AU2001235496A1 - Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents - Google Patents

Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents

Info

Publication number
AU2001235496A1
AU2001235496A1 AU2001235496A AU3549601A AU2001235496A1 AU 2001235496 A1 AU2001235496 A1 AU 2001235496A1 AU 2001235496 A AU2001235496 A AU 2001235496A AU 3549601 A AU3549601 A AU 3549601A AU 2001235496 A1 AU2001235496 A1 AU 2001235496A1
Authority
AU
Australia
Prior art keywords
alkylating agents
protein transferase
transferase inhibitor
farnesyl protein
inhibitor combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001235496A
Inventor
Mary Ellen Margaret Rybak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of AU2001235496A1 publication Critical patent/AU2001235496A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AU2001235496A 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents Abandoned AU2001235496A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00200691 2000-02-29
EP00200691 2000-02-29
PCT/EP2001/002168 WO2001064217A2 (en) 2000-02-29 2001-02-26 Combinations of a farnesyl protein transferase inhibitor with nitrogen mustard or nitrosourea alkylating agents

Publications (1)

Publication Number Publication Date
AU2001235496A1 true AU2001235496A1 (en) 2001-09-12

Family

ID=8171110

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001235496A Abandoned AU2001235496A1 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents

Country Status (6)

Country Link
US (1) US20030078281A1 (en)
EP (1) EP1261348A2 (en)
JP (1) JP2003525244A (en)
AU (1) AU2001235496A1 (en)
CA (1) CA2397446A1 (en)
WO (1) WO2001064217A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8619901A1 (en) 2003-12-12 2005-11-25 Wyeth Corp USEFUL KINOLINES IN THE TREATMENT OF CARDIOVASCULAR DISEASES
EP1744751A4 (en) * 2004-03-18 2010-03-10 Brigham & Womens Hospital Methods for the treatment of synucleinopathies
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
JP2007529555A (en) * 2004-03-18 2007-10-25 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド How to treat synucleinopathy
US20050272722A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20050272068A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. UCH-L1 expression and cancer therapy
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
WO2007075923A2 (en) 2005-12-23 2007-07-05 Link Medicine Corporation Treatment of synucleinopathies
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
MX2011005096A (en) * 2008-11-13 2011-11-18 Link Medicine Corp Azaquinolinone derivatives and uses thereof.
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
ES2628365T3 (en) 2012-10-16 2017-08-02 Janssen Pharmaceutica N.V. Phenyl-linked quinolinyl modulators of ROR-GAMA-T
PL2909192T3 (en) 2012-10-16 2017-09-29 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
AU2013331493A1 (en) 2012-10-16 2015-04-09 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORyt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
BR112016008258A2 (en) 2013-10-15 2017-10-10 Janssen Pharmaceutica Nv quinolinyl ror? t modulators
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
AU2014334619A1 (en) 2013-10-15 2016-04-21 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORyt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
IL123568A (en) * 1995-12-08 2001-08-08 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibiting (imidazole-5-yl) methyl-2-quinolinone derivatives, their preparation, pharmaceutical compositions containing them and their preparation, and medicaments comprising them
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
HUP0001122A3 (en) * 1997-04-25 2002-03-28 Janssen Pharmaceutica Nv Farnesyltransferase inhibiting quinazolinones
PT1041985E (en) * 1997-12-22 2006-07-31 Schering Corp COMBINATION OF BENZOCYCLO-HEPTAPIRIDINE COMPOUNDS AND ANTINEOPLASTIC DRUGS TO TREAT PROLIFERATIVE DISEASES
FR2772764B1 (en) * 1997-12-23 2000-01-14 Rhone Poulenc Rorer Sa NOVEL FARNESYLE TRANSFERASE INHIBITORS, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE IN THE PREPARATION OF MEDICAMENTS
EP1087770A4 (en) * 1998-06-15 2001-11-14 Merck & Co Inc Inhibitors of prenyl-protein transferase
EP1091736A4 (en) * 1998-07-02 2001-10-24 Merck & Co Inc Inhibitors of prenyl-protein transferase
SK286072B6 (en) * 1998-12-23 2008-02-05 Janssen Pharmaceutica N. V. 1,2-Annelated quinoline derivatives, method for their preparation, intermediates, pharmaceutical composition and their use

Also Published As

Publication number Publication date
EP1261348A2 (en) 2002-12-04
WO2001064217A3 (en) 2002-03-28
CA2397446A1 (en) 2001-09-07
JP2003525244A (en) 2003-08-26
US20030078281A1 (en) 2003-04-24
WO2001064217A2 (en) 2001-09-07

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