Gmbh | COMBINATION OF A BRAF INHIBITOR, AN EGFR INHIBITOR AND A PD-1 ANTAGONIST FOR THE TREATMENT OF COLORECTAL CANCER MSI-H/DMMR, WITH BRAF V600E MUTATION |
| TW202410916A (zh) | 2022-05-27 | 2024-03-16 | 日商武田藥品工業股份有限公司 | Cd38結合融合蛋白之給藥 |
| AR129423A1 (es) | 2022-05-27 | 2024-08-21 | Viiv Healthcare Co | Compuestos útiles en la terapia contra el hiv |
| US20250332252A1 (en) | 2022-06-02 | 2025-10-30 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| IL317449A (en) | 2022-06-07 | 2025-02-01 | Genentech Inc | Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist |
| AU2023284958A1 (en) | 2022-06-08 | 2025-01-02 | Incyte Corporation | Tricyclic triazolo compounds as dgk inhibitors |
| CA3258298A1 (en) | 2022-06-08 | 2023-12-14 | Tidal Therapeutics, Inc. | IONIZABLE LIPID NANOPARTICLES AND CATIONIC LIPIDS, AND THEIR PROCESSES FOR SYNTHESIS AND USE |
| CN119998298A (zh) | 2022-06-10 | 2025-05-13 | 锐新医药公司 | 大环ras抑制剂 |
| IL317511A (en) | 2022-06-16 | 2025-02-01 | Cephalon Llc | IL-2 immunoconjugates attenuated by anti-PD-1 antibody and their uses |
| AU2023291779A1 (en) | 2022-06-16 | 2024-10-17 | Lamkap Bio Beta Ltd | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
| JP2025521543A (ja) | 2022-06-22 | 2025-07-10 | ジュノー セラピューティクス インコーポレイテッド | Cd19標的car t細胞のセカンドライン治療のための処置方法 |
| WO2023250430A1 (en) | 2022-06-22 | 2023-12-28 | Incyte Corporation | Bicyclic amine cdk12 inhibitors |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| EP4547705A1 (en) | 2022-07-01 | 2025-05-07 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
| EP4551681A1 (en) | 2022-07-06 | 2025-05-14 | Iovance Biotherapeutics, Inc. | Devices and processes for automated production of tumor infiltrating lymphocytes |
| US20240101557A1 (en) | 2022-07-11 | 2024-03-28 | Incyte Corporation | Fused tricyclic compounds as inhibitors of kras g12v mutants |
| AU2023306375A1 (en) | 2022-07-12 | 2025-02-06 | Hotspot Therapeutics, Inc. | Cbl-b inhibitors and anti-pd1/anti-pd-l1 for use in the treatment of cancer |
| EP4554943A1 (en) | 2022-07-14 | 2025-05-21 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| IL318188A (en) | 2022-07-15 | 2025-03-01 | Pheon Therapeutics Ltd | Antibody-drug conjugates |
| TW202413433A (zh) | 2022-07-19 | 2024-04-01 | 美商建南德克公司 | 用抗fcrh5/抗cd3雙特異性抗體進行治療之給藥 |
| EP4310197A1 (en) | 2022-07-21 | 2024-01-24 | Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda | Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy |
| JP2025526369A (ja) | 2022-07-27 | 2025-08-13 | アストラゼネカ・アクチエボラーグ | Pd-1/pd-l1阻害剤を有するインターロイキン12を発現する組換えウイルスの組み合わせ |
| TW202412859A (zh) | 2022-07-28 | 2024-04-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及雙特異性檢查點抑制劑之組合 |
| WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
| WO2024028794A1 (en) | 2022-08-02 | 2024-02-08 | Temple Therapeutics BV | Methods for treating endometrial and ovarian hyperproliferative disorders |
| MA71693A (fr) | 2022-08-02 | 2025-05-30 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement du cancer de la prostate métastatique résistant à la castration avec des anticorps bispécifiques anti-psma x anti-cd28 en combinaison avec des anticorps anti-pd-1 |
| AU2023320568A1 (en) | 2022-08-05 | 2025-02-06 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| WO2024033400A1 (en) | 2022-08-10 | 2024-02-15 | Institut National de la Santé et de la Recherche Médicale | Sk2 inhibitor for the treatment of pancreatic cancer |
| WO2024033399A1 (en) | 2022-08-10 | 2024-02-15 | Institut National de la Santé et de la Recherche Médicale | Sigmar1 ligand for the treatment of pancreatic cancer |
| JP2025527578A (ja) | 2022-08-18 | 2025-08-22 | パルマトリックス オペレーティング カンパニー,インコーポレイテッド | 吸入用血管新生阻害剤を用いてがんを治療する方法 |
| WO2024040264A1 (en) | 2022-08-19 | 2024-02-22 | Massachusetts Institute Of Technology | Compositions and methods for targeting dendritic cell lectins |
| TW202417488A (zh) | 2022-08-23 | 2024-05-01 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
| WO2024043319A1 (ja) | 2022-08-26 | 2024-02-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗体薬物複合体 |
| EP4581366A1 (en) | 2022-09-01 | 2025-07-09 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
| WO2024052356A1 (en) | 2022-09-06 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Inhibitors of the ceramide metabolic pathway for overcoming immunotherapy resistance in cancer |
| WO2024056716A1 (en) | 2022-09-14 | 2024-03-21 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of dilated cardiomyopathy |
| EP4593868A1 (en) | 2022-09-26 | 2025-08-06 | Institut Curie | Myeloid cells expressing il-2 and uses thereof for quick anticancer therapy |
| CN120379691A (zh) | 2022-09-30 | 2025-07-25 | 爱兰蒂斯疗法股份公司 | 耐药性肝细胞癌的治疗 |
| EP4598634A1 (en) | 2022-10-03 | 2025-08-13 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer with bispecific egfr x cd28 antibodies alone or in combination with anti-pd-1 antibodies |
| EP4599088A1 (en) | 2022-10-05 | 2025-08-13 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
| EP4599089A1 (en) | 2022-10-05 | 2025-08-13 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
| WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| WO2024081736A2 (en) | 2022-10-11 | 2024-04-18 | Yale University | Compositions and methods of using cell-penetrating antibodies |
| KR20250102034A (ko) | 2022-10-14 | 2025-07-04 | 블랙 다이아몬드 테라퓨틱스, 인코포레이티드 | 이소퀴놀린 또는 6-아자-퀴놀린 유도체를 사용하여 암을 치료하는 방법 |
| EP4606384A1 (en) | 2022-10-19 | 2025-08-27 | Astellas Pharma, Inc. | Use of anti-cldn4-anti-cd137 bispecific antibody combined with pd-1 signal inhibitor for cancer treatment |
| WO2024084013A1 (en) | 2022-10-20 | 2024-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination therapy for the treatment of cancer |
| WO2024086827A2 (en) | 2022-10-20 | 2024-04-25 | Repertoire Immune Medicines, Inc. | Cd8 t cell targeted il2 |
| WO2024086739A1 (en) | 2022-10-20 | 2024-04-25 | Synthekine, Inc. | Methods and compositions of il12 muteins and il2 muteins |
| EP4605000A1 (en) | 2022-10-21 | 2025-08-27 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of osteoarthritis |
| EP4608995A1 (en) | 2022-10-24 | 2025-09-03 | Memorial Sloan-Kettering Cancer Center | Tumour stratification for responsiveness to an immune checkpoint inhibitor |
| JP2025535474A (ja) | 2022-10-24 | 2025-10-24 | キャンサー・リサーチ・テクノロジー・リミテッド | 酸化還元状態改変剤によるチェックポイント阻害剤に対する腫瘍の感応化 |
| TW202426505A (zh) | 2022-10-25 | 2024-07-01 | 美商建南德克公司 | 癌症之治療及診斷方法 |
| EP4611897A1 (en) | 2022-11-01 | 2025-09-10 | Heidelberg Pharma Research GmbH | Anti-gucy2c antibody and uses thereof |
| KR20250089492A (ko) | 2022-11-07 | 2025-06-18 | 네오이뮨텍, 인코퍼레이티드 | 비메틸화된 mgmt 프로모터를 갖는 종양의 치료 방법 |
| CN120202222A (zh) | 2022-11-16 | 2025-06-24 | 勃林格殷格翰国际有限公司 | 抗SIRPa抗体的疗效预测性生物标志物 |
| TW202428272A (zh) | 2022-11-18 | 2024-07-16 | 美商英塞特公司 | 作為dgk抑制劑之雜芳基氟烯烴 |
| WO2024107477A1 (en) * | 2022-11-18 | 2024-05-23 | Massachusetts Institute Of Technology | Compositions and methods for antibody mediated delivery of antigen to b cell follicles |
| WO2024112571A2 (en) | 2022-11-21 | 2024-05-30 | Iovance Biotherapeutics, Inc. | Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom |
| WO2024112867A1 (en) | 2022-11-23 | 2024-05-30 | University Of Georgia Research Foundation, Inc. | Compositions and methods of use thereof for increasing immune responses |
| EP4622677A1 (en) | 2022-11-24 | 2025-10-01 | BeiGene Switzerland GmbH | Anti-cea antibody drug conjugates and methods of use |
| WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
| AU2023403103A1 (en) | 2022-12-01 | 2025-07-10 | Medimmune Limited | Combination therapy for treatment of cancer comprising anti-pd-l1 and anti-cd73 antibodies |
| AU2023401158A1 (en) | 2022-12-01 | 2025-05-29 | BioNTech SE | Multispecific antibody against cd40 and cd137 in combination therapy with anti-pd1 ab and chemotherapy |
| KR20250112761A (ko) | 2022-12-01 | 2025-07-24 | 이나뜨 파르마 에스.에이. | 항-cd39 항체를 포함하는 암의 신보조 치료를 위한 조성물 및 방법 |
| WO2024119193A2 (en) | 2022-12-02 | 2024-06-06 | AskGene Pharma, Inc. | Mutant il-2 polypeptides and il-2 prodrugs |
| WO2024129778A2 (en) | 2022-12-13 | 2024-06-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for baff-r and cd19 and methods and uses thereof |
| IL321098A (en) | 2022-12-14 | 2025-07-01 | Astellas Pharma Europe Bv | Combination therapy including bispecific binding agents that bind to CLDN18.2- and CD3- and immune checkpoint inhibitors |
| WO2024129555A1 (en) * | 2022-12-15 | 2024-06-20 | Merck Sharp & Dohme Llc | Lyospheres containing programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| TW202440154A (zh) | 2022-12-20 | 2024-10-16 | 美商建南德克公司 | 用pd-1軸結合拮抗劑及rna疫苗治療胰臟癌之方法 |
| IL321575A (en) | 2022-12-21 | 2025-08-01 | Bristol Myers Squibb Co | Combination therapy for lung cancer |
| CN120530131A (zh) | 2023-01-06 | 2025-08-22 | 拉森医疗公司 | 抗il-18bp抗体 |
| EP4646432A1 (en) | 2023-01-06 | 2025-11-12 | Lassen Therapeutics, Inc. | Anti-il-18bp antibodies |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2024150177A1 (en) | 2023-01-11 | 2024-07-18 | Advesya | Treatment methods for solid tumors |
| AR131101A1 (es) | 2023-01-12 | 2025-02-19 | Incyte Corp | Heteroarilfluoroalquenos como inhibidores de dgk |
| EP4649173A1 (en) | 2023-01-13 | 2025-11-19 | Akrivia Biomedics Limited | Method of profiling diseases |
| WO2024151885A1 (en) | 2023-01-13 | 2024-07-18 | Iovance Biotherapeutics, Inc. | Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy |
| EP4652200A2 (en) | 2023-01-19 | 2025-11-26 | Beone Medicines I GmbH | Anti-cmet antibodies and methods of use |
| US20240262879A1 (en) | 2023-01-20 | 2024-08-08 | Boehringer Ingelheim International Gmbh | IL-12 Fc FUSION PROTEINS |
| EP4658310A1 (en) | 2023-01-30 | 2025-12-10 | Kymab Limited | Antibodies |
| WO2024163477A1 (en) | 2023-01-31 | 2024-08-08 | University Of Rochester | Immune checkpoint blockade therapy for treating staphylococcus aureus infections |
| AR132064A1 (es) | 2023-03-06 | 2025-05-21 | Beigene Switzerland Gmbh | Anticuerpos anti-cldn6 y métodos de uso |
| TW202436353A (zh) | 2023-03-06 | 2024-09-16 | 瑞士商百濟神州瑞士有限責任公司 | 抗cldn6與抗cd3多重特異性抗體以及使用方法 |
| AR132062A1 (es) | 2023-03-06 | 2025-05-21 | Beigene Switzerland Gmbh | Anticuerpos multiespecíficos anti-cd3 y métodos de uso |
| CN116218786B (zh) * | 2023-03-09 | 2024-01-23 | 山东大学齐鲁医院 | 一种多重基因编辑的通用型巨噬细胞及在制备抗肿瘤药物中的应用 |
| CN120835901A (zh) | 2023-03-13 | 2025-10-24 | 豪夫迈·罗氏有限公司 | 采用pd1-lag3双特异性抗体和hla-g t细胞双特异性抗体的组合疗法 |
| WO2024192033A1 (en) | 2023-03-13 | 2024-09-19 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating melanoma |
| WO2024189048A1 (en) | 2023-03-13 | 2024-09-19 | Heidelberg Pharma Research Gmbh | Subcutaneously administered antibody-drug conjugates for use in cancer treatment |
| WO2024192051A1 (en) | 2023-03-13 | 2024-09-19 | Turnstone Biologics Corp. | Composition of selected tumor infiltrating lymphocytes and related methods of producing and using the same |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| WO2024197157A1 (en) | 2023-03-21 | 2024-09-26 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| WO2024194402A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Farnesyl transferase inhibitor for use in methods for the treatment of hrd cancer |
| WO2024194673A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Methods for the treatment of dedifferentiated liposarcoma |
| WO2024194401A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Vps4b inhibitor for use in methods for the treatment of hrd cancer |
