HUE030269T2 - FC RIIB-specifikus ellenanyagok és eljárások az alkalmazásukra - Google Patents

FC RIIB-specifikus ellenanyagok és eljárások az alkalmazásukra Download PDF

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HUE030269T2
HUE030269T2 HUE07812341A HUE07812341A HUE030269T2 HU E030269 T2 HUE030269 T2 HU E030269T2 HU E07812341 A HUE07812341 A HU E07812341A HU E07812341 A HUE07812341 A HU E07812341A HU E030269 T2 HUE030269 T2 HU E030269T2
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antibody
antibodies
fcyriib
cells
cell
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HUE07812341A
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Leslie S Johnson
Ling Huang
Robyn Gerena
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Macrogenics Inc
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Claims (8)

  1. FÖ RIÍB-specilikus ellenanyagok és öljásások az ÄteiÄite SZA1$ \ DA LMJ K iÉN Y FONT« >K í. Izolált ell&uanyag, vagy annak aokgénAóló imgtnen.se, ahöl a szóban forgó ílltt ellenanyag, vagy a szobán forgó antigén-kötő ifogmens: spciflfcusas kötődik a természetes humán FcyRIIB eforaedluláps Étménjéhez, nagyobb affinitássak Mim amekkorával a szóban forgó ete* anyag vágy apaóbaiyíórió anügétokötö fingmens kötődik a természetes humán FcyRI!B-hez> fe ahol; 3 szóban forgó ellenanyag a 8S53.4 alimtaayag, amelyet a BTA-?b|§ ATOG leiM márnk bibrMóma szívónál termel;; vagy it) a: szóban forgó ellenanyag vagy a szóban forgó egy nehéz lánc variábilis dorném, amelynéfc a szckvœlàia a 4, számú szekvencia-vázlaton: bemutatott áminosav szekvencia, és egy körmyú lánc variábilis doméök amelynek i szekvenciája a 3, számú szekvencia" vázlaton bemutatott amtnosav szekvencia; vagy ii> a szóban forgó eilenanÿag vagy a szóban forgó antiién-kOtö IVagmens íahahnazza a PTA--76IÜ ATCC letéti számú bibridónm sejivonal 8113.4 lilndóma Mén által termeit ellenanyag bat CDU-jég a szóban forgó hat ÖSR szekvenciái az 5--10,: széni: szekvencia-vázlaton bemutatott aminosav szekvenciák; ahol n szóban forgó ellenanyag vagy a szóban forgó ami gén-kötó foagmens tes Feyfottü-nek: ugyanálihoz az epltofphoz kötődik, mint amelyiket a ΡΎΑ-761Θ AXt'C leteti számú Mbridoma seitvonal által ienaelt RBSA4 hibridóma klón ismer leb es verseng a szóban forgó SBS J,i ellenanyaggal a tettnészetes humán FeyEIlB-hcz való kötodlfofo: és ahol a szóban forgó ellenanyag vagy a szobm vuv armgen-foto u gumv* KA disszociációs állandója IfogglfoDkisebbymmi 5x10 M, a iélülei piázthon rezonancia alapján meghatározva,
  2. 2, Az 1, igénypont szerinti ellenanyag, vagy annak aoilgéa-köfo fefufodáfo ahöl a szobán forgó ellenanyag vagy a szóban forgó antigén-kötő Ragmens iptaimazza a PfA-'folO AÍ'CC letéti számó hibridóma sejivonal 8853.4 hibridóma klón által termeit ellenanyag hat öliRyét, a szobán forgó hat CDi. szekvenciái az 5-10. számú; szekvencia-vázlaton benrntatnit aminosav szekvenciák;: ahol a Szóban forgó ellenanyag vagy a szóban forgó: ahli gén-kötö bs|rnéns az bcyRiilá-nek ugyanafo hoz az, épitófoáhöz kótödlk, mint amelyiket a FTÁ-7ÖÍÍ5 ATClC letéti számú hibridóma sedvonal által termeli S15 J.4 hibridóma klón ismer lék ék verseng a szóban forgó SB$,:3,4 ellenanyaggal a. természetes humán FcyEUB-hez való kofodésért, és ahol a szóban forgó ellenanyag vágy a szóban fegd mnlgén-koiö feamtmns Kg rilaiiiőja (¾¾¾}.