MX2018012376A - Sistemas de replicón de arterivirus recombinantes y usos de estos. - Google Patents

Sistemas de replicón de arterivirus recombinantes y usos de estos.

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Publication number
MX2018012376A
MX2018012376A MX2018012376A MX2018012376A MX2018012376A MX 2018012376 A MX2018012376 A MX 2018012376A MX 2018012376 A MX2018012376 A MX 2018012376A MX 2018012376 A MX2018012376 A MX 2018012376A MX 2018012376 A MX2018012376 A MX 2018012376A
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Mexico
Prior art keywords
viral
expression
heterologous polypeptides
genome
disclosure
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MX2018012376A
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English (en)
Inventor
Iver Kamrud Kurt
Stephen Wang Nathaniel
Felderman Martina
C Carrico Nancy
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Synthetic Genomics Inc
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Application filed by Synthetic Genomics Inc filed Critical Synthetic Genomics Inc
Publication of MX2018012376A publication Critical patent/MX2018012376A/es

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    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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Abstract

La presente descripción se refiere en general a sistemas de expresión a base de virus adecuados para la producción de moléculas de interés en células hospederas recombinantes. La descripción se refiere en particular a constructos de ácido nucleico, tales como vectores de expresión, que contienen un. genoma o ARN replicón de arterivirus modificado en el que al menos parte de su secuencia viral original se ha eliminado. También se incluyen en la descripción vectores de expresión a base de virus que incluyen uno o más casetes de expresión que codifican polipéptidos heterólogos. En algunas modalidades, los casetes de expresión están configurados y posicionados en ubicaciones definidas en el genoma viral para permitir la expresión de los polipéptidos heterólogos de una manera ajustable.
MX2018012376A 2016-04-13 2017-04-12 Sistemas de replicón de arterivirus recombinantes y usos de estos. MX2018012376A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662322149P 2016-04-13 2016-04-13
PCT/US2017/027249 WO2017180770A1 (en) 2016-04-13 2017-04-12 Recombinant arterivirus replicon systems and uses thereof

Publications (1)

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MX2018012376A true MX2018012376A (es) 2019-08-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012376A MX2018012376A (es) 2016-04-13 2017-04-12 Sistemas de replicón de arterivirus recombinantes y usos de estos.

Country Status (7)

Country Link
US (3) US10538786B2 (es)
EP (1) EP3443107A1 (es)
JP (1) JP7250520B2 (es)
AU (1) AU2017249424B2 (es)
CA (1) CA3020426A1 (es)
MX (1) MX2018012376A (es)
WO (1) WO2017180770A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3431099B1 (en) 2007-03-30 2024-01-03 The Research Foundation for The State University of New York Attenuated viruses useful for vaccines
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
JP7382230B2 (ja) 2016-10-17 2023-11-16 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組み換えウイルスレプリコン系及びその使用
KR102655641B1 (ko) 2016-12-05 2024-04-05 얀센 파마슈티칼즈, 인코포레이티드 유전자 발현을 향상시키기 위한 조성물 및 방법
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
BR112020014525A2 (pt) * 2018-01-19 2020-12-08 Janssen Pharmaceuticals, Inc. Induzir e intensificar respostas imunes utilizando sistemas de replicon recombinantes
CA3091478A1 (en) 2018-02-17 2019-08-22 Flagship Pioneering Innovations V, Inc. Compositions and methods for membrane protein delivery
TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 前列腺新抗原及其用途
US11679163B2 (en) 2019-09-20 2023-06-20 Hdt Bio Corp. Compositions and methods for delivery of RNA
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
CN116134131A (zh) 2019-12-31 2023-05-16 伊利克斯根治疗公司 核酸和蛋白质向细胞和组织的基于温度的瞬时递送
TW202144389A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在多發性骨髓瘤中表現之新抗原及其用途
TW202144388A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在卵巢癌中表現之新抗原及其用途
AU2021241355A1 (en) 2020-03-23 2022-10-13 Hdt Bio Corp. Compositions and methods for delivery of RNA
JP2023531123A (ja) * 2020-04-12 2023-07-21 ノヴォスコープ アイピー リミテッド 粒子、ｄｎａ、及びｒｎａ
WO2022009052A2 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022009051A1 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. A method for determining responsiveness to prostate cancer treatment
US20230024133A1 (en) 2020-07-06 2023-01-26 Janssen Biotech, Inc. Prostate Neoantigens And Their Uses
WO2023019274A1 (en) * 2021-08-13 2023-02-16 Purdue Research Foundation Methods and compositions for vaccination against heterosubtypic influenza viruses using an adenoviral vector leading to enhanced t cell response through autophagy
WO2023147498A1 (en) * 2022-01-27 2023-08-03 Replicate Bioscience, Inc. Methods for generating functional self-replicating rna molecules

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561343B2 (en) 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
EP0091539B2 (en) 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
US4966843A (en) 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
US4892743A (en) 1983-12-21 1990-01-09 Schering Corporation Novel hybrid interferon species
WO1985002862A1 (en) 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
AU594014B2 (en) 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US5017691A (en) 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
PT92479A (pt) 1988-12-01 1990-06-29 Univ North Carolina Processo de preparacao de genes recombinantes e suas proteinas de codificacao
US5225337A (en) 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Ribozyme compositions and methods for use
US5246921A (en) 1990-06-26 1993-09-21 The Wistar Institute Of Anatomy And Biology Method for treating leukemias
US5780036A (en) 1991-08-26 1998-07-14 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus
ATE227118T1 (de) 1993-08-02 2002-11-15 Scripps Research Inst Peptide zum induzieren einer antwort der zytotoxischen t-lymphozythen gerichetetgegen das hepatitis b-virus
SE9401709D0 (sv) 1994-05-18 1994-05-18 Mathilda Sjoeberg Improved alphavirus vectors for expression of heterologous DNA
US5792462A (en) 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
DE19712889A1 (de) 1997-03-27 1998-10-01 Bosch Gmbh Robert Verfahren und Vorrichtung zur Ermittlung einer den Systemdruck in einem Bremskreis beschreibenden Größe
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
CA2285056C (en) 1997-04-03 2004-12-14 Iacob Mathiesen Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
GB0023203D0 (en) 2000-09-21 2000-11-01 Isis Innovation Vaccination method
US6117660A (en) 1997-06-10 2000-09-12 Cytopulse Sciences, Inc. Method and apparatus for treating materials with electrical fields having varying orientations
IL133710A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into the striped muscle and combination thereof
US5958060A (en) 1998-01-02 1999-09-28 General Electric Company Method and apparatus for clock control and synchronization
WO2000002621A1 (en) 1998-07-13 2000-01-20 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6319901B1 (en) 1998-10-15 2001-11-20 Ichor Medical Systems, Inc. Methods for prolonging cell membrane permeability
US20040213805A1 (en) 1999-10-12 2004-10-28 Verheije Monique Helene Deletions in arterivirus replicons
AU2001290642A1 (en) 2000-09-07 2002-03-22 University Of North Carolina At Chapel Hill Vectors derived from south african arbovirus no. 86
US6538922B1 (en) 2000-09-27 2003-03-25 Sandisk Corporation Writable tracking cells
NZ524661A (en) 2000-11-23 2005-03-24 Bavarian Nordic As Modified vaccinia ankara virus variant
WO2002061113A2 (en) 2001-02-01 2002-08-08 The Johns Hopkins University Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation
ATE354260T1 (de) 2001-07-19 2007-03-15 Ericsson Telefon Ab L M Verfahren und vorrichtung für die lösung der nummernübertragbarkeit am ursprungsort
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US6943015B2 (en) 2002-12-12 2005-09-13 Ilya Frolov Large scale production of packaged alphavirus replicons
