MX2020003361A - Combinacion de un inhibidor parp y un antagonista de union al eje pd-1. - Google Patents

Combinacion de un inhibidor parp y un antagonista de union al eje pd-1.

Info

Publication number
MX2020003361A
MX2020003361A MX2020003361A MX2020003361A MX2020003361A MX 2020003361 A MX2020003361 A MX 2020003361A MX 2020003361 A MX2020003361 A MX 2020003361A MX 2020003361 A MX2020003361 A MX 2020003361A MX 2020003361 A MX2020003361 A MX 2020003361A
Authority
MX
Mexico
Prior art keywords
combination
binding antagonist
axis binding
parp inhibitor
parp
Prior art date
Application number
MX2020003361A
Other languages
English (en)
Inventor
John Andrew Blake-Haskins
Dimitry Serge Antoine Nuyten
Ross Anthony Stewart
Christoffel Hendrik Boshoff
Rossano Cesari
Fabian Zohren
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2020003361A publication Critical patent/MX2020003361A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Esta invención se refiere a un método de tratar cáncer al administrar un inhibidor de PARP en combinación con un antagonista de unión al eje PD-1 a un paciente en necesidad del mismo.
MX2020003361A 2017-10-13 2018-10-10 Combinacion de un inhibidor parp y un antagonista de union al eje pd-1. MX2020003361A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572024P 2017-10-13 2017-10-13
US201862697587P 2018-07-13 2018-07-13
PCT/US2018/055174 WO2019075032A1 (en) 2017-10-13 2018-10-10 COMBINATION OF A PARP INHIBITOR AND A PD-1 AXIS BINDING ANTAGONIST

Publications (1)

Publication Number Publication Date
MX2020003361A true MX2020003361A (es) 2020-07-29

Family

ID=64049735

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003361A MX2020003361A (es) 2017-10-13 2018-10-10 Combinacion de un inhibidor parp y un antagonista de union al eje pd-1.

Country Status (13)

Country Link
US (1) US20200254091A1 (es)
EP (1) EP3694551A1 (es)
JP (1) JP2020536887A (es)
KR (1) KR20200071097A (es)
CN (1) CN111225685A (es)
AU (1) AU2018347331A1 (es)
BR (1) BR112020006371A2 (es)
CA (1) CA3078806A1 (es)
IL (1) IL273994A (es)
MX (1) MX2020003361A (es)
RU (1) RU2020113246A (es)
TW (1) TW201922288A (es)
WO (1) WO2019075032A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11274154B2 (en) * 2016-10-06 2022-03-15 Pfizer Inc. Dosing regimen of avelumab for the treatment of cancer
CA3163564A1 (en) * 2019-12-31 2021-07-08 Xiaokun SHEN A drug combination for treating tumors and its application
CA3177576A1 (en) * 2020-05-04 2021-11-11 Merck Sharp & Dohme Llc Methods of treating cancer using a combination of a pd-1 antagonist, a chemoradiation therapy and a parp inhibitor
WO2024074959A1 (en) 2022-10-02 2024-04-11 Pfizer Inc. Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CN102171214B (zh) 2008-08-06 2015-06-24 生物马林药物股份有限公司 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
CN102869258A (zh) 2010-02-03 2013-01-09 生物马林药物股份有限公司 用于pten基因缺失相关疾病的治疗的聚（adp-核糖）聚合酶（parp）的二氢吡啶并酞嗪酮抑制剂
US8765945B2 (en) 2010-02-08 2014-07-01 Biomarin Pharmaceutical Inc. Processes of synthesizing dihydropyridophthalazinone derivatives
RU2598606C3 (ru) 2010-10-21 2021-12-20 МЕДИВЭЙШН ТЕКНОЛОДЖИЗ ЭлЭлСи Кристаллическая тозилатная соль (8s,9r)-5-фтор-8-(4-фторфенил)-9-(1-метил-1н-1,2,4-триазол-5-ил)-8-9-дигидро-2н-пиридо[4,3,2-de]фталазин-3(7н)-она
AU2012344260B2 (en) 2011-11-28 2017-09-07 Merck Patent Gmbh Anti-PD-L1 antibodies and uses thereof
CN105916846A (zh) 2013-11-07 2016-08-31 麦迪韦逊科技有限公司 用于合成经保护的n-烷基三唑甲醛的三唑中间体
SI3102605T1 (sl) * 2014-02-04 2019-04-30 Pfizer Inc. Kombinacija PD-1 antagonista in VEGFR inhibitorja za zdravljenje raka
EP3169361B1 (en) * 2014-07-15 2019-06-19 F.Hoffmann-La Roche Ag Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
EP3174855B1 (en) 2014-07-31 2023-05-10 Medivation Technologies LLC Coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate and methods of preparing them
CN107206088A (zh) * 2014-12-05 2017-09-26 豪夫迈·罗氏有限公司 使用pd‑1轴拮抗剂和hpk1拮抗剂用于治疗癌症的方法和组合物
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
KR20170132171A (ko) * 2015-02-26 2017-12-01 메르크 파텐트 게엠베하 암 치료를 위한 ｐｄ­１ ／ ｐｄ­ｌ１ 저해제
US20170000885A1 (en) * 2015-06-08 2017-01-05 Genentech, Inc. Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
BR112018008503A2 (pt) 2015-10-26 2018-10-23 Medivation Tech Llc método para tratar câncer de pulmão de células pequenas, método para tratar um sujeito, método para selecionar um sujeito com câncer

Also Published As

Publication number Publication date
IL273994A (en) 2020-05-31
US20200254091A1 (en) 2020-08-13
RU2020113246A (ru) 2021-11-15
WO2019075032A1 (en) 2019-04-18
EP3694551A1 (en) 2020-08-19
JP2020536887A (ja) 2020-12-17
BR112020006371A2 (pt) 2020-09-29
TW201922288A (zh) 2019-06-16
RU2020113246A3 (es) 2021-11-15
CA3078806A1 (en) 2019-04-18
KR20200071097A (ko) 2020-06-18
AU2018347331A1 (en) 2020-04-09
CN111225685A (zh) 2020-06-02

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