UA117220C2 - Способи лікування раку з використанням антагоністів, що зв'язуються з віссю pd-1, і інгібіторів mek - Google Patents

Способи лікування раку з використанням антагоністів, що зв'язуються з віссю pd-1, і інгібіторів mek

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Publication number
UA117220C2
UA117220C2 UAA201402084A UAA201402084A UA117220C2 UA 117220 C2 UA117220 C2 UA 117220C2 UA A201402084 A UAA201402084 A UA A201402084A UA A201402084 A UAA201402084 A UA A201402084A UA 117220 C2 UA117220 C2 UA 117220C2
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Ukraine
Prior art keywords
methods
axis binding
treating cancer
mek inhibitors
binding antagonists
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UAA201402084A
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English (en)
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Хітер Мекер
Брайан Ірвінг
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Дженентек, Інк.
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Application filed by Дженентек, Інк. filed Critical Дженентек, Інк.
Publication of UA117220C2 publication Critical patent/UA117220C2/uk

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Abstract

Даний винахід стосується лікування колоректального раку або меланоми у суб'єкта, що включає введення вказаному суб'єкту ефективної кількості антитіла проти PD-L1 і інгібітору МЕК, де антитіло проти PD-L1 включає важкий ланцюг, що містить послідовність HVR-H1 SEQ ID NО:15, послідовність HVR-H2 SEQ ID NО:16 і послідовність HVR-H3 SEQ ID NО:3, і легкий ланцюг, що містить послідовність HVR-L1 SEQ ID NО:17, послідовність HVR-L2 SEQ ID NО:18 і послідовність HVR-L3 SEQ ID NО:19, і де інгібітор МЕК вибирають з групи, яка складається з G02442104, G-38963, G02443714, G00039805 і GDC-0973, їх фармацевтично прийнятної солі або сольвату.
UAA201402084A 2011-08-01 2012-08-01 Способи лікування раку з використанням антагоністів, що зв'язуються з віссю pd-1, і інгібіторів mek UA117220C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161574406P 2011-08-01 2011-08-01
PCT/US2012/049233 WO2013019906A1 (en) 2011-08-01 2012-08-01 Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors

Publications (1)

Publication Number Publication Date
UA117220C2 true UA117220C2 (uk) 2018-07-10

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JP (3) JP6238459B2 (uk)
KR (2) KR102049817B1 (uk)
CN (1) CN103842030B (uk)
AR (2) AR087405A1 (uk)
AU (4) AU2012290121B2 (uk)
BR (2) BR112014002353B1 (uk)
CA (1) CA2843595C (uk)
CO (1) CO6900118A2 (uk)
CR (1) CR20140034A (uk)
EA (1) EA026924B1 (uk)
EC (1) ECSP14013223A (uk)
ES (1) ES2708669T3 (uk)
IL (2) IL230647B (uk)
MA (1) MA35366B1 (uk)
MX (2) MX368257B (uk)
MY (2) MY170117A (uk)
PE (2) PE20141693A1 (uk)
PH (1) PH12018500365B1 (uk)
PL (1) PL2739358T3 (uk)
SG (1) SG10201606284UA (uk)
TR (1) TR201820873T4 (uk)
TW (3) TW201840336A (uk)
UA (1) UA117220C2 (uk)
WO (1) WO2013019906A1 (uk)
ZA (1) ZA201400612B (uk)

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