MX2022012855A - Virus adenoasociado con cápside modificada geneticamente. - Google Patents
Virus adenoasociado con cápside modificada geneticamente.Info
- Publication number
- MX2022012855A MX2022012855A MX2022012855A MX2022012855A MX2022012855A MX 2022012855 A MX2022012855 A MX 2022012855A MX 2022012855 A MX2022012855 A MX 2022012855A MX 2022012855 A MX2022012855 A MX 2022012855A MX 2022012855 A MX2022012855 A MX 2022012855A
- Authority
- MX
- Mexico
- Prior art keywords
- capsid
- associated virus
- engineered
- adeno
- virions
- Prior art date
Links
- 210000000234 capsid Anatomy 0.000 title abstract 4
- 241000702421 Dependoparvovirus Species 0.000 title abstract 2
- 210000002845 virion Anatomy 0.000 abstract 2
- 241001634120 Adeno-associated virus - 5 Species 0.000 abstract 1
- 108090000565 Capsid Proteins Proteins 0.000 abstract 1
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 1
- 210000002064 heart cell Anatomy 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/075—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente descripción proporciona viriones de virus adenoasociados recombinantes (rAAV) con una proteína de la cápside modificada genéticamente. En particular, la descripción proporciona viriones de AAV9 con cápside de AAV9 modificada genéticamente, cápside quimérica de AAV5/9 o cápside combinatoria que logra una mayor eficiencia de transducción en células cardíacas, una mayor selectividad de tipo celular y/u otras propiedades convenientes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063012703P | 2020-04-20 | 2020-04-20 | |
PCT/US2021/027979 WO2021216456A2 (en) | 2020-04-20 | 2021-04-19 | Adeno-associated virus with engineered capsid |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022012855A true MX2022012855A (es) | 2023-01-04 |
Family
ID=78269888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022012855A MX2022012855A (es) | 2020-04-20 | 2021-04-19 | Virus adenoasociado con cápside modificada geneticamente. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230220014A1 (es) |
EP (1) | EP4139443A2 (es) |
JP (1) | JP2023522106A (es) |
KR (1) | KR20230004719A (es) |
CN (1) | CN115997011A (es) |
AU (1) | AU2021259422A1 (es) |
BR (1) | BR112022021134A2 (es) |
CA (1) | CA3180202A1 (es) |
CO (1) | CO2022016592A2 (es) |
IL (1) | IL297391A (es) |
MX (1) | MX2022012855A (es) |
WO (1) | WO2021216456A2 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116096734A (zh) | 2020-05-13 | 2023-05-09 | 沃雅戈治疗公司 | Aav衣壳的向性的重定向 |
KR20230043869A (ko) | 2020-08-07 | 2023-03-31 | 스페이스크래프트 세븐, 엘엘씨 | Aav 벡터를 사용한 플라코필린-2(pkp2) 유전자 요법 |
WO2023091934A1 (en) * | 2021-11-16 | 2023-05-25 | California Institute Of Technology | Adeno-associated virus compositions having preferred heart and skeletal muscle enrichment |
TW202404993A (zh) | 2022-04-11 | 2024-02-01 | 美商特納亞治療股份有限公司 | 具經工程化蛋白殼之腺相關病毒 |
WO2024038345A1 (en) * | 2022-08-19 | 2024-02-22 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
WO2024064863A2 (en) * | 2022-09-22 | 2024-03-28 | Biomarin Pharmaceutical Inc. | Treatment of arrhythmogenic cardiomyopathy with aav gene therapy vectors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015164757A1 (en) * | 2014-04-25 | 2015-10-29 | Oregon Health & Science University | Methods of viral neutralizing antibody epitope mapping |
US20210371471A1 (en) * | 2018-04-03 | 2021-12-02 | Stridebio, Inc. | Antibody-evading virus vectors |
-
2021
- 2021-04-19 US US17/996,611 patent/US20230220014A1/en active Pending
- 2021-04-19 AU AU2021259422A patent/AU2021259422A1/en active Pending
- 2021-04-19 CA CA3180202A patent/CA3180202A1/en active Pending
- 2021-04-19 MX MX2022012855A patent/MX2022012855A/es unknown
- 2021-04-19 WO PCT/US2021/027979 patent/WO2021216456A2/en active Application Filing
- 2021-04-19 CN CN202180043726.1A patent/CN115997011A/zh active Pending
- 2021-04-19 BR BR112022021134A patent/BR112022021134A2/pt not_active Application Discontinuation
- 2021-04-19 EP EP21793043.7A patent/EP4139443A2/en active Pending
- 2021-04-19 IL IL297391A patent/IL297391A/en unknown
- 2021-04-19 KR KR1020227040546A patent/KR20230004719A/ko unknown
- 2021-04-19 JP JP2022563387A patent/JP2023522106A/ja active Pending
-
2022
- 2022-11-17 CO CONC2022/0016592A patent/CO2022016592A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112022021134A2 (pt) | 2023-02-14 |
WO2021216456A3 (en) | 2021-12-02 |
US20230220014A1 (en) | 2023-07-13 |
CN115997011A (zh) | 2023-04-21 |
AU2021259422A1 (en) | 2022-12-08 |
WO2021216456A2 (en) | 2021-10-28 |
IL297391A (en) | 2022-12-01 |
KR20230004719A (ko) | 2023-01-06 |
CA3180202A1 (en) | 2021-10-28 |
CO2022016592A2 (es) | 2022-11-29 |
EP4139443A2 (en) | 2023-03-01 |
JP2023522106A (ja) | 2023-05-26 |
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