BR9907746A - 2,3,4,5-tetrahydro-1h [1,4] -benzodiazepine-3-hydroxamic acids as metalloproteinase matrix inhibitors - Google Patents
2,3,4,5-tetrahydro-1h [1,4] -benzodiazepine-3-hydroxamic acids as metalloproteinase matrix inhibitorsInfo
- Publication number
- BR9907746A BR9907746A BR9907746-9A BR9907746A BR9907746A BR 9907746 A BR9907746 A BR 9907746A BR 9907746 A BR9907746 A BR 9907746A BR 9907746 A BR9907746 A BR 9907746A
- Authority
- BR
- Brazil
- Prior art keywords
- benzodiazepine
- tetrahydro
- hydroxamic acids
- matrix inhibitors
- metalloproteinase matrix
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Patente de Invenção:<B>"áCIDOS 2,3,4,5-TETRAIDRO-1H[1,4]-BENZODIAZEPINA -3-HIDROXâMICOS COMO INIBIDORES DE MATRIZ DE METALOPROTEINASE"<D>. São fornecidos compostos tendo a fórmula (I), em que R, R~ 1~, R~ 2~, R~ 3~ e R~ 4~ são conforme definido na especificação, os quais têm atividade inibidora de matriz de metaloproteinase.Invention Patent: <B> "2,3,4,5-TETRAHYDRO-1H ACIDS [1,4] -BENZODIAZEPINE -3-HYDROXAMICS AS METHALOPROTEINASE MATRIX INHIBITORS" <D>. Compounds having the formula (I) are provided, wherein R, R ~ 1 ~, R ~ 2 ~, R ~ 3 ~ and R ~ 4 ~ are as defined in the specification, which have metalloproteinase matrix inhibitory activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1437498A | 1998-01-27 | 1998-01-27 | |
PCT/US1999/001325 WO1999037625A1 (en) | 1998-01-27 | 1999-01-22 | 2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9907746A true BR9907746A (en) | 2000-10-17 |
Family
ID=21765097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9907746-9A BR9907746A (en) | 1998-01-27 | 1999-01-22 | 2,3,4,5-tetrahydro-1h [1,4] -benzodiazepine-3-hydroxamic acids as metalloproteinase matrix inhibitors |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1051407A1 (en) |
JP (1) | JP2002501056A (en) |
KR (1) | KR20010034406A (en) |
CN (1) | CN1293663A (en) |
AR (1) | AR017230A1 (en) |
AU (1) | AU2240299A (en) |
BR (1) | BR9907746A (en) |
CA (1) | CA2317546A1 (en) |
HU (1) | HUP0100277A3 (en) |
IL (1) | IL137162A0 (en) |
NO (1) | NO20003828L (en) |
PL (1) | PL342045A1 (en) |
WO (1) | WO1999037625A1 (en) |
ZA (1) | ZA99569B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458783B1 (en) * | 1997-09-29 | 2002-10-01 | Bristol-Myers Squibb Company | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase |
US6544984B1 (en) | 1999-01-27 | 2003-04-08 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids |
AR022423A1 (en) * | 1999-01-27 | 2002-09-04 | American Cyanamid Co | COMPOUNDS DERIVED FROM ACIDS 2,3,4,5-TETRAHIDRO-1H- [1,4] BENZODIAZEPINA-3-HYDROXAMICS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
JP4212470B2 (en) | 2001-06-26 | 2009-01-21 | アムジェン フレモント インク. | Antibody to OPGL |
EP2121088B1 (en) | 2007-03-09 | 2016-07-13 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
FR2950056B1 (en) | 2009-09-17 | 2011-08-26 | Galderma Res & Dev | NOVEL BENZENE CARBOXYLAMIDE COMPOUNDS, PROCESS FOR THEIR SYNTHESIS AND THEIR USE IN MEDICINE AND COSMETICS |
FR2950057B1 (en) | 2009-09-17 | 2011-08-26 | Galderma Res & Dev | NOVEL BENZENE CARBOXYLAMIDE COMPOUNDS, PROCESS FOR THEIR SYNTHESIS AND THEIR USE IN MEDICINE AND COSMETICS |
CN113194954A (en) | 2018-10-04 | 2021-07-30 | 国家医疗保健研究所 | EGFR inhibitors for the treatment of keratoderma |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0861236T4 (en) * | 1995-11-13 | 2006-12-18 | Sanofi Aventis Deutschland | Cyclic and heterocyclic N-substituted alpha-amino hydroxamic and carboxylic acids |
DK0874830T3 (en) * | 1995-12-08 | 2003-04-22 | Agouron Pharma | Metalloproteinase Inhibitor, Pharmaceutical Preparation Containing It and its Pharmaceutical Use, and a Method for Preparation thereof |
-
1999
- 1999-01-22 CN CN99804237A patent/CN1293663A/en active Pending
- 1999-01-22 AU AU22402/99A patent/AU2240299A/en not_active Abandoned
- 1999-01-22 EP EP99902417A patent/EP1051407A1/en not_active Withdrawn
- 1999-01-22 WO PCT/US1999/001325 patent/WO1999037625A1/en not_active Application Discontinuation
- 1999-01-22 BR BR9907746-9A patent/BR9907746A/en not_active Application Discontinuation
- 1999-01-22 PL PL99342045A patent/PL342045A1/en unknown
- 1999-01-22 KR KR1020007008171A patent/KR20010034406A/en not_active Application Discontinuation
- 1999-01-22 HU HU0100277A patent/HUP0100277A3/en unknown
- 1999-01-22 JP JP2000528549A patent/JP2002501056A/en active Pending
- 1999-01-22 CA CA002317546A patent/CA2317546A1/en not_active Abandoned
- 1999-01-22 IL IL13716299A patent/IL137162A0/en unknown
- 1999-01-26 ZA ZA9900569A patent/ZA99569B/en unknown
- 1999-01-26 AR ARP990100299A patent/AR017230A1/en unknown
-
2000
- 2000-07-26 NO NO20003828A patent/NO20003828L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999037625A1 (en) | 1999-07-29 |
AU2240299A (en) | 1999-08-09 |
EP1051407A1 (en) | 2000-11-15 |
PL342045A1 (en) | 2001-05-21 |
ZA99569B (en) | 2000-07-26 |
NO20003828L (en) | 2000-09-26 |
NO20003828D0 (en) | 2000-07-26 |
CA2317546A1 (en) | 1999-07-29 |
JP2002501056A (en) | 2002-01-15 |
HUP0100277A2 (en) | 2002-02-28 |
CN1293663A (en) | 2001-05-02 |
IL137162A0 (en) | 2001-07-24 |
HUP0100277A3 (en) | 2002-03-28 |
KR20010034406A (en) | 2001-04-25 |
AR017230A1 (en) | 2001-08-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69700384D1 (en) | Telemetry system, in particular for medical purposes | |
NO20002217D0 (en) | Cyclopentane-heptanoic acid, 2-heteroarylalkenyl derivatives as therapeutic agents | |
ID28833A (en) | 3-ARIL-2-HYDROXYOPROPIONATIC ACID DEGREE | |
IS5619A (en) | (4-Arylsulfonylamino) -tetrahydropyran-4-carboxylic acid hydroxamide | |
DK1114032T3 (en) | 4-Amino-substituted-2-substituted-1,2,3,4-tetrahydroquinolines as CETB inhibitors | |
DE69820906D1 (en) | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINAS INHIBITORS | |
MA26782A1 (en) | PYRAZOLOBENZODIAZEPINES AS CDK2 INHIBITORS. | |
MA26812A1 (en) | PYRIMIDINE-2,4,6-TRIONES INHIBITORS OF METALLOPROTEINASES | |
NO20021367L (en) | Indolyl-3-glycosyl acid derivatives having therapeutically valuable properties | |
NO20013675L (en) | 2,3,4,5-tetrahydro-1H- [1,4) benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors | |
BR9907746A (en) | 2,3,4,5-tetrahydro-1h [1,4] -benzodiazepine-3-hydroxamic acids as metalloproteinase matrix inhibitors | |
NO981846D0 (en) | Goggles, especially work goggles | |
BR9713207A (en) | Derivatives of 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepane useful as matrix metalloproteinase inhibitors | |
NO991994L (en) | Substituted 4-biphenyl-4-hydroxy acid derivatives as matrix metalloprotease inhibitors | |
ID28810A (en) | AMIDA-OMEGA ACID N-ARILSULFONILAMINO COMPOUNDS | |
PT1047665E (en) | MATRIX METALOPROTEASE INHIBITORS | |
BR0004161B1 (en) | acid sauce solution. | |
BR9813897A (en) | Biphenyl derivatives as pharmacists | |
BR9902041A (en) | Process of preparation of phenoxyphenylsulfonyl halides. | |
DE29716973U1 (en) | Apron for single use, especially for medical purposes | |
IT1303333B1 (en) | FOOTWEAR FOR FOOTWEAR. | |
BR9803717A (en) | indole-2-carbocyclic acids substituted as glucosyl transferase inhibitors. | |
ES2185042T3 (en) | THROMBIN INHIBITORS. | |
DK1147095T3 (en) | 2,3,4,5-Tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors | |
IT1311300B1 (en) | SHIRT FOR CYLINDER. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |