MX2017016324A - Tratamientos de combinacion de antagonista de ligando 1 de muerte programada (pd-l1). - Google Patents

Tratamientos de combinacion de antagonista de ligando 1 de muerte programada (pd-l1).

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Publication number
MX2017016324A
MX2017016324A MX2017016324A MX2017016324A MX2017016324A MX 2017016324 A MX2017016324 A MX 2017016324A MX 2017016324 A MX2017016324 A MX 2017016324A MX 2017016324 A MX2017016324 A MX 2017016324A MX 2017016324 A MX2017016324 A MX 2017016324A
Authority
MX
Mexico
Prior art keywords
combination treatments
antagonist combination
combination therapies
antagonist
receptor
Prior art date
Application number
MX2017016324A
Other languages
English (en)
Inventor
Lin Chia-Yang
Chen Shihao
Di Pietro Alessandra
Fontana David
Goldberg Zelanna
Long Hua
MARTIGNONI Marcella
David Thall Aron
Woolfson Adrian
Serge Antoine Nuyten Dimitry
Ian ANDREWS Glen
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2017016324A publication Critical patent/MX2017016324A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente descripción describe terapias de combinación que comprenden un antagonista de un receptor de Ligando 1 de Muerte Programada (PD-L1) y otro agente terapéutico, y el uso de las terapias de combinación para el tratamiento de cáncer.
MX2017016324A 2015-06-16 2016-06-15 Tratamientos de combinacion de antagonista de ligando 1 de muerte programada (pd-l1). MX2017016324A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562180543P 2015-06-16 2015-06-16
US201562219995P 2015-09-17 2015-09-17
US201662286501P 2016-01-25 2016-01-25
US201662337489P 2016-05-17 2016-05-17
PCT/US2016/037498 WO2016205277A1 (en) 2015-06-16 2016-06-15 Pd-l1 antagonist combination treatments

Publications (1)

Publication Number Publication Date
MX2017016324A true MX2017016324A (es) 2018-03-02

Family

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Application Number Title Priority Date Filing Date
MX2017016324A MX2017016324A (es) 2015-06-16 2016-06-15 Tratamientos de combinacion de antagonista de ligando 1 de muerte programada (pd-l1).

Country Status (16)

Country Link
US (2) US10869924B2 (es)
EP (1) EP3310810A1 (es)
JP (2) JP6876629B2 (es)
KR (1) KR20180018762A (es)
CN (1) CN107750166B (es)
AU (1) AU2016280003B2 (es)
CA (1) CA2989586A1 (es)
HK (1) HK1248530A1 (es)
IL (1) IL256245B (es)
MX (1) MX2017016324A (es)
MY (1) MY193229A (es)
PH (1) PH12017501857A1 (es)
RU (1) RU2766890C2 (es)
TW (1) TWI772261B (es)
UA (1) UA126892C2 (es)
WO (1) WO2016205277A1 (es)

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