BR112023022097A2 - Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso - Google Patents

Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso

Info

Publication number
BR112023022097A2
BR112023022097A2 BR112023022097A BR112023022097A BR112023022097A2 BR 112023022097 A2 BR112023022097 A2 BR 112023022097A2 BR 112023022097 A BR112023022097 A BR 112023022097A BR 112023022097 A BR112023022097 A BR 112023022097A BR 112023022097 A2 BR112023022097 A2 BR 112023022097A2
Authority
BR
Brazil
Prior art keywords
cxcr5
cells
icos
methods
tumor
Prior art date
Application number
BR112023022097A
Other languages
English (en)
Inventor
D Weinberg Andrew
Jacob Moses
Rebekka Duhen
Thomas Duhen
Original Assignee
Agonox Inc
Providence Health & Services Oregon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agonox Inc, Providence Health & Services Oregon filed Critical Agonox Inc
Publication of BR112023022097A2 publication Critical patent/BR112023022097A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor

Abstract

cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso. a presente invenção refere-se a métodos descritos para tratar um indivíduo com um tumor. esses métodos incluem a administração ao indivíduo de uma quantidade terapeuticamente eficaz de células t cd4+icos+pd-1+cxcr5+. métodos são da mesma forma descritos para isolar um ácido nucleico que codifica um receptor de células t (tcr) que se liga especificamente a um antígeno de célula tumoral. esses métodos incluem o isolamento de células t cd4+icos+pd-1+cxcr5+ de uma amostra de um indivíduo com um tumor que expressa o antígeno de célula tumoral e a clonagem de uma molécula de ácido nucleico que codifica um tcr das células t cd4+icos+pd-1+cxcr5+. além disso, métodos são descritos para expansão de células t cd4+icos+pd-1+cxcr5+. em modalidades adicionais, métodos são descritos para determinar se um indivíduo com tumor responderá a um inibidor de ponto de verificação. os métodos incluem a detecção da presença de células t cd4+icos+pd-1+cxcr5+ em uma amostra biológica de um indivíduo. composições para utilização nestes métodos são da mesma forma descritas.
BR112023022097A 2021-06-07 2022-06-06 Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso BR112023022097A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163197780P 2021-06-07 2021-06-07
PCT/US2022/032381 WO2022261018A1 (en) 2021-06-07 2022-06-06 Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use

Publications (1)

Publication Number Publication Date
BR112023022097A2 true BR112023022097A2 (pt) 2023-12-19

Family

ID=82483012

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022097A BR112023022097A2 (pt) 2021-06-07 2022-06-06 Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso

Country Status (5)

Country Link
EP (1) EP4351595A1 (pt)
AU (1) AU2022288058A1 (pt)
BR (1) BR112023022097A2 (pt)
CA (1) CA3218590A1 (pt)
WO (1) WO2022261018A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116179483B (zh) * 2022-12-16 2024-03-01 青岛海尔生物科技有限公司 一种体外快速扩增干细胞样记忆性宫颈癌肿瘤浸润淋巴细胞的方法

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EP4351595A1 (en) 2024-04-17
AU2022288058A1 (en) 2023-11-16
WO2022261018A1 (en) 2022-12-15
CA3218590A1 (en) 2022-12-15

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