EA201590750A1 - СВЯЗАННЫЕ С ФЕНИЛОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγT - Google Patents
СВЯЗАННЫЕ С ФЕНИЛОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγTInfo
- Publication number
- EA201590750A1 EA201590750A1 EA201590750A EA201590750A EA201590750A1 EA 201590750 A1 EA201590750 A1 EA 201590750A1 EA 201590750 A EA201590750 A EA 201590750A EA 201590750 A EA201590750 A EA 201590750A EA 201590750 A1 EA201590750 A1 EA 201590750A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- phenyl
- syndrome
- disorder
- disease
- provides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Изобретение содержит соединения формулы Iгде R, R, R, R, R, R, R, Rи Rопределены в описании. Настоящее изобретение также содержит способ лечения или облегчения синдрома, расстройства или заболевания, причем указанный синдром, расстройство или заболевание выбирают из группы, состоящей из ревматоидного артрита или псориаза. Изобретение также содержит способ модулирования активности RORγt у млекопитающего путем введения терапевтически эффективного количества по меньшей мере одного соединения по п.1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261714433P | 2012-10-16 | 2012-10-16 | |
US201261725537P | 2012-11-13 | 2012-11-13 | |
PCT/US2013/065026 WO2014062667A1 (en) | 2012-10-16 | 2013-10-15 | Phenyl linked quinolinyl modulators of ror-gamma-t |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201590750A1 true EA201590750A1 (ru) | 2015-09-30 |
Family
ID=49943493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590750A EA201590750A1 (ru) | 2012-10-16 | 2013-10-15 | СВЯЗАННЫЕ С ФЕНИЛОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγT |
Country Status (21)
Country | Link |
---|---|
US (1) | US9309222B2 (ru) |
EP (1) | EP2909193B1 (ru) |
JP (1) | JP6251277B2 (ru) |
KR (1) | KR20150070350A (ru) |
CN (1) | CN105073729A (ru) |
AU (1) | AU2013331505A1 (ru) |
CA (1) | CA2888485C (ru) |
CL (1) | CL2015000946A1 (ru) |
CO (1) | CO7350658A2 (ru) |
CR (1) | CR20150192A (ru) |
EA (1) | EA201590750A1 (ru) |
EC (1) | ECSP15015155A (ru) |
ES (1) | ES2628365T3 (ru) |
GT (1) | GT201500092A (ru) |
HK (1) | HK1213887A1 (ru) |
IL (1) | IL238122A0 (ru) |
MX (1) | MX2015004784A (ru) |
PE (1) | PE20151203A1 (ru) |
PH (1) | PH12015500776A1 (ru) |
SG (1) | SG11201502935VA (ru) |
WO (1) | WO2014062667A1 (ru) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
CA2927182A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Quinolinyl modulators of ror.gamma.t |
KR20160068959A (ko) * | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | Ror-gamma-t의 페닐 결합 퀴놀리닐 조절제 |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
BR112016008215A2 (pt) * | 2013-10-15 | 2017-09-26 | Janssen Pharmaceutica Nv | moduladores de quinolinila ligados por alquila de roryt |
EP3560920A1 (en) * | 2013-10-15 | 2019-10-30 | Janssen Pharmaceutica NV | Secondary alcohol quinolinyl modulators of ror gamma t |
US9988374B2 (en) | 2014-08-11 | 2018-06-05 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
JOP20200117A1 (ar) * | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
EP3240778A4 (en) | 2014-12-31 | 2018-07-11 | Angion Biomedica Corp. | Methods and agents for treating disease |
JP6854776B2 (ja) | 2015-01-08 | 2021-04-07 | インぺティス バイオサイエンス リミテッド | 二環式化合物、その組成物および医薬用途 |
WO2016128908A1 (en) | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
TWI757266B (zh) * | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
JP6967577B2 (ja) | 2016-07-14 | 2021-11-17 | クリネティックス ファーマシューティカルズ,インク. | ソマトスタチンモジュレーターとその使用 |
WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
CN111868049B (zh) | 2018-01-17 | 2023-06-30 | 克林提克斯医药股份有限公司 | 制备促生长素抑制素调节剂的方法 |
CN108503581A (zh) * | 2018-04-12 | 2018-09-07 | 苏州康润医药有限公司 | 一种3-溴-6-氟-2-吡啶乙酮的合成方法 |
KR20230066379A (ko) | 2020-09-09 | 2023-05-15 | 크리네틱스 파마슈티칼스, 인크. | 소마토스타틴 조절제 제형 |
CN117682980A (zh) * | 2024-02-02 | 2024-03-12 | 济南悟通生物科技有限公司 | 一种2-乙酰基四氢吡啶的制备方法 |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3472859A (en) | 1966-11-01 | 1969-10-14 | Sterling Drug Inc | 1-alkyl-1,4-dihydro-4-oxo-3 quinoline-carboxylic acids and esters |
JPS4826772U (ru) | 1971-08-02 | 1973-03-31 | ||
DE3276432D1 (en) | 1981-03-24 | 1987-07-02 | Ciba Geigy Ag | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use |
US4656283A (en) | 1982-05-25 | 1987-04-07 | American Cyanamid Company | Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid |
US4910327A (en) | 1982-05-25 | 1990-03-20 | American Cyanamid Company | Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid: dialkyl 3-(substituted)phenylaminobut-2-ene-dioates and methods for the preparation thereof |
US4710507A (en) | 1983-12-22 | 1987-12-01 | Pfizer Inc. | Quinolone inotropic agents |
FR2634483B2 (fr) | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments |
CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
EP0584222B1 (en) | 1991-05-10 | 1997-10-08 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
US5478832A (en) | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
JPH0826772A (ja) | 1994-07-22 | 1996-01-30 | Sony Corp | 融着用ガラス、その製造方法及び製造装置、並びに磁気ヘッドの製造方法 |
DE69512495T2 (de) | 1994-10-27 | 2000-02-03 | Yoshitomi Pharmaceutical | Verfahren zur Herstellung von Chinolin-2-yl-benzoesäure |
GB9523267D0 (en) | 1995-11-14 | 1996-01-17 | Sandoz Ltd | Organic compounds |
PT1162201E (pt) | 1995-12-08 | 2006-08-31 | Janssen Pharmaceutica Nv | Derivados de ( imidazol-5-il ) metil-2-quinolinona como inibidores da proteina farnesil transferase |
WO1997044339A1 (en) | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
CA2290992C (en) * | 1997-06-02 | 2008-02-12 | Janssen Pharmaceutica N.V. | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
PL341364A1 (en) | 1997-12-22 | 2001-04-09 | Upjohn Co | 4-hydroxyqinoline-3-carboxamides and hydrazides as antiviral agents |
FR2776388B1 (fr) | 1998-03-20 | 2006-04-28 | Lipha | Utilisation de recepteurs de la famille ror pour le criblage de substances utiles pour le traitement de l'atherosclerose |
US6399629B1 (en) | 1998-06-01 | 2002-06-04 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
KR100674122B1 (ko) | 1998-07-06 | 2007-01-26 | 얀센 파마슈티카 엔.브이. | 관절증 치료용 파네실 단백질 트랜스퍼라제 억제제 |
SK284723B6 (sk) | 1998-07-06 | 2005-10-06 | Janssen Pharmaceutica N. V. | Použitie inhibítora farnesyl-proteín transferázy na prípravu farmaceutickej kompozície, majúcej rádiosenzibilizačné vlastnosti |
JP2000169451A (ja) | 1998-09-30 | 2000-06-20 | Kyorin Pharmaceut Co Ltd | 6,7―ジ置換キノリンカルボン酸誘導体とその付加塩及びそれらの製造方法 |
PT1140935E (pt) | 1998-12-23 | 2003-10-31 | Janssen Pharmaceutica Nv | Derivados da quinolina 1,2-ciclizada |
