ATE397063T1 - Fibroblasten-wachstumsfaktor-19 - Google Patents
Fibroblasten-wachstumsfaktor-19Info
- Publication number
- ATE397063T1 ATE397063T1 AT98961795T AT98961795T ATE397063T1 AT E397063 T1 ATE397063 T1 AT E397063T1 AT 98961795 T AT98961795 T AT 98961795T AT 98961795 T AT98961795 T AT 98961795T AT E397063 T1 ATE397063 T1 AT E397063T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptides
- present
- methods
- treatment
- diagnosis
- Prior art date
Links
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 title 1
- 101710153349 Fibroblast growth factor 19 Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 230000004544 DNA amplification Effects 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000008267 autocrine signaling Effects 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6684097P | 1997-11-25 | 1997-11-25 | |
| US15834298A | 1998-09-21 | 1998-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397063T1 true ATE397063T1 (de) | 2008-06-15 |
Family
ID=26747212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98961795T ATE397063T1 (de) | 1997-11-25 | 1998-11-25 | Fibroblasten-wachstumsfaktor-19 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1032668B1 (de) |
| JP (1) | JP3653469B2 (de) |
| KR (2) | KR100506786B1 (de) |
| AT (1) | ATE397063T1 (de) |
| AU (1) | AU733222B2 (de) |
| CA (1) | CA2309783C (de) |
| DE (1) | DE69839571D1 (de) |
| DK (1) | DK1032668T3 (de) |
| IL (2) | IL136055A0 (de) |
| NZ (1) | NZ504425A (de) |
| WO (1) | WO1999027100A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605441B1 (en) | 1995-06-05 | 2003-08-12 | Human Genome Sciences, Inc. | Antibodies against fibroblast growth factor 11 |
| US6787640B2 (en) | 1995-06-05 | 2004-09-07 | Human Genome Sciences, Inc. | Fibroblast growth factor 14 |
| US20050043234A1 (en) | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| KR100506786B1 (ko) * | 1997-11-25 | 2005-08-08 | 제넨테크, 인크. | 섬유아세포 성장인자-19 |
| AU3900000A (en) * | 1999-03-19 | 2000-10-09 | Chiron Corporation | Human fgf gene and gene expression products |
| ATE444971T1 (de) * | 1999-06-09 | 2009-10-15 | Genentech Inc | Zusammensetzungen und verfahren für die tumor- behandlung |
| US7459540B1 (en) * | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| DK1214409T3 (da) * | 1999-09-08 | 2006-09-04 | Genentech Inc | Fibroblast vækstfaktor-19 (FGF-19) nucleinsyrer og polypeptider samt anvendelsesmetoder til behandling af fedme |
| DE60028054T2 (de) * | 1999-09-08 | 2006-12-21 | Genentech, Inc., South San Francisco | Fibroblasten-wachstumsfaktor-19 (fgf-19) nukleinsäure und polypeptide und verfahren zu deren verwendung für behandlung von fettleibigkeit |
| ES2335386T3 (es) * | 1999-11-18 | 2010-03-26 | Novartis Vaccines And Diagnostics, Inc. | Gen fgf-21 humano y productos de expresion genica. |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| EP1246843A1 (de) * | 2000-01-05 | 2002-10-09 | ZymoGenetics, Inc. | Neues fgf homolog zfgf12 |
| WO2001049849A1 (en) * | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf11 |
| MXPA02007619A (es) * | 2000-02-15 | 2002-12-13 | Amgen Inc | Moleculas de factor 23 de crecimiento de fibroblastos y su uso. |
| EP1947182A1 (de) * | 2000-02-15 | 2008-07-23 | Amgen Inc. | Fibroblastenwachstumsfaktor-23-Moleküle und ihre Verwendung |
| CN1311212A (zh) * | 2000-03-02 | 2001-09-05 | 上海博德基因开发有限公司 | 一种新的多肽——人成纤维细胞生长因子14和编码这种多肽的多核苷酸 |
| EP2316494A1 (de) * | 2000-06-02 | 2011-05-04 | Board Of Regents, The University Of Texas | Ethylenedicysteine (EC)-Neomycin Konjugate und deren Verwendung in Imaging |
| WO2002041911A2 (en) * | 2000-11-22 | 2002-05-30 | Bayer Corporation | Use of fgf-19 for inhibiting angiogenesis |
| FI20011542A (fi) * | 2001-07-13 | 2003-01-14 | Fit Biotech Oyj Plc | Urosognaasigeenin monistuman käyttö |
| KR20050004914A (ko) | 2002-06-07 | 2005-01-12 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
| US20040136970A1 (en) | 2002-10-07 | 2004-07-15 | Ellsworth Jeff L. | Methods for administering FGF18 |
| EP1989230B1 (de) | 2006-02-10 | 2016-06-01 | Genentech, Inc. | Anti-fgf19-antikörper und verfahren damit |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| ES2622107T3 (es) | 2007-08-03 | 2017-07-05 | Genentech, Inc. | Antagonistas anti-FGF19 humanizados y métodos de uso de los mismos |
| WO2009105709A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| EA201990619A1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Fgf21 мутанты и их применение |
| EP2358790B2 (de) | 2008-12-16 | 2016-09-21 | Dow Corning Corporation | Herstellung von siloxanen |
| UY32607A (es) | 2009-05-05 | 2010-12-31 | Amgen Inc | Mutantes de fgf21 y usos del mismo |
| EP2427207B1 (de) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Fgf21-mutanten und ihre verwendungen |
| JP2012530493A (ja) * | 2009-06-17 | 2012-12-06 | アムジエン・インコーポレーテツド | キメラポリペプチドおよびその使用 |
| JP6016636B2 (ja) * | 2009-10-15 | 2016-10-26 | ジェネンテック， インコーポレイテッド | 改変したレセプター特異性を持つキメラ線維芽細胞増殖因子 |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| TWI670283B (zh) | 2013-12-23 | 2019-09-01 | 美商建南德克公司 | 抗體及使用方法 |
| EP3108893A1 (de) * | 2015-06-25 | 2016-12-28 | Universite Claude Bernard - Lyon 1 | Neuartige therapeutische verwendung von fgf19 |
| KR102315601B1 (ko) | 2020-05-13 | 2021-10-21 | 전남대학교산학협력단 | 재조합 벡터 및 이를 이용한 재조합 섬유아세포 성장인자 19의 제조 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015666A2 (en) * | 1998-09-10 | 2000-03-23 | Genentech, Inc. | Compositions and methods for the treatment of tumors |
| AU9312198A (en) * | 1997-09-17 | 1999-04-05 | Genentech Inc. | Genes amplified in tumours, antibodies against the proteins encoded thereby, andtheir use in diagnosis and treatment of cancer |
| NZ503343A (en) * | 1997-09-17 | 2002-09-27 | Genentech Inc | Secreted and transmembrane polypeptides and use to induce apoptosis of tumour cells |
| KR100506786B1 (ko) * | 1997-11-25 | 2005-08-08 | 제넨테크, 인크. | 섬유아세포 성장인자-19 |
| CA2343577A1 (en) * | 1998-09-16 | 2000-03-23 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
-
1998
- 1998-11-25 KR KR10-2000-7005645A patent/KR100506786B1/ko not_active IP Right Cessation
- 1998-11-25 DE DE69839571T patent/DE69839571D1/de not_active Expired - Lifetime
- 1998-11-25 IL IL13605598A patent/IL136055A0/xx not_active IP Right Cessation
- 1998-11-25 AU AU17033/99A patent/AU733222B2/en not_active Expired
- 1998-11-25 AT AT98961795T patent/ATE397063T1/de not_active IP Right Cessation
- 1998-11-25 NZ NZ504425A patent/NZ504425A/en not_active IP Right Cessation
- 1998-11-25 JP JP2000522242A patent/JP3653469B2/ja not_active Expired - Lifetime
- 1998-11-25 KR KR10-2004-7021388A patent/KR20050009764A/ko not_active Application Discontinuation
- 1998-11-25 CA CA2309783A patent/CA2309783C/en not_active Expired - Lifetime
- 1998-11-25 DK DK98961795T patent/DK1032668T3/da active
- 1998-11-25 WO PCT/US1998/025190 patent/WO1999027100A1/en active Application Filing
- 1998-11-25 EP EP98961795A patent/EP1032668B1/de not_active Expired - Lifetime
-
2008
- 2008-08-11 IL IL193366A patent/IL193366A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1032668T3 (da) | 2008-09-29 |
| AU1703399A (en) | 1999-06-15 |
| KR20010032405A (ko) | 2001-04-16 |
| JP2002503446A (ja) | 2002-02-05 |
| NZ504425A (en) | 2001-10-26 |
| IL193366A0 (en) | 2009-02-11 |
| EP1032668B1 (de) | 2008-05-28 |
| KR20050009764A (ko) | 2005-01-25 |
| JP3653469B2 (ja) | 2005-05-25 |
| KR100506786B1 (ko) | 2005-08-08 |
| AU733222B2 (en) | 2001-05-10 |
| EP1032668A1 (de) | 2000-09-06 |
| IL136055A0 (en) | 2001-05-20 |
| WO1999027100A9 (en) | 2000-05-11 |
| DE69839571D1 (de) | 2008-07-10 |
| WO1999027100A1 (en) | 1999-06-03 |
| CA2309783C (en) | 2011-06-28 |
| CA2309783A1 (en) | 1999-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |