MX2020010262A - Manufactura de neurotoxinas de clostridium botulinum recombinantes. - Google Patents
Manufactura de neurotoxinas de clostridium botulinum recombinantes.Info
- Publication number
- MX2020010262A MX2020010262A MX2020010262A MX2020010262A MX2020010262A MX 2020010262 A MX2020010262 A MX 2020010262A MX 2020010262 A MX2020010262 A MX 2020010262A MX 2020010262 A MX2020010262 A MX 2020010262A MX 2020010262 A MX2020010262 A MX 2020010262A
- Authority
- MX
- Mexico
- Prior art keywords
- manufacture
- clostridium botulinum
- botulinum neurotoxins
- recombinant clostridium
- recombinant
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title 1
- 241000193155 Clostridium botulinum Species 0.000 title 1
- 231100001103 botulinum neurotoxin Toxicity 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 101710117542 Botulinum neurotoxin type A Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- A—HUMAN NECESSITIES
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- A61K47/02—Inorganic compounds
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
Abstract
La presente invención proporciona métodos para producir una proteína de BoNT/A de di-cadena soluble.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1407525.3A GB201407525D0 (en) | 2014-04-29 | 2014-04-29 | Manufacture of recombinant clostridium botulinum neurotoxins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020010262A true MX2020010262A (es) | 2020-10-28 |
Family
ID=50972048
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013803A MX2016013803A (es) | 2014-04-29 | 2015-04-29 | Manufactura de neurotoxinas del clostridium botulinum recombinantes. |
| MX2020010262A MX2020010262A (es) | 2014-04-29 | 2016-10-20 | Manufactura de neurotoxinas de clostridium botulinum recombinantes. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013803A MX2016013803A (es) | 2014-04-29 | 2015-04-29 | Manufactura de neurotoxinas del clostridium botulinum recombinantes. |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10307468B2 (es) |
| EP (3) | EP4309668A3 (es) |
| JP (2) | JP6656171B2 (es) |
| KR (2) | KR20230152778A (es) |
| CN (1) | CN106414759B (es) |
| AU (3) | AU2015255068B2 (es) |
| CA (1) | CA2941160A1 (es) |
| DK (1) | DK3137621T3 (es) |
| EA (1) | EA201692188A1 (es) |
| ES (2) | ES2749049T3 (es) |
| GB (1) | GB201407525D0 (es) |
| HU (1) | HUE045564T2 (es) |
| MX (2) | MX2016013803A (es) |
| PL (1) | PL3137621T3 (es) |
| PT (1) | PT3137621T (es) |
| SA (2) | SA516380060B1 (es) |
| SG (1) | SG11201607400VA (es) |
| WO (1) | WO2015166242A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168206B1 (en) * | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
| AU2010265888A1 (en) * | 2009-06-25 | 2012-01-19 | Revance Therapeutics, Inc. | Albumin-free botulinum toxin formulations |
| MX365496B (es) * | 2009-10-21 | 2019-06-05 | Revance Therapeutics Inc | Metodos y sistemas para purificar la neurotoxina botulinica no acomplejada. |
| GB201219602D0 (en) * | 2012-10-31 | 2012-12-12 | Syntaxin Ltd | Recombinant clostridium botulinum neurotoxins |
| KR20180077343A (ko) | 2012-11-21 | 2018-07-06 | 입센 바이오이노베이션 리미티드 | 단백질 가수분해 처리된 폴리펩티드의 제조방법 |
| GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| JP2018525021A (ja) | 2015-08-27 | 2018-09-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 疼痛の治療を目的とする組成物及び方法 |
| GB201517450D0 (en) * | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| GB201607901D0 (en) * | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| RS62832B1 (sr) * | 2016-05-27 | 2022-02-28 | Ipsen Biopharm Ltd | Tečna neurotoksin formulacija stabilizovana sa triptofanom ili tirozinom |
| MX2019002835A (es) | 2016-09-13 | 2019-09-04 | Allergan Inc | Composiciones no proteínicas de toxina clostridial. |
| KR20200070310A (ko) * | 2017-10-13 | 2020-06-17 | 위스콘신 얼럼나이 리서어치 화운데이션 | 보툴리눔 신경독 a 서브타입 6 및 약리학적 사용 방법 |
| US11707510B2 (en) * | 2018-02-16 | 2023-07-25 | Preclinics Discovery Gmbh | Nucleic acid-based botulinum neurotoxin for therapeutic use |
| US20220016221A1 (en) | 2018-12-05 | 2022-01-20 | Ipsen Biopharm Limited | Treatment of symptoms of traumatic brain injury |
| KR102516203B1 (ko) * | 2019-04-15 | 2023-03-30 | (주)제테마 | 보툴리눔 독소의 제조방법 |
| KR102485146B1 (ko) | 2019-04-15 | 2023-01-06 | (주)제테마 | 보툴리눔 독소의 제조방법 |
| GB202003813D0 (en) | 2020-03-16 | 2020-04-29 | Ipsen Biopharm Ltd | Treatment of upper facial lines |
| AU2021238924A1 (en) | 2020-03-16 | 2022-08-25 | Ipsen Biopharm Limited | Modified botulinum neurotoxin for treating limb spasticity |
| EP4401759A1 (en) | 2021-09-16 | 2024-07-24 | Ipsen Biopharm Limited | Modified bont/a for use in the treatment of cervical dystonia |
| GB202113602D0 (en) | 2021-09-23 | 2021-11-10 | Ipsen Biopharm Ltd | Treatment of a disorder affecting an eyelid muscle of a subject |
| EP4404955A1 (en) | 2021-09-23 | 2024-07-31 | Ipsen Biopharm Limited | Modified bont/a for use in the treatment of a disorder affecting an eyelid muscle of a subject |
| CN118126144A (zh) * | 2024-03-14 | 2024-06-04 | 河北平朴生物科技合伙企业(有限合伙) | 一种a型重组肉毒素的纯化方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996005222A1 (en) * | 1994-08-08 | 1996-02-22 | Wisconsin Alumni Research Foundation | Purification and pharmaceutical compositions containing type g botulinum neurotoxin |
| DE19856897A1 (de) | 1998-12-10 | 2000-06-15 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum zur Unterdrückung von Schnarchgeräuschen |
| AU783450B2 (en) * | 1999-05-12 | 2005-10-27 | United States Army Medical Research Materiel Command (Usamrmc) | Recombinant vaccine against botulinum neurotoxin |
| US7452697B2 (en) * | 2003-09-25 | 2008-11-18 | Allergan, Inc. | Chromatographic method and system for purifying a botulinum toxin |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| CA2556796C (en) * | 2005-03-03 | 2018-01-23 | Allergan, Inc. | Animal product free system and process for purifying a botulinum toxin |
| DK2154151T3 (da) * | 2005-09-19 | 2011-09-05 | Allergan Inc | Clostridiumtoksinaktiverbare clostridiumtoksiner |
| CN101175478A (zh) * | 2005-10-06 | 2008-05-07 | 阿勒根公司 | 非蛋白稳定的梭菌毒素药物组合物 |
| US8137677B2 (en) * | 2005-10-06 | 2012-03-20 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
| US8129139B2 (en) * | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| MX365496B (es) * | 2009-10-21 | 2019-06-05 | Revance Therapeutics Inc | Metodos y sistemas para purificar la neurotoxina botulinica no acomplejada. |
| PL2677029T3 (pl) | 2011-05-19 | 2017-10-31 | Ipsen Bioinnovation Ltd | Sposoby wytwarzania poddanych obróbce proteolitycznej polipeptydów |
| KR20180077343A (ko) * | 2012-11-21 | 2018-07-06 | 입센 바이오이노베이션 리미티드 | 단백질 가수분해 처리된 폴리펩티드의 제조방법 |
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2014
- 2014-04-29 GB GBGB1407525.3A patent/GB201407525D0/en not_active Ceased
-
2015
- 2015-04-29 EP EP23211865.3A patent/EP4309668A3/en active Pending
- 2015-04-29 EP EP15721027.9A patent/EP3137621B1/en active Active
- 2015-04-29 CN CN201580022941.8A patent/CN106414759B/zh active Active
- 2015-04-29 PT PT157210279T patent/PT3137621T/pt unknown
- 2015-04-29 DK DK15721027.9T patent/DK3137621T3/da active
- 2015-04-29 MX MX2016013803A patent/MX2016013803A/es active IP Right Grant
- 2015-04-29 US US15/306,006 patent/US10307468B2/en active Active
- 2015-04-29 CA CA2941160A patent/CA2941160A1/en active Pending
- 2015-04-29 EP EP19178079.0A patent/EP3591065B1/en active Active
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