IL223048A - Polypeptide variants that bind fcrn with increased binding affinity and methods for their preparation - Google Patents

Polypeptide variants that bind fcrn with increased binding affinity and methods for their preparation

Info

Publication number
IL223048A
IL223048A IL223048A IL22304812A IL223048A IL 223048 A IL223048 A IL 223048A IL 223048 A IL223048 A IL 223048A IL 22304812 A IL22304812 A IL 22304812A IL 223048 A IL223048 A IL 223048A
Authority
IL
Israel
Prior art keywords
preparation
methods
binding affinity
increased binding
polypeptide variants
Prior art date
Application number
IL223048A
Other languages
Hebrew (he)
Other versions
IL223048A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL223048A0 publication Critical patent/IL223048A0/en
Publication of IL223048A publication Critical patent/IL223048A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL223048A 1999-01-15 2012-11-15 Polypeptide variants that bind fcrn with increased binding affinity and methods for their preparation IL223048A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11602399P 1999-01-15 1999-01-15
PCT/US2000/000973 WO2000042072A2 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function

Publications (2)

Publication Number Publication Date
IL223048A0 IL223048A0 (en) 2012-12-31
IL223048A true IL223048A (en) 2016-09-29

Family

ID=22364785

Family Applications (5)

Application Number Title Priority Date Filing Date
IL14405600A IL144056A0 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function
IL144056A IL144056A (en) 1999-01-15 2001-06-28 Polypeptide variants with altered effector function
IL222149A IL222149B (en) 1999-01-15 2012-09-27 A polypeptide comprising a variant human igg fc region that has increased fcrn binding affinity
IL223047A IL223047A (en) 1999-01-15 2012-11-15 Antibody comprising an fc region and uses thereof
IL223048A IL223048A (en) 1999-01-15 2012-11-15 Polypeptide variants that bind fcrn with increased binding affinity and methods for their preparation

Family Applications Before (4)

Application Number Title Priority Date Filing Date
IL14405600A IL144056A0 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function
IL144056A IL144056A (en) 1999-01-15 2001-06-28 Polypeptide variants with altered effector function
IL222149A IL222149B (en) 1999-01-15 2012-09-27 A polypeptide comprising a variant human igg fc region that has increased fcrn binding affinity
IL223047A IL223047A (en) 1999-01-15 2012-11-15 Antibody comprising an fc region and uses thereof

Country Status (16)

Country Link
US (4) US7371826B2 (en)
EP (4) EP2386574A3 (en)
JP (4) JP2003512019A (en)
KR (5) KR101155191B1 (en)
CN (2) CN1763097B (en)
AU (2) AU778683B2 (en)
BR (1) BR0008758A (en)
CA (1) CA2359067C (en)
ES (1) ES2694002T3 (en)
HU (2) HUP0104865A3 (en)
IL (5) IL144056A0 (en)
MX (2) MXPA01007170A (en)
NZ (1) NZ539776A (en)
PL (3) PL209786B1 (en)
WO (1) WO2000042072A2 (en)
ZA (1) ZA200105484B (en)

Families Citing this family (1788)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
EP1637160A3 (en) 1999-05-07 2006-05-03 Genentech, Inc. Treatment of autoimmune diseases with antagonists which bind to B cell surface markers
US6855493B2 (en) 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
ES2727425T3 (en) 2000-12-12 2019-10-16 Medimmune Llc Molecules with prolonged half-lives, compositions and uses thereof
US7658921B2 (en) 2000-12-12 2010-02-09 Medimmune, Llc Molecules with extended half-lives, compositions and uses thereof
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
JP4524074B2 (en) * 2001-03-09 2010-08-11 アーナソン， バリー ジー． Polymeric immunoglobulin fusion proteins targeting low affinity Fcγ receptors
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
PL213948B1 (en) * 2001-10-25 2013-05-31 Genentech Inc Glycoprotein compositions
US20040002587A1 (en) * 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JP4524181B2 (en) 2002-05-30 2010-08-11 マクロジェニクス，インコーポレーテッド CD16A binding protein and use for treatment of immune disorders
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US8968730B2 (en) 2002-08-14 2015-03-03 Macrogenics Inc. FcγRIIB specific antibodies and methods of use thereof
ES2381617T5 (en) 2002-08-14 2016-02-24 Macrogenics, Inc. Specific antibodies against FcgammaRIIB and its procedures for use
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
CN101987871A (en) 2002-09-27 2011-03-23 赞科股份有限公司 Optimized fc variants and methods for their generation
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7365168B2 (en) 2002-10-15 2008-04-29 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
ATE480562T1 (en) 2002-10-15 2010-09-15 Facet Biotech Corp CHANGE IN FCRN BINDING AFFINITIES OR SERUM HALF-LIFE TIMES OF ANTIBODIES USING MUtagenesis
EP2301966A1 (en) 2002-12-16 2011-03-30 Genentech, Inc. Immunoglobulin variants and uses thereof
AU2011265460B2 (en) * 2003-01-09 2014-07-17 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
JP2006524039A (en) 2003-01-09 2006-10-26 マクロジェニクス，インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
AU2004204817C1 (en) 2003-01-13 2011-01-20 Macrogenics, Inc. Soluble FcyR fusion proteins and methods of use thereof
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
UA91961C2 (en) 2003-04-09 2010-09-27 Дженентек, Инк. Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor
JP4685764B2 (en) * 2003-04-10 2011-05-18 アボット バイオセラピューティクス コーポレイション Modification of antibody FcRn binding affinity or serum half-life by mutagenesis
KR100973564B1 (en) * 2003-05-02 2010-08-03 젠코어 인코포레이티드 Optimized Fc Variants and Methods of Making the Same
US9051373B2 (en) 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
AR044388A1 (en) 2003-05-20 2005-09-07 Applied Molecular Evolution CD20 UNION MOLECULES
CA2526402A1 (en) 2003-06-05 2005-01-20 Genentech, Inc. Blys antagonists and uses thereof
CA2532547C (en) 2003-07-24 2020-02-25 Innate Pharma Methods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
CN1871259A (en) 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 Improved antibodies having altered effector function and methods for making the same
US8101720B2 (en) * 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
JP2007531707A (en) 2003-10-15 2007-11-08 ピーディーエル バイオファーマ， インコーポレイテッド Modification of Fc fusion protein serum half-life by mutagenesis of heavy chain constant region positions 250, 314 and / or 428 of IG
GB0324368D0 (en) * 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
DE602004026470D1 (en) 2003-11-05 2010-05-20 Roche Glycart Ag FC RECEPTOR AND EFFECTOR FUNCTION
WO2005063815A2 (en) * 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
EP1697415A1 (en) 2003-11-12 2006-09-06 Biogen Idec MA Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
US20080193441A1 (en) * 2003-11-18 2008-08-14 Iconic Therapeutics, Inc. Homogeneous Preparations of Chimeric Protein
WO2005056759A2 (en) 2003-12-04 2005-06-23 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
DK2418220T3 (en) 2003-12-10 2017-11-06 Squibb & Sons Llc INTERFERON-ALPHA ANTIBODIES AND APPLICATIONS THEREOF
KR20060135690A (en) 2003-12-10 2006-12-29 메다렉스, 인코포레이티드 IP-10 antibody and uses thereof
BRPI0506771A (en) 2004-01-12 2007-05-22 Applied Molecular Evolution antibody and pharmaceutical composition
EP1716181B1 (en) 2004-02-19 2009-12-16 Genentech, Inc. Cdr-repaired antibodies
CA2561264A1 (en) 2004-03-24 2005-10-06 Xencor, Inc. Immunoglobulin variants outside the fc region
PL1737891T3 (en) * 2004-04-13 2013-08-30 Hoffmann La Roche Anti-p-selectin antibodies
EP1761563A4 (en) 2004-05-10 2008-05-14 Macrogenics Inc HUMANIZED Fc gamma RIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
KR100545720B1 (en) * 2004-05-31 2006-01-24 메덱스젠 주식회사 Glycated immunoglobulins and immunoconjugates comprising them
TW201422238A (en) 2004-06-04 2014-06-16 Genentech Inc Use of CD20 antibody in treatment of multiple sclerosis and an article for the use
DK1781705T3 (en) 2004-06-21 2015-01-12 Squibb & Sons Llc Interferon-alpha receptor 1 antibodies and uses thereof
CN101189028B (en) * 2004-07-12 2013-05-29 马克罗基因公司 Identification and engineering of antibodies with variant Fc regions and methods of use
BRPI0510674A (en) * 2004-07-15 2007-12-26 Xencor Inc optimized fc variants
US20150010550A1 (en) 2004-07-15 2015-01-08 Xencor, Inc. OPTIMIZED Fc VARIANTS
US8647625B2 (en) 2004-07-26 2014-02-11 Biogen Idec Ma Inc. Anti-CD154 antibodies
MX2007001345A (en) 2004-08-04 2008-03-11 Applied Molecular Evolution Variant fc regions.
AU2005277567A1 (en) * 2004-08-16 2006-03-02 Medimmune, Llc Integrin antagonists with enhanced antibody dependent cell-mediated cytotoxicity activity
ZA200701715B (en) * 2004-08-19 2008-07-30 Genentech Inc Polypeptide variants with altered effector function
KR20070100228A (en) 2004-10-05 2007-10-10 제넨테크, 인크. How to treat vasculitis
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
CA2587766A1 (en) * 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
US8802820B2 (en) * 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US20070135620A1 (en) * 2004-11-12 2007-06-14 Xencor, Inc. Fc variants with altered binding to FcRn
EP1817340B1 (en) 2004-11-12 2012-05-16 Xencor, Inc. Fc variants with altered binding to fcrn
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8367805B2 (en) * 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
KR20070107687A (en) * 2004-12-31 2007-11-07 제넨테크, 인크. Polypeptides that bind to JR3, and uses thereof
KR20150083139A (en) 2005-01-21 2015-07-16 제넨테크, 인크. Fixed dosing of her antibodies
US8029783B2 (en) * 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
US8444973B2 (en) 2005-02-15 2013-05-21 Duke University Anti-CD19 antibodies and uses in B cell disorders
CA2597924C (en) 2005-02-15 2018-10-02 Duke University Anti-cd19 antibodies and uses in oncology
DK1850874T3 (en) 2005-02-23 2013-11-11 Genentech Inc Extension of time to disease progression or survival for ovarian cancer using pertuzumab
SG10201912554TA (en) 2005-03-23 2020-02-27 Genmab As Antibodies against cd38 for treatment of multiple myeloma
US20110123440A1 (en) * 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
WO2006105338A2 (en) * 2005-03-31 2006-10-05 Xencor, Inc. Fc VARIANTS WITH OPTIMIZED PROPERTIES
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US11254748B2 (en) 2005-04-15 2022-02-22 Macrogenics, Inc. Covalent diabodies and uses thereof
EP3479844B1 (en) 2005-04-15 2023-11-22 MacroGenics, Inc. Covalent diabodies and uses thereof
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
JO3058B1 (en) 2005-04-29 2017-03-15 Applied Molecular Evolution Inc Anti-IL-6 Antibodies,Compositions,Methods and uses
JP5047947B2 (en) 2005-05-05 2012-10-10 デューク ユニバーシティ Anti-CD19 antibody treatment for autoimmune disease
CA3151350A1 (en) 2005-05-09 2006-11-16 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
ATE460672T1 (en) 2005-05-20 2010-03-15 Genentech Inc PRETREATMENT OF A BIOLOGICAL SAMPLE FROM AN INDIVIDUAL WITH AUTOIMMUNE DISEASE
EP1893647A2 (en) 2005-06-23 2008-03-05 MedImmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
TR201902033T4 (en) 2005-06-30 2019-03-21 Janssen Biotech Inc Anti-IL-23 antibodies, compositions, methods and uses.
CA3201163A1 (en) 2005-07-01 2007-01-11 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
US7557190B2 (en) 2005-07-08 2009-07-07 Xencor, Inc. Optimized proteins that target Ep-CAM
SG164379A1 (en) * 2005-07-21 2010-09-29 Genmab As Potency assays for antibody drug substance binding to an fc receptor
EP1919505A2 (en) 2005-07-25 2008-05-14 Trubion Pharmaceuticals, Inc. Single dose use of cd20-specific binding molecules
EP2586798A3 (en) 2005-07-25 2013-08-07 Emergent Product Development Seattle, LLC B-cell reduction using CD37-specific and CD20-specific binding molecules
US8217147B2 (en) 2005-08-10 2012-07-10 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
CA2619298C (en) 2005-08-26 2017-07-04 Glycart Biotechnology Ag Modified antigen binding molecules with altered cell signaling activity
DK1931709T3 (en) * 2005-10-03 2017-03-13 Xencor Inc FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
WO2007044616A2 (en) 2005-10-06 2007-04-19 Xencor, Inc. Optimized anti-cd30 antibodies
KR101461263B1 (en) 2005-10-21 2014-11-17 노파르티스 아게 Human antibodies against IL-13 and therapeutic uses
CN107929731A (en) 2005-11-04 2018-04-20 健泰科生物技术公司 Utilize complement pathway inhibitors to treat ocular diseases
AU2006312148B2 (en) 2005-11-07 2012-04-12 The Rockefeller University Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
ES2577292T3 (en) 2005-11-07 2016-07-14 Genentech, Inc. Binding polypeptides with diversified VH / VL hypervariable sequences and consensus
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
AU2006318539B2 (en) 2005-11-23 2012-09-13 Genentech, Inc. Methods and compositions related to B cell assays
EP3006466B1 (en) 2005-12-02 2018-08-01 Genentech, Inc. Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r
JP5808070B2 (en) 2005-12-02 2015-11-10 ジェネンテック， インコーポレイテッド Binding polypeptides and uses thereof
US8383118B2 (en) 2005-12-08 2013-02-26 Medarex, Inc. Human monoclonal antibodies to fucosyl-GM1 and methods for using anti-fucosyl-GM1
AU2006326937B2 (en) 2005-12-20 2012-01-19 Cephalon Australia Pty Ltd Anti-inflammatory dAb
HUE049832T2 (en) 2005-12-29 2020-10-28 Janssen Biotech Inc Human anti-il-23 antibodies, compositions, method and uses
KR101589391B1 (en) 2006-01-05 2016-01-29 제넨테크, 인크. Anti-ephb4 antibodies and methods using same
US8197815B2 (en) 2006-01-20 2012-06-12 Genentech, Inc. Anti-EphrinB2 antibodies and methods using same
CN101400703B (en) 2006-02-01 2013-05-08 赛法隆澳大利亚控股有限公司 domain antibody constructs
EP2650306A1 (en) 2006-03-06 2013-10-16 Aeres Biomedical Limited Humanized Anti-CD22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
AR059851A1 (en) 2006-03-16 2008-04-30 Genentech Inc ANTIBODIES OF EGFL7 AND METHODS OF USE
JP5298007B2 (en) 2006-03-21 2013-09-25 ジェネンテック， インコーポレイテッド Combinatorial therapy with alpha5beta1 antagonist
EP2009101B1 (en) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
EP2006381B1 (en) 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Method for controlling blood pharmacokinetics of antibodies
US20100080794A1 (en) 2006-04-14 2010-04-01 Takashi Tsuji Mutant polypeptide having effector function
SG172656A1 (en) 2006-05-30 2011-07-28 Genentech Inc Antibodies and immunoconjugates and uses therefor
NZ572177A (en) 2006-06-06 2012-02-24 Genentech Inc Anti-dll4 antibodies and methods using same
EP3805269A1 (en) 2006-06-12 2021-04-14 Aptevo Research and Development LLC Single-chain multivalent binding proteins with effector function
WO2008002933A2 (en) 2006-06-26 2008-01-03 Macrogenics, Inc. Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
EP2505209A1 (en) 2006-06-26 2012-10-03 MacroGenics, Inc. Fcgamma-RIIB-specific antibodies and methods of the use thereof
WO2008011348A2 (en) 2006-07-14 2008-01-24 Ac Immune S.A. Humanized antibody against amyloid beta
JP2009543579A (en) 2006-07-19 2009-12-10 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア WSX-1 / p28 as a target for anti-inflammatory response
EP2059536B1 (en) 2006-08-14 2014-01-08 Xencor, Inc. Optimized antibodies that target cd19
EA200970250A1 (en) 2006-09-05 2010-02-26 Медарекс, Инк. ANTIBODIES TO BONE MORPHOGENETIC PROTEINS AND THEIR RECEPTORS AND METHODS OF THEIR APPLICATION
ES2383710T3 (en) 2006-09-08 2012-06-25 Medimmune, Llc Humanized anti-CD19 antibodies and their use in the treatment of tumors, transplants and autoimmune diseases
EP2845912A1 (en) 2006-09-12 2015-03-11 Genentech, Inc. Methods and compositions for the diagnosis and treatment of lung cancer using KIT gene as genetic marker