US6248736B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents |
US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
IL144307A0 (en) | 1999-02-11 | 2002-05-23 | Pfizer Prod Inc | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents |
TR200400342T4 (tr) | 1999-11-30 | 2004-03-22 | Pfizer Products Inc. | Farnezil protein transferazı önlemek için kinolin türevleri. |
US20030027839A1 (en) | 2000-02-04 | 2003-02-06 | Palmer Peter Albert | Farnesyl protein transferase inhiitors for treating breast cancer |
ES2293972T3 (es) | 2000-02-24 | 2008-04-01 | Janssen Pharmaceutica N.V. | Regimen de dosificacion que comprende un inhibidor de la farnesil proteina transferasa para el tratamiento del cancer. |
AU2001235496A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents |
WO2001064196A2 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with vinca alkaloids |
US20030212008A1 (en) | 2000-02-29 | 2003-11-13 | Palmer Peter Albert | Farnesyl protein transferase inhibitor combinations with further anti-cancer agents |
AU2001256166A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives |
AU2001246478A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with taxane compounds |
EP1261341A2 (en) | 2000-02-29 | 2002-12-04 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with camptothecin compounds |
US20030022918A1 (en) | 2000-02-29 | 2003-01-30 | Horak Ivan David | Farnesyl protein transferase inhibitor combinations with an her2 antibody |
WO2001064226A2 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with platinum compounds |
CA2397253A1 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives |
AU2001239275A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives |
CA2397694A1 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica Inc. | Farnesyl protein transferase inhibitor combinations |
US6844357B2 (en) | 2000-05-01 | 2005-01-18 | Pfizer Inc. | Substituted quinolin-2-one derivatives useful as antiproliferative agents |
US6525049B2 (en) | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
US6624159B2 (en) | 2000-07-12 | 2003-09-23 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
DE60105614T2 (de) | 2000-07-12 | 2005-10-06 | Pharmacia & Upjohn Co., Kalamazoo | Oxazinochinolone für die behandlung viraler infektionen |
EP1322635B1 (en) | 2000-09-25 | 2006-03-22 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors |
AU2002220559A1 (en) | 2000-09-25 | 2002-04-02 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives |
JP4974439B2 (ja) | 2000-09-25 | 2012-07-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼを阻害する6−ヘテロシクリルメチルキノリノン誘導体 |
AU9384701A (en) | 2000-10-02 | 2002-04-15 | Janssen Pharmaceutica Nv | Metabotropic glutamate receptor antagonists |
US20040044032A1 (en) | 2000-11-28 | 2004-03-04 | End David William | Farnesyl protein transfer inhibitors for the treatment of inflammatory bowel disease |
ATE319704T1 (de) | 2000-12-27 | 2006-03-15 | Janssen Pharmaceutica Nv | Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate |
WO2002064142A1 (en) | 2001-02-15 | 2002-08-22 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with antiestrogen agents |
WO2002070487A1 (en) | 2001-03-01 | 2002-09-12 | Pharmacia & Upjohn Company | Substituted quinolinecarboxamides as antiviral agents |
