TR200400342T4 - Farnezil protein transferazı önlemek için kinolin türevleri. - Google Patents

Farnezil protein transferazı önlemek için kinolin türevleri.

Info

Publication number
TR200400342T4
TR200400342T4 TR2004/00342T TR200400342T TR200400342T4 TR 200400342 T4 TR200400342 T4 TR 200400342T4 TR 2004/00342 T TR2004/00342 T TR 2004/00342T TR 200400342 T TR200400342 T TR 200400342T TR 200400342 T4 TR200400342 T4 TR 200400342T4
Authority
TR
Turkey
Prior art keywords
protein transferase
farnezil
compounds
quinoline derivatives
inhibit protein
Prior art date
Application number
TR2004/00342T
Other languages
English (en)
Inventor
Vera Yang Bingwei
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of TR200400342T4 publication Critical patent/TR200400342T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Bulus asagidaki formüle sahip bilesimler, ve bunlarin farmasötik açidan kabul edilebilir tuzlari ve solvatlari ile ilgilidir, burada Y, R1, R2, R3, R4, R5, R6, R7, R8, R9 ve R10 tarifnamede belirtilen anlamlara sahiptir. Bulus ayrica söz konusu bilesimleri içeren farmasötik kompozisyonlar ve söz konusu bilesimlerin memelilerde anormal hücre büyümesini inhibe etmek için kullanimiyla da ilgilidir. Yukaridaki formüle sahip bilesimler farnezil protein transferaz inhibitörleri olarak faaliyet gösterir.
TR2004/00342T 1999-11-30 2000-11-01 Farnezil protein transferazı önlemek için kinolin türevleri. TR200400342T4 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16820799P 1999-11-30 1999-11-30
US17011999P 1999-12-10 1999-12-10

Publications (1)

Publication Number Publication Date
TR200400342T4 true TR200400342T4 (tr) 2004-03-22

Family

ID=26863889

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/00342T TR200400342T4 (tr) 1999-11-30 2000-11-01 Farnezil protein transferazı önlemek için kinolin türevleri.

Country Status (12)

Country Link
US (1) US6596735B1 (tr)
EP (1) EP1106612B1 (tr)
JP (1) JP2001213876A (tr)
AT (1) ATE259365T1 (tr)
BR (1) BR0005633A (tr)
CA (1) CA2327026A1 (tr)
DE (1) DE60008206T2 (tr)
DK (1) DK1106612T3 (tr)
ES (1) ES2212971T3 (tr)
MX (1) MXPA00011856A (tr)
PT (1) PT1106612E (tr)
TR (1) TR200400342T4 (tr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11209350A (ja) * 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬
EP1322635B1 (en) * 2000-09-25 2006-03-22 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
CA2510850A1 (en) 2002-12-19 2004-07-08 Pfizer Inc. 2-(1h-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophthalmic diseases
WO2005051392A1 (en) 2003-11-20 2005-06-09 Children's Hospital Medical Center Gtpase inhibitors and methods of use
WO2005058834A2 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
BRPI0509580A (pt) * 2004-03-30 2007-11-27 Pfizer Prod Inc combinações de inibidores de transdução de sinal
JP2008510792A (ja) * 2004-08-26 2008-04-10 ファイザー・インク タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物
NZ552946A (en) * 2004-08-26 2010-09-30 Pfizer Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
CN101023064B (zh) 2004-08-26 2011-02-16 辉瑞大药厂 作为蛋白激酶抑制剂的对映异构体纯的氨基杂芳基化合物
US20060107555A1 (en) * 2004-11-09 2006-05-25 Curtis Marc D Universal snow plow adapter
WO2007016539A2 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
HUE025608T2 (en) * 2005-09-07 2016-03-29 Amgen Fremont Inc Human monoclonal antibody against activin receptor-like kinase-1 (ALK-1)
WO2007035744A1 (en) 2005-09-20 2007-03-29 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
TW200812615A (en) 2006-03-22 2008-03-16 Hoffmann La Roche Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
PL2056874T3 (pl) 2006-08-21 2013-02-28 Hoffmann La Roche Leczenie nowotworu przeciwciałem przeciw VEGF
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
JP2012518657A (ja) 2009-02-25 2012-08-16 オーエスアイ・ファーマシューティカルズ，エルエルシー 併用抗癌治療
WO2010099137A2 (en) 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
EP2401614A1 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2011093365A1 (ja) * 2010-01-27 2011-08-04 協和発酵キリン株式会社 含窒素複素環化合物
WO2011109584A2 (en) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
CA2783656A1 (en) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
WO2012116040A1 (en) 2011-02-22 2012-08-30 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
EP2702173A1 (en) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
CN105073729A (zh) 2012-10-16 2015-11-18 詹森药业有限公司 RORγt的苯基连接的喹啉基调节剂
AR093017A1 (es) 2012-10-16 2015-05-13 Janssen Pharmaceutica Nv MODULARES DE RORgT DE QUINOLINILO UNIDOS POR METILENO
BR112015008515A2 (pt) 2012-10-16 2017-07-04 Janssen Pharmaceutica Nv moduladores de ror t de quinolinila ligada à heteroarila
AR094403A1 (es) 2013-01-11 2015-07-29 Hoffmann La Roche Terapia de combinación de anticuerpos anti-her3
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
CA2927182A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same
CN108601752A (zh) 2015-12-03 2018-09-28 安吉奥斯医药品有限公司 用于治疗mtap缺失型癌症的mat2a抑制剂
WO2021155006A1 (en) 2020-01-31 2021-08-05 Les Laboratoires Servier Sas Inhibitors of cyclin-dependent kinases and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
PT1162201E (pt) * 1995-12-08 2006-08-31 Janssen Pharmaceutica Nv Derivados de ( imidazol-5-il ) metil-2-quinolinona como inibidores da proteina farnesil transferase
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
CA2290992C (en) * 1997-06-02 2008-02-12 Janssen Pharmaceutica N.V. (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation
KR100674122B1 (ko) * 1998-07-06 2007-01-26 얀센 파마슈티카 엔.브이. 관절증 치료용 파네실 단백질 트랜스퍼라제 억제제
IL144307A0 (en) * 1999-02-11 2002-05-23 Pfizer Prod Inc Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents

Also Published As

Publication number Publication date
CA2327026A1 (en) 2001-05-30
DE60008206D1 (de) 2004-03-18
PT1106612E (pt) 2004-06-30
MXPA00011856A (es) 2002-06-04
EP1106612A1 (en) 2001-06-13
ATE259365T1 (de) 2004-02-15
ES2212971T3 (es) 2004-08-16
US6596735B1 (en) 2003-07-22
DE60008206T2 (de) 2004-12-02
DK1106612T3 (da) 2004-05-17
BR0005633A (pt) 2001-07-17
JP2001213876A (ja) 2001-08-07
EP1106612B1 (en) 2004-02-11

Similar Documents

Publication Publication Date Title
TR200400342T4 (tr) Farnezil protein transferazı önlemek için kinolin türevleri.
ATE242231T1 (de) Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
PT1029853E (pt) Derivados biciclicos heteroaromaticos uteis como agentes anticancerigenos
UY25679A1 (es) Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
BR0008202A (pt) Derivados de quinolin-2-ona substituìdos com heteroarilas úteis como agentes contra o câncer
BG66087B1 (bg) Хинолинонови производни като тирозин киназни инхибитори
BR9916980A (pt) Derivados bicìclicos substituìdos úteis como agentes anticancerìgenos
EP1259487B8 (en) 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors
TW200613306A (en) Imidazotriazines as protein kinase inhibitors
HUP0101146A2 (hu) Foszfolipáz enzim inhibitor hatású indolszármazékok, valamint a vegyületeket tartalmazó gyógyászati készítmények
BR9913138A (pt) Derivados de quinolin-2-ona substituìdos com alquinila úteis como agentes contra o câncer
EA200500174A1 (ru) Новые производные бензимидазола, полезные в качестве антипролиферативных агентов
DE69811329T2 (de) Imidazolidin-4-on Derivate verwendbar als Antikrebsmittel
AU7517400A (en) N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
PT992509E (pt) Novos derivados macrolidos
TW200420545A (en) 1-(4-benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives
HUP0004142A2 (hu) 5-HT1F agonista hatású karboxamidszármazékok és a vegyületeket tartalmazó gyógyászati készítmények
NO20014864L (no) Substituerte 1,4-dihydro-indeno [1,2-C] pyrazoler som inhibitorer av tyrosin kinase
YU49902A (sh) Supstituisani derivati piperazina kao mtp inhibitori
NO983444L (no) Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
DK1340757T3 (da) 1-methylcarbapenemderivater
PT1351954E (pt) Derivados 4-heterociclil-quinolina e quinazolina inibidores da farnesil-transferase
IL149306A0 (en) Benzamidine derivatives and pharmaceutical compositions containing the same
BR9908948A (pt) Composição farmacêutica contendo um inibidor de protease cisteìna para profilaxia e terapia de dano ao tecido cerebral