EP2083017A4 (en) 2006-09-14 2011-01-12 Med & Biological Lab Co Ltd Antibody having enhanced adcc activity and method for production thereof
JP5562031B2 (en) * 2006-09-18 2014-07-30 ゼンコー・インコーポレイテッド Optimized antibody targeting HM1.24
AU2007320024B2 (en) 2006-10-02 2012-11-08 E. R. Squibb & Sons, L.L.C. Human antibodies that bind CXCR4 and uses thereof
EP2084188A2 (en) * 2006-10-12 2009-08-05 Genentech, Inc. Antibodies to lymphotoxin-alpha
JP2010506842A (en) * 2006-10-16 2010-03-04 メディミューン，エルエルシー Molecules with reduced half-life, compositions thereof and uses
EP2068922B1 (en) 2006-10-19 2012-06-27 CSL Limited Anti-il-13r alpha 1 antibodies and their uses thereof
WO2008060813A2 (en) 2006-10-19 2008-05-22 Merck & Co., Inc. High affinity antibody antagonists of interleukin-13 receptor alpha 1
DK2502938T3 (en) 2006-10-27 2015-04-20 Genentech Inc Antibodies and immunoconjugates and uses thereof
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
RU2474589C9 (en) 2006-11-02 2019-08-15 Дженентек, Инк. Humanised anti-factor d antibodies and use thereof
CL2007003291A1 (en) 2006-11-15 2008-07-04 Medarex Inc ISOLATED HUMAN MONOCLONAL ANTIBODY THAT LINKS THE BTLA PROTEIN OR FRAGMENTS OF THE SAME; NUCLEIC ACID THAT CODIFIES IT; METHOD OF PRODUCTION; COMPOSITION AND IMMUNOCUJUGADO THAT UNDERSTANDS THEM; AND METHOD TO INHIBIT THE GROWTH OF TUMOR CELLS AND
CA2671264C (en) 2006-11-30 2015-11-24 Research Development Foundation Improved immunoglobulin libraries
CN101626782B (en) 2006-12-01 2013-03-27 梅达雷克斯公司 Human antibodies that bind cd22 and uses thereof
US20080127996A1 (en) * 2006-12-04 2008-06-05 Weinhold Dennis G Method and apparatus to remediate an acid and/or liquid spill
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method.
MX2009006277A (en) 2006-12-14 2009-07-24 Medarex Inc Human antibodies that bind cd70 and uses thereof.
KR20140148491A (en) 2006-12-19 2014-12-31 제넨테크, 인크. Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
AU2008208288B2 (en) 2007-01-24 2014-04-03 Kyowa Kirin Co., Ltd. Genetically recombinant antibody composition having enhanced effector activity
JPWO2008090960A1 (en) 2007-01-24 2010-05-20 協和発酵キリン株式会社 Recombinant antibody composition that specifically binds to ganglioside GM2
KR20090114443A (en) 2007-02-09 2009-11-03 제넨테크, 인크. Anti-RWF4 antibodies and uses thereof
NZ578824A (en) 2007-03-02 2012-03-30 Genentech Inc Predicting response to a her dimerisation inhibitor based on low her3 expression
EP2136838B1 (en) 2007-03-08 2017-03-08 KaloBios Pharmaceuticals, Inc. Epha3 antibodies for the treatment of solid tumors
LT2125894T (en) 2007-03-22 2019-03-25 Biogen Ma Inc. Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
WO2008118324A2 (en) 2007-03-26 2008-10-02 Macrogenics, Inc. Composition and method of treating cancer with an anti-uroplakin ib antibody
WO2008134046A1 (en) 2007-04-27 2008-11-06 Genentech, Inc. Potent, stable and non-immunosuppressive anti-cd4 antibodies
WO2008137475A2 (en) 2007-05-01 2008-11-13 Research Development Foundation Immunoglobulin fc libraries
EP2703011A3 (en) 2007-05-07 2014-03-26 MedImmune, LLC Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
WO2008141197A1 (en) * 2007-05-10 2008-11-20 Sea Lane Biotechnologies, Llc Chain reaction creating oligomers from repeat units of binding molecules
CA2689680C (en) 2007-05-14 2017-11-07 Novimmune Sa Fc receptor-binding polypeptides with modified effector functions
EP3392273A1 (en) 2007-05-30 2018-10-24 Xencor, Inc. Methods and compositions for inhibiting cd32b expressing cells
EP4119579A1 (en) * 2007-05-31 2023-01-18 Genmab A/S Stable igg4 antibodies
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
PE20090321A1 (en) 2007-06-04 2009-04-20 Genentech Inc ANTI-NOTCH1 NRR ANTIBODIES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION
SI2171090T1 (en) 2007-06-08 2013-07-31 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
DK2170389T3 (en) * 2007-06-12 2015-01-19 Ac Immune Sa Humanized antibodies against amyloid beta
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
CN101821288A (en) 2007-06-21 2010-09-01 宏观基因有限公司 Covalent diabodies and their uses
CN101827610A (en) * 2007-06-29 2010-09-08 森托科尔奥索生物科技公司 Anti- MCP-1 antibodies, compositions, methods and uses
SI2188302T1 (en) 2007-07-09 2018-07-31 Genentech, Inc. Prevention of disulfide bond reduction during recombinant production of polypeptides
EP2078091A4 (en) * 2007-07-10 2010-09-01 Medimmune Llc CRYSTALS AND STRUCTURE OF HUMAN IgG Fc VARIANT
RU2557319C2 (en) 2007-07-16 2015-07-20 Дженентек, Инк. HUMANISED ANTIBODIES AGAINST CD79b AND IMMUNOCONJUGATES AND METHODS OF APPLICATION
DK2176296T3 (en) 2007-07-16 2012-05-21 Genentech Inc Anti-CD79B antibodies and immune conjugates and methods of use.
AU2008282218A1 (en) 2007-07-31 2009-02-05 Medimmune, Llc Multispecific epitope binding proteins and uses thereof
AU2008296361B2 (en) 2007-09-04 2013-04-11 Compugen, Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
ES2566957T3 (en) 2007-09-26 2016-04-18 Chugai Seiyaku Kabushiki Kaisha Constant region of modified antibody
JP5334319B2 (en) 2007-09-26 2013-11-06 中外製薬株式会社 Method for modifying isoelectric point of antibody by amino acid substitution of CDR
SI2238166T1 (en) 2007-10-05 2014-03-31 Genentech, Inc. Use of anti-amyloid beta antibody in ocular diseases
ES2609918T3 (en) * 2007-10-05 2017-04-25 Genentech, Inc. Use of anti-amyloid beta antibody in eye diseases
TWI489993B (en) 2007-10-12 2015-07-01 Novartis Ag Compositions and methods of use for antibodies against sclerostin
US8956611B2 (en) 2007-10-16 2015-02-17 Zymogenetics, Inc. Combination of BLyS inhibition and anti-CD 20 agents for treatment of autoimmune disease
WO2009054435A1 (en) 2007-10-24 2009-04-30 Otsuka Chemical Co., Ltd. Polypeptide having enhanced effector function
AU2008345242B2 (en) * 2007-10-31 2014-02-27 Xencor, Inc. Fc variants with altered binding to FcRn
WO2009056634A2 (en) 2007-11-02 2009-05-07 Novartis Ag Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6)
LT2514436T (en) 2007-11-07 2018-04-10 Genentech, Inc. Il-22 for use in treating microbial disorders
TWI580694B (en) 2007-11-30 2017-05-01 建南德克公司 Anti-vegf antibodies
TWI468174B (en) 2007-12-14 2015-01-11 Novo Nordisk As Antibodies against human kng2d and uses thereof
WO2009117030A2 (en) 2007-12-19 2009-09-24 Macrogenics, Inc. Improved compositions for the prevention and treatment of smallpox
EP2245064B1 (en) 2007-12-21 2014-07-23 Medimmune Limited BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ralpha)
US7914785B2 (en) 2008-01-02 2011-03-29 Bergen Teknologieverforing As B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
EP2077281A1 (en) 2008-01-02 2009-07-08 Bergen Teknologioverforing AS Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
JP2011509675A (en) 2008-01-18 2011-03-31 メディミューン，エルエルシー Cysteine engineered antibodies for site-specific conjugation
TWI472339B (en) 2008-01-30 2015-02-11 Genentech Inc Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof
MX351557B (en) 2008-01-31 2017-10-19 Genentech Inc ANTI-CD79B ANTIBODIES and IMMUNOCONJUGATES and METHODS OF USE.
CA2714071A1 (en) 2008-02-05 2009-08-13 Bristol-Myers Squibb Company Alpha 5 - beta 1 antibodies and their uses
BRPI0907735B1 (en) 2008-02-08 2021-10-05 Astrazeneca Ab MODIFIED IGG-CLASS MONOCLONAL ANTIBODY SPECIFIC TO IFNAR1, ISOLATED NUCLEIC ACID AND PHARMACEUTICAL COMPOSITION
AU2009231733B2 (en) * 2008-03-31 2015-12-24 Genentech, Inc. Compositions and methods for treating and diagnosing asthma
SG189730A1 (en) 2008-04-02 2013-05-31 Macrogenics Inc Her2/neu-specific antibodies and methods of using same
KR101614494B1 (en) 2008-04-02 2016-04-22 마크로제닉스, 인크. Bcr-complex-specific antibodies and methods of using same
CN107469077A (en) 2008-04-11 2017-12-15 中外制药株式会社 The antigen binding molecules combined repeatedly with the antigen of multiple molecules
CR20170001A (en) 2008-04-28 2017-08-10 Genentech Inc ANTI FACTOR D HUMANIZED ANTIBODIES
CA2722466A1 (en) * 2008-04-29 2009-11-05 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
RU2010153580A (en) 2008-06-03 2012-07-20 Эбботт Лэборетриз (Us) IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION
NZ589436A (en) 2008-06-03 2012-12-21 Abbott Lab Dual variable domain immunoglobulins and uses thereof
WO2010033279A2 (en) 2008-06-04 2010-03-25 Macrogenics, Inc. Antibodies with altered binding to fcrn and methods of using same
CN102149825B (en) 2008-07-08 2015-07-22 Abbvie公司 Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
TW201016233A (en) * 2008-07-15 2010-05-01 Genentech Inc Methods of treating autoimmune diseases using CD4 antibodies
UA105009C2 (en) 2008-08-05 2014-04-10 Новартіс Аг Compositions and methods for antibodies targeting complement protein c5
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
TW201438738A (en) 2008-09-16 2014-10-16 Genentech Inc Method for treating progressive multiple sclerosis
RU2581962C2 (en) 2008-09-19 2016-04-20 Медиммун Ллк Targeted binding agents against dll4 and application thereof
ES2828721T3 (en) * 2008-10-14 2021-05-27 Genentech Inc Immunoglobulin variants and their uses
US8298533B2 (en) 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
WO2010056804A1 (en) 2008-11-12 2010-05-20 Medimmune, Llc Antibody formulation
DK2361085T4 (en) 2008-11-22 2018-10-08 Hoffmann La Roche USE OF ANTI-VEGF ANTIBODY IN COMBINATION WITH CHEMOTHERY TO TREAT CANCER CANCER
US20110311450A1 (en) 2008-12-08 2011-12-22 Zurit Levine Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
WO2010068722A1 (en) 2008-12-12 2010-06-17 Medimmune, Llc Crystals and structure of a human igg fc variant with enhanced fcrn binding
CN106432503B (en) 2008-12-19 2020-03-06 宏观基因有限公司 Covalent diabodies and uses thereof
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
JP2012513194A (en) 2008-12-23 2012-06-14 アストラゼネカ アクチボラグ Targeted binding agents directed to α5β1 and uses thereof
WO2010078526A1 (en) 2008-12-31 2010-07-08 Biogen Idec Ma Inc. Anti-lymphotoxin antibodies
US20110046060A1 (en) 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
SG173654A1 (en) 2009-02-23 2011-09-29 Glenmark Pharmaceuticals Sa Humanized antibodies that bind to cd19 and their uses
EA028336B1 (en) 2009-03-05 2017-11-30 МЕДАРЕКС Л.Л.Си. Fully human antibodies specific to cadm1
WO2010102244A1 (en) 2009-03-06 2010-09-10 Kalobios Pharmaceuticals, Inc. Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3
EP2408820A4 (en) 2009-03-16 2013-01-23 Cephalon Australia Pty Ltd Humanised antibodies with anti-tumour activity
KR20150036824A (en) 2009-03-20 2015-04-07 제넨테크, 인크. Bispecific anti-her antibodies
EP2233500A1 (en) 2009-03-20 2010-09-29 LFB Biotechnologies Optimized Fc variants
CN102427823A (en) * 2009-03-24 2012-04-25 拜耳医药保健有限公司 Factor VIII variants and methods of use
BRPI1006270B1 (en) 2009-03-25 2022-08-16 Genentech, Inc ANTI-A5SS1 ANTIBODY, IMMUNOCONJUGATE, PHARMACEUTICAL COMPOSITION, IN VITRO OR EX VIVO METHOD TO DETECT A5SS1 PROTEIN, USE OF AN ANTIBODY AND KIT TO DETECT A5SS1 PROTEIN
HRP20150965T1 (en) 2009-03-25 2015-11-06 Genentech, Inc. ANTI-FGR3 ANTIBODIES AND METHODS USED
ES2363358B1 (en) 2009-04-03 2012-06-21 FUNDACIÓ INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL D'HEBRON (Titular al THERAPEUTIC AGENTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AN INDESEABLE CELLULAR PROLIFERATION.
PT2417156E (en) 2009-04-07 2015-04-29 Roche Glycart Ag Trivalent, bispecific antibodies
US9181339B2 (en) 2009-04-20 2015-11-10 Oxford Bio Therapeutics Ltd. Antibodies specific to cadherin-17
US9062116B2 (en) 2009-04-23 2015-06-23 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
AR076402A1 (en) 2009-04-27 2011-06-08 Novartis Ag COMPOSITIONS AND METHODS TO INCREASE MUSCLE GROWTH
AU2010230311B9 (en) 2009-04-27 2012-09-20 Novartis Ag Composition and methods of use for therapeutic antibodies specific for the IL-12 receptore betal subunit
MX2011011670A (en) * 2009-05-01 2011-11-18 Abbott Lab Dual variable domain immunoglobulins and uses thereof.
