UA120923C2 - Молекула нуклеїнової кислоти, яка кодує капсидний протеїн aav5 - Google Patents
Молекула нуклеїнової кислоти, яка кодує капсидний протеїн aav5Info
- Publication number
- UA120923C2 UA120923C2 UAA201609350A UAA201609350A UA120923C2 UA 120923 C2 UA120923 C2 UA 120923C2 UA A201609350 A UAA201609350 A UA A201609350A UA A201609350 A UAA201609350 A UA A201609350A UA 120923 C2 UA120923 C2 UA 120923C2
- Authority
- UA
- Ukraine
- Prior art keywords
- further improved
- insect cells
- aav vectors
- vectors produced
- improved aav
- Prior art date
Links
- 241000238631 Hexapoda Species 0.000 title abstract 3
- 239000013598 vector Substances 0.000 title 1
- 241001634120 Adeno-associated virus - 5 Species 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000002845 virion Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Винахід стосується молекули нуклеїнової кислоти, конструкта, що містить молекулу нуклеїнової кислоти, клітини комахи, яка містить конструкт, AAV5 віріону та способу отримання AAV5 в клітині комахи.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14158610 | 2014-03-10 | ||
PCT/NL2015/050149 WO2015137802A1 (en) | 2014-03-10 | 2015-03-10 | Further improved aav vectors produced in insect cells |
Publications (1)
Publication Number | Publication Date |
---|---|
UA120923C2 true UA120923C2 (uk) | 2020-03-10 |
Family
ID=50238253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201609350A UA120923C2 (uk) | 2014-03-10 | 2015-03-10 | Молекула нуклеїнової кислоти, яка кодує капсидний протеїн aav5 |
Country Status (17)
Country | Link |
---|---|
US (2) | US10837027B2 (uk) |
EP (1) | EP3117005B1 (uk) |
JP (2) | JP6683397B2 (uk) |
KR (1) | KR102572449B1 (uk) |
CN (1) | CN106459984B (uk) |
AU (1) | AU2015230094B2 (uk) |
BR (1) | BR112016020783A2 (uk) |
CA (1) | CA2942289C (uk) |
DK (1) | DK3117005T3 (uk) |
EA (1) | EA201691809A1 (uk) |
FI (1) | FI3117005T3 (uk) |
IL (1) | IL247729B2 (uk) |
MX (1) | MX2016011585A (uk) |
PT (1) | PT3117005T (uk) |
UA (1) | UA120923C2 (uk) |
WO (1) | WO2015137802A1 (uk) |
ZA (1) | ZA201606552B (uk) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
CN107106689A (zh) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
MX2018012663A (es) | 2016-04-16 | 2019-07-08 | Univ Florida | Metodos para aumentar la capacidad de actividad biológica del virus adenoasociado recombinante producido mediante el sistema baculovirus. |
US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
KR102392236B1 (ko) | 2016-05-18 | 2022-05-03 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
SG11201809643UA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
SG11201901221YA (en) * | 2016-08-15 | 2019-03-28 | Genzyme Corp | Methods for detecting aav |
EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING PERSONAL HEARING LOSS IN A PERSON |
EP3831281A1 (en) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
EP3619308A4 (en) | 2017-05-05 | 2021-01-27 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT FOR HUNTINGTON'S MORBUS |
CA3061652A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
EA202090260A1 (ru) * | 2017-07-10 | 2020-05-08 | ЮНИКЬЮРЕ АйПи Б.В. | Средства и способы для генотерапии aav у человека |
JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
AU2018303230B2 (en) | 2017-07-20 | 2024-08-22 | Uniqure Ip B.V. | Improved AAV capsid production in insect cells |
KR20200044793A (ko) | 2017-08-03 | 2020-04-29 | 보이저 테라퓨틱스, 인크. | Aav의 전달을 위한 조성물 및 방법 |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
JP7502991B2 (ja) | 2017-10-16 | 2024-06-19 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症(als)の治療 |
CN111527201A (zh) * | 2017-12-29 | 2020-08-11 | 优尼科Ip有限公司 | 修饰的病毒载体及其制备和使用方法 |
GB201800903D0 (en) | 2018-01-19 | 2018-03-07 | Oxford Genetics Ltd | Vectors |
WO2019241486A1 (en) | 2018-06-13 | 2019-12-19 | Voyager Therapeutics, Inc. | Engineered 5' untranslated regions (5' utr) for aav production |
US11702673B2 (en) * | 2018-10-18 | 2023-07-18 | University Of Florida Research Foundation, Incorporated | Methods of enhancing biological potency of baculovirus system-produced recombinant adeno-associated virus |
WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
CA3119721A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | A companion diagnostic to monitor the effects of gene therapy |
EP3883582A1 (en) | 2018-11-19 | 2021-09-29 | uniQure IP B.V. | Method and means to deliver mirna to target cells |
SG11202107645RA (en) | 2019-01-18 | 2021-08-30 | Voyager Therapeutics Inc | Methods and systems for producing aav particles |
WO2020168222A1 (en) * | 2019-02-15 | 2020-08-20 | Generation Bio Co. | Modulation of rep protein activity in closed-ended dna (cedna) production |
CN111084888B (zh) * | 2019-03-15 | 2021-12-28 | 北京锦篮基因科技有限公司 | 一种用于治疗严重高甘油三酯血症的基因药物 |
MX2021013267A (es) * | 2019-04-29 | 2021-11-17 | Univ Pennsylvania | Nuevas capsides de aav y composiciones que las contienen. |
PE20212357A1 (es) * | 2019-05-24 | 2021-12-17 | Regeneron Pharma | Particulas virales modificadas y usos de estas |
US20220251600A1 (en) * | 2019-06-27 | 2022-08-11 | X-Chem, Inc. | Recombinant transfer vectors for protein expression in insect and mammalian cells |
US10557149B1 (en) * | 2019-07-15 | 2020-02-11 | Vigene Biosciences, Inc. | Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus |
WO2021053018A1 (en) | 2019-09-16 | 2021-03-25 | Uniqure Ip B.V. | Targeting misspliced transcripts in genetic disorders |
BR112022016596A2 (pt) | 2020-02-21 | 2022-11-16 | Akouos Inc | Composições e métodos para o tratamento de debilitação auditiva não associada à idade em um indivíduo humano |
WO2021195491A2 (en) * | 2020-03-26 | 2021-09-30 | Asklepios Biopharmaceutical, Inc. | Inducible promoter for viral vector production |
CA3169087A1 (en) | 2020-04-02 | 2021-10-07 | David Johannes Francois DU PLESSIS | Dual bifunctional vectors for aav production |
CN115867647A (zh) | 2020-04-02 | 2023-03-28 | 优尼科生物制药有限公司 | 新型细胞系 |
WO2022188797A1 (en) | 2021-03-09 | 2022-09-15 | Huigene Therapeutics Co., Ltd. | Engineered crispr/cas13 system and uses thereof |
WO2022207899A1 (en) | 2021-04-02 | 2022-10-06 | Uniqure Biopharma B.V. | Methods for producing single insect cell clones |
CA3219847A1 (en) | 2021-06-02 | 2022-12-08 | Sander Jan Hendrik Van Deventer | Adeno-associated virus vectors modified to bind high-density lipoprotein |
AU2022286647A1 (en) | 2021-06-02 | 2023-11-30 | Uniqure Biopharma B.V. | Insect cell production of parvoviral vectors with modified capsid proteins |
US20240287545A1 (en) | 2021-06-21 | 2024-08-29 | Uniqure Biopharma B.V. | Improved lysis procedures |
WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
EP4392434A1 (en) | 2021-08-26 | 2024-07-03 | uniQure biopharma B.V. | Insect cell-produced high potency aav vectors with cns-tropism |
CN114703203B (zh) * | 2022-02-11 | 2024-08-06 | 上海渤因生物科技有限公司 | 杆状病毒载体及其用途 |
WO2023198745A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of apoe |
WO2023198702A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of c9orf72 |
WO2023198662A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Novel systems for nucleic acid regulation |
WO2023198663A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of snca |
WO2024078584A1 (zh) * | 2022-10-13 | 2024-04-18 | 康霖生物科技(杭州)有限公司 | 腺相关病毒的衣壳蛋白编码基因改造方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
DE60039880D1 (en) | 1999-06-24 | 2008-09-25 | Amsterdam Molecular Therapeutics Bv | Therapie mit lipoproteinlipase (lpl) variant |
US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
AU2002360355B2 (en) | 2001-11-09 | 2005-07-07 | Government Of The United States Of America, Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
AU2002359284A1 (en) | 2001-12-17 | 2003-06-30 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor |
WO2003074714A1 (en) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
DK2292780T3 (en) | 2003-09-30 | 2017-12-04 | Univ Pennsylvania | Clades and sequences of adeno-associated virus (AAV), vectors containing them, and uses thereof |
WO2006036502A2 (en) | 2004-09-22 | 2006-04-06 | St. Jude Children's Research Hospital | Improved expression of factor ix in gene therapy vectors |
AU2006304997B2 (en) * | 2005-10-20 | 2012-03-01 | Uniqure Ip B.V. | Improved AAV vectors produced in insect cells |
EP3705577A1 (en) * | 2006-06-21 | 2020-09-09 | uniQure IP B.V. | Aav vectors with improved rep coding sequences for production in insect cells |
JP5634262B2 (ja) | 2007-07-26 | 2014-12-03 | ユニキュアー アイピー ビー.ブイ. | 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター |
WO2009154452A1 (en) | 2008-06-17 | 2009-12-23 | Amsterdam Molecular Therapeutics B.V. | Parvoviral capsid with incorporated Gly-Ala repeat region |
WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
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2015
- 2015-03-10 IL IL247729A patent/IL247729B2/en unknown
- 2015-03-10 AU AU2015230094A patent/AU2015230094B2/en active Active
- 2015-03-10 PT PT157154766T patent/PT3117005T/pt unknown
- 2015-03-10 BR BR112016020783A patent/BR112016020783A2/pt not_active Application Discontinuation
- 2015-03-10 FI FIEP15715476.6T patent/FI3117005T3/fi active
- 2015-03-10 MX MX2016011585A patent/MX2016011585A/es unknown
- 2015-03-10 CA CA2942289A patent/CA2942289C/en active Active
- 2015-03-10 US US15/124,139 patent/US10837027B2/en active Active
- 2015-03-10 KR KR1020167026098A patent/KR102572449B1/ko active IP Right Grant
- 2015-03-10 EA EA201691809A patent/EA201691809A1/ru unknown
- 2015-03-10 DK DK15715476.6T patent/DK3117005T3/da active
- 2015-03-10 WO PCT/NL2015/050149 patent/WO2015137802A1/en active Application Filing
- 2015-03-10 JP JP2016555770A patent/JP6683397B2/ja active Active
- 2015-03-10 EP EP15715476.6A patent/EP3117005B1/en active Active
- 2015-03-10 CN CN201580019215.0A patent/CN106459984B/zh active Active
- 2015-03-10 UA UAA201609350A patent/UA120923C2/uk unknown
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2016
- 2016-09-22 ZA ZA2016/06552A patent/ZA201606552B/en unknown
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2020
- 2020-01-06 JP JP2020000121A patent/JP2020062045A/ja active Pending
- 2020-11-05 US US17/090,807 patent/US20210222198A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2020062045A (ja) | 2020-04-23 |
EA201691809A1 (ru) | 2017-01-30 |
AU2015230094A1 (en) | 2016-09-15 |
CN106459984B (zh) | 2021-09-07 |
CA2942289A1 (en) | 2015-09-17 |
AU2015230094A9 (en) | 2016-09-22 |
CA2942289C (en) | 2024-05-21 |
US20170356008A1 (en) | 2017-12-14 |
EP3117005A1 (en) | 2017-01-18 |
US20210222198A1 (en) | 2021-07-22 |
CN106459984A (zh) | 2017-02-22 |
BR112016020783A2 (pt) | 2017-10-03 |
PT3117005T (pt) | 2024-07-30 |
JP6683397B2 (ja) | 2020-04-22 |
FI3117005T3 (fi) | 2024-08-29 |
DK3117005T3 (da) | 2024-08-12 |
ZA201606552B (en) | 2017-11-29 |
IL247729A0 (en) | 2016-11-30 |
JP2017510264A (ja) | 2017-04-13 |
KR20160131032A (ko) | 2016-11-15 |
WO2015137802A1 (en) | 2015-09-17 |
US10837027B2 (en) | 2020-11-17 |
EP3117005B1 (en) | 2024-07-03 |
IL247729B1 (en) | 2023-05-01 |
KR102572449B1 (ko) | 2023-08-31 |
MX2016011585A (es) | 2016-11-29 |
AU2015230094B2 (en) | 2021-05-27 |
IL247729B2 (en) | 2023-09-01 |
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