HUP0104865A2 - Módosított effektor-funkciójú polipeptid-változatok - Google Patents

Módosított effektor-funkciójú polipeptid-változatok

Info

Publication number
HUP0104865A2
HUP0104865A2 HU0104865A HUP0104865A HUP0104865A2 HU P0104865 A2 HUP0104865 A2 HU P0104865A2 HU 0104865 A HU0104865 A HU 0104865A HU P0104865 A HUP0104865 A HU P0104865A HU P0104865 A2 HUP0104865 A2 HU P0104865A2
Authority
HU
Hungary
Prior art keywords
effector function
polypeptide variants
altered effector
region
nucleic acid
Prior art date
Application number
HU0104865A
Other languages
English (en)
Inventor
Leonard G. Presta
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of HUP0104865A2 publication Critical patent/HUP0104865A2/hu
Publication of HUP0104865A3 publication Critical patent/HUP0104865A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Abstract

A tal lm ny t rgy t Fc-régiót tartalmazó polipeptidek képezik, amelyekaz Fc-régiójukban bek"vetkezett egy vagy t"bb aminosav-módosít sk"vetkeztében módosított effektorfunkcióval bírnak. Atal lm ny t rgy tképezi tov bb egy tal lm ny szerint polipeptidet tartalmazókészítmény; egy tal lm ny szerinti polipeptideket kódoló, izol ltnukleinsav; az izol lt nukleinsavat tartalmazó vektor, tov bb avektort tartalmazó gazdasejt. Szintén a tal lm ny t rgy t képezik atal lm ny szerinti polipeptid-v ltozatok elő llít si elj r sai. Ó
HU0104865A 1999-01-15 2000-01-14 Polypeptide variants with altered effector function HUP0104865A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11602399P 1999-01-15 1999-01-15
PCT/US2000/000973 WO2000042072A2 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function

Publications (2)

Publication Number Publication Date
HUP0104865A2 true HUP0104865A2 (hu) 2002-04-29
HUP0104865A3 HUP0104865A3 (en) 2004-07-28

Family

ID=22364785

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1500355A HU230769B1 (hu) 1999-01-15 2000-01-14 Módosított effektor-funkciójú polipeptid-változatok
HU0104865A HUP0104865A3 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU1500355A HU230769B1 (hu) 1999-01-15 2000-01-14 Módosított effektor-funkciójú polipeptid-változatok

Country Status (17)

Country Link
US (4) US20060194290A1 (hu)
EP (4) EP2386574A3 (hu)
JP (4) JP2003512019A (hu)
KR (5) KR20060067983A (hu)
CN (2) CN1237076C (hu)
AU (2) AU778683B2 (hu)
BR (1) BR0008758A (hu)
CA (1) CA2359067C (hu)
ES (1) ES2694002T3 (hu)
HK (1) HK1090066A1 (hu)
HU (2) HU230769B1 (hu)
IL (5) IL144056A0 (hu)
MX (2) MX353234B (hu)
NZ (1) NZ539776A (hu)
PL (3) PL209786B1 (hu)
WO (1) WO2000042072A2 (hu)
ZA (1) ZA200105484B (hu)

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IL223048A (en) 2016-09-29
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IL144056A (en) 2014-04-30
IL223047A0 (en) 2012-12-31
IL222149B (en) 2018-11-29
US20080274105A1 (en) 2008-11-06
JP2016136951A (ja) 2016-08-04
KR20010102976A (ko) 2001-11-17
US7371826B2 (en) 2008-05-13
IL144056A0 (en) 2002-04-21
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US7790858B2 (en) 2010-09-07
BR0008758A (pt) 2001-12-04
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JP6230257B2 (ja) 2017-11-15
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