MX364495B - Composición para usarse en el tratamiento de enfermedades oculares relacionadas con ácidos nucleicos. - Google Patents

Composición para usarse en el tratamiento de enfermedades oculares relacionadas con ácidos nucleicos.

Info

Publication number
MX364495B
MX364495B MX2014007103A MX2014007103A MX364495B MX 364495 B MX364495 B MX 364495B MX 2014007103 A MX2014007103 A MX 2014007103A MX 2014007103 A MX2014007103 A MX 2014007103A MX 364495 B MX364495 B MX 364495B
Authority
MX
Mexico
Prior art keywords
composition
nucleic acid
eye disease
related eye
treating nucleic
Prior art date
Application number
MX2014007103A
Other languages
English (en)
Other versions
MX2014007103A (es
Inventor
Jain Sandeep
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of MX2014007103A publication Critical patent/MX2014007103A/es
Publication of MX364495B publication Critical patent/MX364495B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Eyeglasses (AREA)

Abstract

La presente invención se refiere a una composición para usarse en el tratamiento de una enfermedad ocular relacionada con ácido nucleico, en donde la composición comprende una nucleasa y un excipiente, oftálmico; en donde la nucleasa es seleccionada del grupo consistente de Desoxirribonucleasa I (ADNasa I), Desoxirribonucleasa II (ADNasa II) , Desoxirribonucleasa III (ADNasa III), nucleasa micrococal y una ADNasa recombinante; y en donde la enfermedad ocular relacionada con ácido nucleico es seleccionada del grupo que consiste de la enfermedad de ojo seco, queratitis, laminar, queratitis asociada con lente de contacto, endoftalmitis, querotapatía cristalina infecciosa, pénfigo de cicatrización ocular (OCP), queratoconjuntivitis seca (Kcs), síndrome de Sjögren, queratoconjuntivitis seca asocaiada con síndrome de no Sjögren, queratitis seca, síndrome seco, xeroftalmia, trastorno de película lagrimal, producción disminuida de lágrimas, difidencia lagrimal acuosa (ATD), una infección bacteriana ocular y disfunción de la glándula de Meibomio (MGD).
MX2014007103A 2011-12-12 2012-08-20 Composición para usarse en el tratamiento de enfermedades oculares relacionadas con ácidos nucleicos. MX364495B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161569604P 2011-12-12 2011-12-12
US201261600377P 2012-02-17 2012-02-17
PCT/US2012/051562 WO2013089835A1 (en) 2011-12-12 2012-08-20 Composition and method for treating nucleic acid-related eye disease

Publications (2)

Publication Number Publication Date
MX2014007103A MX2014007103A (es) 2015-05-11
MX364495B true MX364495B (es) 2019-04-29

Family

ID=48613071

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007103A MX364495B (es) 2011-12-12 2012-08-20 Composición para usarse en el tratamiento de enfermedades oculares relacionadas con ácidos nucleicos.

Country Status (15)

Country Link
US (3) US9867871B2 (es)
EP (1) EP2790722B1 (es)
JP (1) JP6202400B2 (es)
KR (1) KR101898438B1 (es)
CN (1) CN104220087A (es)
AU (1) AU2012352983B2 (es)
BR (1) BR112014014378A2 (es)
CA (1) CA2858983C (es)
DK (1) DK2790722T3 (es)
ES (1) ES2713519T3 (es)
IL (1) IL232999B (es)
MX (1) MX364495B (es)
RU (1) RU2642609C2 (es)
WO (1) WO2013089835A1 (es)
ZA (1) ZA201404320B (es)

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WO2013169382A1 (en) * 2012-05-07 2013-11-14 DePuy Synthes Products, LLC Methods and devices for treating intervertebral disc disease
US9919034B2 (en) 2014-03-28 2018-03-20 Tamir Biotechnology, Inc. Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V
US10835598B2 (en) 2014-08-18 2020-11-17 Orgenesis Inc. Prophylactic protection against viral infections, particularly HIV
EP3307238A1 (en) * 2015-06-15 2018-04-18 Tamir Biotechnology, Inc. Pharmaceuticals for treatment of viral infections of the eye
EP3351263A1 (en) 2017-01-20 2018-07-25 Universitätsklinikum Hamburg-Eppendorf Pharmaceutical preparation for treating or preventing tissue adhesion
WO2019005222A1 (en) * 2017-06-29 2019-01-03 Advaite LLC. TREATMENT AND DIAGNOSIS OF OCULAR SURFACE DISORDERS
AU2018318313A1 (en) 2017-08-18 2020-03-19 Neutrolis Inc.. Engineered DNase enzymes and use in therapy
WO2019065936A1 (ja) * 2017-09-29 2019-04-04 参天製薬株式会社 涙液中のｍｕｃ５ａｃ量の測定方法
WO2019231853A1 (en) 2018-06-01 2019-12-05 Aurora Tears Technology, Inc. Systems and methods for generating and applying biomimicry tear films
US11253395B2 (en) * 2018-06-01 2022-02-22 Aurora Tears Technology, Inc. Systems and methods for generating and applying biomimicry tear films
US10988746B2 (en) 2018-10-08 2021-04-27 Neutrolis, Inc. Manufacturing and engineering of DNASE enzymes for therapy
KR20210072790A (ko) 2018-10-08 2021-06-17 뉴트롤리스 인코포레이티드 제조 및 치료를 위한 dnase 효소의 엔지니어링
US11058724B2 (en) 2018-10-08 2021-07-13 Neutrolis, Inc. Methods of using DNASE1-like 3 in therapy
US11352613B2 (en) 2019-02-04 2022-06-07 Neutrolis, Inc. Engineered human extracellular DNASE enzymes
RU2740363C1 (ru) * 2020-08-03 2021-01-13 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ оценки эффективности лечения синдрома сухого глаза у больных сахарным диабетом
BE1028712B1 (fr) 2020-10-16 2022-05-18 Onelife S A Composition para-pharmaceutique ou pharmaceutique administrable à un être vivant, de préférence un être humain comprenant au moins une enzyme pour le traitement et/ou la prévention d'infections bactériennes impliquant la formation de biofilm
CN115595315A (zh) * 2021-06-28 2023-01-13 四川大学华西医院（Cn） 核糖核酸酶i在抑制疼痛的药物中的新用途

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Also Published As

Publication number Publication date
US9867871B2 (en) 2018-01-16
EP2790722A4 (en) 2015-09-09
CA2858983A1 (en) 2013-06-20
ZA201404320B (en) 2015-11-25
US11376312B2 (en) 2022-07-05
BR112014014378A2 (pt) 2020-05-19
US10328129B2 (en) 2019-06-25
DK2790722T3 (en) 2019-03-25
JP2015506920A (ja) 2015-03-05
ES2713519T3 (es) 2019-05-22
US20150010524A1 (en) 2015-01-08
IL232999B (en) 2019-03-31
AU2012352983A1 (en) 2014-07-03
JP6202400B2 (ja) 2017-09-27
WO2013089835A1 (en) 2013-06-20
KR20140101857A (ko) 2014-08-20
EP2790722B1 (en) 2018-12-05
CA2858983C (en) 2020-06-09
RU2642609C2 (ru) 2018-01-25
IL232999A0 (en) 2014-07-31
MX2014007103A (es) 2015-05-11
CN104220087A (zh) 2014-12-17
US20190314461A1 (en) 2019-10-17
EP2790722A1 (en) 2014-10-22
AU2012352983B2 (en) 2017-09-21
US20170106057A1 (en) 2017-04-20
KR101898438B1 (ko) 2018-09-14
RU2014128564A (ru) 2016-02-10

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