US20040157773A1 (en) | 2001-04-25 | 2004-08-12 | End David William | Farnesyl protein transferase inhibitors for treating cachexia |
WO2003000705A1 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel quinolines and uses thereof |
JP2005516957A (ja) | 2001-12-20 | 2005-06-09 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | ピリドキノキサリン抗ウイルス剤 |
EP1458719A1 (en) | 2001-12-20 | 2004-09-22 | PHARMACIA & UPJOHN COMPANY | Pyridoquinoxaline antivirals |
MXPA04009435A (es) | 2002-03-29 | 2005-01-25 | Janssen Pharmaceutica Nv | Derivados de quinolina y quinolinona radiomarcados y su uso como ligandos de receptor de glutamato metabotropico. |
AU2003257822A1 (en) | 2002-08-13 | 2004-04-30 | Shionogi And Co., Ltd. | Heterocyclic compound having hiv integrase inhibitory activity |
AU2003262947A1 (en) | 2002-08-30 | 2004-03-19 | Pharmacia And Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
GB0222516D0 (en) | 2002-09-27 | 2002-11-06 | Karobio Ab | Novel compounds |
JP4920410B2 (ja) | 2003-07-14 | 2012-04-18 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 代謝モジュレーターとしての縮合アリールおよびヘテロアリール誘導体ならびに代謝に関連する障害の予防および治療 |
SG150533A1 (en) | 2003-11-20 | 2009-03-30 | Janssen Pharmaceutica Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors |
AU2004295059B2 (en) | 2003-12-05 | 2010-12-16 | Janssen Pharmaceutica N.V. | 6-substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
WO2005058843A1 (en) | 2003-12-10 | 2005-06-30 | Janssen Pharmaceutica N.V. | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
WO2005058834A2 (en) | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
US7902225B2 (en) | 2004-01-23 | 2011-03-08 | Janssen Pharmaceutica Nv | Mycobacterial inhibitors |
JP4919810B2 (ja) | 2004-01-29 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | マイコバクテリア抑制剤としての使用のためのキノリン誘導体 |
UA85593C2 (ru) | 2004-06-30 | 2009-02-10 | Янссен Фармацевтика Н.В. | Производные хиназолинона как ингибиторы parp |
AU2005268166B2 (en) | 2004-08-04 | 2011-10-20 | Meiji Seika Pharma Co., Ltd. | Quinoline derivative and insecticide containing same as active constituent |
KR100686531B1 (ko) | 2004-08-31 | 2007-02-23 | 한국화학연구원 | 히스톤 디아세틸라제 저해활성을 갖는 아릴아미노메틸프로페닐 벤즈하이드록시아마이드 유도체 및 그의 제조방법 |
EP1815247B1 (en) | 2004-11-05 | 2013-02-20 | Janssen Pharmaceutica NV | Therapeutic use of farnesyltransferase inhibitors and methods of monitoring the efficacy thereof |
JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
JO2952B1 (en) | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
WO2007088978A1 (ja) | 2006-02-03 | 2007-08-09 | Meiji Seika Kaisha, Ltd. | 新規キノリン誘導体およびこれを有効成分として含有する農園芸用殺菌剤 |
US8389739B1 (en) | 2006-10-05 | 2013-03-05 | Orphagen Pharmaceuticals | Modulators of retinoid-related orphan receptor gamma |
AU2007309237B2 (en) | 2006-10-23 | 2012-03-22 | Sgx Pharmaceuticals, Inc. | Triazolo-pyridazine protein kinase modulators |
JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
AR065093A1 (es) | 2007-02-05 | 2009-05-13 | Merck Frosst Canada Ltd | Compuestos farmacéuticos inhibidores de la biosintesis de leucotrienos |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
WO2008112525A2 (en) | 2007-03-09 | 2008-09-18 | Link Medicine Corporation | Treatment of lysosomal storage diseases |
CN101678014B (zh) | 2007-05-21 | 2012-12-12 | Sgx药品公司 | 杂环激酶调节剂 |
