EA201490369A1 - Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek - Google Patents

Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek

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Publication number
EA201490369A1
EA201490369A1 EA201490369A EA201490369A EA201490369A1 EA 201490369 A1 EA201490369 A1 EA 201490369A1 EA 201490369 A EA201490369 A EA 201490369A EA 201490369 A EA201490369 A EA 201490369A EA 201490369 A1 EA201490369 A1 EA 201490369A1
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EA
Eurasian Patent Office
Prior art keywords
methods
axis
antagonists
cancer treatment
mek inhibitors
Prior art date
Application number
EA201490369A
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English (en)
Other versions
EA026924B1 (ru
Inventor
Хитер Мекер
Брайан Ирвинг
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Дженентек, Инк.
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Application filed by Дженентек, Инк. filed Critical Дженентек, Инк.
Publication of EA201490369A1 publication Critical patent/EA201490369A1/ru
Publication of EA026924B1 publication Critical patent/EA026924B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/3053—Skin, nerves, brain
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    • A—HUMAN NECESSITIES
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    • A61K2039/515—Animal cells
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Abstract

Изобретение относится к комбинированной терапии, включающей антагонист, связывающийся с осью PD-1, и ингибитор MEK, и к способам применения указанной комбинированной терапии, в том числе к способам лечения состояний, требующих повышения иммуногенности, например повышения иммуногенности опухоли при лечении рака.
EA201490369A 2011-08-01 2012-08-01 Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek EA026924B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161574406P 2011-08-01 2011-08-01
PCT/US2012/049233 WO2013019906A1 (en) 2011-08-01 2012-08-01 Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors

Publications (2)

Publication Number Publication Date
EA201490369A1 true EA201490369A1 (ru) 2014-08-29
EA026924B1 EA026924B1 (ru) 2017-05-31

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EA201490369A EA026924B1 (ru) 2011-08-01 2012-08-01 Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek

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US (2) US9724413B2 (ru)
EP (1) EP2739358B1 (ru)
JP (3) JP6238459B2 (ru)
KR (2) KR102049817B1 (ru)
CN (1) CN103842030B (ru)
AR (2) AR087405A1 (ru)
AU (4) AU2012290121B2 (ru)
BR (2) BR112014002353B1 (ru)
CA (1) CA2843595C (ru)
CO (1) CO6900118A2 (ru)
CR (1) CR20140034A (ru)
EA (1) EA026924B1 (ru)
EC (1) ECSP14013223A (ru)
ES (1) ES2708669T3 (ru)
IL (2) IL230647B (ru)
MA (1) MA35366B1 (ru)
MX (2) MX368257B (ru)
MY (2) MY193562A (ru)
PE (2) PE20141693A1 (ru)
PH (1) PH12018500365B1 (ru)
PL (1) PL2739358T3 (ru)
SG (1) SG10201606284UA (ru)
TR (1) TR201820873T4 (ru)
TW (3) TWI654994B (ru)
UA (1) UA117220C2 (ru)
WO (1) WO2013019906A1 (ru)
ZA (1) ZA201400612B (ru)

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