EP1651666B1 (en) 2003-07-11 2009-05-27 Alphavax, Inc. Alphavirus-based cytomegalovirus vaccines
US8080255B2 (en) * 2003-07-11 2011-12-20 Novavax Inc. Functional influenza virus like particles (VLPs)
US20050070700A1 (en) 2003-09-30 2005-03-31 Matthias Giese Equine arteritis virus vaccine
CN102886101B (zh) 2004-03-08 2015-10-28 艾科医疗系统公司 改进的治疗剂电介导输送设备
US8859198B2 (en) 2006-06-06 2014-10-14 Abl Sa Detection and use of antiviral resistance mutations
WO2008115199A2 (en) 2006-08-18 2008-09-25 The University Of North Carolina At Chapel Hill Chimeric virus vaccines
WO2008048632A1 (en) 2006-10-17 2008-04-24 Vgx Pharmaceuticals, Inc. Electroporation devices and methods of using same for electroporation of cells in mammals
US20090018031A1 (en) 2006-12-07 2009-01-15 Switchgear Genomics Transcriptional regulatory elements of biological pathways tools, and methods
KR100836745B1 (ko) 2007-01-31 2008-06-10 (주)두비엘 Ｈｂｖ 백신 및 그의 제조 방법
ES2588906T3 (es) 2007-06-21 2016-11-07 Alphavax, Inc. Casetes sin promotor para la expresión de proteínas estructurales de alfavirus
JP4457135B2 (ja) 2007-09-26 2010-04-28 株式会社日立ハイテクノロジーズ 液体クロマトグラフ分析装置及び試料導入装置
WO2009056535A2 (en) 2007-10-29 2009-05-07 Genimmune N.V. Methods and kits for inducing a ctl response using a prime boost regimen
WO2011015656A2 (en) 2009-08-07 2011-02-10 Transgene Sa Composition for treating hbv infection
EP2590670B1 (en) 2010-07-06 2017-08-23 GlaxoSmithKline Biologicals SA Methods of raising an immune response by delivery of rna
EP2655621B1 (en) 2010-12-20 2018-05-23 The General Hospital Corporation Polycomb-associated non-coding rnas
PT2672992T (pt) 2011-02-11 2020-07-27 Univ Pennsylvania Molécula de ácidos nucleicos codificando proteína nuclear do vírus da hepatite b e vacina compreendendo a mesma
TWI623618B (zh) 2011-07-12 2018-05-11 傳斯堅公司 Ｈｂｖ聚合酶突變體
US8961995B2 (en) 2012-09-20 2015-02-24 Uab Research Foundation Methods and compositions for alphavirus replicons
WO2014170493A2 (en) 2013-04-19 2014-10-23 Novartis Ag Alphavirus vector
CA2915730A1 (en) 2013-08-21 2015-02-26 Karl-Josef Kallen A combination rsv/influenza a vaccine
WO2016020538A1 (en) 2014-08-08 2016-02-11 Transgene Sa Hbv vaccine and antibody combination therapy to treat hbv infections
CN106794263A (zh) 2014-10-01 2017-05-31 宾夕法尼亚大学理事会 具有抗原和作为佐剂的白细胞介素‑21的疫苗
KR20170134642A (ko) 2015-04-08 2017-12-06 노파르티스 아게 Cd20 요법, cd22 요법, 및 cd19 키메라 항원 수용체 (car) - 발현 세포와의 조합 요법
CN107810009A (zh) 2015-05-15 2018-03-16 库瑞瓦格股份公司 涉及施用至少一种mRNA构建体的初免‑加强方案
WO2017024000A1 (en) 2015-08-03 2017-02-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use
MX2018011742A (es) 2016-03-28 2019-02-14 Ichor Medical Systems Inc Metodo y aparato para suministro de agentes terapeuticos.
CN109414496B (zh) 2016-04-06 2024-01-26 华盛顿大学 用于乙型肝炎病毒（hbv）的使用hbv核心抗原的治疗性疫苗
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
JP7382230B2 (ja) 2016-10-17 2023-11-16 ヤンセン ファーマシューティカルズ，インコーポレーテッド 組み換えウイルスレプリコン系及びその使用
KR102655641B1 (ko) 2016-12-05 2024-04-05 얀센 파마슈티칼즈, 인코포레이티드 유전자 발현을 향상시키기 위한 조성물 및 방법
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)

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US20230227850A1 (en) 2023-07-20
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CA3020426A1 (en) 2017-10-19
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