AU2001253197A1 - Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase - Google Patents
Non-imidazole benzodiazepine inhibitors of farnesyl protein transferaseInfo
- Publication number
- AU2001253197A1 AU2001253197A1 AU2001253197A AU5319701A AU2001253197A1 AU 2001253197 A1 AU2001253197 A1 AU 2001253197A1 AU 2001253197 A AU2001253197 A AU 2001253197A AU 5319701 A AU5319701 A AU 5319701A AU 2001253197 A1 AU2001253197 A1 AU 2001253197A1
- Authority
- AU
- Australia
- Prior art keywords
- imidazole
- protein transferase
- farnesyl protein
- benzodiazepine
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title 1
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/556,740 US6458783B1 (en) | 1997-09-29 | 2000-04-21 | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase |
| US09556740 | 2000-04-21 | ||
| PCT/US2001/011209 WO2001081322A1 (en) | 2000-04-21 | 2001-04-06 | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001253197A1 true AU2001253197A1 (en) | 2001-11-07 |
Family
ID=24222653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001253197A Abandoned AU2001253197A1 (en) | 2000-04-21 | 2001-04-06 | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US6458783B1 (en) |
| AU (1) | AU2001253197A1 (en) |
| WO (1) | WO2001081322A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6949642B2 (en) * | 2001-04-19 | 2005-09-27 | Bristol-Myers Squibb Co. | Production of tertiary amines by reductive amination |
| EP1443936A4 (en) * | 2001-11-13 | 2006-01-11 | Bristol Myers Squibb Co | Process for the preparation of 3,7-disubstituted-2,3,4,5- tetrahydro-1h-1,4-benzodiazepine compounds |
| EP1534862A4 (en) * | 2002-08-07 | 2007-10-10 | Exelixis Inc | Modulators of rabggt and methods of use thereof |
| JP4691041B2 (en) | 2003-11-20 | 2011-06-01 | チルドレンズ ホスピタル メディカル センター | GTPase inhibitors and methods of use |
| NZ563003A (en) * | 2005-04-27 | 2011-03-31 | Univ Florida | Use of a farnesyl transferase inhibitor to enhance autophagic protein degradation in protein conformation disorders |
| EP1920048A4 (en) | 2005-07-29 | 2009-12-09 | Childrens Hosp Medical Center | GTPASE INHIBITORS AND METHODS OF USE AND CRYSTALLINE STRUCTURE OF GTPASE RAC-1 |
| AU2008251557B2 (en) * | 2007-05-10 | 2012-12-06 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| CN101270093B (en) * | 2008-04-28 | 2010-06-16 | 大连凯飞精细化工有限公司 | A method for synthesizing 2,3,4, 5-tetrahydro-1H-1, 4-benzodiazepine |
| US8343996B2 (en) | 2008-11-13 | 2013-01-01 | Astrazeneca Ab | Azaquinolinone derivatives and uses thereof |
| WO2012111002A2 (en) | 2011-02-14 | 2012-08-23 | Hoter-Ishay Idit | Rescue battery |
| KR102101478B1 (en) * | 2011-08-10 | 2020-04-16 | 란케나우 인스티튜트 포 메디칼 리서치 | Methods and compositions for the treatment of autoimmune and inflammatory diseases |
| WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| US9580394B2 (en) * | 2014-03-07 | 2017-02-28 | Atomic Energy Council—Institute of Nuclear Energy Research | Benzodiazepine derivative and method of producing the same |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| EP4013402B1 (en) | 2019-08-16 | 2024-11-06 | Children's Hospital Medical Center | Cdc-42 inhibitors for use in the treatment of age-related depression, sarcopenia or frailty |
| WO2024158698A1 (en) * | 2023-01-23 | 2024-08-02 | Lucy Therapeutics, Inc. | Novel f-atpase hydrolase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274194A (en) * | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
| JPH09500615A (en) | 1993-05-14 | 1997-01-21 | ジェネンテク，インコーポレイテッド | Ras-farnesyl transferase inhibitor |
| US5753650A (en) | 1994-05-20 | 1998-05-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| AU735366B2 (en) | 1997-09-29 | 2001-07-05 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| BR9907746A (en) | 1998-01-27 | 2000-10-17 | American Cyanamid Co | 2,3,4,5-tetrahydro-1h [1,4] -benzodiazepine-3-hydroxamic acids as metalloproteinase matrix inhibitors |
| US6071903A (en) * | 1998-01-27 | 2000-06-06 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids |
-
2000
- 2000-04-21 US US09/556,740 patent/US6458783B1/en not_active Expired - Fee Related
-
2001
- 2001-04-06 AU AU2001253197A patent/AU2001253197A1/en not_active Abandoned
- 2001-04-06 WO PCT/US2001/011209 patent/WO2001081322A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US6458783B1 (en) | 2002-10-01 |
| WO2001081322A1 (en) | 2001-11-01 |
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