CN101143845B (zh) | 2007-10-15 | 2010-08-25 | 中国药科大学 | 取代喹啉甲酰胍衍生物、其制备方法及其医药用途 |
WO2009091735A1 (en) | 2008-01-18 | 2009-07-23 | Allergan.Inc | Substitued-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors |
WO2009098576A1 (en) | 2008-02-05 | 2009-08-13 | Pfizer Inc. | Pyridinyl amides for the treatment of cns and metabolic disorders |
US20090286829A1 (en) | 2008-05-13 | 2009-11-19 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
WO2010068296A1 (en) | 2008-12-11 | 2010-06-17 | Stiefel Laboratories, Inc. | Piperazine carboxamidines as antimicrobial agents |
WO2010127208A1 (en) | 2009-04-30 | 2010-11-04 | Forest Laboratories Holdings Limited | Inhibitors of acetyl-coa carboxylase |
CN101899011B (zh) | 2009-05-26 | 2013-01-16 | 北京大学 | 氨基二硫代甲酸酯类化合物、其制备方法和应用 |
TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
EA201270013A1 (ru) | 2009-06-25 | 2012-06-29 | Амген Инк. | Гетероциклические соединения и их применение |
IN2012DN01453A (ru) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
EP2368886A1 (en) | 2010-03-01 | 2011-09-28 | Phenex Pharmaceuticals AG | Novel compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR gamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune desease |
WO2011112264A1 (en) | 2010-03-11 | 2011-09-15 | New York University | Compounds as rorϒt modulators and uses thereof |
EP2558067A4 (en) | 2010-04-15 | 2016-05-25 | Chromocell Corp | COMPOUNDS, COMPOSITIONS, AND METHODS OF REDUCING OR ELIMINATING AMERTUME |
AU2011326071A1 (en) * | 2010-11-08 | 2013-05-23 | Lycera Corporation | N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of RORy activity and the treatment of diseases |
WO2012116137A2 (en) | 2011-02-24 | 2012-08-30 | Emory University | Jab1 blocking compositions for ossification and methods related thereto |
SG194526A1 (en) | 2011-04-28 | 2013-12-30 | Japan Tobacco Inc | Amide compound and pharmaceutical application therefor |
WO2012158784A2 (en) | 2011-05-16 | 2012-11-22 | Theodore Mark Kamenecka | Modulators of the nuclear hormone receptor ror |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
EP2800745B1 (en) | 2011-12-02 | 2020-02-12 | Phenex Pharmaceuticals AG | Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
-
2013
- 2013-10-15 CN CN201380065774.6A patent/CN105073729A/zh active Pending
- 2013-10-15 EP EP13818857.8A patent/EP2909193B1/en active Active
- 2013-10-15 KR KR1020157012866A patent/KR20150070350A/ko not_active Application Discontinuation
- 2013-10-15 MX MX2015004784A patent/MX2015004784A/es unknown
- 2013-10-15 JP JP2015537770A patent/JP6251277B2/ja not_active Expired - Fee Related
- 2013-10-15 EA EA201590750A patent/EA201590750A1/ru unknown
- 2013-10-15 SG SG11201502935VA patent/SG11201502935VA/en unknown
- 2013-10-15 ES ES13818857T patent/ES2628365T3/es active Active
- 2013-10-15 US US14/053,707 patent/US9309222B2/en active Active
- 2013-10-15 WO PCT/US2013/065026 patent/WO2014062667A1/en active Application Filing
- 2013-10-15 PE PE2015000492A patent/PE20151203A1/es not_active Application Discontinuation
- 2013-10-15 AU AU2013331505A patent/AU2013331505A1/en not_active Abandoned
- 2013-10-15 CA CA2888485A patent/CA2888485C/en active Active
-
2015
- 2015-04-02 IL IL238122A patent/IL238122A0/en unknown
- 2015-04-08 PH PH12015500776A patent/PH12015500776A1/en unknown
- 2015-04-13 CR CR20150192A patent/CR20150192A/es unknown
- 2015-04-15 GT GT201500092A patent/GT201500092A/es unknown
- 2015-04-15 CO CO15084078A patent/CO7350658A2/es unknown
- 2015-04-15 CL CL2015000946A patent/CL2015000946A1/es unknown
- 2015-04-16 EC ECIEPI201515155A patent/ECSP15015155A/es unknown
-
2016
- 2016-02-18 HK HK16101837.7A patent/HK1213887A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2909193B1 (en) | 2017-04-19 |
MX2015004784A (es) | 2015-08-14 |
US20140107097A1 (en) | 2014-04-17 |
PH12015500776A1 (en) | 2015-06-22 |
CO7350658A2 (es) | 2015-08-10 |
CN105073729A (zh) | 2015-11-18 |
CA2888485C (en) | 2021-01-26 |
SG11201502935VA (en) | 2015-09-29 |
JP2015536321A (ja) | 2015-12-21 |
CL2015000946A1 (es) | 2015-10-02 |
ES2628365T3 (es) | 2017-08-02 |
EP2909193A1 (en) | 2015-08-26 |
KR20150070350A (ko) | 2015-06-24 |
AU2013331505A1 (en) | 2015-04-30 |
GT201500092A (es) | 2015-12-31 |
CR20150192A (es) | 2015-05-18 |
HK1213887A1 (zh) | 2016-07-15 |
WO2014062667A1 (en) | 2014-04-24 |
PE20151203A1 (es) | 2015-08-31 |
CA2888485A1 (en) | 2014-04-24 |
ECSP15015155A (es) | 2016-01-29 |
IL238122A0 (en) | 2015-05-31 |
US9309222B2 (en) | 2016-04-12 |
JP6251277B2 (ja) | 2017-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201590750A1 (ru) | СВЯЗАННЫЕ С ФЕНИЛОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγT | |
EA201590736A1 (ru) | СВЯЗАННЫЕ С МЕТИЛЕНОМ ХИНОЛИНИЛОВЫЕ МОДУЛЯТОРЫ RORγt | |
EA201891562A2 (ru) | ТРИФТОРМЕТИЛОВЫЕ СПИРТЫ КАК МОДУЛЯТОРЫ RORγt | |
PH12019501321A1 (en) | Methods of treating or preventing cholesterol related disorders | |
EA201892438A1 (ru) | 6-АМИНОПИРИДИН-3-ИЛТИАЗОЛЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγt | |
UA113543C2 (xx) | Сполуки та композиції для модулювання egfr активності | |
EA201591746A1 (ru) | Способы и композиции для ингибирования бромодомен-содержащих белков | |
EA201490407A1 (ru) | Содержащие гидразид модуляторы нуклеарного транспорта и их применения | |
EA201391615A1 (ru) | Дейтерированные потенциаторы cftr | |
UA110338C2 (en) | Chemical compounds | |
BR112015022197A2 (pt) | tratamento de cataplexia | |
EA201491151A1 (ru) | Соединения, ингибирующие металлоферменты | |
EA201401053A1 (ru) | Новые производные инданилоксидигидробензофуранилуксусной кислоты и их применение в качестве агонистов рецептора gpr40 | |
EA201590951A1 (ru) | Дигидропиразольные модуляторы gpr40 | |
MX2016003263A (es) | Moduladores del factor del complemento b. | |
EA201491857A1 (ru) | АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ α7 НИКОТИНОВОГО ХОЛИНОРЕЦЕПТОРА, ИХ ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ | |
BR112016008258A2 (pt) | moduladores de ror?t de quinolinila | |
EA201590954A1 (ru) | Дигидропиразольные модуляторы gpr40 | |
EA201491610A1 (ru) | Модуляторы x рецепторов печени | |
EA201491970A1 (ru) | Циклические мостиковые простые эфиры в качестве ингибиторов dgat1 | |
EA201300946A1 (ru) | Асимметричные мочевины и их медицинское применение | |
EA201490614A1 (ru) | ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ И НАРУШЕНИЙ, ВЫЗВАННЫХ АКТИВНОСТЬЮ ТРАНСКРИПЦИОННОГО ФАКТОРА NF-kB | |
EA201301090A1 (ru) | Антидоты антикоагулянтов | |
EA201690763A1 (ru) | Лечение рака поджелудочной железы | |
EA201590656A1 (ru) | Азаиндолины |