EA201491286A1 - Способ лечения потери костной массы альвеолярного отростка посредством применения антител к склеростину - Google Patents

Способ лечения потери костной массы альвеолярного отростка посредством применения антител к склеростину

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Publication number
EA201491286A1
EA201491286A1 EA201491286A EA201491286A EA201491286A1 EA 201491286 A1 EA201491286 A1 EA 201491286A1 EA 201491286 A EA201491286 A EA 201491286A EA 201491286 A EA201491286 A EA 201491286A EA 201491286 A1 EA201491286 A1 EA 201491286A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sclerostin
bone loss
antibodies
treating bone
alveolar process
Prior art date
Application number
EA201491286A
Other languages
English (en)
Other versions
EA036740B1 (ru
Inventor
Хуа Чжу Кэ
Минь Лю
Уилльям В. Джаннобайл
Original Assignee
Эмджен Инк.
Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47429046&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491286(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эмджен Инк., Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган filed Critical Эмджен Инк.
Publication of EA201491286A1 publication Critical patent/EA201491286A1/ru
Publication of EA036740B1 publication Critical patent/EA036740B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение предоставляет способ лечения потери костной массы альвеолярного отростка, включающий в себя введение ингибитора склеростина субъекту, нуждающемуся в этом.
EA201491286A 2011-12-28 2012-12-11 Способ увеличения высоты альвеолярного отростка посредством применения антител к склеростину EA036740B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161580964P 2011-12-28 2011-12-28
PCT/US2012/068975 WO2013101451A1 (en) 2011-12-28 2012-12-11 Method of treating alvelor bone loss through the use of anti-sclerostin antibodies

Publications (2)

Publication Number Publication Date
EA201491286A1 true EA201491286A1 (ru) 2014-09-30
EA036740B1 EA036740B1 (ru) 2020-12-15

Family

ID=47429046

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201491286A EA036740B1 (ru) 2011-12-28 2012-12-11 Способ увеличения высоты альвеолярного отростка посредством применения антител к склеростину
EA202091676A EA202091676A1 (ru) 2011-12-28 2012-12-11 Способ лечения потери костной массы альвеолярного отростка посредством применения антител к склеростину

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202091676A EA202091676A1 (ru) 2011-12-28 2012-12-11 Способ лечения потери костной массы альвеолярного отростка посредством применения антител к склеростину

Country Status (20)

Country Link
US (3) US9657090B2 (ru)
EP (2) EP2797953B1 (ru)
JP (3) JP6363954B2 (ru)
KR (3) KR20190120401A (ru)
CN (2) CN104039828B (ru)
AR (1) AR089509A1 (ru)
AU (3) AU2012362898B2 (ru)
BR (1) BR112014016108A2 (ru)
CA (1) CA2858974A1 (ru)
CL (1) CL2014001719A1 (ru)
EA (2) EA036740B1 (ru)
ES (1) ES2813524T3 (ru)
HK (1) HK1198367A1 (ru)
IL (2) IL232942B (ru)
IN (1) IN2014CN04634A (ru)
MX (1) MX354270B (ru)
SG (2) SG11201403718YA (ru)
TW (3) TWI706787B (ru)
WO (1) WO2013101451A1 (ru)
ZA (1) ZA201404610B (ru)

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JP6437914B2 (ja) * 2013-07-19 2018-12-12 株式会社 アクシオン・ジャパン パノラマ画像撮影装置及び同装置で用いる画像診断方法
HUE052528T2 (hu) * 2015-03-13 2021-05-28 Jiangsu Hengrui Medicine Co Anti szklerosztin antitest, antigénkötõ fragmens és annak orvosi használata
WO2018115879A1 (en) 2016-12-21 2018-06-28 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
WO2019154410A1 (zh) * 2018-02-12 2019-08-15 翼高生物科技有限公司 针对骨硬化蛋白的适体及其用途
US20210217170A1 (en) * 2018-10-30 2021-07-15 Diagnocat Inc. System and Method for Classifying a Tooth Condition Based on Landmarked Anthropomorphic Measurements.
IL296545A (en) * 2020-03-26 2022-11-01 Bone Sci Bio Ltd Pharmaceutical preparations containing amphiphilic peptides and methods of using them
KR102472582B1 (ko) * 2020-08-20 2022-11-30 한림대학교 산학협력단 인공관절 마모편에 의한 활막염과 골용해의 진단 및 치료 방법
CN115279787A (zh) * 2020-09-28 2022-11-01 安济盛生物医药技术(广州)有限公司 抗硬骨抑素构建体及其用途

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MX2014007965A (es) 2014-11-25
AU2012362898A1 (en) 2014-07-24
IN2014CN04634A (ru) 2015-09-18
IL259939B (en) 2020-05-31
BR112014016108A2 (pt) 2018-09-11
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AR089509A1 (es) 2014-08-27
WO2013101451A8 (en) 2014-06-26
US9913900B2 (en) 2018-03-13
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AU2012362898B2 (en) 2017-11-09
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