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
RU2011151287A (en) 2009-06-18 2013-07-27 Пфайзер Инк. ANTI NOTCH-1 ANTIBODIES
JP5918129B2 (en) 2009-06-22 2016-05-18 メディミューン，エルエルシー Engineered Fc region for site-specific conjugation
WO2011008517A2 (en) * 2009-06-30 2011-01-20 Research Development Foundation Immunoglobulin fc polypeptides
WO2011008696A2 (en) 2009-07-13 2011-01-20 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
TW201106972A (en) 2009-07-27 2011-03-01 Genentech Inc Combination treatments
AR077594A1 (en) 2009-07-31 2011-09-07 Organon Nv COMPLETELY HUMAN ANTIBODIES FOR BTLA (ATTENUANT OF B AND T LYMPHOCYTES)
JP2013500993A (en) 2009-07-31 2013-01-10 ジェネンテック， インコーポレイテッド Inhibition of tumor metastasis using BV8 antagonists or G-CSF antagonists
FI2464725T4 (en) 2009-08-11 2025-03-21 Hoffmann La Roche Production of proteins in glutamine-free cell culture media
WO2011020049A1 (en) 2009-08-14 2011-02-17 Genentech, Inc. Biological markers for monitoring patient response to vegf antagonists
NZ598131A (en) 2009-08-15 2014-08-29 Genentech Inc Anti-angiogenesis therapy for the treatment of previously treated breast cancer
WO2011021146A1 (en) 2009-08-20 2011-02-24 Pfizer Inc. Osteopontin antibodies
GB0914691D0 (en) * 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
ES2599076T3 (en) 2009-09-02 2017-01-31 Genentech, Inc. Smoothened mutant and methods of use thereof
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
US8728730B2 (en) 2009-09-03 2014-05-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
AU2010292060A1 (en) 2009-09-11 2012-04-12 Genentech, Inc. Method to identify a patient with an increased likelihood of responding to an anti-cancer agent
KR101557545B1 (en) 2009-09-17 2015-10-06 에프. 호프만-라 로슈 아게 Methods and compositions for diagnostics use in cancer patients
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
DK2486141T3 (en) 2009-10-07 2018-04-23 Macrogenics Inc FC-REGION-CONTAINING POLYPEPTIDES THAT PROVIDE IMPROVED EFFECTOR FUNCTION BASED ON CHANGES OF THE SCOPE OF FUCOSYLATION AND PROCEDURES FOR THEIR USE
WO2011047083A1 (en) 2009-10-13 2011-04-21 Oxford Biotherapeutics Ltd. Antibodies against epha10
PL2488554T3 (en) 2009-10-14 2020-03-31 Humanigen, Inc. Antibodies to epha3
WO2011047262A2 (en) * 2009-10-15 2011-04-21 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
JP5814925B2 (en) 2009-10-22 2015-11-17 ジェネンテック， インコーポレイテッド Anti-hepsin antibody and method of use thereof
EA201792376A3 (en) 2009-10-23 2018-08-31 Милленниум Фармасьютикалз, Инк. ANTI-GCC MOLECULES ANTIBODIES AND RELATED COMPOSITIONS AND METHODS
WO2011056502A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Bone morphogenetic protein receptor type ii compositions and methods of use
WO2011056494A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
WO2011056497A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor type iib compositions and methods of use
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
CN102770533B (en) 2009-11-02 2016-11-23 华盛顿大学 Therapeutic nuclease compositions and methods
PE20121646A1 (en) 2009-11-04 2012-12-02 Merck Sharp & Dohme ANTI-TSLP ANTIBODY MODIFIED BY GENETIC ENGINEERING TECHNIQUES
CN102740885B (en) 2009-11-05 2015-04-01 梯瓦制药澳大利亚私人有限公司 Treatment of cancer involving mutated kras or braf genes
ES2636971T3 (en) 2009-11-05 2017-10-10 F. Hoffmann-La Roche Ag Procedures and composition for secretion of heterogeneous polypeptides
WO2011060015A1 (en) 2009-11-11 2011-05-19 Genentech, Inc. Methods and compositions for detecting target proteins
ES2646863T3 (en) 2009-11-24 2017-12-18 Medimmune Limited B7-H1 specific binding agents
EP2506871B1 (en) * 2009-11-30 2016-10-19 Janssen Biotech, Inc. ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
US9428586B2 (en) 2009-12-01 2016-08-30 Compugen Ltd Heparanase splice variant
JP2013512674A (en) 2009-12-02 2013-04-18 アクセルロン ファーマ， インコーポレイテッド Compositions and methods for increasing the serum half-life of an Fc fusion protein
AR078377A1 (en) 2009-12-11 2011-11-02 Genentech Inc ANTI-VEGF-C ANTIBODIES (ISOLATED ANTI-VASCULAR ENDOTELIAL GROWTH FACTOR C) AND ITS METHODS OF USE
MX2012007318A (en) 2009-12-22 2012-07-20 Novartis Ag Tetravalent cd47-antibody constant region fusion protein for use in therapy.
KR20120107503A (en) 2009-12-23 2012-10-02 제넨테크, 인크. Anti-bv8 antibodies and uses thereof
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
WO2011100403A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
US20120296403A1 (en) 2010-02-10 2012-11-22 Novartis Ag Methods and compounds for muscle growth
MY160556A (en) 2010-02-18 2017-03-15 Genentech Inc Neuregulin antagonists and use thereof in treating cancer
UA114277C2 (en) 2010-02-23 2017-05-25 Дженентек, Інк. Anti-angiogenesis therfpy for the treatment of ovarian cancer
SG10201501285RA (en) * 2010-02-23 2015-04-29 Sanofi Sa Anti-alpha2 integrin antibodies and their uses
US9260529B2 (en) 2010-02-24 2016-02-16 The University Of Washington Through Its Center For Commercialization Molecules that bind CD180, compositions and methods of use
CN102782131B (en) 2010-03-02 2015-08-05 协和发酵麒麟株式会社 Modified Antibody Composition
BR122016002916B8 (en) 2010-03-04 2021-05-25 Macrogenics Inc diabody, nucleic acid molecule, pharmaceutical composition and uses of diabody
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
US8846041B2 (en) 2010-03-24 2014-09-30 Genentech, Inc. Anti-LRP6 antibodies
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
CN107098958B (en) 2010-03-26 2021-11-05 达特茅斯大学理事会 VISTA regulatory T cell mediator proteins, VISTA binding agents and uses thereof
CA2794708C (en) 2010-03-29 2021-11-16 Zymeworks Inc. Antibodies with enhanced or suppressed effector function
EP4501956A2 (en) 2010-03-30 2025-02-05 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules that promote antigen clearance
TWI667257B (en) 2010-03-30 2019-08-01 中外製藥股份有限公司 Antibodies with modified affinity to fcrn that promote antigen clearance
EP2371860A1 (en) 2010-04-05 2011-10-05 Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation
US9290573B2 (en) 2010-05-06 2016-03-22 Novartis Ag Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
EP3345926B1 (en) 2010-05-06 2023-04-05 Novartis AG Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
WO2011147834A1 (en) 2010-05-26 2011-12-01 Roche Glycart Ag Antibodies against cd19 and uses thereof
NZ603883A (en) 2010-05-27 2015-01-30 Merck Sharp & Dohme Method for preparing antibodies having improved properties
WO2011153243A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Anti-angiogenesis therapy for treating gastric cancer
WO2011153224A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
RU2613886C2 (en) 2010-06-03 2017-03-21 Дженентек, Инк. Antibodies and immunoconjugates rendered by immuno-positron emission tomography, methods of application
EP3098240B1 (en) 2010-06-18 2021-04-07 F. Hoffmann-La Roche AG Anti-axl antibodies and methods of use
WO2011161119A1 (en) 2010-06-22 2011-12-29 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
CA2803391C (en) 2010-06-22 2021-11-09 Neogenix Oncology, Inc. Npc1 antibodies that bind a muc5ac epitope
WO2011161189A1 (en) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anti-hepsin antibodies and methods of use
CA2803792A1 (en) 2010-07-09 2012-01-12 Genentech, Inc. Anti-neuropilin antibodies and methods of use
LT2591006T (en) 2010-07-09 2019-08-26 Bioverativ Therapeutics Inc. Processable single chain molecules and polypeptides made using same
MX2013000676A (en) 2010-07-19 2013-02-27 Hoffmann La Roche Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy.
CN103109189A (en) 2010-07-19 2013-05-15 霍夫曼-拉罗奇有限公司 Method of identifying patients with increased likelihood of responding to anticancer therapy
WO2012010582A1 (en) 2010-07-21 2012-01-26 Roche Glycart Ag Anti-cxcr5 antibodies and methods of use
CN106432495A (en) 2010-07-22 2017-02-22 加利福尼亚大学董事会 Anti-tumor antigen antibodies and methods of use
CN103261225A (en) 2010-07-23 2013-08-21 波士顿大学董事会 Anti-desupr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
EP2598526B1 (en) 2010-07-29 2018-09-05 Eleven Biotherapeutics, Inc. Chimeric il-1 receptor type i agonists and antagonists
CA2806909C (en) 2010-07-30 2019-12-17 Ac Immune S.A. Safe and functional humanized antibodies
ES2667100T3 (en) 2010-08-02 2018-05-09 Macrogenics, Inc. Covalent Diabodies and Their Uses
KR20130100118A (en) 2010-08-03 2013-09-09 아비에 인코포레이티드 Dual variable domain immunoglobulins and uses therof
MX2013001302A (en) 2010-08-03 2013-03-08 Hoffmann La Roche Chronic lymphocytic leukemia (cll) biomarkers.
