MX2016011585A - Vectores aav mejorados adicionales producidos en celulas de insecto. - Google Patents
Vectores aav mejorados adicionales producidos en celulas de insecto.Info
- Publication number
- MX2016011585A MX2016011585A MX2016011585A MX2016011585A MX2016011585A MX 2016011585 A MX2016011585 A MX 2016011585A MX 2016011585 A MX2016011585 A MX 2016011585A MX 2016011585 A MX2016011585 A MX 2016011585A MX 2016011585 A MX2016011585 A MX 2016011585A
- Authority
- MX
- Mexico
- Prior art keywords
- amino acid
- nucleotide sequence
- adeno
- insect cells
- aav
- Prior art date
Links
- 241000238631 Hexapoda Species 0.000 title abstract 6
- 239000013598 vector Substances 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 5
- 125000003729 nucleotide group Chemical group 0.000 abstract 5
- 125000000539 amino acid group Chemical group 0.000 abstract 4
- 108090000565 Capsid Proteins Proteins 0.000 abstract 3
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 3
- 108091081024 Start codon Proteins 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000013603 viral vector Substances 0.000 abstract 2
- 101100524317 Adeno-associated virus 2 (isolate Srivastava/1982) Rep40 gene Proteins 0.000 abstract 1
- 101100524319 Adeno-associated virus 2 (isolate Srivastava/1982) Rep52 gene Proteins 0.000 abstract 1
- 101100524321 Adeno-associated virus 2 (isolate Srivastava/1982) Rep68 gene Proteins 0.000 abstract 1
- 101100524324 Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 gene Proteins 0.000 abstract 1
- 108020004705 Codon Proteins 0.000 abstract 1
- 241000702421 Dependoparvovirus Species 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 210000000234 capsid Anatomy 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 230000014621 translational initiation Effects 0.000 abstract 1
- 235000014393 valine Nutrition 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a la producción de vectores víricos asociados a adeno en las células de insecto. Las células de insecto por lo tanto comprenden una primera secuencia de nucleótidos que codifica las proteínas de la cápside del virus asociado a adeno (AAV), mediante lo cual el codón de inicio para la traducción de la proteína de la cápside AAV VP1 es un codón de inicio subóptimo, no ATG, y en donde la secuencia de codificación para uno o más residuos de aminoácidos se ha insertado entre el codón de inicio de traducción subóptimo y el codón que codifica el residuo de aminoácido que corresponde al residuo de aminoácido en la posición 2 de la secuencia de aminoácido de la cápside de tipo natural de la cual el primer residuo de aminoácido es alanina, glicina, valina, ácido aspártico o ácido glutámico. La célula de insecto comprende además una segunda secuencia de nucleótidos que comprende al menos una secuencia de nucleótidos de repetición terminal invertida (ITR) AAV; una tercera secuencia de nucleótidos que comprende una secuencia de codificación Rep52 o Rep40 operablemente ligada a las secuencias de control de expresión para la expresión en una célula de insecto; y, una cuarta secuencia de nucleótidos que comprende una secuencia de codificación Rep78 o Rep68 operablemente ligada a las secuencias de control de expresión para la expresión en la célula de insecto. La invención se refiere adicionalmente a los vectores víricos asociados a adeno con una relación alterada de las proteínas de la cápside víricas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14158610 | 2014-03-10 | ||
| PCT/NL2015/050149 WO2015137802A1 (en) | 2014-03-10 | 2015-03-10 | Further improved aav vectors produced in insect cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016011585A true MX2016011585A (es) | 2016-11-29 |
Family
ID=50238253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016011585A MX2016011585A (es) | 2014-03-10 | 2015-03-10 | Vectores aav mejorados adicionales producidos en celulas de insecto. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10837027B2 (es) |
| EP (1) | EP3117005B1 (es) |
| JP (2) | JP6683397B2 (es) |
| KR (1) | KR102572449B1 (es) |
| CN (1) | CN106459984B (es) |
| AU (1) | AU2015230094B2 (es) |
| BR (1) | BR112016020783A2 (es) |
| CA (1) | CA2942289C (es) |
| EA (1) | EA201691809A1 (es) |
| IL (1) | IL247729B2 (es) |
| MX (1) | MX2016011585A (es) |
| UA (1) | UA120923C2 (es) |
| WO (1) | WO2015137802A1 (es) |
| ZA (1) | ZA201606552B (es) |
Families Citing this family (54)
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| WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
| BR112017009497A2 (pt) | 2014-11-05 | 2018-02-06 | Voyager Therapeutics, Inc. | polinucleotídeos de aadc para o tratamento da doença de parkinson |
| BR112017010087A2 (pt) | 2014-11-14 | 2018-06-05 | Voyager Therapeutics, Inc. | composições e métodos para tratar esclerose lateral amiotrófica (ela) |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
| RU2762948C2 (ru) * | 2016-04-16 | 2021-12-24 | Юниверсити Оф Флорида Рисерч Фаундэйшн, Инкорпорейтед | Способы усиления биологической активности рекомбинантного аденоассоциированного вуруса, продуцируемого бакуловирусной системой |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR THE TREATMENT OF DISEASES |
| WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| RU2764587C2 (ru) | 2016-05-18 | 2022-01-18 | Вояджер Терапьютикс, Инк. | Способы и композиции для лечения хореи гентингтона |
| MX2018014154A (es) | 2016-05-18 | 2019-05-06 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| TN2019000047A1 (en) * | 2016-08-15 | 2020-07-15 | Genzyme Corp | Methods for detecting aav |
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| EP3831281A1 (en) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| AU2018261790A1 (en) | 2017-05-05 | 2019-11-28 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| EP3619308A4 (en) | 2017-05-05 | 2021-01-27 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT FOR HUNTINGTON'S MORBUS |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| EP3652326A1 (en) * | 2017-07-10 | 2020-05-20 | uniQure IP B.V. | Means and methods for aav gene therapy in humans |
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| EA202090332A1 (ru) * | 2017-07-20 | 2020-04-29 | ЮНИКЬЮРЕ АйПи Б.В. | Улучшенная продукция капсида aav в клетках насекомых |
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| WO2019129859A1 (en) | 2017-12-29 | 2019-07-04 | Uniqure Ip B.V. | Modified viral vectors and methods of making and using the same |
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| AU2020221312A1 (en) * | 2019-02-15 | 2021-10-07 | Generation Bio Co. | Modulation of rep protein activity in closed-ended dna (cedna) production |
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| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| DK1200117T3 (da) | 1999-06-24 | 2008-11-17 | Univ British Columbia | Behandling med lipoprotein-lipase (LPL) variant |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| CA2467959C (en) | 2001-11-09 | 2009-03-10 | Robert M. Kotin | Production of adeno-associated virus in insect cells |
| ES2664505T3 (es) | 2001-12-17 | 2018-04-19 | The Trustees Of The University Of Pennsylvania | Secuencias de serotipo 9 de virus adeno-asociado (AAV), vectores que las contienen, y usos de las mismas |
| WO2003074714A1 (en) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
| DK3211085T3 (da) | 2003-09-30 | 2021-06-21 | Univ Pennsylvania | Klader af adeno-associeret virus (aav), sekvenser, vektorer indeholdende disse og anvendelser deraf |
| DK1804839T3 (da) | 2004-09-22 | 2012-04-10 | St Jude Childrens Res Hospital | Forbedret ekspression af faktor ix i genterapivektorer |
| AU2006304997B2 (en) | 2005-10-20 | 2012-03-01 | Uniqure Ip B.V. | Improved AAV vectors produced in insect cells |
| EP3023500B1 (en) * | 2006-06-21 | 2020-02-12 | uniQure IP B.V. | Insect cells for the production of aav vectors |
| EP3093345B8 (en) | 2007-07-26 | 2019-07-24 | UniQure IP B.V. | Baculoviral vectors comprising repeated coding sequences with differential codon biases |
| EP2297185A1 (en) | 2008-06-17 | 2011-03-23 | Amsterdam Molecular Therapeutics (AMT) B.V. | Parvoviral capsid with incorporated gly-ala repeat region |
| WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
-
2015
- 2015-03-10 CA CA2942289A patent/CA2942289C/en active Active
- 2015-03-10 JP JP2016555770A patent/JP6683397B2/ja active Active
- 2015-03-10 MX MX2016011585A patent/MX2016011585A/es unknown
- 2015-03-10 EA EA201691809A patent/EA201691809A1/ru unknown
- 2015-03-10 US US15/124,139 patent/US10837027B2/en active Active
- 2015-03-10 UA UAA201609350A patent/UA120923C2/uk unknown
- 2015-03-10 KR KR1020167026098A patent/KR102572449B1/ko active IP Right Grant
- 2015-03-10 WO PCT/NL2015/050149 patent/WO2015137802A1/en active Application Filing
- 2015-03-10 EP EP15715476.6A patent/EP3117005B1/en active Active
- 2015-03-10 IL IL247729A patent/IL247729B2/en unknown
- 2015-03-10 AU AU2015230094A patent/AU2015230094B2/en active Active
- 2015-03-10 CN CN201580019215.0A patent/CN106459984B/zh active Active
- 2015-03-10 BR BR112016020783A patent/BR112016020783A2/pt not_active Application Discontinuation
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2016
- 2016-09-22 ZA ZA2016/06552A patent/ZA201606552B/en unknown
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2020
- 2020-01-06 JP JP2020000121A patent/JP2020062045A/ja active Pending
- 2020-11-05 US US17/090,807 patent/US20210222198A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| UA120923C2 (uk) | 2020-03-10 |
| AU2015230094A9 (en) | 2016-09-22 |
| JP2017510264A (ja) | 2017-04-13 |
| BR112016020783A2 (pt) | 2017-10-03 |
| US10837027B2 (en) | 2020-11-17 |
| EP3117005A1 (en) | 2017-01-18 |
| EP3117005B1 (en) | 2024-07-03 |
| IL247729B1 (en) | 2023-05-01 |
| JP2020062045A (ja) | 2020-04-23 |
| KR102572449B1 (ko) | 2023-08-31 |
| ZA201606552B (en) | 2017-11-29 |
| CN106459984B (zh) | 2021-09-07 |
| CN106459984A (zh) | 2017-02-22 |
| IL247729A0 (en) | 2016-11-30 |
| CA2942289C (en) | 2024-05-21 |
| CA2942289A1 (en) | 2015-09-17 |
| IL247729B2 (en) | 2023-09-01 |
| WO2015137802A1 (en) | 2015-09-17 |
| KR20160131032A (ko) | 2016-11-15 |
| US20170356008A1 (en) | 2017-12-14 |
| EA201691809A1 (ru) | 2017-01-30 |
| JP6683397B2 (ja) | 2020-04-22 |
| AU2015230094B2 (en) | 2021-05-27 |
| US20210222198A1 (en) | 2021-07-22 |
| AU2015230094A1 (en) | 2016-09-15 |
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