ECSP15015155A - Moduladores de quinolinilo unidos a fenilo de rorgammat - Google Patents
Moduladores de quinolinilo unidos a fenilo de rorgammatInfo
- Publication number
- ECSP15015155A ECSP15015155A ECIEPI201515155A ECPI201515155A ECSP15015155A EC SP15015155 A ECSP15015155 A EC SP15015155A EC IEPI201515155 A ECIEPI201515155 A EC IEPI201515155A EC PI201515155 A ECPI201515155 A EC PI201515155A EC SP15015155 A ECSP15015155 A EC SP15015155A
- Authority
- EC
- Ecuador
- Prior art keywords
- rorgammat
- phenyl linked
- syndrome
- disorder
- disease
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención comprende compuestos de la Fórmula I (ver anexo) en donde: R1, R2, R3, R4, R5, R6, R7, R8 y R9 son tal como se definieron en la especificación. La invención comprende, además, un método para tratar o mejorar un síndrome, trastorno o enfermedad, caracterizados además porque el síndrome, trastorno o enfermedad es artritis reumatoide o soriasis. La invención comprende, además, un método para modular la actividad de RORyt en un mamífero por medio de la administración de una cantidad terapéuticamente eficaz de por lo menos un compuesto de la reivindicación 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261714433P | 2012-10-16 | 2012-10-16 | |
US201261725537P | 2012-11-13 | 2012-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP15015155A true ECSP15015155A (es) | 2016-01-29 |
Family
ID=49943493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECIEPI201515155A ECSP15015155A (es) | 2012-10-16 | 2015-04-16 | Moduladores de quinolinilo unidos a fenilo de rorgammat |
Country Status (21)
Country | Link |
---|---|
US (1) | US9309222B2 (es) |
EP (1) | EP2909193B1 (es) |
JP (1) | JP6251277B2 (es) |
KR (1) | KR20150070350A (es) |
CN (1) | CN105073729A (es) |
AU (1) | AU2013331505A1 (es) |
CA (1) | CA2888485C (es) |
CL (1) | CL2015000946A1 (es) |
CO (1) | CO7350658A2 (es) |
CR (1) | CR20150192A (es) |
EA (1) | EA201590750A1 (es) |
EC (1) | ECSP15015155A (es) |
ES (1) | ES2628365T3 (es) |
GT (1) | GT201500092A (es) |
HK (1) | HK1213887A1 (es) |
IL (1) | IL238122A0 (es) |
MX (1) | MX2015004784A (es) |
PE (1) | PE20151203A1 (es) |
PH (1) | PH12015500776A1 (es) |
SG (1) | SG11201502935VA (es) |
WO (1) | WO2014062667A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2739621T3 (es) * | 2013-10-15 | 2020-02-03 | Janssen Pharmaceutica Nv | Moduladores de alcohol secundario de ROR Gamma T de tipo quinolinilo |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
KR20160068956A (ko) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | RORyT의 퀴놀리닐 조절제 |
ES2770727T3 (es) * | 2013-10-15 | 2020-07-02 | Janssen Pharmaceutica Nv | Moduladores de quinilonila enlazados a alquilo de ROR(gamma)t |
CA2927152C (en) * | 2013-10-15 | 2021-09-14 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror-gamma-t |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9988374B2 (en) | 2014-08-11 | 2018-06-05 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
JOP20200117A1 (ar) * | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
AU2015374231B2 (en) | 2014-12-31 | 2020-07-23 | Angion Biomedica Corp. | Methods and agents for treating disease |
CN107207500A (zh) | 2015-01-08 | 2017-09-26 | 阿迪维纳斯治疗有限公司 | 双环化合物及其组合物和医药用途 |
WO2016128908A1 (en) | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
TW202220968A (zh) * | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
LT3484865T (lt) | 2016-07-14 | 2022-11-10 | Crinetics Pharmaceuticals, Inc. | Somatostatino moduliatoriai ir jų panaudojimas |
WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
EP3740475B1 (en) | 2018-01-17 | 2022-04-20 | Crinetics Pharmaceuticals, Inc. | Process of making somatostatin modulators |
CN108503581A (zh) * | 2018-04-12 | 2018-09-07 | 苏州康润医药有限公司 | 一种3-溴-6-氟-2-吡啶乙酮的合成方法 |
US11266641B1 (en) | 2020-09-09 | 2022-03-08 | Crinetics Pharmaceuticals, Inc. | Formulations of a somatostatin modulator |
CN117682980B (zh) * | 2024-02-02 | 2024-05-10 | 济南悟通生物科技有限公司 | 一种2-乙酰基四氢吡啶的制备方法 |
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-
2013
- 2013-10-15 ES ES13818857T patent/ES2628365T3/es active Active
- 2013-10-15 CA CA2888485A patent/CA2888485C/en not_active Expired - Fee Related
- 2013-10-15 CN CN201380065774.6A patent/CN105073729A/zh active Pending
- 2013-10-15 MX MX2015004784A patent/MX2015004784A/es unknown
- 2013-10-15 KR KR1020157012866A patent/KR20150070350A/ko not_active Application Discontinuation
- 2013-10-15 WO PCT/US2013/065026 patent/WO2014062667A1/en active Application Filing
- 2013-10-15 US US14/053,707 patent/US9309222B2/en not_active Expired - Fee Related
- 2013-10-15 SG SG11201502935VA patent/SG11201502935VA/en unknown
- 2013-10-15 EP EP13818857.8A patent/EP2909193B1/en active Active
- 2013-10-15 AU AU2013331505A patent/AU2013331505A1/en not_active Abandoned
- 2013-10-15 JP JP2015537770A patent/JP6251277B2/ja not_active Expired - Fee Related
- 2013-10-15 EA EA201590750A patent/EA201590750A1/ru unknown
- 2013-10-15 PE PE2015000492A patent/PE20151203A1/es not_active Application Discontinuation
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2015
- 2015-04-02 IL IL238122A patent/IL238122A0/en unknown
- 2015-04-08 PH PH12015500776A patent/PH12015500776A1/en unknown
- 2015-04-13 CR CR20150192A patent/CR20150192A/es unknown
- 2015-04-15 CL CL2015000946A patent/CL2015000946A1/es unknown
- 2015-04-15 CO CO15084078A patent/CO7350658A2/es unknown
- 2015-04-15 GT GT201500092A patent/GT201500092A/es unknown
- 2015-04-16 EC ECIEPI201515155A patent/ECSP15015155A/es unknown
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Also Published As
Publication number | Publication date |
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AU2013331505A1 (en) | 2015-04-30 |
EA201590750A1 (ru) | 2015-09-30 |
SG11201502935VA (en) | 2015-09-29 |
JP6251277B2 (ja) | 2017-12-20 |
MX2015004784A (es) | 2015-08-14 |
CN105073729A (zh) | 2015-11-18 |
ES2628365T3 (es) | 2017-08-02 |
JP2015536321A (ja) | 2015-12-21 |
WO2014062667A1 (en) | 2014-04-24 |
KR20150070350A (ko) | 2015-06-24 |
CL2015000946A1 (es) | 2015-10-02 |
US9309222B2 (en) | 2016-04-12 |
CR20150192A (es) | 2015-05-18 |
IL238122A0 (en) | 2015-05-31 |
EP2909193A1 (en) | 2015-08-26 |
PH12015500776A1 (en) | 2015-06-22 |
EP2909193B1 (en) | 2017-04-19 |
CA2888485A1 (en) | 2014-04-24 |
US20140107097A1 (en) | 2014-04-17 |
HK1213887A1 (zh) | 2016-07-15 |
GT201500092A (es) | 2015-12-31 |
PE20151203A1 (es) | 2015-08-31 |
CA2888485C (en) | 2021-01-26 |
CO7350658A2 (es) | 2015-08-10 |
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