MX2020002809A - Genes rep de aav inducibles. - Google Patents
Genes rep de aav inducibles.Info
- Publication number
- MX2020002809A MX2020002809A MX2020002809A MX2020002809A MX2020002809A MX 2020002809 A MX2020002809 A MX 2020002809A MX 2020002809 A MX2020002809 A MX 2020002809A MX 2020002809 A MX2020002809 A MX 2020002809A MX 2020002809 A MX2020002809 A MX 2020002809A
- Authority
- MX
- Mexico
- Prior art keywords
- aav
- aav rep
- rep genes
- rep68
- rep78
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14161—Methods of inactivation or attenuation
Abstract
La presente invención se refiere a células huésped que comprenden un ácido nucleico que codifica las proteínas Rep78 y Rep68 del virus adenoasociado (AAV), en donde el promotor interno de AAV p19 ha sido inactivado por una o más mutaciones que mantienen la funcionalidad de dichas proteínas Rep78 y Rep68. La presente invención se refiere además a ácidos nucleicos respectivos y vectores que comprenden los mismos, así como a métodos respectivos para la producción de AAV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17001562.2A EP3456822A1 (en) | 2017-09-19 | 2017-09-19 | Inducible aav rep genes |
PCT/EP2018/075158 WO2019057691A1 (en) | 2017-09-19 | 2018-09-18 | INDAVTIBLE AAV GEN GENES |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020002809A true MX2020002809A (es) | 2020-10-12 |
Family
ID=59930156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020002809A MX2020002809A (es) | 2017-09-19 | 2018-09-18 | Genes rep de aav inducibles. |
Country Status (13)
Country | Link |
---|---|
US (2) | US11685932B2 (es) |
EP (2) | EP3456822A1 (es) |
JP (1) | JP7254777B2 (es) |
KR (1) | KR20200052283A (es) |
CN (1) | CN111108197A (es) |
AU (1) | AU2018337571A1 (es) |
BR (1) | BR112020005404A2 (es) |
CA (1) | CA3073622A1 (es) |
IL (1) | IL273176A (es) |
MX (1) | MX2020002809A (es) |
SG (1) | SG11202000443SA (es) |
WO (1) | WO2019057691A1 (es) |
ZA (1) | ZA202000862B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230257770A1 (en) * | 2020-02-04 | 2023-08-17 | Oxford Genetics Limited | Process for Making Adenoassociated Viral Vectors |
WO2023086822A2 (en) * | 2021-11-09 | 2023-05-19 | Asimov Inc. | Stable production systems for aav vector production |
WO2023171698A1 (ja) * | 2022-03-08 | 2023-09-14 | 富士フイルム株式会社 | プロデューサー細胞、プロデューサー細胞の製造方法、およびアデノ随伴ウイルスの製造方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE264398T1 (de) | 1995-12-01 | 2004-04-15 | Crucell Holland Bv | Regulierte expression von proteinen in stabil transformierten säugetierzellen |
DE19905501B4 (de) | 1999-02-10 | 2005-05-19 | MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie | Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels |
AU2002367943A1 (en) * | 2001-12-18 | 2003-12-22 | University Of North Carolina At Chapel Hill | Improved reagents and methods for producing parvoviruses |
US9441206B2 (en) * | 2011-10-28 | 2016-09-13 | The University Of North Carolina At Chapel Hill | Cell line for production of adeno-associated virus |
-
2017
- 2017-09-19 EP EP17001562.2A patent/EP3456822A1/en not_active Withdrawn
-
2018
- 2018-09-18 BR BR112020005404-6A patent/BR112020005404A2/pt unknown
- 2018-09-18 SG SG11202000443SA patent/SG11202000443SA/en unknown
- 2018-09-18 US US16/646,741 patent/US11685932B2/en active Active
- 2018-09-18 AU AU2018337571A patent/AU2018337571A1/en active Pending
- 2018-09-18 WO PCT/EP2018/075158 patent/WO2019057691A1/en unknown
- 2018-09-18 CA CA3073622A patent/CA3073622A1/en active Pending
- 2018-09-18 MX MX2020002809A patent/MX2020002809A/es unknown
- 2018-09-18 CN CN201880050619.XA patent/CN111108197A/zh active Pending
- 2018-09-18 KR KR1020207006686A patent/KR20200052283A/ko not_active Application Discontinuation
- 2018-09-18 EP EP18766289.5A patent/EP3649239A1/en active Pending
- 2018-09-18 JP JP2020514507A patent/JP7254777B2/ja active Active
-
2020
- 2020-02-10 ZA ZA2020/00862A patent/ZA202000862B/en unknown
- 2020-03-09 IL IL273176A patent/IL273176A/en unknown
-
2023
- 2023-04-17 US US18/301,818 patent/US20230348936A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2018337571A1 (en) | 2020-01-30 |
US11685932B2 (en) | 2023-06-27 |
EP3456822A1 (en) | 2019-03-20 |
JP7254777B2 (ja) | 2023-04-10 |
RU2020111459A3 (es) | 2021-11-29 |
CN111108197A (zh) | 2020-05-05 |
CA3073622A1 (en) | 2019-03-28 |
JP2020536505A (ja) | 2020-12-17 |
KR20200052283A (ko) | 2020-05-14 |
IL273176A (en) | 2020-04-30 |
US20230348936A1 (en) | 2023-11-02 |
RU2020111459A (ru) | 2021-10-20 |
ZA202000862B (en) | 2021-02-24 |
BR112020005404A2 (pt) | 2020-09-29 |
EP3649239A1 (en) | 2020-05-13 |
US20200277628A1 (en) | 2020-09-03 |
WO2019057691A1 (en) | 2019-03-28 |
SG11202000443SA (en) | 2020-02-27 |
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