BR0011046A - Métodos para a melhorada produção de um agente viral, para a produção de linhagens de célula exibindo permanente modificação genética, para a produção de linhagens de células eucarióticas permissivas, para melhorar o rendimento de produtos recombinantes funcionais, agente viral, linhagem de célula selecionada para exibição de modificação genética permante, linhagem de células eucarióticas permissivas, e, produto recombinante funcional - Google Patents
Métodos para a melhorada produção de um agente viral, para a produção de linhagens de célula exibindo permanente modificação genética, para a produção de linhagens de células eucarióticas permissivas, para melhorar o rendimento de produtos recombinantes funcionais, agente viral, linhagem de célula selecionada para exibição de modificação genética permante, linhagem de células eucarióticas permissivas, e, produto recombinante funcionalInfo
- Publication number
- BR0011046A BR0011046A BR0011046-9A BR0011046A BR0011046A BR 0011046 A BR0011046 A BR 0011046A BR 0011046 A BR0011046 A BR 0011046A BR 0011046 A BR0011046 A BR 0011046A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- cell lines
- genetic modification
- viral agent
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18451—Methods of production or purification of viral material
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
"METODOS PARA A MELHORADA PRODUçãO DE UM AGENTE VIRAL, PARA A PRODUçãO DE LINHAGENS DE CéLULA EXIBINDO PERMANENTE MODIFICAçãO GENéTICA, PARA A PRODUçãO DE LINHAGENS DE CéLULAS EUCARIóTICAS PERMISSIVAS, PARA MELHORAR O RENDIMENTO DE PRODUTOS RECOMBINANTES FUNCIONAIS, AGENTE VIRAL, LINHAGEM DE CéLULA SELECIONADA PARA EXIBIçãO DE MODIFICAçãO GENéTICA PERMANENTE, LINHAGEM DE CéLULAS EUCARIOTICAS PERMISSIVAS, E, PRODUTO RECOMBINANTE FUNCIONAL". Método para aumentar o rendimento de produção de vírus, proteínas virais, e outros materiais biológicos relacionados através de controle melhorado e estabilização de produção de proteínas via proteínas de estresse e os produtos de proteína resultantes. A presente invenção é também dirigida a métodos para seleção ou engenharia de linhagens de célula dando estes produtos estabilizados melhorados. Mais especificamente, formas de realização de exemplo da presente invenção são dirigidas a métodos para melhorar a produção de um agente viral, produção de linhagens de célula demonstrando permanente modificação genética, produção de linhagens de células eucarióticas permissivas, melhorando rendimento de produto recombinante funcional, e os produtos destes métodos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13667699P | 1999-05-28 | 1999-05-28 | |
US09/543,479 US6495360B1 (en) | 1999-05-28 | 2000-04-06 | Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins |
PCT/US2000/013666 WO2000073319A1 (en) | 1999-05-28 | 2000-05-18 | Method for enhanced protein stabilization and production of cell lines useful for production of such stabilized proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011046A true BR0011046A (pt) | 2002-04-16 |
Family
ID=26834532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011046-9A BR0011046A (pt) | 1999-05-28 | 2000-05-18 | Métodos para a melhorada produção de um agente viral, para a produção de linhagens de célula exibindo permanente modificação genética, para a produção de linhagens de células eucarióticas permissivas, para melhorar o rendimento de produtos recombinantes funcionais, agente viral, linhagem de célula selecionada para exibição de modificação genética permante, linhagem de células eucarióticas permissivas, e, produto recombinante funcional |
Country Status (12)
Country | Link |
---|---|
US (4) | US6495360B1 (pt) |
EP (1) | EP1187841A4 (pt) |
JP (1) | JP2003501014A (pt) |
KR (1) | KR20020028884A (pt) |
CN (1) | CN1359388A (pt) |
AR (1) | AR024122A1 (pt) |
AU (1) | AU4857000A (pt) |
BR (1) | BR0011046A (pt) |
CA (1) | CA2372243A1 (pt) |
IL (1) | IL146711A0 (pt) |
MX (1) | MXPA01012216A (pt) |
WO (1) | WO2000073319A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10121235A1 (de) * | 2001-04-30 | 2002-10-31 | Roche Diagnostics Gmbh | Verfahren zur Expression von Proteinen in in vitro Translations-Systemen unter Ko-Expression von Faltungshelferproteinen |
US7244616B2 (en) | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
EP2199385A1 (en) | 2008-12-16 | 2010-06-23 | ProBioGen AG | Specific and persistent activation of heat shock response in cell lines using a viral factor |
EP2580232A1 (en) * | 2010-06-08 | 2013-04-17 | National University of Ireland, Galway | Manipulation of hsp70 and ire1alpha protein interactions |
GB201104897D0 (en) | 2011-03-23 | 2011-05-04 | Immunobiology Ltd | Method for the production of protein complexes and vaccine compositions comprising the same |
EP2845904A1 (en) * | 2013-09-06 | 2015-03-11 | Ceva Sante Animale | Recombinant Marek's disease viruses and uses thereof |
CN107841514A (zh) * | 2017-12-15 | 2018-03-27 | 浙江省萧山棉麻研究所 | 一种提高印度梨形孢液体发酵产物产量的方法 |
US20240150807A1 (en) * | 2021-03-10 | 2024-05-09 | Sumitomo Pharma Co., Ltd. | Method for Producing Cysteine Knot Protein |
KR20230155484A (ko) * | 2021-03-10 | 2023-11-10 | 스미토모 파마 가부시키가이샤 | 융합 단백질의 제조 방법 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1596653A (en) * | 1977-01-26 | 1981-08-26 | Gist Brocades Nv | Vaccine |
US4211843A (en) * | 1977-11-30 | 1980-07-08 | L'institut Armand-Frappier | Strain of measles virus and process of producing the same |
US4303645A (en) * | 1980-04-18 | 1981-12-01 | Cornell Research Foundation, Inc. | Modified living canine parvovirus vaccine |
US4957737A (en) * | 1986-05-27 | 1990-09-18 | Hoffmann-La Roche Inc. | HTLV-III (LAV) envelope peptides |
DE3926103A1 (de) | 1989-08-08 | 1991-02-14 | Hoechst Ag | Verfahren zur biokatalytischen korrekten kettenfaltung denaturierter rekombinanter fusionsproteine |
WO1991006666A1 (en) * | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
US5348945A (en) | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
US5188964A (en) | 1990-04-12 | 1993-02-23 | Board Of Regents, The University Of Texas System | Method and kit for the prognostication of breast cancer patient via heat shock/stress protein determination |
US5347945A (en) | 1990-10-26 | 1994-09-20 | Mcalpine Peter M | Spinnaker pole control system and spinnaker pole end therefor |
DE4201181A1 (de) | 1992-01-17 | 1993-07-22 | Boehringer Mannheim Gmbh | Verfahren zur stabilisierung von proteinen |
CA2118015A1 (en) | 1992-04-14 | 1993-10-28 | Jeffrey R. Marks | Method of detecting tumors containing complexes of p53 and hsp70 |
DE69329202T2 (de) * | 1992-10-02 | 2001-03-29 | Research Corp. Technologies, Inc. | Methoden der erhöhung der sekretion von überexpremierten proteinen |
GB9223816D0 (en) * | 1992-11-13 | 1993-01-06 | Medical Res Council | Heat shock proteins and the treatment of tumours |
US5674703A (en) * | 1992-12-02 | 1997-10-07 | Woo; Savio L. C. | Episomal vector systems and related methods |
US5750119A (en) | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
US5872005A (en) * | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
JP3656277B2 (ja) | 1995-05-17 | 2005-06-08 | 味の素株式会社 | 組換えdna法によるトランスグルタミナーゼの効率的製造法 |
US5837251A (en) | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
US5739018A (en) * | 1996-08-07 | 1998-04-14 | The Regents Of The University Of California | Packaging cell lines for pseudotyped retroviral vectors |
US5830464A (en) | 1997-02-07 | 1998-11-03 | Fordham University | Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy |
JP3344618B2 (ja) * | 1997-06-20 | 2002-11-11 | 株式会社エイチ・エス・ピー研究所 | シャペロン発現プラスミド |
WO1999020108A1 (en) * | 1997-10-23 | 1999-04-29 | Uab Research Foundation | Human papillomavirus vectors for the episomal transduction of host cells and method of making same |
ATE359084T1 (de) * | 1998-02-20 | 2007-05-15 | Univ Miami | Modifizierter hitzeschockprotein/peptidantigen komplex |
WO1999063064A1 (en) * | 1998-06-03 | 1999-12-09 | American Cyanamid Company | Novel methods for rescue of rna viruses |
-
2000
- 2000-04-06 US US09/543,479 patent/US6495360B1/en not_active Expired - Lifetime
- 2000-05-18 EP EP00930813A patent/EP1187841A4/en not_active Withdrawn
- 2000-05-18 MX MXPA01012216A patent/MXPA01012216A/es unknown
- 2000-05-18 CA CA002372243A patent/CA2372243A1/en not_active Abandoned
- 2000-05-18 BR BR0011046-9A patent/BR0011046A/pt not_active Application Discontinuation
- 2000-05-18 AU AU48570/00A patent/AU4857000A/en not_active Abandoned
- 2000-05-18 KR KR1020017015259A patent/KR20020028884A/ko not_active Application Discontinuation
- 2000-05-18 CN CN00809670A patent/CN1359388A/zh active Pending
- 2000-05-18 IL IL14671100A patent/IL146711A0/xx unknown
- 2000-05-18 JP JP2001500644A patent/JP2003501014A/ja active Pending
- 2000-05-18 WO PCT/US2000/013666 patent/WO2000073319A1/en not_active Application Discontinuation
- 2000-05-26 AR ARP000102591A patent/AR024122A1/es unknown
-
2001
- 2001-03-09 US US09/803,634 patent/US6468777B2/en not_active Expired - Lifetime
- 2001-03-09 US US09/803,609 patent/US6541223B2/en not_active Expired - Lifetime
- 2001-03-09 US US09/803,498 patent/US6451597B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20010044146A1 (en) | 2001-11-22 |
CN1359388A (zh) | 2002-07-17 |
MXPA01012216A (es) | 2002-07-02 |
KR20020028884A (ko) | 2002-04-17 |
US20010041361A1 (en) | 2001-11-15 |
EP1187841A4 (en) | 2004-12-08 |
AR024122A1 (es) | 2002-09-04 |
IL146711A0 (en) | 2002-07-25 |
US6468777B2 (en) | 2002-10-22 |
CA2372243A1 (en) | 2000-12-07 |
US20010041354A1 (en) | 2001-11-15 |
WO2000073319A1 (en) | 2000-12-07 |
US6495360B1 (en) | 2002-12-17 |
JP2003501014A (ja) | 2003-01-14 |
AU4857000A (en) | 2000-12-18 |
EP1187841A1 (en) | 2002-03-20 |
US6451597B2 (en) | 2002-09-17 |
US6541223B2 (en) | 2003-04-01 |
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Legal Events
Date | Code | Title | Description |
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FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |