MX2022010549A - Moleculas de union compuestas que se dirigen a celulas b inmunodepresoras. - Google Patents

Moleculas de union compuestas que se dirigen a celulas b inmunodepresoras.

Info

Publication number
MX2022010549A
MX2022010549A MX2022010549A MX2022010549A MX2022010549A MX 2022010549 A MX2022010549 A MX 2022010549A MX 2022010549 A MX2022010549 A MX 2022010549A MX 2022010549 A MX2022010549 A MX 2022010549A MX 2022010549 A MX2022010549 A MX 2022010549A
Authority
MX
Mexico
Prior art keywords
bispecific antibodies
effectively
therapeutic intervention
targeting molecules
potential pathway
Prior art date
Application number
MX2022010549A
Other languages
English (en)
Inventor
Nils Lonberg
Omar Duramad
Leonard Presta
Paul Tumeh
Original Assignee
Biograph 55 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biograph 55 Inc filed Critical Biograph 55 Inc
Publication of MX2022010549A publication Critical patent/MX2022010549A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Dirigirse a poblaciones de células B inmunosupresoras con moléculas dirigidas biespecíficas o multivalentes presenta una ruta potencial para la intervención terapéutica que modula de manera efectiva la respuesta inmunitaria antitumoral para mejorar los resultados terapéuticos. En consecuencia, sigue existiendo la necesidad de tratamientos basados en anticuerpos modificados por ingeniería que puedan dirigirse efectivamente y selectivamente a las poblaciones de células B inmunosupresoras para el tratamiento de cáncer. Se proporcionan moléculas de unión compuestas dirigidas a células B inmunosupresoras.
MX2022010549A 2020-02-26 2021-02-25 Moleculas de union compuestas que se dirigen a celulas b inmunodepresoras. MX2022010549A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062981990P 2020-02-26 2020-02-26
US202062990330P 2020-03-16 2020-03-16
US202063094838P 2020-10-21 2020-10-21
PCT/US2021/019685 WO2021173844A1 (en) 2020-02-26 2021-02-25 C19 c38 bispecific antibodies

Publications (1)

Publication Number Publication Date
MX2022010549A true MX2022010549A (es) 2022-11-16

Family

ID=75108863

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010549A MX2022010549A (es) 2020-02-26 2021-02-25 Moleculas de union compuestas que se dirigen a celulas b inmunodepresoras.

Country Status (10)

Country Link
US (5) US11299551B2 (es)
EP (1) EP4110818A1 (es)
JP (1) JP7811176B2 (es)
KR (1) KR20220159989A (es)
CN (1) CN115515980A (es)
AU (1) AU2021226582A1 (es)
CA (1) CA3173257A1 (es)
IL (1) IL295896A (es)
MX (1) MX2022010549A (es)
WO (1) WO2021173844A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022010549A (es) 2020-02-26 2022-11-16 Biograph 55 Inc Moleculas de union compuestas que se dirigen a celulas b inmunodepresoras.
CA3229824A1 (en) * 2021-08-25 2023-03-02 Leonard Presta Methods of treating cancers associated with immunosuppressive b cells
EP4392063A4 (en) * 2021-08-25 2025-11-19 Biograph 55 Inc IMMUNOSUPPRESSANT B-LYMPHOCYTE ANTIBODIES
CN115850479B (zh) * 2021-09-16 2025-08-12 盛禾(中国)生物制药有限公司 一种抗cd24抗体或其抗原结合片段及其应用
CN114921497A (zh) * 2022-05-17 2022-08-19 郑州大学第一附属医院 一种双靶向cd19/cd38嵌合抗原受体t细胞的制备方法和应用
CN121263449A (zh) * 2023-03-21 2026-01-02 拜格拉夫55公司 Cd19/cd38多特异性抗体
CN120648654A (zh) * 2024-03-13 2025-09-16 深圳太力生物技术有限责任公司 重组细胞的制备方法、重组细胞及其应用

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Also Published As

Publication number Publication date
US12540194B2 (en) 2026-02-03
EP4110818A1 (en) 2023-01-04
US20220185907A1 (en) 2022-06-16
US20220185908A1 (en) 2022-06-16
CA3173257A1 (en) 2021-09-02
US12509527B2 (en) 2025-12-30
IL295896A (en) 2022-10-01
JP7811176B2 (ja) 2026-02-04
CN115515980A (zh) 2022-12-23
WO2021173844A1 (en) 2021-09-02
JP2023516195A (ja) 2023-04-18
US11299551B2 (en) 2022-04-12
US20260103536A1 (en) 2026-04-16
AU2021226582A1 (en) 2022-10-13
US20220185906A1 (en) 2022-06-16
US20220363774A2 (en) 2022-11-17
US20210269545A1 (en) 2021-09-02
KR20220159989A (ko) 2022-12-05

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