| WO2024206155A1 (en) | 2023-03-24 | 2024-10-03 | Cornell University | Utilizing t cells derived from tumor draining lymph nodes for chimeric antigen receptor (car) t cell therapy for the treatment of cancer |
| WO2024200571A1 (en) | 2023-03-28 | 2024-10-03 | Institut National de la Santé et de la Recherche Médicale | Method for discriminating mono-immunotherapy from combined immunotherapy in cancers |
| WO2024206357A1 (en) | 2023-03-29 | 2024-10-03 | Merck Sharp & Dohme Llc | Il4i1 inhibitors and methods of use |
| TW202444760A (zh) | 2023-03-29 | 2024-11-16 | 日商第一三共股份有限公司 | 抗cd25抗體及抗cd25抗體-藥物複合體 |
| TW202504611A (zh) | 2023-03-30 | 2025-02-01 | 美商銳新醫藥公司 | 用於誘導ras gtp水解之組合物及其用途 |
| AU2024254671A1 (en) | 2023-03-30 | 2025-10-02 | Ose Immunotherapeutics | Method of synthesis of targeted lipid nanoparticle and uses thereof |
| WO2024200823A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
| WO2024209072A1 (en) | 2023-04-06 | 2024-10-10 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 for treating cancer |
| AU2024252845A1 (en) | 2023-04-06 | 2025-10-16 | Glaxosmithkline Intellectual Property (No.4) Limited | Methods for treating and monitoring cancer |
| CN121263418A (zh) | 2023-04-07 | 2026-01-02 | 锐新医药公司 | 大环ras抑制剂 |
| AU2024253668A1 (en) | 2023-04-07 | 2025-11-13 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2024216028A1 (en) | 2023-04-12 | 2024-10-17 | Agenus Inc. | Methods of treating cancer using an anti-ctla4 antibody and an enpp1 inhibitor |
| WO2024213533A1 (en) | 2023-04-13 | 2024-10-17 | Alligator Bioscience Ab | Combination therapies |
| WO2024213782A1 (en) | 2023-04-13 | 2024-10-17 | Institut Curie | Methods for the treatment of t-cell acute lymphoblastic leukemia |
| CN121100123A (zh) | 2023-04-14 | 2025-12-09 | 锐新医药公司 | Ras抑制剂的结晶形式 |
| WO2024213767A1 (en) | 2023-04-14 | 2024-10-17 | Institut National de la Santé et de la Recherche Médicale | Engraftment of mesenchymal stromal cells engineered to stimulate immune infiltration in tumors |
| US20240352038A1 (en) | 2023-04-14 | 2024-10-24 | Revolution Medicines, Inc. | Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof |
| WO2024220532A1 (en) | 2023-04-18 | 2024-10-24 | Incyte Corporation | Pyrrolidine kras inhibitors |
| WO2024223299A2 (en) | 2023-04-26 | 2024-10-31 | Isa Pharmaceuticals B.V. | Methods of treating cancer by administering immunogenic compositions and a pd-1 inhibitor |
| WO2024228167A1 (en) | 2023-05-03 | 2024-11-07 | Iox Therapeutics Inc. | Inkt cell modulator liposomal compositions and methods of use |
| WO2024229461A2 (en) | 2023-05-04 | 2024-11-07 | Novasenta, Inc. | Anti-cd161 antibodies and methods of use thereof |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2024233341A1 (en) | 2023-05-05 | 2024-11-14 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| AU2024268933A1 (en) | 2023-05-10 | 2025-11-20 | Chugai Seiyaku Kabushiki Kaisha | Methods and compositions for treating cancer |
| WO2024231384A1 (en) | 2023-05-10 | 2024-11-14 | Institut National de la Santé et de la Recherche Médicale | Compositions for treating senescence related disease |
| WO2024235862A1 (en) | 2023-05-12 | 2024-11-21 | Genmab A/S | Antibodies capable of binding to ox40, variants thereof and uses thereof |
| WO2024245951A1 (en) | 2023-05-26 | 2024-12-05 | Institut National de la Santé et de la Recherche Médicale | Combination of slc8a1 inhibitor and mitochondria-targeted antioxidant for treating melanoma |
| EP4470542A1 (en) | 2023-05-31 | 2024-12-04 | Fundación Miguel Servet | Oleuropein in the management of cancer |
| WO2024254245A1 (en) | 2023-06-09 | 2024-12-12 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
| WO2024256635A1 (en) | 2023-06-15 | 2024-12-19 | Institut National de la Santé et de la Recherche Médicale | Dpm1 inhibitor for treating cancer |
| WO2024261302A1 (en) | 2023-06-22 | 2024-12-26 | Institut National de la Santé et de la Recherche Médicale | Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders |
| WO2024263904A1 (en) | 2023-06-23 | 2024-12-26 | Genentech, Inc. | Methods for treatment of liver cancer |
| WO2024263195A1 (en) | 2023-06-23 | 2024-12-26 | Genentech, Inc. | Methods for treatment of liver cancer |
| WO2024261239A1 (en) | 2023-06-23 | 2024-12-26 | Imcheck Therapeutics | Bispecific antibodies targeting btn3a and the pd-1/pd-l1 inhibitory axis |
| WO2025003193A1 (en) | 2023-06-26 | 2025-01-02 | Institut National de la Santé et de la Recherche Médicale | Sertraline and indatraline for disrupting intracellular cholesterol trafficking and subsequently inducing lysosomal damage and anti-tumor immunity |
| WO2025006811A1 (en) | 2023-06-27 | 2025-01-02 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
| WO2025012620A1 (en) | 2023-07-07 | 2025-01-16 | Mestag Therapeutics Ltd | Binding constructs |
| WO2025012417A1 (en) | 2023-07-13 | 2025-01-16 | Institut National de la Santé et de la Recherche Médicale | Anti-neurotensin long fragment and anti-neuromedin n long fragment antibodies and uses thereof |
| WO2025024257A1 (en) | 2023-07-21 | 2025-01-30 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| IL304887A (en) | 2023-07-31 | 2025-02-01 | Yeda Res & Dev | T-cell receptor directed against RAS neoantigen |
| WO2025030044A1 (en) | 2023-08-02 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Methods of treating clear cell renal cell carcinoma with bispecific anti-psma x anti-cd28 antibodies |
| WO2025030041A1 (en) | 2023-08-02 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd28 antibodies |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025034883A1 (en) | 2023-08-08 | 2025-02-13 | Quanta Therapeutics, Inc. | Combination therapies with kras modulators |
