EA201892438A1 - 6-АМИНОПИРИДИН-3-ИЛТИАЗОЛЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγt - Google Patents

6-АМИНОПИРИДИН-3-ИЛТИАЗОЛЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγt

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Publication number
EA201892438A1
EA201892438A1 EA201892438A EA201892438A EA201892438A1 EA 201892438 A1 EA201892438 A1 EA 201892438A1 EA 201892438 A EA201892438 A EA 201892438A EA 201892438 A EA201892438 A EA 201892438A EA 201892438 A1 EA201892438 A1 EA 201892438A1
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EA
Eurasian Patent Office
Prior art keywords
ilhiazoles
aminopiridin
rorγt
syndrome
disorder
Prior art date
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EA201892438A
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English (en)
Other versions
EA036318B1 (ru
Inventor
Стивен Голдберг
Келли Макклур
Вирджиния М. Танис
Элизабет Г. Феннема
Алек Д. Лебсак
Коннор Л. Мартин
Харихаран Венкатесан
Сяохуа Сюэ
Крейг Р. Вудс
Original Assignee
Янссен Фармацевтика Нв
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Publication of EA201892438A1 publication Critical patent/EA201892438A1/ru
Publication of EA036318B1 publication Critical patent/EA036318B1/ru

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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Image Processing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение содержит соединения формулы (I):где A, A, A, A, A, Rи Rопределены в описании изобретения. Изобретение также включает способ лечения или облегчения синдрома, расстройства или заболевания, где синдром, расстройство или заболевание представляет собой ревматоидный артрит или псориаз. Изобретение также включает способ модуляции активности RORγt у млекопитающего путем введения терапевтически эффективного количества по меньшей мере одного соединения формулы I.
EA201892438A 2016-04-27 2017-04-26 6-аминопиридин-3-илтиазолы в качестве модуляторов rort EA036318B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662328074P 2016-04-27 2016-04-27
PCT/US2017/029531 WO2017189661A1 (en) 2016-04-27 2017-04-26 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORγT

Publications (2)

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EA201892438A1 true EA201892438A1 (ru) 2019-04-30
EA036318B1 EA036318B1 (ru) 2020-10-26

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US (5) US10975068B2 (ru)
EP (1) EP3448856B1 (ru)
JP (1) JP6893218B2 (ru)
KR (1) KR20180135962A (ru)
CN (1) CN109415358B (ru)
AR (1) AR108344A1 (ru)
AU (1) AU2017255525A1 (ru)
BR (1) BR112018071942A2 (ru)
CA (1) CA3022318A1 (ru)
CL (1) CL2018003044A1 (ru)
CO (1) CO2018011633A2 (ru)
CR (1) CR20180505A (ru)
EA (1) EA036318B1 (ru)
EC (1) ECSP18088146A (ru)
ES (1) ES2906258T3 (ru)
IL (1) IL262381A (ru)
MA (1) MA44772A (ru)
MX (1) MX2018013143A (ru)
NI (1) NI201800109A (ru)
PE (1) PE20190150A1 (ru)
PH (1) PH12018502209A1 (ru)
SG (1) SG11201809162XA (ru)
SV (1) SV2018005772A (ru)
TW (1) TW201803869A (ru)
UY (1) UY37213A (ru)
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US20170313691A1 (en) 2017-11-02
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US20230123208A1 (en) 2023-04-20
UY37213A (es) 2017-10-31
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ECSP18088146A (es) 2018-11-30
BR112018071942A2 (pt) 2019-02-05
WO2017189661A1 (en) 2017-11-02
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