MA55142A - Amino-triazolopyrimidine et amino-triazolopyrazine substitués antagoniste du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation - Google Patents
Amino-triazolopyrimidine et amino-triazolopyrazine substitués antagoniste du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisationInfo
- Publication number
- MA55142A MA55142A MA055142A MA55142A MA55142A MA 55142 A MA55142 A MA 55142A MA 055142 A MA055142 A MA 055142A MA 55142 A MA55142 A MA 55142A MA 55142 A MA55142 A MA 55142A
- Authority
- MA
- Morocco
- Prior art keywords
- amino
- triazolopyrazine
- triazolopyrimidine
- pharmaceutical compositions
- receptor antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862769843P | 2018-11-20 | 2018-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA55142A true MA55142A (fr) | 2022-02-23 |
Family
ID=70774154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA055142A MA55142A (fr) | 2018-11-20 | 2019-11-15 | Amino-triazolopyrimidine et amino-triazolopyrazine substitués antagoniste du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12466831B2 (fr) |
| EP (1) | EP3883575B1 (fr) |
| JP (1) | JP2022507734A (fr) |
| KR (1) | KR20210093964A (fr) |
| CN (1) | CN113015530A (fr) |
| AU (1) | AU2019383948A1 (fr) |
| BR (1) | BR112021009078A8 (fr) |
| CA (1) | CA3119774A1 (fr) |
| MA (1) | MA55142A (fr) |
| MX (1) | MX2021005839A (fr) |
| WO (1) | WO2020106558A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210093964A (ko) | 2018-11-20 | 2021-07-28 | 머크 샤프 앤드 돔 코포레이션 | 치환된 아미노 트리아졸로피리미딘 및 아미노 트리아졸로피라진 아데노신 수용체 길항제, 제약 조성물 및 그의 용도 |
| EP3883576B1 (fr) | 2018-11-20 | 2025-12-17 | Merck Sharp & Dohme LLC | Composés amino-triazolopyrimidine et amino-triazolopyrazine substitués utilisés en tant qu'antagonistes de récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation |
| CA3120331A1 (fr) | 2018-11-30 | 2020-06-04 | Merck Sharp & Dohme Corp. | Derives d'amino triazolo quinazoline a substitution en positions 7, 8 et 10 utilises en tant qu'antagonistes du recepteur de l'adenosine, compositions pharmaceutiques et leur utilisation |
| KR102653800B1 (ko) | 2018-11-30 | 2024-04-01 | 머크 샤프 앤드 돔 엘엘씨 | 아데노신 수용체 길항제로서의 9-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도 |
| CA3150766A1 (fr) * | 2019-08-26 | 2021-03-04 | Incyte Corporation | Triazolopyrimidines servant d'inhibiteurs a2a/a2b |
| US20240217978A1 (en) * | 2021-04-23 | 2024-07-04 | Chong Kun Dang Pharmaceutical Corp. | COMPOUND AS ADENOSINE A2a RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION COMPRISING SAME |
| AU2023252914A1 (en) | 2022-04-13 | 2024-10-17 | Arcus Biosciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| WO2025137640A1 (fr) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Inhibiteurs azaspiro de wrn |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9524395D0 (en) | 1995-11-29 | 1996-01-31 | Nickerson Biocem Ltd | Promoters |
| CA2284737C (fr) | 1997-03-24 | 2007-03-13 | Kyowa Hakko Kogyo Co., Ltd. | Derives [1,2,4]triazolo[1,5-c]pyrimidiniques |
| US6759759B2 (en) | 2000-08-29 | 2004-07-06 | Tamagawa Seiki Kabushiki Kaisha | Rotary contactless connector and non-rotary contactless connector |
| EP1430898A4 (fr) | 2001-09-28 | 2005-11-02 | Kyowa Hakko Kogyo Kk | Antagoniste de recepteur |
| HUP0401777A3 (en) | 2001-10-15 | 2008-06-30 | Schering Corp | 3h-[1,2,4]triazolo[5,1-i]purin-5-yl amines as adenosine a2a receptor antagonists and pharmaceutical compositions containing the compounds |
| US6916811B2 (en) | 2001-11-30 | 2005-07-12 | Schering Corporation | Adenosine A2a receptor antagonists |
| PE20030739A1 (es) * | 2001-11-30 | 2003-08-28 | Schering Corp | Antagonistas del receptor de adenosina a2a |
| AU2003211993A1 (en) | 2002-02-15 | 2003-09-04 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVES |
| EP2206517B1 (fr) | 2002-07-03 | 2023-08-02 | Ono Pharmaceutical Co., Ltd. | Compositions immunostimulantes contenant un anticorps anti-PD-L1 |
| AU2003272886A1 (en) * | 2002-09-24 | 2004-04-19 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| US7674791B2 (en) * | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| ATE353331T1 (de) | 2003-10-28 | 2007-02-15 | Schering Corp | Verfahren zur herstellung substituierter 5-amino- pyrazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidin |
| EP1745047B1 (fr) | 2004-04-21 | 2010-03-24 | Schering Corporation | Antagonistes du recepteur a2a de l'adenosine a base de pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidine |
| US7472383B2 (en) | 2004-08-13 | 2008-12-30 | Sun Microsystems, Inc. | System and method for providing exceptional flow control in protected code through memory layers |
| WO2006068954A2 (fr) | 2004-12-21 | 2006-06-29 | Schering Corporation | Antagonistes de recepteur a2a de pyrazolo [1,5-a]pyrimidine adenosine |
| ES2720160T3 (es) | 2005-05-09 | 2019-07-18 | Ono Pharmaceutical Co | Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas |
| EA019344B1 (ru) | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| CA2622741A1 (fr) | 2005-09-19 | 2007-03-29 | Schering Corporation | 2-heteroaryl-pyrazolo-[4, 3-e]-1, 2, 4-triazolo-[1,5-c]-pyrimidine en tant qu'antagonistes du recepteur a2a d'adenosine |
| EP2038285B1 (fr) | 2006-06-26 | 2010-02-17 | Schering Corporation | Antagonistes du récepteur a2a de l'adénosine |
| JP5191537B2 (ja) | 2007-06-18 | 2013-05-08 | エム・エス・ディー・オス・ベー・フェー | ヒトのプログラムされたデスレセプターpd−1に対する抗体 |
| PE20091101A1 (es) | 2007-12-18 | 2009-07-26 | Pharminox Ltd | AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO |
| JP2011514350A (ja) | 2008-03-04 | 2011-05-06 | シェーリング コーポレイション | アデノシンA2a受容体アンタゴニストとして使用するためのアミノ−キノキサリンおよびアミノ−キノリン化合物 |
| EP2262837A4 (fr) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Protéines de liaison avec pd-1 |
| DE102008023801A1 (de) * | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
| GB0906579D0 (en) * | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| EP2328920A2 (fr) | 2008-08-25 | 2011-06-08 | Amplimmune, Inc. | Polypeptides co-stimulateurs ciblés et leurs procédés d'utilisation dans le traitement du cancer |
| BRPI0919377A2 (pt) | 2008-09-26 | 2016-09-27 | Dana Farber Cancer Inst Inc | anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento |
| HUE065752T2 (hu) | 2008-12-09 | 2024-06-28 | Hoffmann La Roche | Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére |
| WO2011060207A1 (fr) | 2009-11-16 | 2011-05-19 | Schering Corporation | Composés tricycliques condensés possédant une activité antagoniste des récepteurs a2a de l'adénosine |
| EP2504028A4 (fr) | 2009-11-24 | 2014-04-09 | Amplimmune Inc | Inhibition simultanée de pd-l1/pd-l2 |
| EA026924B1 (ru) | 2011-08-01 | 2017-05-31 | Дженентек, Инк. | Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek |
| WO2014101113A1 (fr) | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution pipérazine présentant des propriétés d'antagoniste d'a2a |
| WO2014101120A1 (fr) | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution hétérobicyclo présentant des propriétés d'antagoniste d'a2a |
| WO2015027431A1 (fr) | 2013-08-29 | 2015-03-05 | Merck Sharp & Dohme Corp. | Antagonistes 2,2-difluorodioxolo du récepteur a2a |
| US10472347B2 (en) | 2014-11-18 | 2019-11-12 | Merck Sharp & Dohme Corp. | Aminopyrazine compounds with A2A antagonist properties |
| US10085991B2 (en) | 2014-12-04 | 2018-10-02 | Merck Sharp & Dohme Corp. | Formulation inhibiting effects of low acid environment |
| EP3253390B1 (fr) | 2015-02-06 | 2022-04-13 | Merck Sharp & Dohme Corp. | Composés d'aminoquinazoline comme antagonistes d'a2a |
| EP3307067B1 (fr) | 2015-06-11 | 2022-11-02 | Merck Sharp & Dohme LLC | Composés d'aminopyrazine ayant des propriétés d'antagoniste a2a |
| WO2016209787A1 (fr) | 2015-06-26 | 2016-12-29 | Merck Sharp & Dohme Corp. | Formulation à libération prolongée et comprimés préparés à partir de celle-ci |
| WO2017008205A1 (fr) | 2015-07-10 | 2017-01-19 | Merck Sharp & Dohme Corp. | Composés d'aminoquinazoline substitués a titre d'antagonistes du récepteur a2a |
| WO2017223414A1 (fr) * | 2016-06-24 | 2017-12-28 | Incyte Corporation | Composants hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-y |
| ES2919474T3 (es) | 2017-04-07 | 2022-07-26 | Medshine Discovery Inc | Derivado de [1,2,4]triazolo[1,5-c]pirimidina como inhibidor del receptor A2A |
| CN109535161B (zh) | 2017-09-22 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 三唑并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| EP3723754A4 (fr) | 2017-12-13 | 2021-05-19 | Merck Sharp & Dohme Corp. | Composés imidazo[1,2-c]quinazolin-5-amine présentant des propriétés antagonistes du a2a |
| US20190292188A1 (en) | 2018-02-27 | 2019-09-26 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
| CN113166153B (zh) | 2018-07-05 | 2024-11-01 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| EP3883576B1 (fr) | 2018-11-20 | 2025-12-17 | Merck Sharp & Dohme LLC | Composés amino-triazolopyrimidine et amino-triazolopyrazine substitués utilisés en tant qu'antagonistes de récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation |
| KR20210093964A (ko) | 2018-11-20 | 2021-07-28 | 머크 샤프 앤드 돔 코포레이션 | 치환된 아미노 트리아졸로피리미딘 및 아미노 트리아졸로피라진 아데노신 수용체 길항제, 제약 조성물 및 그의 용도 |
| KR102653800B1 (ko) | 2018-11-30 | 2024-04-01 | 머크 샤프 앤드 돔 엘엘씨 | 아데노신 수용체 길항제로서의 9-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도 |
| CA3120331A1 (fr) | 2018-11-30 | 2020-06-04 | Merck Sharp & Dohme Corp. | Derives d'amino triazolo quinazoline a substitution en positions 7, 8 et 10 utilises en tant qu'antagonistes du recepteur de l'adenosine, compositions pharmaceutiques et leur utilisation |
-
2019
- 2019-11-15 KR KR1020217018498A patent/KR20210093964A/ko not_active Withdrawn
- 2019-11-15 JP JP2021527186A patent/JP2022507734A/ja active Pending
- 2019-11-15 EP EP19886307.8A patent/EP3883575B1/fr active Active
- 2019-11-15 AU AU2019383948A patent/AU2019383948A1/en not_active Abandoned
- 2019-11-15 MX MX2021005839A patent/MX2021005839A/es unknown
- 2019-11-15 BR BR112021009078A patent/BR112021009078A8/pt not_active Application Discontinuation
- 2019-11-15 US US17/292,511 patent/US12466831B2/en active Active
- 2019-11-15 MA MA055142A patent/MA55142A/fr unknown
- 2019-11-15 WO PCT/US2019/061622 patent/WO2020106558A1/fr not_active Ceased
- 2019-11-15 CN CN201980076511.2A patent/CN113015530A/zh active Pending
- 2019-11-15 CA CA3119774A patent/CA3119774A1/fr active Pending
-
2025
- 2025-08-18 US US19/302,594 patent/US20250382300A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12466831B2 (en) | 2025-11-11 |
| JP2022507734A (ja) | 2022-01-18 |
| BR112021009078A8 (pt) | 2023-02-07 |
| KR20210093964A (ko) | 2021-07-28 |
| CA3119774A1 (fr) | 2020-05-28 |
| EP3883575A4 (fr) | 2022-06-15 |
| EP3883575B1 (fr) | 2025-10-08 |
| EP3883575A1 (fr) | 2021-09-29 |
| CN113015530A (zh) | 2021-06-22 |
| BR112021009078A2 (pt) | 2021-08-10 |
| MX2021005839A (es) | 2021-07-15 |
| WO2020106558A1 (fr) | 2020-05-28 |
| AU2019383948A1 (en) | 2021-05-20 |
| US20250382300A1 (en) | 2025-12-18 |
| US20210395255A1 (en) | 2021-12-23 |
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