MX2018013499A - Modulacion del metabolismo lipidico para la produccion de proteinas. - Google Patents
Modulacion del metabolismo lipidico para la produccion de proteinas.Info
- Publication number
- MX2018013499A MX2018013499A MX2018013499A MX2018013499A MX2018013499A MX 2018013499 A MX2018013499 A MX 2018013499A MX 2018013499 A MX2018013499 A MX 2018013499A MX 2018013499 A MX2018013499 A MX 2018013499A MX 2018013499 A MX2018013499 A MX 2018013499A
- Authority
- MX
- Mexico
- Prior art keywords
- lipid metabolism
- modulation
- cells
- protein production
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente descripción presenta métodos y composiciones para modular el metabolismo lipídico para lograr una mejor producción y calidad de productos recombinantes, tales como los productos biológicos de próxima generación. La modulación del metabolismo lipídico tal como se describe en la presente incluye, por ejemplo, la introducción de un modulador del metabolismo lipídico descrito en la presente en una célula o un sistema libre de células. La presente descripción también abarca las células modificadas con una mejor capacidad de producción y una mejor calidad de producto, métodos para la modificación de dichas células, y preparaciones y mezclas que comprenden los productos de dichas células.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330973P | 2016-05-03 | 2016-05-03 | |
| PCT/EP2017/060484 WO2017191165A1 (en) | 2016-05-03 | 2017-05-03 | Modulation of lipid metabolism for protein production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018013499A true MX2018013499A (es) | 2019-09-11 |
Family
ID=58745198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018013499A MX2018013499A (es) | 2016-05-03 | 2017-05-03 | Modulacion del metabolismo lipidico para la produccion de proteinas. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10655111B2 (es) |
| EP (1) | EP3452608B1 (es) |
| JP (1) | JP6959942B2 (es) |
| KR (1) | KR102536221B1 (es) |
| CN (1) | CN109415748A (es) |
| AU (1) | AU2017259010B2 (es) |
| BR (1) | BR112018072434A2 (es) |
| CA (1) | CA3023038C (es) |
| EA (1) | EA201892503A1 (es) |
| ES (1) | ES2938626T3 (es) |
| IL (2) | IL262646B (es) |
| MX (1) | MX2018013499A (es) |
| SG (1) | SG11201809626PA (es) |
| WO (1) | WO2017191165A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017259010B2 (en) * | 2016-05-03 | 2021-04-22 | Lonza Ltd | Modulation of lipid metabolism for protein production |
| WO2020014483A1 (en) * | 2018-07-11 | 2020-01-16 | Cornell University | Supported plant plasma membrane lipid bilayer on-a-chip |
| WO2020084528A1 (en) * | 2018-10-24 | 2020-04-30 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| CN116889627A (zh) | 2019-03-20 | 2023-10-17 | 雷杰纳荣制药公司 | 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 |
| CN110317799A (zh) * | 2019-07-18 | 2019-10-11 | 江南大学 | 一种人源岩藻糖转移酶8的原核表达方法及其产品 |
| JP2023502916A (ja) | 2019-11-14 | 2023-01-26 | ロンザ リミテッド | 細胞の選択方法 |
| CN115029307A (zh) * | 2022-07-28 | 2022-09-09 | 吉林大学 | 一种延缓MSCs衰老的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| DK0985039T3 (da) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Kunstige antistof-polypeptider |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| WO2002095008A2 (en) | 2001-02-02 | 2002-11-28 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
| CA2528418A1 (en) | 2003-06-11 | 2004-12-23 | Biogen Idec Ma Inc. | Method to increase protein production in culture |
| US8211667B2 (en) | 2004-04-16 | 2012-07-03 | Dsm Ip Assets B.V. | Fungal promoter for expressing a gene in a fungal cell |
| US20080182249A1 (en) * | 2006-09-01 | 2008-07-31 | Fox Brian G | Expression systems for mammalian and mycobacterial desaturases |
| US20110281301A1 (en) * | 2007-11-13 | 2011-11-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | The secretory capacity in host cells |
| BR122021003836B1 (pt) * | 2008-11-18 | 2022-02-01 | Commonwealth Scientific And Industrial Research Organisation | Polinucleotídeo isolado e/ou exógeno que não ocorre de forma natural, vetor e método para produzir óleo contendo ácidos graxos insaturados |
| LT2951309T (lt) * | 2013-02-01 | 2019-03-25 | Selexis S.A. | Pagerinti transgeno raiška ir brendimas |
| AU2017259010B2 (en) | 2016-05-03 | 2021-04-22 | Lonza Ltd | Modulation of lipid metabolism for protein production |
-
2017
- 2017-05-03 AU AU2017259010A patent/AU2017259010B2/en active Active
- 2017-05-03 EP EP17724770.7A patent/EP3452608B1/en active Active
- 2017-05-03 IL IL262646A patent/IL262646B/en unknown
- 2017-05-03 WO PCT/EP2017/060484 patent/WO2017191165A1/en active Application Filing
- 2017-05-03 SG SG11201809626PA patent/SG11201809626PA/en unknown
- 2017-05-03 BR BR112018072434-3A patent/BR112018072434A2/pt unknown
- 2017-05-03 CN CN201780039286.6A patent/CN109415748A/zh active Pending
- 2017-05-03 JP JP2018557851A patent/JP6959942B2/ja active Active
- 2017-05-03 CA CA3023038A patent/CA3023038C/en active Active
- 2017-05-03 IL IL294241A patent/IL294241B2/en unknown
- 2017-05-03 EA EA201892503A patent/EA201892503A1/ru unknown
- 2017-05-03 ES ES17724770T patent/ES2938626T3/es active Active
- 2017-05-03 US US15/585,570 patent/US10655111B2/en active Active
- 2017-05-03 MX MX2018013499A patent/MX2018013499A/es unknown
- 2017-05-03 KR KR1020187034453A patent/KR102536221B1/ko active IP Right Grant
-
2020
- 2020-03-13 US US16/818,162 patent/US11434474B2/en active Active
-
2022
- 2022-07-27 US US17/815,465 patent/US20230047838A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3023038C (en) | 2023-03-14 |
| IL262646A (en) | 2018-12-31 |
| CN109415748A (zh) | 2019-03-01 |
| EP3452608B1 (en) | 2022-11-30 |
| ES2938626T3 (es) | 2023-04-13 |
| IL294241B2 (en) | 2023-10-01 |
| WO2017191165A1 (en) | 2017-11-09 |
| US11434474B2 (en) | 2022-09-06 |
| KR102536221B1 (ko) | 2023-05-23 |
| JP6959942B2 (ja) | 2021-11-05 |
| AU2017259010A1 (en) | 2018-11-22 |
| SG11201809626PA (en) | 2018-11-29 |
| AU2017259010B2 (en) | 2021-04-22 |
| US20230047838A1 (en) | 2023-02-16 |
| BR112018072434A2 (pt) | 2019-02-19 |
| EP3452608A1 (en) | 2019-03-13 |
| CA3023038A1 (en) | 2017-11-09 |
| IL294241A (en) | 2022-08-01 |
| US10655111B2 (en) | 2020-05-19 |
| US20170321194A1 (en) | 2017-11-09 |
| KR20190003651A (ko) | 2019-01-09 |
| IL294241B1 (en) | 2023-06-01 |
| US20200231944A1 (en) | 2020-07-23 |
| EA201892503A1 (ru) | 2019-09-30 |
| JP2019514399A (ja) | 2019-06-06 |
| IL262646B (en) | 2022-08-01 |
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