MX2020010028A - Actividad lactogenica modulada en celulas de mamifero. - Google Patents
Actividad lactogenica modulada en celulas de mamifero.Info
- Publication number
- MX2020010028A MX2020010028A MX2020010028A MX2020010028A MX2020010028A MX 2020010028 A MX2020010028 A MX 2020010028A MX 2020010028 A MX2020010028 A MX 2020010028A MX 2020010028 A MX2020010028 A MX 2020010028A MX 2020010028 A MX2020010028 A MX 2020010028A
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- Prior art keywords
- cells
- lactogenic activity
- present disclosure
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/102—Mutagenizing nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/0104—Pyruvate kinase (2.7.1.40)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente divulgación se refiere a métodos, células y composiciones para producir un producto de interés, por ejemplo, una proteína recombinante. En particular, la presente divulgación proporciona células de mamífero que expresan el producto de interés, en donde las células (por ejemplo, células de ovario de hámster chino (CHO)) tienen actividad lactogénica modulada. La presente divulgación también se refiere a métodos y composiciones para modular la expresión de piruvato quinasa de músculo (PKM) (por ejemplo, la expresión de PKM-1) en una célula de mamífero para así reducir o eliminar la actividad lactogénica de la célula, así como composiciones que comprenden una célula que tiene actividad lactogénica reducida o eliminada y métodos de uso de estas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862649963P | 2018-03-29 | 2018-03-29 | |
PCT/US2019/024774 WO2019191552A1 (en) | 2018-03-29 | 2019-03-29 | Modulating lactogenic activity in mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020010028A true MX2020010028A (es) | 2020-10-14 |
Family
ID=66448608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020010028A MX2020010028A (es) | 2018-03-29 | 2019-03-29 | Actividad lactogenica modulada en celulas de mamifero. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20210009988A1 (es) |
EP (1) | EP3775184A1 (es) |
JP (2) | JP2021519073A (es) |
KR (2) | KR20200135510A (es) |
CN (1) | CN111936625A (es) |
AR (1) | AR115318A1 (es) |
AU (1) | AU2019245243A1 (es) |
BR (1) | BR112020019726A2 (es) |
CA (1) | CA3091231A1 (es) |
IL (1) | IL277591A (es) |
MX (1) | MX2020010028A (es) |
SG (1) | SG11202009542PA (es) |
TW (1) | TW202003839A (es) |
WO (1) | WO2019191552A1 (es) |
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LT2748201T (lt) | 2011-08-23 | 2018-02-26 | Roche Glycart Ag | Dvigubai specifinė t ląsteles aktyvinantį antigeną surišanti molekulė |
JP6152120B2 (ja) | 2012-02-15 | 2017-06-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Fc受容体に基づくアフィニティークロマトグラフィー |
CN103152739A (zh) | 2013-02-06 | 2013-06-12 | 北京奇虎科技有限公司 | 一种移动终端通话请求信息处理的方法、装置及系统 |
SG10201800492PA (en) | 2013-04-29 | 2018-03-28 | Hoffmann La Roche | Human fcrn-binding modified antibodies and methods of use |
MX2016006529A (es) | 2013-12-20 | 2016-08-03 | Genentech Inc | Anticuerpos dobles especificos. |
ES2797050T3 (es) * | 2014-03-04 | 2020-12-01 | Sigma Aldrich Co Llc | Células virales resistentes y sus usos |
US9745365B2 (en) | 2014-03-27 | 2017-08-29 | Genentech, Inc. | Anti-influenza B virus hemagglutinin antibodies and methods of use |
HUE046767T2 (hu) | 2014-03-31 | 2020-03-30 | Hoffmann La Roche | Anti-OX40 antitestek és alkalmazási eljárások |
UA117289C2 (uk) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифічне антитіло |
WO2016016299A1 (en) | 2014-07-29 | 2016-02-04 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
DK3177643T3 (da) | 2014-08-04 | 2019-07-15 | Hoffmann La Roche | Bispecifikke T-celle-aktiverende antigenbindende molekyler |
BR112017003236A2 (pt) | 2014-09-12 | 2017-11-28 | Genentech Inc | anticorpos elaborados com cisteína, conjugados de droga e anticorpos, método de preparação de conjugado de droga e anticorpo e composição farmacêutica |
WO2016098356A1 (en) | 2014-12-19 | 2016-06-23 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use |
JP6952605B2 (ja) | 2015-04-24 | 2021-10-20 | ジェネンテック, インコーポレイテッド | 多特異性抗原結合タンパク質 |
CN109536474A (zh) * | 2015-06-18 | 2019-03-29 | 布罗德研究所有限公司 | 降低脱靶效应的crispr酶突变 |
JP6802626B2 (ja) * | 2015-10-15 | 2020-12-16 | シーシーアイホールディングス株式会社 | がん細胞の薬物感受性増強剤、薬物感受性を予測する方法、および薬物感受性バイオマーカー |
RU2768186C2 (ru) * | 2015-12-11 | 2022-03-23 | Рупрехт-Карлс-Университет Гейдельберг | Комбинированные лекарственные средства, содержащие модуляторы pkm2 и hmgb1 |
US11242510B2 (en) * | 2016-05-02 | 2022-02-08 | The Regents Of The University Of California | Mammalian cells devoid of lactate dehydrogenase activity |
-
2019
- 2019-03-29 EP EP19722967.7A patent/EP3775184A1/en active Pending
- 2019-03-29 WO PCT/US2019/024774 patent/WO2019191552A1/en active Application Filing
- 2019-03-29 AR ARP190100834A patent/AR115318A1/es unknown
- 2019-03-29 TW TW108111362A patent/TW202003839A/zh unknown
- 2019-03-29 SG SG11202009542PA patent/SG11202009542PA/en unknown
- 2019-03-29 AU AU2019245243A patent/AU2019245243A1/en not_active Abandoned
- 2019-03-29 KR KR1020207030786A patent/KR20200135510A/ko not_active Application Discontinuation
- 2019-03-29 KR KR1020237009266A patent/KR20230042407A/ko not_active Application Discontinuation
- 2019-03-29 CA CA3091231A patent/CA3091231A1/en active Pending
- 2019-03-29 JP JP2020551556A patent/JP2021519073A/ja not_active Withdrawn
- 2019-03-29 MX MX2020010028A patent/MX2020010028A/es unknown
- 2019-03-29 BR BR112020019726-2A patent/BR112020019726A2/pt not_active Application Discontinuation
- 2019-03-29 CN CN201980023064.4A patent/CN111936625A/zh active Pending
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2020
- 2020-09-24 IL IL277591A patent/IL277591A/en unknown
- 2020-09-29 US US17/036,075 patent/US20210009988A1/en active Pending
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2022
- 2022-12-16 JP JP2022200840A patent/JP2023040016A/ja active Pending
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EP3775184A1 (en) | 2021-02-17 |
CA3091231A1 (en) | 2019-10-03 |
AR115318A1 (es) | 2020-12-23 |
IL277591A (en) | 2020-11-30 |
BR112020019726A2 (pt) | 2021-01-26 |
US20210009988A1 (en) | 2021-01-14 |
SG11202009542PA (en) | 2020-10-29 |
JP2023040016A (ja) | 2023-03-22 |
JP2021519073A (ja) | 2021-08-10 |
AU2019245243A1 (en) | 2020-09-03 |
TW202003839A (zh) | 2020-01-16 |
KR20200135510A (ko) | 2020-12-02 |
WO2019191552A1 (en) | 2019-10-03 |
CN111936625A (zh) | 2020-11-13 |
KR20230042407A (ko) | 2023-03-28 |
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