KR920700287A - 신규의 프로테아제 억제물질 및 그것의 제조방법 - Google Patents
신규의 프로테아제 억제물질 및 그것의 제조방법Info
- Publication number
- KR920700287A KR920700287A KR1019900702307A KR900702307A KR920700287A KR 920700287 A KR920700287 A KR 920700287A KR 1019900702307 A KR1019900702307 A KR 1019900702307A KR 900702307 A KR900702307 A KR 900702307A KR 920700287 A KR920700287 A KR 920700287A
- Authority
- KR
- South Korea
- Prior art keywords
- gly
- ala
- cys
- lys
- pro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8135—Kazal type inhibitors, e.g. pancreatic secretory inhibitor, ovomucoid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 메티오닌 트립스타틴 유전자를 6개 단편으로 절단한 DNA 서열을 도시하며;
제2도는 6개의 합성 단편물의 DNA 서열을 도시하며;
제3도는 메티오닌 트립스타틴 합성 유전자를 수득하기 위한 단편물의 연결반응을 도시함.
Claims (7)
- 하기의 아미노산 서열을 코오딩한 메티오닌 트리스타틴.Met Ile Ala Ala Cys Asn Leu Pro Ile Val Gln Gly Pro Cys Arg Ala Phe Ala Glu Leu Leu Ala Phe Asp Ala Ala Gln Gly Lys Cys Ile Gln Phe Ile Tyr Gly Gly Cys Lys Gly Asn Asn Asn Lys Gly Tyr Ser Glu Pro Lys Cys Lys Trp Tyr Cys Gly Val Pro Gly Asp Gly Tyr
- 하기의 염기 서열을 갖는, 메티오닌 트립스타틴을 코오딩한 서열.
- N1, N2및 N3가 C 또는 T를 나타내며 하기의 서열을 갖는 메티오닌 트립스타틴을 코오딩한 DNA 서열.
- 제2항 또는 제3항 DNA를 형질발현 벡터에 삽입한 재조합 플라즈미드.
- 제4항의 재조합 플라즈미드에 의해 형질전환된 미생물.
- 제4항의 미생물을 배양하는 것을 특징으로 하는 메티오닌 트립스타틴 제조방법.
- 하기의 아미노산 서열을 포함하는 프로테아제 억제제 메티오닌 트립스타틴.Met Ile Ala Ala Cys Asn Leu Pro Ile Val Gln Gly Pro Cys Arg Ala Phe Ala Glu Leu Leu Ala Phe Asp Ala Ala Gln Gly Lys Cys Ile Gln Phe Ile Tyr Gly Gly Cys Lys Gly Asn Asn Asn Lys Gly Tyr Ser Glu Pro Lys Cys Lys Trp Tyr Cys Gly Val Pro Gly Asp Gly Tyr※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1-40175 | 1989-02-22 | ||
| JP4017589 | 1989-02-22 | ||
| PCT/JP1990/000216 WO1990010066A1 (fr) | 1989-02-22 | 1990-02-22 | Nouvel inhibiteur de protease et production de ce compose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920700287A true KR920700287A (ko) | 1992-02-19 |
Family
ID=12573438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900702307A KR920700287A (ko) | 1989-02-22 | 1990-02-22 | 신규의 프로테아제 억제물질 및 그것의 제조방법 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0426860A4 (ko) |
| KR (1) | KR920700287A (ko) |
| CA (1) | CA2025537A1 (ko) |
| WO (1) | WO1990010066A1 (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW492975B (en) * | 1993-07-26 | 2002-07-01 | Novartis Ag | Tryptase inhibitor |
| US5633227A (en) * | 1994-09-12 | 1997-05-27 | Miles, Inc. | Secretory leukocyte protease inhibitor as an inhibitor of tryptase |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59125895A (ja) * | 1983-01-07 | 1984-07-20 | Rikagaku Kenkyusho | ヒト生長ホルモン遺伝子の合成法 |
| GB2188933A (en) * | 1986-04-10 | 1987-10-14 | Bayer Ag | Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby |
-
1990
- 1990-02-22 CA CA002025537A patent/CA2025537A1/en not_active Abandoned
- 1990-02-22 EP EP19900903427 patent/EP0426860A4/en not_active Withdrawn
- 1990-02-22 WO PCT/JP1990/000216 patent/WO1990010066A1/ja not_active Application Discontinuation
- 1990-02-22 KR KR1019900702307A patent/KR920700287A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990010066A1 (fr) | 1990-09-07 |
| EP0426860A4 (en) | 1991-10-02 |
| CA2025537A1 (en) | 1990-08-23 |
| EP0426860A1 (en) | 1991-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |