AR123997A1 - ANTICUERPOS NEUTRALIZANTES CONTRA EL SARS-CoV-2 - Google Patents

ANTICUERPOS NEUTRALIZANTES CONTRA EL SARS-CoV-2

Info

Publication number
AR123997A1
AR123997A1 ARP210103063A ARP210103063A AR123997A1 AR 123997 A1 AR123997 A1 AR 123997A1 AR P210103063 A ARP210103063 A AR P210103063A AR P210103063 A ARP210103063 A AR P210103063A AR 123997 A1 AR123997 A1 AR 123997A1
Authority
AR
Argentina
Prior art keywords
cov
antibody
sars
antigen
binding fragment
Prior art date
Application number
ARP210103063A
Other languages
English (en)
Inventor
Michel C Nussenzweig
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of AR123997A1 publication Critical patent/AR123997A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona anticuerpos ampliamente neutralizantes contra el SARS-CoV-2, novedosos o el fragmento de unión al antígeno de ellos. Los anticuerpos contra el SARS-CoV-2 divulgados constituyen una estrategia terapéutica novedosa en la protección contra la infección por el SARS-CoV-2. Reivindicación 1: Un anticuerpo anti-SARS-CoV-2 aislado o un fragmento de unión a antígeno del mismo que se une específicamente a un antígeno del SARS-CoV-2. Reivindicación 18: Una composición farmacéutica que comprende el anticuerpo o fragmento de unión a antígeno del mismo de acuerdo con cualquiera de las reivindicaciones precedentes y opcionalmente un portador o excipiente farmacéuticamente aceptable. Reivindicación 24: Una molécula de ácido nucleico que codifica una cadena polipeptídica del anticuerpo o fragmento de unión a antígeno del mismo de acuerdo con cualquiera de las reivindicaciones 1 a 17. Reivindicación 25: Un vector que comprende la molécula de ácido nucleico de la reivindicación 24. Reivindicación 26: Una célula huésped cultivada que comprende el vector de acuerdo con la reivindicación 25. Reivindicación 27: Un método para preparar un anticuerpo, o una porción del mismo que se une a un antígeno, que comprende: obtener la célula huésped cultivada de la reivindicación 26; cultivar la célula huésped cultivada en un medio en condiciones que permitan la expresión de un polipéptido codificado por el vector y ensamblar un anticuerpo o fragmento del mismo; y purificar el anticuerpo o fragmento de la célula cultivada o el medio de la célula. Reivindicación 40: Un método para detectar la presencia de SARS-CoV-2 en una muestra que comprende: poner en contacto una muestra con el anticuerpo o fragmento de unión a antígeno del mismo de acuerdo con cualquiera de las reivindicaciones 1 a 17; y determinar la unión del anticuerpo o el fragmento de unión al antígeno a uno o más antígenos del SARS-CoV-2, en donde la unión del anticuerpo a uno o más antígenos de SARS-CoV-2 es indicativa de la presencia de SARS-CoV-2 en la muestra.
ARP210103063A 2020-11-04 2021-11-04 ANTICUERPOS NEUTRALIZANTES CONTRA EL SARS-CoV-2 AR123997A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063109567P 2020-11-04 2020-11-04

Publications (1)

Publication Number Publication Date
AR123997A1 true AR123997A1 (es) 2023-02-01

Family

ID=78806719

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103063A AR123997A1 (es) 2020-11-04 2021-11-04 ANTICUERPOS NEUTRALIZANTES CONTRA EL SARS-CoV-2

Country Status (6)

Country Link
US (1) US11919945B2 (es)
EP (1) EP4240758A1 (es)
JP (1) JP2023548878A (es)
AR (1) AR123997A1 (es)
TW (1) TW202227481A (es)
WO (1) WO2022098870A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12060411B2 (en) * 2021-01-15 2024-08-13 The Rockefeller University Neutralizing anti-SARS-CoV-2 antibodies
WO2023020474A1 (en) * 2021-08-16 2023-02-23 Utc Therapeutics (Shanghai) Co., Ltd. Bcma targetting antibodies and uses thereof in cancer therapies
WO2024036313A2 (en) * 2022-08-12 2024-02-15 The Rockefeller University Anti-sars-cov-2 antibodies and methods of use thereof
WO2024081269A1 (en) * 2022-10-10 2024-04-18 Dixit Rohan Therapeutic combinations and methods to treat long covid
CN116585484B (zh) * 2022-12-13 2023-12-12 广州医科大学 多肽偶联小分子化合物及其抗病毒应用
CN117586394A (zh) * 2023-03-14 2024-02-23 苏州系统医学研究所 一种结合Dsg3的单克隆抗体及其应用

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Also Published As

Publication number Publication date
US20220195015A1 (en) 2022-06-23
EP4240758A1 (en) 2023-09-13
JP2023548878A (ja) 2023-11-21
TW202227481A (zh) 2022-07-16
US11919945B2 (en) 2024-03-05
WO2022098870A1 (en) 2022-05-12

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