ES2332916T3 - Composiciones y metodo para el tratamiento de tumores. - Google Patents

Composiciones y metodo para el tratamiento de tumores. Download PDF

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Publication number
ES2332916T3
ES2332916T3 ES05024729T ES05024729T ES2332916T3 ES 2332916 T3 ES2332916 T3 ES 2332916T3 ES 05024729 T ES05024729 T ES 05024729T ES 05024729 T ES05024729 T ES 05024729T ES 2332916 T3 ES2332916 T3 ES 2332916T3
Authority
ES
Spain
Prior art keywords
polypeptides
present
treatment
diagnosis
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05024729T
Other languages
English (en)
Inventor
David Botstein
Audrey Goddard
Austin L Gurney
Victoria Smith
Colin K Watanabe
William I Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2332916T3 publication Critical patent/ES2332916T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Abstract

Polipéptido PRO7422 aislado. (a) que tiene por lo menos un 80% de identidad en la secuencia de aminoácidos con la secuencia de aminoácidos mostrada en la figura 2; (b) que tiene por lo menos un 80% de identidad en la secuencia de aminoácidos con la secuencia de aminoácidos codificada por la secuencia codificante de longitud completa del ADN plasmídico depositado bajo el número de acceso de ATCC PTA-551; (c) que tiene por lo menos un 80% de identidad en la secuencia de aminoácidos con el polipéptido mostrado en la figura 2 que carece de su péptido señal asociado; (d) que tiene por lo menos un 80% de identidad en la secuencia de aminoácidos con el dominio extracelular del polipéptido mostrado en la figura 2, con su péptido señal asociado; o (e) que tiene por lo menos un 80% de identidad en la secuencia de aminoácidos con el dominio extracelular del polipéptido mostrado en la figura 2, que carece de su péptido señal asociado; cuyo polipéptido se sobreexpresa en el cáncer de pulmón.
ES05024729T 1999-06-09 2000-05-15 Composiciones y metodo para el tratamiento de tumores. Expired - Lifetime ES2332916T3 (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US13838599P 1999-06-09 1999-06-09
US14479099P 1999-07-20 1999-07-20
US14684399P 1999-08-03 1999-08-03
US14818899P 1999-08-10 1999-08-10
US14939699P 1999-08-17 1999-08-17
US14932799P 1999-08-17 1999-08-17
US14932099P 1999-08-17 1999-08-17
US15011499P 1999-08-20 1999-08-20
US15173499P 1999-08-31 1999-08-31
US15170099P 1999-08-31 1999-08-31

Publications (1)

Publication Number Publication Date
ES2332916T3 true ES2332916T3 (es) 2010-02-15

Family

ID=27581055

Family Applications (2)

Application Number Title Priority Date Filing Date
ES05024729T Expired - Lifetime ES2332916T3 (es) 1999-06-09 2000-05-15 Composiciones y metodo para el tratamiento de tumores.
ES06001196T Expired - Lifetime ES2331657T3 (es) 1999-06-09 2000-05-15 Metodos para el diagnostico de tumores.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES06001196T Expired - Lifetime ES2331657T3 (es) 1999-06-09 2000-05-15 Metodos para el diagnostico de tumores.

Country Status (8)

Country Link
EP (3) EP1683811B1 (es)
JP (5) JP2003501087A (es)
AT (2) ATE440109T1 (es)
AU (1) AU4851900A (es)
CA (1) CA2371434A1 (es)
DE (2) DE60042799D1 (es)
ES (2) ES2332916T3 (es)
WO (1) WO2000075317A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
PT1133558E (pt) 1998-11-27 2007-01-31 Ucb Sa Composições e métodos para aumentar a mineralização óssea
US6960651B2 (en) 1999-06-29 2005-11-01 Millennium Pharmaceuticals, Inc. TANGO 332 polypeptides
WO2001000638A2 (en) * 1999-06-29 2001-01-04 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having diagnostic, preventive, therapeutic, and other uses
CA2388912A1 (en) * 1999-11-12 2001-05-17 Human Genome Sciences, Inc. 6 human secreted proteins
AU2463401A (en) * 1999-12-29 2001-07-09 Zymogenetics Inc. Novel fgf homolog zfgf10
US20020001825A1 (en) * 2000-03-31 2002-01-03 Nobuyuki Itoh Fibroblast growth factor-like molecules and uses thereof
US20040132021A1 (en) * 2000-06-19 2004-07-08 Wendy Balemans Osteolevin gene polymorphisms
WO2003073991A2 (en) * 2002-03-01 2003-09-12 Celltech R & D, Inc. Methods to increase or decrease bone density
US7799523B2 (en) 2002-04-03 2010-09-21 Celltech R & D, Inc. Association of polymorphisms in the SOST gene region with bone mineral density
CN1835974A (zh) 2003-06-16 2006-09-20 细胞技术研究与发展公司 对硬化素特异的抗体和用于增加骨矿化的方法
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
CN102946903B (zh) 2010-05-14 2014-11-26 安进公司 高浓度抗体制剂
CA2828000A1 (en) 2011-03-01 2012-09-07 Amgen Inc. Bispecific binding agents
CA2830538C (en) 2011-03-25 2020-05-12 Amgen Inc. Anti - sclerostin antibody crystals and formulations thereof
EP2739311B9 (en) 2011-08-04 2018-09-19 Amgen Inc. Method for treating bone gap defects
SG11201403718YA (en) 2011-12-28 2014-07-30 Amgen Inc Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
CN104619342A (zh) 2012-07-05 2015-05-13 Ucb医药有限公司 骨疾病的治疗
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
AU2019243595A1 (en) 2018-03-30 2020-09-17 Amgen Inc. C-terminal antibody variants

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
DE69333202T2 (de) * 1992-06-26 2004-03-18 The Trustees Of Princeton University Verfahren zur erkennung von krebszellen oder ihren vorstadien mittels p90 und p53-antikörper oder p90 und p53-sonden
WO1995026201A1 (en) * 1994-03-28 1995-10-05 La Jolla Cancer Research Foundation Brevican, a glial cell proteoglycan
US5635370A (en) * 1994-04-08 1997-06-03 Yale University DNA encoding BEHAB, a brain hyaluronan-binding protein, and recombinant expression systems for production of BEHAB polypeptides
EP1007663A2 (en) * 1997-01-21 2000-06-14 Human Genome Sciences, Inc. Human proteins
AU9312198A (en) * 1997-09-17 1999-04-05 Genentech Inc. Genes amplified in tumours, antibodies against the proteins encoded thereby, andtheir use in diagnosis and treatment of cancer
DE69839571D1 (de) * 1997-11-25 2008-07-10 Genentech Inc Fibroblasten-wachstumsfaktor-19
EP1049708A4 (en) * 1998-01-23 2002-09-04 Human Genome Sciences Inc METH1 AND METH2 POLYNUCLEOTIDES AND POLYPEPTIDES
WO2001000638A2 (en) * 1999-06-29 2001-01-04 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having diagnostic, preventive, therapeutic, and other uses

Also Published As

Publication number Publication date
EP1683811A2 (en) 2006-07-26
DE60042799D1 (de) 2009-10-01
EP1657256A2 (en) 2006-05-17
EP1185642A2 (en) 2002-03-13
JP4252501B2 (ja) 2009-04-08
ATE440109T1 (de) 2009-09-15
JP4260778B2 (ja) 2009-04-30
ES2331657T3 (es) 2010-01-12
DE60043125D1 (de) 2009-11-19
JP2006006332A (ja) 2006-01-12
EP1683811A3 (en) 2006-10-11
EP1657256B1 (en) 2009-10-07
ATE444971T1 (de) 2009-10-15
EP1683811B1 (en) 2009-08-19
EP1657256A3 (en) 2006-08-09
JP2005027667A (ja) 2005-02-03
WO2000075317A3 (en) 2001-02-08
JP2006006331A (ja) 2006-01-12
AU4851900A (en) 2000-12-28
CA2371434A1 (en) 2000-12-14
JP2006006330A (ja) 2006-01-12
WO2000075317A2 (en) 2000-12-14
JP2003501087A (ja) 2003-01-14

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