JO3783B1 - مشتق كوينولين عالي النقاء وطريقة لإنتاجه - Google Patents

مشتق كوينولين عالي النقاء وطريقة لإنتاجه

Info

Publication number
JO3783B1
JO3783B1 JOP/2015/0203A JOP20150203A JO3783B1 JO 3783 B1 JO3783 B1 JO 3783B1 JO P20150203 A JOP20150203 A JO P20150203A JO 3783 B1 JO3783 B1 JO 3783B1
Authority
JO
Jordan
Prior art keywords
producing
same
highly pure
quinoline derivative
pure quinoline
Prior art date
Application number
JOP/2015/0203A
Other languages
English (en)
Inventor
Abe Taichi
Akao Atsushi
Miyashita Yusuke
Ayata Yusuke
Nakamura Taiju
Kuroda Hirofumi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55399727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3783(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of JO3783B1 publication Critical patent/JO3783B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

يتعلق الاختراع الحالي بتقديم مركب ممثل بواسطة الصيغة (IV) أو ملح منه، حيثيكون محتوى المركب الممثل بواسطة الصيغة (I) هو 350 جزء بالمليون بالكتلة أو أقل.
JOP/2015/0203A 2014-08-28 2015-08-26 مشتق كوينولين عالي النقاء وطريقة لإنتاجه JO3783B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014174062 2014-08-28
JP2015034729 2015-02-25

Publications (1)

Publication Number Publication Date
JO3783B1 true JO3783B1 (ar) 2021-01-31

Family

ID=55399727

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2015/0203A JO3783B1 (ar) 2014-08-28 2015-08-26 مشتق كوينولين عالي النقاء وطريقة لإنتاجه
JOP/2020/0225A JOP20200225A1 (ar) 2014-08-28 2020-09-10 مشتق كوينولين عالي النقاء وطريقة لإنتاجه

Family Applications After (1)

Application Number Title Priority Date Filing Date
JOP/2020/0225A JOP20200225A1 (ar) 2014-08-28 2020-09-10 مشتق كوينولين عالي النقاء وطريقة لإنتاجه

Country Status (23)

Country Link
US (5) US10259791B2 (ar)
EP (4) EP3825305A1 (ar)
JP (1) JP6659554B2 (ar)
KR (3) KR20230043234A (ar)
CN (2) CN106660964B (ar)
AU (1) AU2015309862C1 (ar)
BR (1) BR112017002827B1 (ar)
CA (1) CA2957005C (ar)
DK (1) DK3524595T3 (ar)
ES (1) ES2926687T3 (ar)
HR (1) HRP20221047T1 (ar)
HU (1) HUE059606T2 (ar)
IL (2) IL302218A (ar)
JO (2) JO3783B1 (ar)
LT (1) LT3524595T (ar)
MX (3) MX2017001980A (ar)
PL (1) PL3524595T3 (ar)
PT (1) PT3524595T (ar)
RS (1) RS63559B1 (ar)
SG (2) SG10202100272RA (ar)
SI (1) SI3524595T1 (ar)
TW (1) TWI721954B (ar)
WO (1) WO2016031841A1 (ar)

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HRP20221047T1 (hr) 2014-08-28 2022-11-11 Eisai R&D Management Co., Ltd. Derivat kinolina visoke čistoće i postupak za njegovu proizvodnju
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CN105801481A (zh) * 2016-05-20 2016-07-27 湖南欧亚生物有限公司 一种乐伐替尼的合成方法
CN108299294A (zh) * 2017-01-11 2018-07-20 江苏恒瑞医药股份有限公司 一种乐伐替尼杂质的制备方法
WO2019228485A1 (zh) * 2018-06-01 2019-12-05 成都苑东生物制药股份有限公司 一种甲磺酸乐伐替尼新晶型及其制备方法
CN111320580B (zh) * 2018-12-14 2022-12-20 江苏先声药业有限公司 一种仑伐替尼中间体的制备方法
CN111377864B (zh) * 2018-12-27 2022-03-18 江苏先声药业有限公司 一种仑伐替尼杂质及其制备方法和应用
CN109824590B (zh) * 2019-02-21 2022-03-22 扬子江药业集团有限公司 仑伐替尼及其盐的制备方法
CN109851556A (zh) * 2019-03-18 2019-06-07 扬子江药业集团有限公司 仑伐替尼或其甲磺酸盐药物杂质的制备方法
CN110283122B (zh) * 2019-06-26 2021-05-25 石药集团中奇制药技术（石家庄）有限公司 一种高纯度仑伐替尼及其盐的制备方法
CN110229103A (zh) * 2019-06-27 2019-09-13 尚科生物医药（上海）有限公司 一种乐伐替尼甲磺酸盐晶型b的制备方法
CN110563644A (zh) * 2019-10-30 2019-12-13 北京赛思源生物医药技术有限公司 一种仑伐替尼甲磺酸盐的新晶型
CN113045491A (zh) * 2019-12-26 2021-06-29 罗欣药业(上海)有限公司 一种仑伐替尼及中间体的制备方法
WO2021217537A1 (zh) * 2020-04-30 2021-11-04 天津睿创康泰生物技术有限公司 一种乐伐替尼游离碱晶型及其制备方法
WO2021226738A1 (zh) * 2020-05-09 2021-11-18 北京睿创康泰医药研究院有限公司 包含仑伐替尼的分子水平的药物组合物及其制备方法和应用
CN113999173A (zh) * 2020-07-28 2022-02-01 药源药物化学（上海）有限公司 一种高纯度结晶的制备方法
CN112142662B (zh) * 2020-10-27 2022-03-08 南京法恩化学有限公司 一种甲磺酸乐伐替尼的制备方法
KR102576608B1 (ko) 2020-12-16 2023-09-12 쌍용씨앤이 주식회사 칼슘설포알루미네이트를 함유한 수경성 조성물 및 이를 포함하는 페이스트, 모르타르 및 콘크리트의 유동성 유지방법
JP6953054B1 (ja) * 2021-03-31 2021-10-27 Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 湿度に敏感な医薬用途物質を安定化する方法及び安定製剤
CN115322149A (zh) * 2022-08-22 2022-11-11 思科(深圳)药物研发有限公司 一种甲磺酸仑伐替尼杂质及其制备方法

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