SA520412669B1 - تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية - Google Patents

تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية

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Publication number
SA520412669B1
SA520412669B1 SA520412669A SA520412669A SA520412669B1 SA 520412669 B1 SA520412669 B1 SA 520412669B1 SA 520412669 A SA520412669 A SA 520412669A SA 520412669 A SA520412669 A SA 520412669A SA 520412669 B1 SA520412669 B1 SA 520412669B1
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Saudi Arabia
Prior art keywords
protein
bont
soluble
manufacture
clostridium botulinum
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SA520412669A
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English (en)
Inventor
ستيفن هاكيت جافين
مان ليو ساي
بالان شيلبا
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ابسين بيوانوفيشن المحدودة
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Publication of SA520412669B1 publication Critical patent/SA520412669B1/ar

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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

يتعلق الاختراع الحالي بتوفير طرق لإنتاج بروتين BoNT/A ثنائي السلسلة قابل للذوبان soluble di-chain، تشتمل على : (أ) توفير بروتين protein BoNT/A القابل للذوبان أحادي السلسلة soluble single-chain ؛ (ب) ملامسة بروتينBoNT/A المذكور مع إنزيم بروتيناز الداخلي Lys-C endoproteinase (Lys-C) في المحلول ؛ و (ج) فصل بروتين BoNT/A القابل للذوبان من Lys-C بملامسة المحلول المحتوي على بروتين BoNT/A القابل للذوبان و Lys-Cغير آلف للماء، حيث يرتبط بروتين BoNT/A القابل للذوبان بأفضلية للسطح غير الآلف للماء hydrophobic surface. شكل 1.
SA520412669A 2014-04-29 2016-10-11 تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية SA520412669B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1407525.3A GB201407525D0 (en) 2014-04-29 2014-04-29 Manufacture of recombinant clostridium botulinum neurotoxins
PCT/GB2015/051250 WO2015166242A1 (en) 2014-04-29 2015-04-29 Manufacture of recombinant clostridium botulinum neurotoxins

Publications (1)

Publication Number Publication Date
SA520412669B1 true SA520412669B1 (ar) 2022-08-02

Family

ID=50972048

Family Applications (2)

Application Number Title Priority Date Filing Date
SA516380060A SA516380060B1 (ar) 2014-04-29 2016-10-11 تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية
SA520412669A SA520412669B1 (ar) 2014-04-29 2016-10-11 تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية

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Application Number Title Priority Date Filing Date
SA516380060A SA516380060B1 (ar) 2014-04-29 2016-10-11 تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية

Country Status (18)

Country Link
US (3) US10307468B2 (ar)
EP (3) EP4309668A3 (ar)
JP (2) JP6656171B2 (ar)
KR (2) KR20230152778A (ar)
CN (1) CN106414759B (ar)
AU (3) AU2015255068B2 (ar)
CA (1) CA2941160A1 (ar)
DK (1) DK3137621T3 (ar)
EA (1) EA201692188A1 (ar)
ES (2) ES2749049T3 (ar)
GB (1) GB201407525D0 (ar)
HU (1) HUE045564T2 (ar)
MX (2) MX2016013803A (ar)
PL (1) PL3137621T3 (ar)
PT (1) PT3137621T (ar)
SA (2) SA516380060B1 (ar)
SG (1) SG11201607400VA (ar)
WO (1) WO2015166242A1 (ar)

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GB201312317D0 (en) 2013-07-09 2013-08-21 Syntaxin Ltd Cationic neurotoxins
JP2018525021A (ja) 2015-08-27 2018-09-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 疼痛の治療を目的とする組成物及び方法
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KR20200070310A (ko) * 2017-10-13 2020-06-17 위스콘신 얼럼나이 리서어치 화운데이션 보툴리눔 신경독 a 서브타입 6 및 약리학적 사용 방법
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KR102516203B1 (ko) * 2019-04-15 2023-03-30 (주)제테마 보툴리눔 독소의 제조방법
KR102485146B1 (ko) 2019-04-15 2023-01-06 (주)제테마 보툴리눔 독소의 제조방법
GB202003813D0 (en) 2020-03-16 2020-04-29 Ipsen Biopharm Ltd Treatment of upper facial lines
AU2021238924A1 (en) 2020-03-16 2022-08-25 Ipsen Biopharm Limited Modified botulinum neurotoxin for treating limb spasticity
EP4401759A1 (en) 2021-09-16 2024-07-24 Ipsen Biopharm Limited Modified bont/a for use in the treatment of cervical dystonia
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