| WO2025038770A1 (en) | 2023-08-15 | 2025-02-20 | Gilead Sciences, Inc. | Treatment of non-small cell lung cancer using sacituzumab govitecan and an anti-pd-1 antibody or antigen binding fragment thereof |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025042742A1 (en) | 2023-08-18 | 2025-02-27 | Bristol-Myers Squibb Company | Compositions comprising antibodies that bind bcma and cd3 and methods of treatment |
| TW202517247A (zh) | 2023-08-24 | 2025-05-01 | 美商英塞特公司 | 雙環dgk抑制劑 |
| TW202515614A (zh) | 2023-08-25 | 2025-04-16 | 美商建南德克公司 | 治療非小細胞肺癌之方法及組成物 |
| WO2025049858A1 (en) | 2023-09-01 | 2025-03-06 | Amgen Inc. | Molecules for treatment of cancer |
| WO2025050009A2 (en) | 2023-09-01 | 2025-03-06 | Children's Hospital Medical Center | Identification of targets for immunotherapy in melanoma using splicing-derived neoantigens |
| WO2025051895A1 (en) | 2023-09-06 | 2025-03-13 | Novimmune Sa | Combination therapy with a cea x cd28 bispecific antibody and blocking anti-pd-1 antibodies for enhanced in vivo anti-tumor activity |
| WO2025056180A1 (en) | 2023-09-15 | 2025-03-20 | BioNTech SE | Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists |
| WO2025068393A1 (en) | 2023-09-27 | 2025-04-03 | Institut Curie | Methods for the treatment of fibrotic related diseases |
| WO2025068452A1 (en) | 2023-09-29 | 2025-04-03 | Negio Therapeutics | Guanfacine derivatives and their use in treating cancer |
| WO2025068461A1 (en) | 2023-09-29 | 2025-04-03 | Negio Therapeutics | Guanfacine derivatives and their use in treating cancer |
| WO2025073765A1 (en) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from melanoma |
| US20250114468A1 (en) | 2023-10-09 | 2025-04-10 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer with a combination of a pd1 inhibitor and a targeted immunocytokine |
| US20250114346A1 (en) | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor |
| WO2025080865A1 (en) | 2023-10-11 | 2025-04-17 | Turnstone Biologics Corp. | Combination of tumor infiltrating lymphocytes (til) and low dose radiation |
| TW202515903A (zh) | 2023-10-12 | 2025-04-16 | 瑞士商百濟神州瑞士有限責任公司 | 手術前後基於抗pd-1之治療 |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025078632A1 (en) | 2023-10-12 | 2025-04-17 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from cancer |
| WO2025081075A1 (en) | 2023-10-13 | 2025-04-17 | Gilead Sciences, Inc. | Combination therapies for treating cancers |
| WO2025085404A1 (en) | 2023-10-16 | 2025-04-24 | Genentech, Inc. | Diagnostic and therapeutic methods for treating lung cancer |
| WO2025085781A1 (en) | 2023-10-19 | 2025-04-24 | Genentech, Inc. | Combinations of il15/il15r alpha heterodimeric fc-fusion proteins and her2xcd3 bispecific antibodies for the treatment of her2-positive cancers |
| WO2025096638A2 (en) | 2023-10-30 | 2025-05-08 | Turnstone Biologics Corp. | Genetically modified tumor infilitrating lymphocytes and methods of producing and using the same |
| US20250163079A1 (en) | 2023-11-01 | 2025-05-22 | Incyte Corporation | Kras inhibitors |
| WO2025093824A1 (en) | 2023-11-02 | 2025-05-08 | Tilt Biotherapeutics Oy | Oncolytic adenovirus, immune checkpoint inhibitor and chemoterapeutic agent combination therapy of cancer |
| WO2025096843A1 (en) | 2023-11-03 | 2025-05-08 | Amgen Inc. | Bispecific molecules |
| WO2025101484A1 (en) | 2023-11-06 | 2025-05-15 | Iovance Biotherapeutics, Inc. | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
| WO2025106736A2 (en) | 2023-11-15 | 2025-05-22 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating lung cancer |
| WO2025106905A1 (en) | 2023-11-17 | 2025-05-22 | Quanta Therapeutics, Inc. | Combination therapies with a kras modulator and an immunomodulator inhibitor |
| WO2025109597A1 (en) | 2023-11-22 | 2025-05-30 | Yeda Research And Development Co. Ltd. | T cell receptors directed against androgen receptor mutation |
| CN117756915B (zh) * | 2023-11-24 | 2025-05-30 | 河南省肿瘤医院 | 一组阻断抗pd-1抗体与细胞表面pd-1分子结合的pd-1分子及其突变体和用途 |
| TW202539732A (zh) | 2023-11-29 | 2025-10-16 | 美商再生元醫藥公司 | 以雙特異性抗muc16×抗cd28抗體與抗pd-1抗體之組合或與雙特異性抗muc16×抗cd3抗體之組合治療復發性卵巢癌及子宮內膜癌之方法 |
| TW202540189A (zh) | 2023-11-30 | 2025-10-16 | 德商生物新技術公司 | 在組合療法中能夠結合ox40之抗體 |
| TW202523667A (zh) | 2023-12-05 | 2025-06-16 | 美商英塞特公司 | 作為dgk抑制劑之三環三唑并化合物 |
| WO2025122695A1 (en) | 2023-12-06 | 2025-06-12 | Incyte Corporation | Combination therapy comprising dgk inhibitors and pd-1/pd-l1 inhibitors |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| WO2025128652A1 (en) | 2023-12-12 | 2025-06-19 | Regeneron Pharmaceuticals, Inc. | Methods of treating endometrial cancer with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies |
| WO2025129002A1 (en) | 2023-12-13 | 2025-06-19 | Incyte Corporation | Bicyclooctane kras inhibitors |
| WO2025132479A1 (en) | 2023-12-18 | 2025-06-26 | Institut National de la Santé et de la Recherche Médicale | Flt3 inhibitor for modulating macrophages polarization |
| WO2025132695A1 (en) | 2023-12-19 | 2025-06-26 | Boehringer Ingelheim International Gmbh | Recombinant rhabdovirus encoding for a gasdermin |
| WO2025132831A1 (en) | 2023-12-19 | 2025-06-26 | Universite D'aix-Marseille | N-heteroaryl derivatives and uses thereof for treating cancer |
| WO2025137093A1 (en) | 2023-12-19 | 2025-06-26 | Cephalon Llc | Uses for attenuated il-2 immunoconjugates |
| WO2025133115A1 (en) | 2023-12-21 | 2025-06-26 | Ose Immunotherapeutics | Lipid-based nanoparticles comprising il-35 |
| WO2025133175A1 (en) | 2023-12-21 | 2025-06-26 | Egle Therapeutics | Immunocytokine for cancer treatment |
| EP4574165A1 (en) | 2023-12-21 | 2025-06-25 | Egle Therapeutics | Immunocytokine for cancer treatment |
| WO2025137507A1 (en) | 2023-12-22 | 2025-06-26 | Regor Pharmaceuticals, Inc. | Sos1 inhibitors and uses thereof |
| WO2025132770A1 (en) | 2023-12-22 | 2025-06-26 | Institut National de la Santé et de la Recherche Médicale | Affitins for the treatment of cancer |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
| WO2025146131A1 (en) | 2024-01-05 | 2025-07-10 | Beigene, Ltd. | ANTI-FGFR2b ANTIBODIES, CONJUGATES AND METHODS OF USE |
| WO2025151487A2 (en) | 2024-01-08 | 2025-07-17 | Regents Of The University Of Michigan | Small-molecule inhibitors of adar1 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| TW202539700A (zh) | 2024-01-16 | 2025-10-16 | 美商建南德克公司 | 用pd-1軸結合拮抗劑及rna疫苗治療泌尿上皮癌之方法 |
| WO2025153834A1 (en) | 2024-01-19 | 2025-07-24 | Institut National de la Santé et de la Recherche Médicale | Methods of predicting the risk of recurrence and/or death of patients suffering from a hepatocellular carcinoma (hcc) |
| WO2025158077A1 (en) | 2024-01-26 | 2025-07-31 | Institut Curie | Lipid degraders to trigger ferroptosis in cancer |
| WO2025163468A1 (en) | 2024-01-30 | 2025-08-07 | Seagen Inc. | Anti-pd-l1 antibodies and antibody-drug conjugates and their use in the treatment of cancer |
| WO2025174825A2 (en) | 2024-02-12 | 2025-08-21 | Aera Therapeutics, Inc. | Delivery compositions |
| WO2025174933A1 (en) | 2024-02-14 | 2025-08-21 | Genentech, Inc. | Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel |
| WO2025184208A1 (en) | 2024-02-27 | 2025-09-04 | Bristol-Myers Squibb Company | Anti-ceacam5 antibodies and uses thereof |
| EP4658320A1 (en) | 2024-02-27 | 2025-12-10 | Bristol-Myers Squibb Company | Anti-ceacam5 antibody drug conjugates |
| US20250282786A1 (en) | 2024-03-05 | 2025-09-11 | Bristol-Myers Squibb Company | Tricyclic TLR7 Agonists and Uses Thereof |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| WO2025191529A1 (en) | 2024-03-14 | 2025-09-18 | Biohaven Therapeutics Ltd. | Next generation riluzole prodrugs |
| WO2025207705A1 (en) | 2024-03-26 | 2025-10-02 | Amgen Inc. | Cancer treatments using mta-cooperative prmt5 inhibitors |
| WO2025202213A1 (en) | 2024-03-26 | 2025-10-02 | Institut National de la Santé et de la Recherche Médicale | Lipid nanoparticle loaded with antitumoral agent and functionnalized to target immosuppressive cells |
| WO2025202450A1 (en) | 2024-03-28 | 2025-10-02 | Institut Curie | Myeloid cells modified by cytokine chimeric receptor and uses thereof |
| EP4624494A1 (en) | 2024-03-29 | 2025-10-01 | Institut Curie | Her2 single domain antibody and uses thereof |
| WO2025210123A1 (en) | 2024-04-03 | 2025-10-09 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical composition for treating cancers |
| WO2025210175A1 (en) | 2024-04-04 | 2025-10-09 | Centre National De La Recherche Scientifique | Mutant csf-1r extracellular domain fusion molecules and therapeutic uses thereof |
| WO2025210252A1 (en) | 2024-04-05 | 2025-10-09 | Institut Curie | Modulators of fam118b protein for use in therapy |
| WO2025213154A1 (en) | 2024-04-05 | 2025-10-09 | Amgen Inc. | Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors |
| WO2025216894A1 (en) | 2024-04-09 | 2025-10-16 | Sensei Biotherapeutics, Inc. | Bispecific anti-vista and anti-cd28 binding proteins and uses thereof |
| WO2025219330A1 (en) | 2024-04-15 | 2025-10-23 | Institut National de la Santé et de la Recherche Médicale | Detection of ppix for use in methods for melanoma ferroptosis sensitivity and targeted therapy resistance prediction |
| WO2025219595A1 (en) | 2024-04-19 | 2025-10-23 | Biper Therapeutics | Method for combination treatments using alkynylbenzenesulphonamides for cancer therapy |
| WO2025223372A1 (en) | 2024-04-22 | 2025-10-30 | Fujian Haixi Pharmaceuticals Co., Ltd. | Combination comprising a pd-1 inhibitor and a pyridine compound for use in treating solid tumors |
| WO2025228998A1 (en) | 2024-04-30 | 2025-11-06 | Institut National de la Santé et de la Recherche Médicale | Use of hdac4 inhibitors for the treatment of melanoma |
| WO2025232879A1 (en) | 2024-05-10 | 2025-11-13 | Cytocares (Shanghai) Inc. | Anti-lilrb2 monospecific and bispecific antibody constructs and uses thereof |
| WO2025240670A2 (en) | 2024-05-15 | 2025-11-20 | Abalytics Oncology, Inc. | Anti-pd-1 antibodies and related binding molecules and methods and uses thereof |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2025242836A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders |
| WO2025245489A1 (en) | 2024-05-24 | 2025-11-27 | Bristol-Myers Squibb Company | Treatment of tumors in subjects having fgl-1 positive samples |
| WO2025247829A1 (en) | 2024-05-27 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical composition for treating prostate cancer |
| NL2037811B1 (en) | 2024-05-29 | 2025-12-12 | Univ Oslo | Treatment for Cancer |
| WO2025248505A1 (en) | 2024-05-31 | 2025-12-04 | Wayne State University | Methods for treating endometrial and ovarian hyperproliferative disorders |
| WO2025252855A1 (en) | 2024-06-05 | 2025-12-11 | Institut National de la Santé et de la Recherche Médicale | IL-15 MUTEINS WITH PH-DEPENDENT BINDING FOR IL-15Rbeta |
| WO2025252857A1 (en) | 2024-06-05 | 2025-12-11 | Institut National de la Santé et de la Recherche Médicale | Il-15 muteins with ph-dependent binding for il-15ralpha |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025257588A1 (en) | 2024-06-10 | 2025-12-18 | Affimed Gmbh | Cd16a/tumor antigen polyspecific binder for use in the treatment of immune checkpoint inhibitor resistance |
| WO2025257220A1 (en) | 2024-06-10 | 2025-12-18 | Merck Patent Gmbh | Muc-1 conditional cd40 agonists |
| WO2025259515A2 (en) | 2024-06-11 | 2025-12-18 | Amgen Inc. | Combination treatment |
| GB202408360D0 (en) | 2024-06-11 | 2024-07-24 | Cancer Research Tech Ltd | Tumour sensitisation |
| WO2025262641A1 (en) | 2024-06-19 | 2025-12-26 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
| WO2025262250A1 (en) | 2024-06-20 | 2025-12-26 | Negio Therapeutics | Guanfacine derivatives and their uses |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026003224A2 (en) | 2024-06-26 | 2026-01-02 | Iomx Therapeutics Ag | Bispecific antigen binding proteins (abp) targeting immune checkpoint molecules and both leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2; combinations and uses thereof |
| WO2026006604A1 (en) | 2024-06-26 | 2026-01-02 | Lyell Immunopharma, Inc. | Feeder cell replacement |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
| US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| WO1988009344A1 (en) | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US5476996A (en) | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69233782D1 (de) | 1991-12-02 | 2010-05-20 | Medical Res Council | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| EP0640094A1 (en) | 1992-04-24 | 1995-03-01 | The Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5260074A (en) | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
| IL108501A (en) | 1994-01-31 | 1998-10-30 | Mor Research Applic Ltd | Antibodies and pharmaceutical compositions containing them |
| JPH07291996A (ja) | 1994-03-01 | 1995-11-07 | Yuu Honshiyo | ヒトにおけるプログラムされた細胞死に関連したポリペプチド、それをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのポリペプチドまたはその抗体を含有する薬学的組成物 |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| ATE352613T1 (de) | 1995-08-29 | 2007-02-15 | Kirin Brewery | Chimäres tier und methode zu dessen herstellung |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| JP4048294B2 (ja) * | 1996-11-08 | 2008-02-20 | バイオジェン・アイデック・インコーポレイテッド | ある種の抗体とヒトb7.1およびb7.2コスティミュラトリー抗原との間の独特の結合相互作用の同定 |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| WO1998042752A1 (en) | 1997-03-21 | 1998-10-01 | Brigham And Women's Hospital Inc. | Immunotherapeutic ctla-4 binding peptides |
| JPH10291996A (ja) | 1997-04-22 | 1998-11-04 | Mitsubishi Chem Corp | ロジウム錯体溶液の調製方法 |
| CA2290485C (en) | 1997-05-21 | 2008-08-05 | Biovation Limited | Method for the production of non-immunogenic proteins |
| WO2004087163A2 (ja) * | 1998-12-02 | 2004-10-14 | Masato Kusunoki | 薬物動態修飾化学療法 |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| EP2261229A3 (en) | 1998-04-20 | 2011-03-23 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| JP5341287B2 (ja) | 1998-12-03 | 2013-11-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ctla−4遮断薬を用いる自己抗原に対するt細胞の刺激 |
| UA76936C2 (en) | 1998-12-23 | 2006-10-16 | Pfizer | Human monoclonal antibody binding the antigen-4 of cytotoxic t-lymphocyte (ctla-4), nucleic acid, cell line, method of obtaining transgenic mammal, method to increase producing il-2 or ifn-? in the t-cells of a patient, method to treat and pharmaceutical composition used in treatment of cancer, inflammation or autoimmune disease, including the antibody |
| US7041474B2 (en) | 1998-12-30 | 2006-05-09 | Millennium Pharmaceuticals, Inc. | Nucleic acid encoding human tango 509 |
| EP2386574A3 (en) | 1999-01-15 | 2012-06-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| AU3672800A (en) | 1999-04-09 | 2000-11-14 | Kyowa Hakko Kogyo Co. Ltd. | Method for controlling the activity of immunologically functional molecule |
| US6316462B1 (en) * | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| FR2794025A1 (fr) | 1999-05-25 | 2000-12-01 | Transgene Sa | Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere |
| JP2003505432A (ja) | 1999-07-23 | 2003-02-12 | グラクソ グループ リミテッド | 抗ep−cam抗体と化学療法剤との組合せ |
| AU6375000A (en) | 1999-07-29 | 2001-02-19 | Medarex, Inc. | Human monoclonal antibodies to her2/neu |
| BR0013542A (pt) | 1999-08-23 | 2002-05-14 | Dana Farber Cancer Inst Inc | Moléculas b7-4 e usos para as mesmas |
| ES2539411T3 (es) | 1999-08-23 | 2015-06-30 | Dana-Farber Cancer Institute, Inc. | PD-1, receptor para la B7-4 y su utilización |
| CN102766210B (zh) | 1999-08-24 | 2015-07-08 | E.R.施贵宝&圣斯有限责任公司 | 人ctla-4抗体及其应用 |
| ES2629683T3 (es) | 1999-11-30 | 2017-08-14 | Mayo Foundation For Medical Education And Research | B7-H1, una nueva molécula inmunorreguladora |
| US6803192B1 (en) | 1999-11-30 | 2004-10-12 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
| US7034121B2 (en) | 2000-01-27 | 2006-04-25 | Genetics Institue, Llc | Antibodies against CTLA4 |
| AU2001249393A1 (en) | 2000-03-22 | 2001-10-03 | Glaxo Group Limited | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| WO2002000730A2 (en) | 2000-06-28 | 2002-01-03 | Genetics Institute, Llc. | Pd-l2 molecules: novel pd-1 ligands and uses therefor |
| WO2002009719A1 (en) * | 2000-07-31 | 2002-02-07 | The Nisshin Oillio, Ltd. | Antitumor agents |
| CA2426366A1 (en) | 2000-10-20 | 2002-04-25 | Tsuneya Ohno | Fusion cells and cytokine compositions for treatment of disease |
| US7132109B1 (en) | 2000-10-20 | 2006-11-07 | University Of Connecticut Health Center | Using heat shock proteins to increase immune response |
| AU2002239422B2 (en) | 2000-11-30 | 2006-12-07 | E. R. Squibb & Sons, L.L.C. | Transgenic transchromosomal rodents for making human antibodies |
| JP2002194491A (ja) | 2000-12-27 | 2002-07-10 | Daido Steel Co Ltd | ばね用鋼材 |
| AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
| CA2442066C (en) * | 2001-04-02 | 2005-11-01 | Wyeth | Pd-1, a receptor for b7-4, and uses therefor |
| US7794710B2 (en) | 2001-04-20 | 2010-09-14 | Mayo Foundation For Medical Education And Research | Methods of enhancing T cell responsiveness |
| US6727072B2 (en) | 2001-05-01 | 2004-04-27 | Dako Corporation | EGF-r detection kit |
| WO2002092780A2 (en) | 2001-05-17 | 2002-11-21 | Diversa Corporation | Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof |
| IL149701A0 (en) * | 2001-05-23 | 2002-11-10 | Pfizer Prod Inc | Use of anti-ctla-4 antibodies |
| US6592849B2 (en) | 2001-06-21 | 2003-07-15 | Colgate Palmolive Company | Chewing gum to control malodorous breath |
| JP2003029846A (ja) | 2001-07-11 | 2003-01-31 | Sanyo Electric Co Ltd | 流量調整器および流量調整器を備えた飲料供給装置 |
| WO2003006636A1 (de) | 2001-07-12 | 2003-01-23 | Genethor Gmbh | Reduktion der stimulationsfähigkeit von antigen präsentierenden zellen |
| EP1445264B1 (en) * | 2001-07-31 | 2011-09-14 | Ono Pharmaceutical Co., Ltd. | Substance specific to pd-1 |
| IL145926A0 (en) | 2001-10-15 | 2002-07-25 | Mor Research Applic Ltd | Peptide epitopes of mimotopes useful in immunomodulation |
| KR100988949B1 (ko) | 2001-10-25 | 2010-10-20 | 제넨테크, 인크. | 당단백질 조성물 |
| CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
| BR0307216A (pt) * | 2002-01-28 | 2005-12-20 | Medarex Inc | Anticorpos monoclonais humanos para antìgeno de membrana especìfica de próstata (psma) |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| JPWO2003085107A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | ゲノムが改変された細胞 |
| IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
| CA2489803A1 (en) * | 2002-06-20 | 2003-12-31 | The Regents Of The University Of California | Compositions and methods for modulating lymphocyte activity |
| SI2206517T1 (sl) | 2002-07-03 | 2023-12-29 | Ono Pharmaceutical Co., Ltd. | Imunopotencirni sestavki,ki obsegajo protitelesa proti PD-L1 |
| TWI323265B (en) | 2002-08-06 | 2010-04-11 | Glaxo Group Ltd | Antibodies |
| US7488802B2 (en) * | 2002-12-23 | 2009-02-10 | Wyeth | Antibodies against PD-1 |
| KR20050107399A (ko) * | 2003-01-23 | 2005-11-11 | 오노 야꾸힝 고교 가부시키가이샤 | 인간 pd-1에 대하여 특이성을 갖는 물질 |
| US7465446B2 (en) * | 2003-05-30 | 2008-12-16 | Medarex, Inc. | Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease |
| EP1661574B1 (en) * | 2003-09-01 | 2017-04-19 | Earthus, Inc. | Beta-hydroxy short to medium chain fatty acid polymer |
| EP1673630A4 (en) * | 2003-10-16 | 2009-04-29 | Inst Virology | MN / CA IX AND CANCER PROGNOSIS |
| WO2006021955A2 (en) | 2004-08-23 | 2006-03-02 | Mor Research Applications Ltd. | Use of bat monoclonal antibody for immunotherapy |
| LT3428191T (lt) | 2004-10-06 | 2025-02-10 | Mayo Foundation For Medical Education And Research | B7-h1 ir pd-1 skirti inkstų ląstelių karcinomos gydymui |
| US7423128B2 (en) | 2004-11-03 | 2008-09-09 | Amgen Fremont Inc. | Anti-properdin antibodies, and methods for making and using same |
| JP4005080B2 (ja) * | 2004-11-25 | 2007-11-07 | オリンパス株式会社 | 内視鏡装置 |
| PL2439273T3 (pl) * | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Ludzkie przeciwciała monoklonalne przeciwko białku programowanej śmierci komórki 1(pd-1) oraz metody leczenia nowotworów z wykorzystaniem przeciwciał anty-pd-1 samodzielnie lub w połączeniu z innymi immunoterapeutykami |
| WO2006124269A2 (en) * | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
| HRP20080053A2 (hr) | 2005-07-01 | 2009-08-31 | Medarex | Ljudska monoklonska protutijela na ligand 1 za programiranu smrt stanice (pd-l1) |
| RS54233B1 (sr) * | 2008-08-25 | 2015-12-31 | Amplimmune Inc. | Kompozicije pd-1 antagonista i postupci za njihovu primenu |
| CA2873402C (en) | 2012-05-15 | 2023-10-24 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| AR091649A1 (es) * | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| EP3232199B1 (en) * | 2014-08-19 | 2022-05-04 | National University Corporation Okayama University | Combination of immunosuppressive factor blocking agent and biguanide antidiabetic drug for use in a method of preventing progression of, treating and/or preventing cancer |
| CN108025069B (zh) * | 2015-09-03 | 2021-11-12 | 小野药品工业株式会社 | 使用变应素-1拮抗剂的癌症免疫增强剂 |
| EP3355875B1 (en) * | 2015-10-01 | 2021-09-29 | Gilead Sciences, Inc. | Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers |
| JP7159007B2 (ja) * | 2017-11-01 | 2022-10-24 | 小野薬品工業株式会社 | 脳腫瘍の治療のための医薬 |
| CN111868091A (zh) * | 2018-01-16 | 2020-10-30 | 百时美施贵宝公司 | 用抗tim3抗体治疗癌症的方法 |
| JP6719117B2 (ja) * | 2018-03-27 | 2020-07-08 | 国立大学法人京都大学 | 免疫チェックポイント阻害剤の奏効性の判定を補助する方法、試薬キット、装置及びコンピュータプログラム |
| KR20200140315A (ko) * | 2018-04-04 | 2020-12-15 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cd27 항체 및 그의 용도 |
| US12240903B2 (en) * | 2018-05-31 | 2025-03-04 | Ono Pharmaceutical Co., Ltd. | Biomarkers for determining the effectiveness of immune checkpoint inhibitors |
| MY205758A (en) * | 2018-11-16 | 2024-11-12 | Bristol Myers Squibb Co | Anti-nkg2a antibodies and uses thereof |
| WO2020111018A1 (ja) * | 2018-11-27 | 2020-06-04 | 小野薬品工業株式会社 | 免疫チェックポイント阻害薬およびfolfirinox療法との併用によるがん治療 |
| US12036204B2 (en) * | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
-
2006
- 2006-05-02 PL PL11178191T patent/PL2439273T3/pl unknown
- 2006-05-02 KR KR1020137004055A patent/KR101498834B1/ko active Active
- 2006-05-02 ES ES09013687.0T patent/ES2427646T5/es active Active
- 2006-05-02 AU AU2006244885A patent/AU2006244885B2/en active Active
- 2006-05-02 CN CN201510568080.5A patent/CN105315373B/zh active Active
- 2006-05-02 BR BRPI0610235A patent/BRPI0610235B8/pt active IP Right Grant
- 2006-05-02 CN CN201210554886.5A patent/CN103059138B/zh active Active
- 2006-05-02 EP EP11178191.0A patent/EP2439273B1/en not_active Revoked
- 2006-05-02 DK DK09013687.0T patent/DK2161336T4/en active
- 2006-05-02 SI SI200632322T patent/SI2439273T1/sl unknown
- 2006-05-02 HU HUE11178191 patent/HUE044719T2/hu unknown
- 2006-05-02 CN CN201811213609.1A patent/CN109485727A/zh active Pending
- 2006-05-02 EP EP19151041.1A patent/EP3530736A3/en active Pending
- 2006-05-02 CA CA2970873A patent/CA2970873C/en active Active
- 2006-05-02 CN CN2006800238600A patent/CN101213297B/zh active Active
- 2006-05-02 WO PCT/JP2006/309606 patent/WO2006121168A1/en not_active Ceased
- 2006-05-02 RU RU2010135087/10A patent/RU2494107C2/ru active
- 2006-05-02 NZ NZ563193A patent/NZ563193A/en unknown
- 2006-05-02 PT PT11178191T patent/PT2439273T/pt unknown
- 2006-05-02 JP JP2006128058A patent/JP4361545B2/ja active Active
- 2006-05-02 PL PL09013687T patent/PL2161336T5/pl unknown
- 2006-05-02 DK DK11178191.0T patent/DK2439273T3/da active
- 2006-05-02 EP EP11178188.6A patent/EP2439272A3/en not_active Withdrawn
- 2006-05-02 CN CN202311341026.8A patent/CN117534755A/zh active Pending
- 2006-05-02 EP EP06746353A patent/EP1896582A4/en not_active Withdrawn
- 2006-05-02 KR KR1020077028376A patent/KR101318469B1/ko active Active
- 2006-05-02 EP EP09013687.0A patent/EP2161336B2/en active Active
- 2006-05-02 CA CA2607147A patent/CA2607147C/en active Active
- 2006-05-02 CA CA3151350A patent/CA3151350A1/en active Pending
- 2006-05-02 SI SI200631652T patent/SI2161336T1/sl unknown
- 2006-05-02 MX MX2007013978A patent/MX2007013978A/es active IP Right Grant
- 2006-05-02 ES ES11178191T patent/ES2720160T3/es active Active
- 2006-05-02 RU RU2007145419A patent/RU2406760C3/ru active
- 2006-05-02 KR KR1020137020114A patent/KR101339628B1/ko active Active
- 2006-05-02 LT LTEP11178191.0T patent/LT2439273T/lt unknown
- 2006-05-02 PT PT90136870T patent/PT2161336E/pt unknown
- 2006-05-02 US US11/913,217 patent/US8008449B2/en active Active
- 2006-05-02 EP EP11178187A patent/EP2418278A3/en not_active Withdrawn
- 2006-05-08 TW TW095116202A patent/TWI379898B/zh active
-
2007
- 2007-11-01 IL IL187108A patent/IL187108A/en active Protection Beyond IP Right Term
- 2007-11-07 NO NO20075697A patent/NO341219B1/no active Protection Beyond IP Right Term
-
2009
- 2009-03-31 JP JP2009086400A patent/JP5028700B2/ja active Active
-
2010
- 2010-10-12 IL IL208642A patent/IL208642A/en active Protection Beyond IP Right Term
-
2011
- 2011-08-15 US US13/210,137 patent/US8779105B2/en active Active
-
2012
- 2012-05-08 JP JP2012106662A patent/JP5872377B2/ja active Active
-
2013
- 2013-07-18 RU RU2013133714A patent/RU2599417C3/ru active
-
2014
- 2014-01-23 JP JP2014010140A patent/JP2014077015A/ja active Pending
- 2014-03-27 US US14/227,733 patent/US9358289B2/en active Active
- 2014-04-03 US US14/244,405 patent/US9387247B2/en active Active
- 2014-04-09 US US14/248,462 patent/US9492539B2/en active Active
- 2014-05-06 US US14/270,750 patent/US9492540B2/en active Active
- 2014-11-18 US US14/547,026 patent/US9084776B2/en active Active
-
2015
- 2015-10-30 JP JP2015213586A patent/JP6185971B2/ja active Active
- 2015-12-10 LU LU92904C patent/LU92904I2/xx unknown
- 2015-12-10 NL NL300782C patent/NL300782I2/nl unknown
- 2015-12-14 BE BE2015C074C patent/BE2015C074I2/fr unknown
- 2015-12-15 HU HUS1500067C patent/HUS1500067I1/hu unknown
- 2015-12-15 FR FR15C0087C patent/FR15C0087I2/fr active Active
- 2015-12-16 LT LTPA2015052C patent/LTC2161336I2/lt unknown
- 2015-12-18 CY CY2015057C patent/CY2015057I1/el unknown
-
2016
- 2016-08-18 RU RU2016133899A patent/RU2732924C2/ru active
- 2016-10-07 US US15/288,545 patent/US10441655B2/en active Active
- 2016-11-11 JP JP2016220640A patent/JP2017052784A/ja active Pending
-
2017
- 2017-01-30 NO NO20170138A patent/NO344818B1/no unknown
-
2018
- 2018-02-14 NO NO2018008C patent/NO2018008I2/no unknown
-
2019
- 2019-02-05 JP JP2019018345A patent/JP6975733B2/ja active Active
- 2019-05-24 CY CY20191100551T patent/CY1121648T1/el unknown
- 2019-10-11 US US16/600,272 patent/US20200138945A1/en not_active Abandoned
-
2020
- 2020-04-17 NO NO20200470A patent/NO20200470A1/no unknown
-
2021
- 2021-09-14 JP JP2021149019A patent/JP7443302B2/ja active Active
-
2023
- 2023-02-09 US US18/167,012 patent/US20230272079A1/en active Pending
- 2023-08-23 NO NO2023031C patent/NO2023031I1/no unknown
- 2023-11-01 NO NO20231166A patent/NO20231166A1/no unknown
- 2023-12-05 JP JP2023205124A patent/JP2024023539A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7443302B2 (ja) | Programmed Death 1(PD-1)に対するヒトモノクローナル抗体および抗PD-1抗体単独または他の免疫療法と併用した癌治療方法 | |
| AU2011203119B2 (en) | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060810 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20061102 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20061120 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20061102 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090310 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090310 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090331 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20090331 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20090428 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090630 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090709 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20090804 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20090812 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4361545 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120821 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120821 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130821 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313115 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R360 | Written notification for declining of transfer of rights |
Free format text: JAPANESE INTERMEDIATE CODE: R360 |
|
| R360 | Written notification for declining of transfer of rights |
Free format text: JAPANESE INTERMEDIATE CODE: R360 |
|
| R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313115 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |