AU2001240658A1 - Farnesyl protein transferase inhibitor combinations with camptothecin compounds - Google Patents

Farnesyl protein transferase inhibitor combinations with camptothecin compounds

Info

Publication number
AU2001240658A1
AU2001240658A1 AU2001240658A AU4065801A AU2001240658A1 AU 2001240658 A1 AU2001240658 A1 AU 2001240658A1 AU 2001240658 A AU2001240658 A AU 2001240658A AU 4065801 A AU4065801 A AU 4065801A AU 2001240658 A1 AU2001240658 A1 AU 2001240658A1
Authority
AU
Australia
Prior art keywords
protein transferase
transferase inhibitor
farnesyl protein
camptothecin compounds
inhibitor combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001240658A
Inventor
Ivan David Horak
Peter Albert Palmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of AU2001240658A1 publication Critical patent/AU2001240658A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001240658A 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with camptothecin compounds Abandoned AU2001240658A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00200688 2000-02-29
EP00200688 2000-02-29
PCT/EP2001/002161 WO2001064194A2 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with camptothecin compounds

Publications (1)

Publication Number Publication Date
AU2001240658A1 true AU2001240658A1 (en) 2001-09-12

Family

ID=8171107

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001240658A Abandoned AU2001240658A1 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with camptothecin compounds

Country Status (6)

Country Link
US (1) US20030100553A1 (en)
EP (1) EP1261341A2 (en)
JP (1) JP2003525234A (en)
AU (1) AU2001240658A1 (en)
CA (1) CA2397240A1 (en)
WO (1) WO2001064194A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060106060A1 (en) * 2004-03-18 2006-05-18 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies (Lansbury)
EP1744751A4 (en) * 2004-03-18 2010-03-10 Brigham & Womens Hospital Methods for the treatment of synucleinopathies
US20050272722A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
US20050288298A1 (en) * 2004-03-18 2005-12-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20050272068A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. UCH-L1 expression and cancer therapy
AU2005244768B2 (en) 2004-04-27 2011-06-09 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
ATE540698T1 (en) 2005-07-14 2012-01-15 Wellstat Biologics Corp CANCER TREATMENT WITH VIRUSES, FLUOROPYRIMIDINES AND CAMPTOTHECINES
CA2634598A1 (en) 2005-12-23 2007-07-05 Link Medicine Corporation Treatment of synucleinopathies
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
CA2743717A1 (en) * 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
WO2014062655A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
CA2888210C (en) 2012-10-16 2021-02-09 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
AU2013331505A1 (en) 2012-10-16 2015-04-30 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ROR-gamma-t
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
EP3057422B1 (en) 2013-10-15 2019-05-15 Janssen Pharmaceutica NV Quinolinyl modulators of ror(gamma)t
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
JP6423423B2 (en) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Rorγt alkyl-linked quinolinyl modulator
CN108135917B (en) 2015-09-25 2021-07-09 Zy医疗 Pharmaceutical formulations based on particles comprising polysaccharide-vitamin conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
DE69620445T2 (en) * 1995-12-08 2002-12-12 Janssen Pharmaceutica N.V., Beerse (IMIDAZOL-5-YL) METHYL-2-CHINOLINO DERIVATIVES AS A FARNESYL PROTEIN TRANSFERASE INHIBITOR
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
EP0977750B1 (en) * 1997-04-25 2007-07-04 Janssen Pharmaceutica N.V. Farnesyltransferase inhibiting quinazolinones
EP1087770A4 (en) * 1998-06-15 2001-11-14 Merck & Co Inc Inhibitors of prenyl-protein transferase
CA2336054A1 (en) * 1998-07-02 2000-01-13 Merck And Co., Inc. Inhibitors of prenyl-protein transferase
FR2787327B1 (en) * 1998-12-21 2003-01-17 Aventis Pharma Sa COMPOSITIONS CONTAINING FARNESYL TRANSFERASE INHIBITORS
TW531533B (en) * 1998-12-23 2003-05-11 Janssen Pharmaceutica Nv 1,2-annelated quinoline derivatives having farnesyl transferase and geranylgeranyl transferase inhibiting activity

Also Published As

Publication number Publication date
EP1261341A2 (en) 2002-12-04
JP2003525234A (en) 2003-08-26
CA2397240A1 (en) 2001-09-07
WO2001064194A2 (en) 2001-09-07
WO2001064194A3 (en) 2002-03-07
US20030100553A1 (en) 2003-05-29

Similar Documents

Publication Publication Date Title
AU2001240658A1 (en) Farnesyl protein transferase inhibitor combinations with camptothecin compounds
AU2001246477A1 (en) Farnesyl protein transferase inhibitor combinations with platinum compounds
AU2001254672A1 (en) Farnesyl protein transferase inhibitor combinations with an her2 antibody
AU2001258771A1 (en) -secretase inhibitors
AU2001234484A1 (en) Amide compounds for inhibiting protein kinases
AU2001235496A1 (en) Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents
AU2001232799A1 (en) Protein c derivatives
AU2001244166A1 (en) Farnesyl protein transferase inhibitor combinations with further anti-cancer agents
AU2001239275A1 (en) Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
AU2001246478A1 (en) Farnesyl protein transferase inhibitor combinations with taxane compounds
AU2001252147A1 (en) Farnesyl protein transferase inhibitor combinations
AU2001230336A1 (en) Fixture
AU2001293835A1 (en) Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
AU2001247882A1 (en) Tricyclic protein kinase inhibitors
AU2001256166A1 (en) Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
HK1036279A1 (en) Farnesyl protein transferase inhibitors.
AU2001253197A1 (en) Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
AU8845101A (en) Tricyclic antitumor compounds being farnesyl protein transferase inhibitors
AU2001244167A1 (en) Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
AU4020897A (en) 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
AU2001242434A1 (en) Farnesyl protein transferase inhibitor combinations with vinca alkaloids
AU2001272651A1 (en) Valves
AU3724701A (en) Family 5 xyloglucanases
AU2435199A (en) Farnesyl transferase inhibitors
PL348293A1 (en) Tricyclic farnesyl protein transferase inhibitors