½¾¾ mMi SACT- hl a felületi plazmon rezonancia alapján meghatározva. % Az 1< íiiinypom mmM áfownpi vagy mmk atiigén-kbtö ftaptense, ahol a MIM forgó ellenanyag a P1A-7610 AICC felét! szátná;Mbrldőma seitvonz! által ittmût 815J.4 ellenanyag. 4. A* I. vagy 2, Igénypont szerinti: éMenanyai; vagy m»k ap$g&amp;>ik#tó Imgmense,: aboi a szóban fmgû élfenanyag egy humán ellenanyag, egy mopökbnálfe ellenanyag, $gy egyláneh ellem anyag, egy bxspeciikas; çhenMyag, vagy a szóban forgó SB5J,4 ellenanyag hűmaplzálrformajá,
  3. 5, Az ;l < Igény pont; szerinti ellenanyag vagy annak: antigénét# hagmease, amely tartz!-egy neMz lánc variábilis doniént, amelynek &amp; széikv^ncláia a 4, számú szekveneia-yazlzton he- nlntatbtt: átmnösav szekveMia, és egy köMfi lábé: variábilis doniÉU, amelynek a székvencláfa a % szekvencia-vázlaton hemtgaiolt mninesav szekvencia. &amp; -M ! - %!'W: 1> Igénypont szerinti ellenanyag: vagy annak antigén-kötő feagmense, amely tartalmaz égy Fe doment, Mtely legalább egy módosítási tartalmaz a nehéz lane Fe öonferphen,
  4. 7, Á Igénypont szerinti ellenanyag, vagy annak amigén-koto tfogmense, ahol az ellenanyag mMz láncának ?c doménié legalább egy aminosav helyettesítési tartalmaz a 240-es, 243-as, 247~es,: 2ÁS-Ís, 270-es, 292-es, öOü-as, 305-ös, 316-os, 37ö-es, 392-es, 396-ös, 416-os, 419-es, vagy 421-és pózíeíöbán, egy másik amirfesavval az adott pozánöhau, g. A ?· igénypont szerinti ellenanyag, ahol az ellenanyag nehéz láncának Fe domlrge loucim tartalma/ a 243-us pozícióban, profod tartalmaz a 292-es pozmióban, lencint tartalmaz a 300-as pazleiéhan, Izpieuelnt tartalmaz a 305-6$ pozícióban, és fedelet tartalmaz a 396-os pozicióban,
  5. 9, Az !.. vagy 2, igénypont szerint! ellenanyag fragmente amely egy Ftabjg vagy egy F(áb) tragmem,
  6. 10, Az A9, Igénypontök: bármelyike szerinti dfenanyag vagy annak autigÉnkÓtő iagtnense, ahol a szobán lorgó ellenanyag vagy a szlhmt forgó antígén-kftő íragmens működés szempontjából egy Ifeforológ polipeptldltez van kápesölva, vagy egy terápiás szerhez van konjugálva. 11. A 19. igénypont szedni ellenanyag vagy annak antlgén-kőtő ífogmense, ahol á terápiás szer: (AVegy eifetianyag, amely immunspeetlikusan kötődik egy, űz FeyliilB-tdi eltérő sejtfelszmi receptorhoz: vagy (1) egy ellenanyag, amely hnmnnspemnkasan kötődik egy íumomoz kapesölödö antigénhez,
  7. 12. Az 1. igénypont szerint! ellenanyag, vagy annak anügén-kötö fragmense, amely csökkenti egy ig-Fe mek az FeyRIlB-hez való kötődését,:
  8. 13, Gyógyászati készihnény, amely tartalmaz (I) egy terápiásán hatásos mennyiséget a/ 1 « 12, igénypontok bármelyike szerinti izolált ellenanyag hol, vagy annak amigérrmötb iragrnensébdi; és (Ili) egy gyégyászatiiag eimgedható hordozót, 14. A 13. Igénypont szerinti gyógyászati készítmény, amely tartalmaz még egy v-vâbbi szert* amelyet a következő csoportból választ hátunk ki; egy kemoterápiás szer, egy besugárzási terápiás szer, egy hormonális terápiás szer, egy knmuuíeráplás szeg egy gyulladáscsökkentő szeg és egy bnmnnmodulátor szer,
HUE07812341A 2006-06-26 2007-06-26 FC RIIB-specifikus ellenanyagok és eljárások az alkalmazásukra HUE030269T2 (hu)

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