BR112022001575A2 - Formulações de anticorpos anti-pvrig e usos dos mesmos - Google Patents
Formulações de anticorpos anti-pvrig e usos dos mesmosInfo
- Publication number
- BR112022001575A2 BR112022001575A2 BR112022001575A BR112022001575A BR112022001575A2 BR 112022001575 A2 BR112022001575 A2 BR 112022001575A2 BR 112022001575 A BR112022001575 A BR 112022001575A BR 112022001575 A BR112022001575 A BR 112022001575A BR 112022001575 A2 BR112022001575 A2 BR 112022001575A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody formulations
- pvrig antibody
- pvrig
- formulations
- liquid pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
formulações de anticorpos anti-pvrig e usos dos mesmos. trata se de anticorpos anti pvrig e formulações farmacêuticas líquidas estáveis dos mesmos.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962880021P | 2019-07-29 | 2019-07-29 | |
US201962893051P | 2019-08-28 | 2019-08-28 | |
US201962930206P | 2019-11-04 | 2019-11-04 | |
US202062968660P | 2020-01-31 | 2020-01-31 | |
US202062985702P | 2020-03-05 | 2020-03-05 | |
US202063009367P | 2020-04-13 | 2020-04-13 | |
PCT/US2020/043921 WO2021021837A2 (en) | 2019-07-29 | 2020-07-28 | Anti-pvrig antibodies formulations and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022001575A2 true BR112022001575A2 (pt) | 2022-04-19 |
Family
ID=72243187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022001575A BR112022001575A2 (pt) | 2019-07-29 | 2020-07-28 | Formulações de anticorpos anti-pvrig e usos dos mesmos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220280643A1 (pt) |
EP (1) | EP4003417A2 (pt) |
JP (1) | JP2022542505A (pt) |
KR (1) | KR20220041881A (pt) |
CN (1) | CN114615993A (pt) |
AU (1) | AU2020323926A1 (pt) |
BR (1) | BR112022001575A2 (pt) |
CA (1) | CA3149093A1 (pt) |
IL (1) | IL290141A (pt) |
MX (1) | MX2022001146A (pt) |
WO (1) | WO2021021837A2 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Tigit及cd112r阻斷 |
EP4222172A1 (en) * | 2020-09-30 | 2023-08-09 | Compugen Ltd. | Combination therapy with anti-pvrig antibodies formulations, anti-tigit antibodies, and anti-pd-1 antibodies |
CA3207791A1 (en) * | 2021-02-09 | 2022-08-18 | Shanghai Junshi Biosciences Co., Ltd. | Anti-cd112r antibody and use thereof |
CA3231320A1 (en) | 2021-09-15 | 2023-03-23 | Zhiliang CAO | Protein specifically binding to pd-1 and pharmaceutical use thereof |
WO2024027824A1 (zh) * | 2022-08-05 | 2024-02-08 | 上海君实生物医药科技股份有限公司 | 抗cd112r抗体药物组合物及其用途 |
WO2024032700A1 (en) * | 2022-08-10 | 2024-02-15 | Beigene, Ltd. | Anti-pvrig antibodies and methods of use |
WO2024046245A1 (zh) * | 2022-08-31 | 2024-03-07 | 石药集团巨石生物制药有限公司 | 抗pvrig抗体及其应用 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9714A (en) | 1853-05-10 | Machine fob making hook-headed spikes | ||
US289A (en) | 1837-07-19 | Cooking-stove | ||
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
EP0640094A1 (en) | 1992-04-24 | 1995-03-01 | The Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
ATE458007T1 (de) | 1998-04-20 | 2010-03-15 | Glycart Biotechnology Ag | Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Hakko Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
HUP0600342A3 (en) | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
BR0309145A (pt) | 2002-04-09 | 2005-02-01 | Kyowa Hakko Kogyo Kk | Células das quais o genoma é modificado |
EP1610820B2 (en) * | 2003-04-04 | 2013-08-21 | Genentech, Inc. | High concentration antibody and protein formulations |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
DK3259597T3 (da) * | 2015-02-19 | 2022-05-09 | Compugen Ltd | Pvrig-polypeptider og fremgangsmåder til behandling |
PT3295951T (pt) | 2015-02-19 | 2020-07-21 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
SI3347379T1 (sl) * | 2016-08-17 | 2020-04-30 | Compugen Ltd. | ANTI-TIGIT protitelesa, ANTI-PVRIG protitelesa in njihove kombinacije |
AU2017380842A1 (en) * | 2016-12-23 | 2019-07-11 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
-
2020
- 2020-07-28 KR KR1020227006619A patent/KR20220041881A/ko unknown
- 2020-07-28 US US17/631,847 patent/US20220280643A1/en active Pending
- 2020-07-28 AU AU2020323926A patent/AU2020323926A1/en active Pending
- 2020-07-28 CN CN202080060763.9A patent/CN114615993A/zh active Pending
- 2020-07-28 CA CA3149093A patent/CA3149093A1/en active Pending
- 2020-07-28 MX MX2022001146A patent/MX2022001146A/es unknown
- 2020-07-28 EP EP20761926.3A patent/EP4003417A2/en active Pending
- 2020-07-28 JP JP2022505499A patent/JP2022542505A/ja active Pending
- 2020-07-28 WO PCT/US2020/043921 patent/WO2021021837A2/en unknown
- 2020-07-28 BR BR112022001575A patent/BR112022001575A2/pt unknown
-
2022
- 2022-01-26 IL IL290141A patent/IL290141A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220041881A (ko) | 2022-04-01 |
IL290141A (en) | 2022-03-01 |
CA3149093A1 (en) | 2021-02-04 |
WO2021021837A2 (en) | 2021-02-04 |
WO2021021837A3 (en) | 2021-03-11 |
US20220280643A1 (en) | 2022-09-08 |
EP4003417A2 (en) | 2022-06-01 |
CN114615993A (zh) | 2022-06-10 |
MX2022001146A (es) | 2022-03-17 |
AU2020323926A1 (en) | 2022-03-10 |
JP2022542505A (ja) | 2022-10-04 |
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