MX2020006171A - Terapia de combinacion con anticuerpos anti interleucina-8 (il-8) y anticuerpos anti receptor de muerte programada (pd-1) para tratar cancer. - Google Patents
Terapia de combinacion con anticuerpos anti interleucina-8 (il-8) y anticuerpos anti receptor de muerte programada (pd-1) para tratar cancer.Info
- Publication number
- MX2020006171A MX2020006171A MX2020006171A MX2020006171A MX2020006171A MX 2020006171 A MX2020006171 A MX 2020006171A MX 2020006171 A MX2020006171 A MX 2020006171A MX 2020006171 A MX2020006171 A MX 2020006171A MX 2020006171 A MX2020006171 A MX 2020006171A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- combination therapy
- treating cancer
- antibody
- tumors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5421—IL-8
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan aquí métodos para el tratamiento clínicode tumores (por ejemplo, tumores sólidos avanzados) en pacientes que tienen ciertos niveles de IL-8 en suero con el uso de un anticuerpo anti-IL-8 en combinación con un anticuerpo anti-PD-1.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862616716P | 2018-01-12 | 2018-01-12 | |
US201862650047P | 2018-03-29 | 2018-03-29 | |
US201862679412P | 2018-06-01 | 2018-06-01 | |
PCT/US2019/013134 WO2019140150A1 (en) | 2018-01-12 | 2019-01-11 | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020006171A true MX2020006171A (es) | 2020-09-03 |
Family
ID=65279657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020006171A MX2020006171A (es) | 2018-01-12 | 2019-01-11 | Terapia de combinacion con anticuerpos anti interleucina-8 (il-8) y anticuerpos anti receptor de muerte programada (pd-1) para tratar cancer. |
Country Status (12)
Country | Link |
---|---|
US (2) | US11572405B2 (es) |
EP (1) | EP3737696A1 (es) |
JP (2) | JP2021510697A (es) |
KR (1) | KR20200108868A (es) |
CN (1) | CN111770936A (es) |
AU (1) | AU2019207812A1 (es) |
BR (1) | BR112020013144A2 (es) |
CA (1) | CA3084370A1 (es) |
IL (1) | IL275940A (es) |
MX (1) | MX2020006171A (es) |
SG (1) | SG11202005323SA (es) |
WO (1) | WO2019140150A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11202005323SA (en) | 2018-01-12 | 2020-07-29 | Bristol Myers Squibb Co | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
EP4127724A1 (en) * | 2020-04-03 | 2023-02-08 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
CA3196737A1 (en) * | 2020-09-24 | 2022-03-31 | Massimiliano Mazzone | Combination of p2y6 inhibitors and immune checkpoint inhibitors |
CN117222436A (zh) * | 2020-12-11 | 2023-12-12 | 上海锦斯生物技术有限公司 | 一种经修饰的溶瘤病毒、包含经修饰的溶瘤病毒的组合物及其用途 |
WO2023192478A1 (en) * | 2022-04-01 | 2023-10-05 | Bristol-Myers Squibb Company | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
WO2024021059A1 (en) * | 2022-07-29 | 2024-02-01 | Jinfeng Laboratory | Non-human mammalian model expressing il-8 and use thereof |
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CN104470949A (zh) | 2012-05-15 | 2015-03-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
TWI612059B (zh) | 2013-03-15 | 2018-01-21 | 美國禮來大藥廠 | 泛-ELR<sup>+</sup>CXC趨化因子抗體 |
EP3022224A2 (en) | 2013-07-18 | 2016-05-25 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
WO2015010100A2 (en) | 2013-07-18 | 2015-01-22 | Fabrus, Inc. | Humanized antibodies with ultralong complementarity determining regions |
WO2016044189A1 (en) * | 2014-09-15 | 2016-03-24 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists |
PE20180926A1 (es) * | 2015-05-29 | 2018-06-08 | Bristol Myers Squibb Co | Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos |
EA201891983A8 (ru) * | 2016-03-04 | 2020-05-28 | Бристол-Майерс Сквибб Компани | Комбинированная терапия антителами к cd73 |
EP4248989A3 (en) * | 2016-06-02 | 2023-12-27 | Bristol-Myers Squibb Company | Use of an anti-pd-1 antibody in combination with an anti-cd30 antibody in lymphoma treatment |
EP4248990A3 (en) * | 2016-06-02 | 2024-01-03 | Bristol-Myers Squibb Company | Pd-1 blockade with nivolumab in refractory hodgkin's lymphoma |
JP2019517512A (ja) * | 2016-06-03 | 2019-06-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 結腸直腸癌を有する患者の処置における抗pd−1抗体の使用 |
SG11202005323SA (en) | 2018-01-12 | 2020-07-29 | Bristol Myers Squibb Co | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
-
2019
- 2019-01-11 SG SG11202005323SA patent/SG11202005323SA/en unknown
- 2019-01-11 CA CA3084370A patent/CA3084370A1/en active Pending
- 2019-01-11 MX MX2020006171A patent/MX2020006171A/es unknown
- 2019-01-11 BR BR112020013144-0A patent/BR112020013144A2/pt unknown
- 2019-01-11 KR KR1020207022931A patent/KR20200108868A/ko not_active Application Discontinuation
- 2019-01-11 EP EP19703442.4A patent/EP3737696A1/en active Pending
- 2019-01-11 US US16/768,838 patent/US11572405B2/en active Active
- 2019-01-11 WO PCT/US2019/013134 patent/WO2019140150A1/en unknown
- 2019-01-11 AU AU2019207812A patent/AU2019207812A1/en active Pending
- 2019-01-11 JP JP2020538637A patent/JP2021510697A/ja active Pending
- 2019-01-11 CN CN201980007986.6A patent/CN111770936A/zh active Pending
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2020
- 2020-07-09 IL IL275940A patent/IL275940A/en unknown
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2022
- 2022-12-29 US US18/090,570 patent/US20230279096A1/en active Pending
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2023
- 2023-11-30 JP JP2023202998A patent/JP2024028805A/ja active Pending
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US11572405B2 (en) | 2023-02-07 |
CN111770936A (zh) | 2020-10-13 |
US20210054063A1 (en) | 2021-02-25 |
BR112020013144A2 (pt) | 2020-12-08 |
AU2019207812A1 (en) | 2020-07-23 |
CA3084370A1 (en) | 2019-07-18 |
WO2019140150A1 (en) | 2019-07-18 |
KR20200108868A (ko) | 2020-09-21 |
IL275940A (en) | 2020-08-31 |
SG11202005323SA (en) | 2020-07-29 |
JP2024028805A (ja) | 2024-03-05 |
US20230279096A1 (en) | 2023-09-07 |
JP2021510697A (ja) | 2021-04-30 |
EP3737696A1 (en) | 2020-11-18 |
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