AR115318A1 - Modulación de la actividad lactogénica en células de mamífero - Google Patents
Modulación de la actividad lactogénica en células de mamíferoInfo
- Publication number
- AR115318A1 AR115318A1 ARP190100834A ARP190100834A AR115318A1 AR 115318 A1 AR115318 A1 AR 115318A1 AR P190100834 A ARP190100834 A AR P190100834A AR P190100834 A ARP190100834 A AR P190100834A AR 115318 A1 AR115318 A1 AR 115318A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- lactogenic activity
- compositions
- methods
- cell
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/0104—Pyruvate kinase (2.7.1.40)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Abstract
La presente descripción hace referencia a métodos, células y composiciones para confeccionar un producto de interés, por ejemplo, una proteína recombinante. En particular, la presente descripción proporciona células de mamífero mejoradas que expresan el producto de interés, donde las células (por ejemplo, células de ovario de hámster chino (CHO, por sus siglas en inglés)) tienen una actividad lactogénica modulada. La presente descripción también hace referencia a métodos y composiciones para modular la expresión del piruvato cinasa muscular (PKM) (por ejemplo, expresión de PKM-1) en una célula de mamífero para reducir o eliminar así la actividad lactogénica de la célula, así como composiciones que comprenden una célula que tiene actividad lactogénica reducida o eliminada, y métodos para utilizarlas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862649963P | 2018-03-29 | 2018-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115318A1 true AR115318A1 (es) | 2020-12-23 |
Family
ID=66448608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190100834A AR115318A1 (es) | 2018-03-29 | 2019-03-29 | Modulación de la actividad lactogénica en células de mamífero |
Country Status (14)
Country | Link |
---|---|
US (1) | US20210009988A1 (es) |
EP (1) | EP3775184A1 (es) |
JP (2) | JP2021519073A (es) |
KR (2) | KR20200135510A (es) |
CN (1) | CN111936625A (es) |
AR (1) | AR115318A1 (es) |
AU (1) | AU2019245243A1 (es) |
BR (1) | BR112020019726A2 (es) |
CA (1) | CA3091231A1 (es) |
IL (1) | IL277591A (es) |
MX (1) | MX2020010028A (es) |
SG (1) | SG11202009542PA (es) |
TW (1) | TW202003839A (es) |
WO (1) | WO2019191552A1 (es) |
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KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
SG11201607165YA (en) | 2014-12-19 | 2016-09-29 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
CA2980189A1 (en) | 2015-04-24 | 2016-10-27 | Genentech, Inc. | Multispecific antigen-binding proteins |
AU2016280893B2 (en) * | 2015-06-18 | 2021-12-02 | Massachusetts Institute Of Technology | CRISPR enzyme mutations reducing off-target effects |
JP6802626B2 (ja) * | 2015-10-15 | 2020-12-16 | シーシーアイホールディングス株式会社 | がん細胞の薬物感受性増強剤、薬物感受性を予測する方法、および薬物感受性バイオマーカー |
JP7107839B2 (ja) * | 2015-12-11 | 2022-07-27 | ルプレヒト-カールス-ウニベルジテート ハイデルベルク | Pkm2モジュレーター及びhmgb1の組合せ製剤 |
US11242510B2 (en) * | 2016-05-02 | 2022-02-08 | The Regents Of The University Of California | Mammalian cells devoid of lactate dehydrogenase activity |
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2019
- 2019-03-29 WO PCT/US2019/024774 patent/WO2019191552A1/en active Application Filing
- 2019-03-29 CA CA3091231A patent/CA3091231A1/en active Pending
- 2019-03-29 JP JP2020551556A patent/JP2021519073A/ja not_active Withdrawn
- 2019-03-29 KR KR1020207030786A patent/KR20200135510A/ko not_active Application Discontinuation
- 2019-03-29 EP EP19722967.7A patent/EP3775184A1/en active Pending
- 2019-03-29 CN CN201980023064.4A patent/CN111936625A/zh active Pending
- 2019-03-29 TW TW108111362A patent/TW202003839A/zh unknown
- 2019-03-29 AR ARP190100834A patent/AR115318A1/es unknown
- 2019-03-29 KR KR1020237009266A patent/KR20230042407A/ko not_active Application Discontinuation
- 2019-03-29 AU AU2019245243A patent/AU2019245243A1/en not_active Abandoned
- 2019-03-29 BR BR112020019726-2A patent/BR112020019726A2/pt not_active Application Discontinuation
- 2019-03-29 MX MX2020010028A patent/MX2020010028A/es unknown
- 2019-03-29 SG SG11202009542PA patent/SG11202009542PA/en unknown
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2020
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- 2020-09-29 US US17/036,075 patent/US20210009988A1/en active Pending
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2022
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KR20200135510A (ko) | 2020-12-02 |
JP2023040016A (ja) | 2023-03-22 |
BR112020019726A2 (pt) | 2021-01-26 |
TW202003839A (zh) | 2020-01-16 |
CA3091231A1 (en) | 2019-10-03 |
IL277591A (en) | 2020-11-30 |
KR20230042407A (ko) | 2023-03-28 |
CN111936625A (zh) | 2020-11-13 |
US20210009988A1 (en) | 2021-01-14 |
AU2019245243A1 (en) | 2020-09-03 |
MX2020010028A (es) | 2020-10-14 |
EP3775184A1 (en) | 2021-02-17 |
JP2021519073A (ja) | 2021-08-10 |
SG11202009542PA (en) | 2020-10-29 |
WO2019191552A1 (en) | 2019-10-03 |
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