MX2017000546A - Composiciones para el tratamiento del cancer mediante el uso de antagonistas de union al eje de pd-1 e inhibidores de mek. - Google Patents
Composiciones para el tratamiento del cancer mediante el uso de antagonistas de union al eje de pd-1 e inhibidores de mek.Info
- Publication number
- MX2017000546A MX2017000546A MX2017000546A MX2017000546A MX2017000546A MX 2017000546 A MX2017000546 A MX 2017000546A MX 2017000546 A MX2017000546 A MX 2017000546A MX 2017000546 A MX2017000546 A MX 2017000546A MX 2017000546 A MX2017000546 A MX 2017000546A
- Authority
- MX
- Mexico
- Prior art keywords
- axis binding
- compositions
- treating cancer
- mek inhibitors
- binding antagonists
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion describe que el tratamiento de combinacion que comprende un antagonista de union al eje de PD-1 y un inhibidor de MEK, y metodos para el uso de estos, que incluye metodos para tratar las afecciones donde se desea la inmunogenicidad potenciada, tal como el aumento de la inmunogenicidad del tumor para el tratamiento del cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462024988P | 2014-07-15 | 2014-07-15 | |
PCT/US2015/040582 WO2016011160A1 (en) | 2014-07-15 | 2015-07-15 | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017000546A true MX2017000546A (es) | 2017-03-08 |
Family
ID=53783950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017000546A MX2017000546A (es) | 2014-07-15 | 2015-07-15 | Composiciones para el tratamiento del cancer mediante el uso de antagonistas de union al eje de pd-1 e inhibidores de mek. |
Country Status (17)
Country | Link |
---|---|
US (2) | US10946093B2 (es) |
EP (2) | EP3563870A1 (es) |
JP (2) | JP6673896B2 (es) |
KR (1) | KR20170026630A (es) |
CN (2) | CN116617401A (es) |
AR (1) | AR101210A1 (es) |
AU (1) | AU2015289672A1 (es) |
BR (1) | BR112017000672A2 (es) |
CA (1) | CA2954508A1 (es) |
ES (1) | ES2742500T3 (es) |
IL (2) | IL250021B (es) |
MX (1) | MX2017000546A (es) |
PL (1) | PL3169361T3 (es) |
RU (1) | RU2733735C2 (es) |
SG (2) | SG11201700074YA (es) |
WO (1) | WO2016011160A1 (es) |
ZA (1) | ZA201701109B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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PE20141693A1 (es) | 2011-08-01 | 2014-11-24 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1e inhibidores de mek |
CA2974651A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
BR112017000672A2 (pt) | 2014-07-15 | 2017-11-14 | Genentech Inc | composições para tratamento de câncer utilizando antagonistas de ligação de eixo pd-1 e inibidores de mek |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
CN108368170B (zh) | 2015-07-13 | 2022-04-15 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
CN109310677A (zh) * | 2016-04-07 | 2019-02-05 | 凯莫森特里克斯股份有限公司 | 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷 |
SG11201810423XA (en) * | 2016-05-26 | 2018-12-28 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
RU2018146886A (ru) * | 2016-06-10 | 2020-07-10 | Новартис Аг | Пути терапевтического применения ингибитора c-raf |
EP3558360A1 (en) * | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
CN108503691B (zh) * | 2017-02-25 | 2021-07-23 | 复旦大学 | 一种人pd-l1蛋白高亲和性肽及其应用 |
BR112019021680A2 (pt) | 2017-04-20 | 2020-05-12 | Adc Therapeutics Sa | Terapia de combinação com conjugado anticorpo-fármaco anti-cd25?? |
CA3057748A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
CN117582495A (zh) * | 2017-06-02 | 2024-02-23 | 拜耳医药保健有限责任公司 | 用于治疗癌症的瑞格菲尼和pd-1/pd-l1(2)抑制剂的组合产品 |
UA127900C2 (uk) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Схема дозування для введення adc до cd19 |
WO2019023786A1 (en) | 2017-08-01 | 2019-02-07 | University Health Network | COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE |
MX2020003361A (es) * | 2017-10-13 | 2020-07-29 | Merck Patent Gmbh | Combinacion de un inhibidor parp y un antagonista de union al eje pd-1. |
KR20200106921A (ko) * | 2018-01-10 | 2020-09-15 | 어레이 바이오파마 인크. | 암을 치료하기 위한 방법 및 조합 요법 |
AU2019272838A1 (en) | 2018-05-23 | 2020-11-26 | Adc Therapeutics Sa | Molecular adjuvant |
US20220133823A1 (en) * | 2018-09-10 | 2022-05-05 | Genesail Biotech (Shanghai) Co. Ltd. | A modified oncolytic virus, composition and use thereof |
CN109053891B (zh) * | 2018-09-17 | 2021-12-21 | 苏州泓迅生物科技股份有限公司 | 一种抗pd-l1抗体及其制备方法和应用 |
CN109879855B (zh) * | 2019-03-26 | 2021-01-05 | 中国医学科学院医药生物技术研究所 | 靶向肿瘤细胞表面pd-l1分子的抑制剂及其应用 |
GB201917254D0 (en) | 2019-11-27 | 2020-01-08 | Adc Therapeutics Sa | Combination therapy |
CN110981943B (zh) * | 2019-12-02 | 2021-08-03 | 清华大学 | 多肽及其在制备药物中的用途和药物 |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
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2015
- 2015-07-15 BR BR112017000672A patent/BR112017000672A2/pt not_active Application Discontinuation
- 2015-07-15 AR ARP150102249A patent/AR101210A1/es unknown
- 2015-07-15 PL PL15747647T patent/PL3169361T3/pl unknown
- 2015-07-15 ES ES15747647T patent/ES2742500T3/es active Active
- 2015-07-15 CN CN202310512479.6A patent/CN116617401A/zh active Pending
- 2015-07-15 CA CA2954508A patent/CA2954508A1/en not_active Abandoned
- 2015-07-15 EP EP19172991.2A patent/EP3563870A1/en not_active Withdrawn
- 2015-07-15 KR KR1020177003776A patent/KR20170026630A/ko not_active Application Discontinuation
- 2015-07-15 MX MX2017000546A patent/MX2017000546A/es unknown
- 2015-07-15 WO PCT/US2015/040582 patent/WO2016011160A1/en active Application Filing
- 2015-07-15 EP EP15747647.4A patent/EP3169361B1/en active Active
- 2015-07-15 JP JP2017501642A patent/JP6673896B2/ja active Active
- 2015-07-15 RU RU2017102926A patent/RU2733735C2/ru active
- 2015-07-15 CN CN201580030345.4A patent/CN106573060A/zh active Pending
- 2015-07-15 AU AU2015289672A patent/AU2015289672A1/en not_active Abandoned
- 2015-07-15 SG SG11201700074YA patent/SG11201700074YA/en unknown
- 2015-07-15 SG SG10202007111TA patent/SG10202007111TA/en unknown
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2017
- 2017-01-05 US US15/399,118 patent/US10946093B2/en active Active
- 2017-01-10 IL IL250021A patent/IL250021B/en active IP Right Grant
- 2017-02-14 ZA ZA2017/01109A patent/ZA201701109B/en unknown
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2019
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2020
- 2020-07-27 IL IL276314A patent/IL276314A/en unknown
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Publication number | Publication date |
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JP2020059721A (ja) | 2020-04-16 |
SG10202007111TA (en) | 2020-09-29 |
SG11201700074YA (en) | 2017-02-27 |
US20220105180A1 (en) | 2022-04-07 |
CN106573060A (zh) | 2017-04-19 |
AR101210A1 (es) | 2016-11-30 |
IL250021B (en) | 2020-08-31 |
KR20170026630A (ko) | 2017-03-08 |
PL3169361T3 (pl) | 2019-11-29 |
ES2742500T8 (es) | 2020-02-27 |
CN116617401A (zh) | 2023-08-22 |
US20170112925A1 (en) | 2017-04-27 |
BR112017000672A2 (pt) | 2017-11-14 |
IL250021A0 (en) | 2017-03-30 |
AU2015289672A1 (en) | 2017-03-02 |
RU2733735C2 (ru) | 2020-10-06 |
RU2017102926A3 (es) | 2018-12-21 |
WO2016011160A1 (en) | 2016-01-21 |
ES2742500T3 (es) | 2020-02-14 |
RU2017102926A (ru) | 2018-08-15 |
JP6673896B2 (ja) | 2020-03-25 |
EP3169361B1 (en) | 2019-06-19 |
CA2954508A1 (en) | 2016-01-21 |
ZA201701109B (en) | 2021-07-28 |
EP3563870A1 (en) | 2019-11-06 |
JP2017522307A (ja) | 2017-08-10 |
US10946093B2 (en) | 2021-03-16 |
EP3169361A1 (en) | 2017-05-24 |
IL276314A (en) | 2020-09-30 |
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