EP1027042A4 - Inhibitors of farnesyl protein transferase - Google Patents
Inhibitors of farnesyl protein transferaseInfo
- Publication number
- EP1027042A4 EP1027042A4 EP98948279A EP98948279A EP1027042A4 EP 1027042 A4 EP1027042 A4 EP 1027042A4 EP 98948279 A EP98948279 A EP 98948279A EP 98948279 A EP98948279 A EP 98948279A EP 1027042 A4 EP1027042 A4 EP 1027042A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- protein transferase
- farnesyl protein
- farnesyl
- transferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6082397P | 1997-09-29 | 1997-09-29 | |
| US60823P | 1997-09-29 | ||
| PCT/US1998/019315 WO1999018951A1 (en) | 1997-09-29 | 1998-09-16 | Inhibitors of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1027042A1 EP1027042A1 (en) | 2000-08-16 |
| EP1027042A4 true EP1027042A4 (en) | 2004-08-18 |
Family
ID=22031967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98948279A Withdrawn EP1027042A4 (en) | 1997-09-29 | 1998-09-16 | Inhibitors of farnesyl protein transferase |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1027042A4 (en) |
| JP (1) | JP2001519387A (en) |
| AU (1) | AU735366B2 (en) |
| CA (1) | CA2304473A1 (en) |
| WO (1) | WO1999018951A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458783B1 (en) | 1997-09-29 | 2002-10-01 | Bristol-Myers Squibb Company | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase |
| WO2000038618A2 (en) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US20020115696A1 (en) | 1999-06-18 | 2002-08-22 | Yoel Kloog | Treatment of post-angioplasty restenosis and atherosclerosis with ras antagonists |
| JP2003502365A (en) * | 1999-06-18 | 2003-01-21 | サイリオス・コーポレイション | Non-malignant disease treatment with Ras antagonist |
| FR2796943A1 (en) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | BENZOXAZINN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE IN THERAPEUTICS |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
| WO2001060826A2 (en) | 2000-02-17 | 2001-08-23 | Bristol-Myers Squibb Pharma Company | SUCCINOYLAMINO CARBOCYCLES AND HETEROCYCLES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| AU2001253108A1 (en) | 2000-04-03 | 2001-10-15 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta protein production |
| WO2001074783A1 (en) | 2000-04-03 | 2001-10-11 | Dupont Pharmaceuticals Company | Cyclic lactams as inhibitors of a βετα protein production |
| WO2001077086A1 (en) | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| MXPA02000862A (en) | 2000-06-01 | 2003-07-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abgr; PROTEIN PRODUCTION. |
| AU2002359412A1 (en) * | 2001-11-13 | 2003-05-26 | Bristol-Myers Squibb Company | Process for the preparation of 3,7-disubstituted-2,3,4,5- tetrahydro-1h-1,4-benzodiazepine compounds |
| EP1744751A4 (en) * | 2004-03-18 | 2010-03-10 | Brigham & Womens Hospital | Methods for the treatment of synucleinopathies |
| KR20080018874A (en) * | 2005-04-27 | 2008-02-28 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | Materials and methods for enhanced degradation of mutant proteins associated with human disease |
| NZ580801A (en) | 2007-05-10 | 2012-09-28 | Bristol Myers Squibb Co | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| KR102101478B1 (en) | 2011-08-10 | 2020-04-16 | 란케나우 인스티튜트 포 메디칼 리서치 | Methods and compositions for the treatment of autoimmune and inflammatory diseases |
| WO2015074081A1 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Benzopiperazine compositions as bet bromodomain inhibitors |
| CN110627770A (en) | 2013-11-18 | 2019-12-31 | 福马疗法公司 | Tetrahydroquinoline compositions as BET bromodomain inhibitors |
| ES2903079T3 (en) * | 2016-04-18 | 2022-03-31 | Vivoryon Therapeutics N V | Novel alpha and beta meprin inhibitors |
| JOP20190024A1 (en) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | Substituted pyrrolizine compounds and uses thereof |
| EP3759109B1 (en) | 2018-02-26 | 2023-08-30 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds as hbv replication inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
-
1998
- 1998-09-16 CA CA002304473A patent/CA2304473A1/en not_active Abandoned
- 1998-09-16 EP EP98948279A patent/EP1027042A4/en not_active Withdrawn
- 1998-09-16 WO PCT/US1998/019315 patent/WO1999018951A1/en not_active Application Discontinuation
- 1998-09-16 JP JP2000515586A patent/JP2001519387A/en active Pending
- 1998-09-16 AU AU94886/98A patent/AU735366B2/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU9488698A (en) | 1999-05-03 |
| WO1999018951A1 (en) | 1999-04-22 |
| CA2304473A1 (en) | 1999-04-22 |
| AU735366B2 (en) | 2001-07-05 |
| EP1027042A1 (en) | 2000-08-16 |
| JP2001519387A (en) | 2001-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20000427 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20040706 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 35/00 B Ipc: 7C 07D 403/06 B Ipc: 7C 07D 403/12 B Ipc: 7C 07D 401/12 B Ipc: 7C 07D 409/06 B Ipc: 7C 07D 401/06 B Ipc: 7C 07D 243/14 B Ipc: 7C 07D 243/12 B Ipc: 7C 07D 241/36 B Ipc: 7C 07D 239/70 B Ipc: 7C 07D 237/26 B Ipc: 7A 61K 31/55 B Ipc: 7A 61K 31/54 B Ipc: 7A 61K 31/535 B Ipc: 7A 61K 31/53 B Ipc: 7A 61K 31/50 B Ipc: 7A 61K 31/495 B Ipc: 7A 61K 31/33 A |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20060331 |