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
CA2805564A1 (en) 2010-08-05 2012-02-09 Stefan Jenewein Anti-mhc antibody anti-viral cytokine fusion protein
PH12013500159B1 (en) 2010-08-13 2018-09-26 Roche Glycart Ag Anti-fap antibodies and methods of use
CA2808154A1 (en) 2010-08-13 2012-02-16 Medimmmune Limited Monomeric polypeptides comprising variant fc regions and methods of use
KR101653030B1 (en) 2010-08-13 2016-08-31 로슈 글리카트 아게 Anti-tenascin-c a2 antibodies and methods of use
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
PL2606070T4 (en) 2010-08-20 2017-06-30 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
ES2553262T3 (en) 2010-08-25 2015-12-07 F. Hoffmann-La Roche Ag Antibodies against IL-18R1 and their uses
RU2013113225A (en) 2010-08-26 2014-10-10 Эббви Инк. IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION
PH12013500379A1 (en) 2010-08-27 2013-03-25 Abbvie Stemcentrx Llc Notum protein modulators and methods of use
UY33578A (en) 2010-08-31 2012-03-30 Sanofi Sa PEPTIDE PEPTIDE OR COMPLEX THAT JOINS INTEGRINE TO (ALPHA) AND METHODS AND USES THAT INVOLVE THE SAME
CA2808236A1 (en) 2010-08-31 2012-03-08 Genentech, Inc. Biomarkers and methods of treatment
JP5955322B2 (en) 2010-09-03 2016-07-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Anti-C-MET antibody and method of use thereof
CN106620693A (en) 2010-09-03 2017-05-10 艾伯维施特姆森特克斯有限责任公司 Novel modulators and methods of use
WO2012032080A1 (en) 2010-09-07 2012-03-15 F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H Stabilised human fc
WO2012035518A1 (en) 2010-09-17 2012-03-22 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
ES2719624T3 (en) 2010-09-23 2019-07-11 Prec Biologics Inc Peptidomimetics of colon and pancreas cancer
NZ607473A (en) 2010-09-27 2014-11-28 Morphosys Ag Anti-cd38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and nhl
JP2013543384A (en) 2010-10-05 2013-12-05 ノバルティス アーゲー Anti-IL12Rbeta1 antibody and its use in the treatment of autoimmune and inflammatory diseases
AU2011312205B2 (en) 2010-10-05 2015-08-13 Curis, Inc. Mutant smoothened and methods of using the same
MX354095B (en) 2010-10-13 2018-02-12 Janssen Biotech Inc Human oncostatin m antibodies and methods of use.
CN103534268B (en) * 2010-10-20 2016-05-18 牛津生物疗法有限公司 Antibody
KR101973930B1 (en) 2010-11-05 2019-04-29 자임워크스 인코포레이티드 Stable heterodimeric antibody design with mutations in the fc domain
KR20220070586A (en) 2010-11-08 2022-05-31 제넨테크, 인크. Subcutaneously administered anti-il-6 receptor antibody
MX346500B (en) 2010-11-10 2017-03-22 Genentech Inc * Methods and compositions for neural disease immunotherapy.
CN103328508B (en) 2010-11-23 2015-12-16 葛兰素集团有限公司 Antigen-binding protein against oncostatin M (OSM)
AU2011332810A1 (en) 2010-11-23 2013-06-13 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of oral mucositis
EA201390611A1 (en) 2010-11-24 2014-01-30 Глаксо Груп Лимитед MULTISPECIFIC ANTIGENSORATING PROTEINS DIRECTED AT HGF
ES2631356T3 (en) 2010-11-30 2017-08-30 F. Hoffmann-La Roche Ag Low affinity transferrin receptor anti-antibodies and their use to transfer therapeutic scFv through the blood brain barrier
KR20240025059A (en) 2010-11-30 2024-02-26 추가이 세이야쿠 가부시키가이샤 Cytotoxicity-inducing therapeutic agent
BR112013013354A2 (en) 2010-11-30 2020-10-06 Chugai Seiyaku Kabushiki Kaisha antigen-binding molecule capable of binding to a plurality of antigen molecules repeatedly
RU2016123839A (en) 2010-12-08 2018-11-30 АббВай Стемсентркс ЭлЭлСи New modulators and methods of their application
NZ611785A (en) 2010-12-15 2015-04-24 Wyeth Llc Anti-notch1 antibodies
BR122020012255B1 (en) 2010-12-16 2022-08-09 Genentech, Inc USE OF AN ANTI-IL-13 ANTIBODY, USES OF A TH2 PATHWAY INHIBITOR AND ANTI-PERIOSTIN ANTIBODIES
BR112013014527A2 (en) 2010-12-20 2017-03-07 Genentech Inc isolated antibody, isolated nucleic acid, host cell, method for producing an antibody, immunoconjugate, pharmaceutical formulation, use of immunoconjugate, method for treating an individual who has mesothelin positive cancer, for inhibiting proliferation of a mesothelin positive cell, for detecting human mesothelin in a biological sample and for detecting mesothelin positive cancer
AR084456A1 (en) 2010-12-22 2013-05-15 Genentech Inc ANTI-PCSK9 ANTIBODY AND METHODS OF USE
HRP20170595T1 (en) * 2010-12-23 2017-06-16 Janssen Biotech, Inc. Active protease-resistant antibody fc mutants
CN102128937B (en) * 2010-12-31 2014-05-28 江苏华冠生物技术股份有限公司 Evaluating and monitoring method for effect of desensitization therapy, detection kit of allergen specificity IgG4 antibody and preparation method thereof
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
BR112013017980A2 (en) 2011-01-14 2017-06-27 Redwood Bioscience Inc aldehyde-labeled immunoglobulin polypeptides and method of use
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
AU2012214643B2 (en) 2011-02-07 2016-12-15 Research Development Foundation Engineered immunoglobulin Fc polypeptides
SA112330278B1 (en) 2011-02-18 2015-10-09 ستيم سينتركس، انك. Novel modulators and methods of use
WO2012132067A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
EP2679681B2 (en) 2011-02-25 2023-11-15 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific FC antibody
CA2825081A1 (en) 2011-02-28 2012-09-07 Birgit Bossenmaier Antigen binding proteins
JP6271254B2 (en) 2011-02-28 2018-01-31 ジェネンテック， インコーポレイテッド Methods for predicting biological markers and responses to B cell antagonists
MX342034B (en) 2011-02-28 2016-09-12 Hoffmann La Roche Monovalent antigen binding proteins.
SG193554A1 (en) * 2011-03-29 2013-11-29 Roche Glycart Ag Antibody fc variants
KR20240027154A (en) 2011-03-30 2024-02-29 추가이 세이야쿠 가부시키가이샤 Method for altering plasma retention and immunogenicity of antigen-binding molecule
EP3825325A3 (en) 2011-03-30 2021-10-13 Chugai Seiyaku Kabushiki Kaisha Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
KR102148063B1 (en) 2011-03-31 2020-08-25 제넨테크, 인크. Methods of administering beta7 integrin antagonists
BR112013024717A2 (en) 2011-04-07 2017-08-08 Genentech Inc isolated antibody, isolated nucleic acid, host cell, immunoconjugate, pharmaceutical formulation, method of treating an individual who has cancer and method of inhibiting cell proliferation in an individual
ES2676499T3 (en) 2011-04-13 2018-07-20 Bristol-Myers Squibb Company Fc fusion proteins comprising new linkers or arrangements
CN103596974B (en) 2011-04-15 2016-08-31 卡姆普根有限公司 Polypeptides and polynucleotides and their use for the treatment of immune-related disorders and cancer
KR101970025B1 (en) 2011-04-20 2019-04-17 메디뮨 엘엘씨 Antibodies and other molecules that bind b7-h1 and pd-1
JP6152090B2 (en) 2011-04-21 2017-06-21 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ Compositions and methods for treating optic neuritis
GB201107170D0 (en) 2011-04-28 2011-06-15 Clark Michael Binding molecules with biased recognition
WO2012146630A1 (en) 2011-04-29 2012-11-01 F. Hoffmann-La Roche Ag N-terminal acylated polypeptides, methods for their production and uses thereof
MX389061B (en) 2011-04-29 2025-03-20 Univ Washington THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS.
CN103608684B (en) 2011-05-12 2016-05-04 基因泰克公司 A Multiple Reaction Monitoring LC-MS/MS Method for the Detection of Therapeutic Antibodies in Animal Samples Using Framework Signature Peptides
EP2707391B1 (en) 2011-05-13 2017-11-08 Gamamabs Pharma Antibodies against her3
MX370233B (en) 2011-05-16 2019-12-06 Genentech Inc Fgfr1 agonists and methods of use.
JP6145088B2 (en) 2011-05-21 2017-06-07 マクロジェニクス，インコーポレーテッド Deimmunized serum binding domain and its use to extend serum half-life
NZ703939A (en) 2011-05-21 2016-01-29 Macrogenics Inc Cd3-binding molecules capable of binding to human and non-human cd3
ES2704038T3 (en) 2011-05-24 2019-03-13 Zyngenia Inc Multivalent and monovalent multispecific complexes and their uses
US9328170B2 (en) 2011-05-25 2016-05-03 Merck Sharp & Dohme Corp. Method for preparing Fc containing polypeptides having improved properties
US9561274B2 (en) 2011-06-07 2017-02-07 University Of Hawaii Treatment and prevention of cancer with HMGB1 antagonists
WO2012170740A2 (en) 2011-06-07 2012-12-13 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
US9486507B2 (en) 2011-06-10 2016-11-08 Biogen Ma Inc. Pro-coagulant compounds and methods of use thereof
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
US8623666B2 (en) 2011-06-15 2014-01-07 Hoffmann-La Roche Inc. Method for detecting erythropoietin (EPO) receptor using anti-human EPO receptor antibodies
US20140193408A1 (en) 2011-06-16 2014-07-10 Novartis Ag Soluble proteins for use as therapeutics
MX354663B (en) 2011-06-22 2018-03-14 Hoffmann La Roche Removal of target cells by circulating virus-specific cytotoxic t-cells using mhc class i comprising complexes.
CA2839508A1 (en) 2011-06-22 2012-12-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-axl antibodies and uses thereof
WO2012175692A1 (en) 2011-06-22 2012-12-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl antibodies and uses thereof
EP2537864B1 (en) * 2011-06-24 2019-08-07 Laboratoire Français du Fractionnement et des Biotechnologies Fc variants with reduced effector functions
UA114478C2 (en) 2011-06-28 2017-06-26 Берлін-Хемі Аг ANTIBODY THAT SPECIFICALLY Binds to BST1
CN103781493A (en) 2011-06-30 2014-05-07 霍夫曼-拉罗奇有限公司 Anti-c-met antibody formulations
WO2013001517A1 (en) 2011-06-30 2013-01-03 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
US9890218B2 (en) 2011-06-30 2018-02-13 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
ES2692519T3 (en) 2011-07-01 2018-12-04 Novartis Ag Method to treat metabolic disorders
UA117901C2 (en) * 2011-07-06 2018-10-25 Ґенмаб Б.В. METHOD FOR STRENGTHENING THE EFFECTORAL FUNCTION OF THE ORIGINAL POLYEPEPTIDE, ITS OPTIONS AND THEIR APPLICATIONS
LT2731677T (en) 2011-07-11 2018-07-10 Glenmark Pharmaceuticals S.A. Antibodies that bind to ox40 and their uses
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP2731970B1 (en) 2011-07-15 2018-11-28 MorphoSys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt)
GB201112429D0 (en) 2011-07-19 2011-08-31 Glaxo Group Ltd Antigen-binding proteins with increased FcRn binding
US20130022551A1 (en) 2011-07-22 2013-01-24 Trustees Of Boston University DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS
EP2736925A2 (en) 2011-07-27 2014-06-04 Glaxo Group Limited Anti-vegf single variable domains fused to fc domains
US9676854B2 (en) 2011-08-15 2017-06-13 Medimmune, Llc Anti-B7-H4 antibodies and their uses
RU2014109985A (en) 2011-08-17 2015-09-27 Дженентек, Инк. INHIBITION OF ANGIOGENESIS IN REFRACTOR TUMORS
CN103890007A (en) 2011-08-17 2014-06-25 霍夫曼-拉罗奇有限公司 Neuregulin antibodies and uses thereof
MX2014002053A (en) 2011-08-23 2014-04-25 Roche Glycart Ag Anti-mcsp antibodies.
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
UY34317A (en) 2011-09-12 2013-02-28 Genzyme Corp T cell antireceptor antibody (alpha) / ß
WO2013039954A1 (en) 2011-09-14 2013-03-21 Sanofi Anti-gitr antibodies
CA2846083A1 (en) 2011-09-15 2013-03-21 Genentech, Inc. Methods of promoting differentiation
WO2013043715A1 (en) 2011-09-19 2013-03-28 Genentech, Inc. Combination treatments comprising c-met antagonists and b-raf antagonists
KR102366029B1 (en) 2011-09-30 2022-02-23 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule inducing immune response to target antigen
WO2013047748A1 (en) 2011-09-30 2013-04-04 中外製薬株式会社 Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
TWI827333B (en) 2011-09-30 2023-12-21 日商中外製藥股份有限公司 Antigen-binding molecules that promote antigen disappearance
TW201817744A (en) * 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule having an FcRn binding domain that promotes antigen clearance
EP3628329B1 (en) 2011-09-30 2022-08-10 Dana-Farber Cancer Institute, Inc. Therapeutic peptides comprising antibodies binding to mhc class 1 polypeptide related sequence a (mica)
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
JP6271251B2 (en) 2011-10-05 2018-01-31 中外製薬株式会社 An antigen-binding molecule that promotes elimination of an antigen containing a sugar chain receptor-binding domain from plasma
HRP20181457T1 (en) 2011-10-14 2018-11-16 F. Hoffmann - La Roche Ag ANTI-HTRA1 ANTIBODIES AND USE PROCEDURES
WO2013054307A2 (en) 2011-10-14 2013-04-18 Novartis Ag Antibodies and methods for wnt pathway-related diseases
MX2014004426A (en) 2011-10-15 2014-07-09 Genentech Inc Scd1 antagonists for treating cancer.
WO2013059531A1 (en) 2011-10-20 2013-04-25 Genentech, Inc. Anti-gcgr antibodies and uses thereof
IN2014CN03062A (en) 2011-10-28 2015-07-31 Hoffmann La Roche
MX360741B (en) 2011-10-28 2018-11-14 Teva Pharmaceuticals Australia Pty Ltd Polypeptide constructs and uses thereof.
RU2681885C2 (en) 2011-10-31 2019-03-13 Чугаи Сейяку Кабусики Кайся Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
AU2012332593B2 (en) 2011-11-01 2016-11-17 Bionomics, Inc. Anti-GPR49 antibodies
JP2014533247A (en) 2011-11-01 2014-12-11 バイオノミクス インコーポレイテッド Antibodies and methods of treating cancer
WO2013067057A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Anti-gpr49 antibodies
EP2773373B1 (en) 2011-11-01 2018-08-22 Bionomics, Inc. Methods of blocking cancer stem cell growth
KR102052774B1 (en) 2011-11-04 2019-12-04 자임워크스 인코포레이티드 Stable heterodimeric antibody design with mutations in the fc domain
AU2012336069A1 (en) 2011-11-07 2014-05-22 Medimmune, Llc Multispecific and multivalent binding proteins and uses thereof
CA2854477A1 (en) 2011-11-21 2013-05-30 Genentech, Inc. Purification of anti-c-met antibodies
MX2014006272A (en) 2011-11-23 2014-10-24 Igenica Biotherapeutics Inc Anti-cd98 antibodies and methods of use thereof.
WO2013081143A1 (en) 2011-11-30 2013-06-06 中外製薬株式会社 Drug containing carrier into cell for forming immune complex
TWI640537B (en) 2011-12-05 2018-11-11 Ｘ 染色體有限公司 PDGF receptor beta-binding polypeptide
AU2012349736A1 (en) 2011-12-05 2014-06-26 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3) directed to domain II of HER3
UY34487A (en) 2011-12-05 2013-07-31 Novartis Ag ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEIVER 3 (HER3)
WO2013083497A1 (en) 2011-12-06 2013-06-13 F. Hoffmann-La Roche Ag Antibody formulation
RU2685867C2 (en) 2011-12-15 2019-04-23 Алтернатив Инновейтив Текнолоджиз Ллц Hybrid proteins and protein conjugates based on heat shock protein-70 (hsp70) and methods for use thereof (versions)
ES2816078T3 (en) 2011-12-20 2021-03-31 Medimmune Llc Modified Polypeptides for Bispecific Antibody Scaffolds
AU2012356170B2 (en) 2011-12-21 2016-06-16 Novartis Ag Compositions and methods for antibodies targeting Factor P
ES3027182T3 (en) 2011-12-23 2025-06-13 Pfizer Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
WO2013096791A1 (en) 2011-12-23 2013-06-27 Genentech, Inc. Process for making high concentration protein formulations
TWI593705B (en) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
CN104159920A (en) 2011-12-30 2014-11-19 艾伯维公司 Dual specific binding proteins directed against il-13 and/or il-17
CN104411717A (en) 2012-01-09 2015-03-11 斯克利普斯研究所 Humanized antibodies with ultralong CDR3S
JP6684490B2 (en) 2012-01-09 2020-04-22 ザ・スクリップス・リサーチ・インスティテュート Ultralong complementarity determining regions and uses thereof
CN109111526A (en) 2012-01-12 2019-01-01 比奥贝拉蒂治疗公司 Chimeric factor VIII polypeptide and application thereof
KR20140114415A (en) 2012-01-13 2014-09-26 제넨테크, 인크. Biological markers for identifying patients for treatment with vegf antagonists
KR20140116490A (en) 2012-01-18 2014-10-02 제넨테크, 인크. Anti-lrp5 antibodies and methods of use
CN104168920A (en) 2012-01-18 2014-11-26 霍夫曼-拉罗奇有限公司 Methods of using FGF19 modulators
JP2015512616A (en) 2012-02-01 2015-04-30 コンピュゲン エルティーディー． C1ORF32 antibody and its use for the treatment of cancer
WO2013117647A1 (en) 2012-02-07 2013-08-15 Innate Pharma Mica binding agents
HK1201296A1 (en) 2012-02-09 2015-08-28 中外制药株式会社 Modified fc region of antibody
KR102148303B1 (en) 2012-02-11 2020-08-26 제넨테크, 인크. R-spondin translocations and methods using the same
WO2013120929A1 (en) 2012-02-15 2013-08-22 F. Hoffmann-La Roche Ag Fc-receptor based affinity chromatography
WO2013123457A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
HRP20192314T1 (en) 2012-02-15 2020-03-20 Bioverativ Therapeutics Inc. Factor viii compositions and methods of making and using same
JP6089047B2 (en) 2012-02-24 2017-03-01 アッヴィ・ステムセントルクス・エル・エル・シー DLL3 modulator and method of use
CN104244980B (en) 2012-02-24 2017-11-10 中外制药株式会社 Antigen binding molecules that promote antigen elimination via Fc γ IIB
CN104220457A (en) 2012-03-27 2014-12-17 霍夫曼-拉罗奇有限公司 Diagnosis and treatments relating to her3 inhibitors
EP2831113B1 (en) 2012-03-28 2018-03-14 Sanofi Antibodies to bradykinin b1 receptor ligands
WO2013147153A1 (en) 2012-03-29 2013-10-03 株式会社未来創薬研究所 Anti-lamp5 antibody and utilization thereof
AU2013240234B2 (en) 2012-03-30 2017-04-27 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
AR090549A1 (en) 2012-03-30 2014-11-19 Genentech Inc ANTI-LGR5 AND IMMUNOCATE PLAYERS
US9657091B2 (en) 2012-04-05 2017-05-23 Ac Immune S.A. Humanized tau antibody
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
WO2013165940A1 (en) 2012-05-01 2013-11-07 Genentech, Inc. Anti-pmel17 antibodies and immunoconjugates
WO2013166290A1 (en) 2012-05-04 2013-11-07 Abbvie Biotherapeutics Inc. P21 biomarker assay
EP2847216A1 (en) 2012-05-07 2015-03-18 Sanofi Methods for preventing biofilm formation
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
HUE071647T2 (en) 2012-05-18 2025-09-28 Genentech Inc High-concentration monoclonal antibody formulations
JP6419068B2 (en) * 2012-05-21 2018-11-07 ジェネンテック， インコーポレイテッド Methods for improving the safety of blood-brain barrier transport
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
EP3605090A1 (en) 2012-05-23 2020-02-05 F. Hoffmann-La Roche AG Selection method for therapeutic agents
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
WO2013177386A1 (en) 2012-05-24 2013-11-28 Abbvie Biotherapeutics Inc. Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy
WO2013180200A1 (en) 2012-05-30 2013-12-05 中外製薬株式会社 Target-tissue-specific antigen-binding molecule
JPWO2013180201A1 (en) 2012-05-30 2016-01-21 中外製薬株式会社 Antigen-binding molecules that eliminate associated antigens
JP6321633B2 (en) 2012-06-04 2018-05-09 ノバルティス アーゲー Site-specific labeling method and molecules produced thereby
WO2013185113A1 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Procoagulant compounds
AU2013273115B2 (en) 2012-06-08 2018-03-01 Ichnos Sciences SA Humanized anti-TrkA antibodies with amino acid substitutions
WO2013185114A2 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Chimeric clotting factors
JP6628966B2 (en) * 2012-06-14 2020-01-15 中外製薬株式会社 Antigen binding molecule containing an altered Fc region
BR112014031310A2 (en) 2012-06-15 2017-07-25 Genentech Inc anti-pcsk9 antibodies, formulations, dosage and methods of use
AR091476A1 (en) * 2012-06-21 2015-02-04 Univ Indiana Res & Tech Corp REGION FUSION POLYPEPTIDES Fc POLYPEPTIDE BINDING RECEIVER OF INCRETINA AND CONJUGADOS WITH EFECTIVE FUNCTION Fc ALTERED
TWI705073B (en) 2012-06-22 2020-09-21 達特茅斯學院基金會 Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory disorders
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
WO2014039983A1 (en) 2012-09-07 2014-03-13 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
WO2014004586A1 (en) 2012-06-25 2014-01-03 Zymeworks Inc. Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
EP2869837B1 (en) 2012-07-04 2016-09-14 F. Hoffmann-La Roche AG Anti-theophylline antibodies and methods of use
KR102090849B1 (en) 2012-07-04 2020-03-19 에프. 호프만-라 로슈 아게 Covalently linked antigen-antibody conjugates
KR20150030755A (en) 2012-07-04 2015-03-20 에프. 호프만-라 로슈 아게 Anti-biotin antibodies and methods of use
WO2014008391A1 (en) 2012-07-05 2014-01-09 Genentech, Inc. Expression and secretion system
EP2869845B1 (en) 2012-07-06 2019-08-28 Genmab B.V. Dimeric protein with triple mutations
EP3632462A1 (en) 2012-07-06 2020-04-08 Genmab B.V. Dimeric protein with triple mutations
EP3404105A1 (en) 2012-07-06 2018-11-21 Bioverativ Therapeutics Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
MX2015000357A (en) 2012-07-09 2015-05-12 Genentech Inc Immunoconjugates comprising anti-cd22 antibodies.
MX2015000359A (en) 2012-07-09 2015-04-14 Genentech Inc Immunoconjugates comprising anti-cd79b antibodies.
EA201590172A1 (en) 2012-07-09 2015-09-30 Дженентек, Инк. IMMUNOCONGATES CONTAINING ANTIBODIES TO CD79b
BR112015000439A2 (en) 2012-07-09 2017-12-19 Genentech Inc immunoconjugate, pharmaceutical formulation and methods of treating an individual and inhibiting proliferation
EP2882450B1 (en) 2012-07-11 2019-11-27 Bioverativ Therapeutics Inc. Factor viii complex with xten and von willebrand factor protein, and uses thereof
AU2013288641B2 (en) 2012-07-13 2017-07-06 Roche Glycart Ag Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases
EA201590237A1 (en) 2012-07-18 2015-05-29 Гликотоп Гмбх NEW METHODS OF ANTIBODY TREATMENT AGAINST HER2 WITH LOW FUZOZYLATION
CN116574185A (en) 2012-07-25 2023-08-11 塞尔德克斯医疗公司 anti-KIT antibodies and uses thereof
EP2888279A1 (en) 2012-08-22 2015-07-01 Glaxo Group Limited Anti lrp6 antibodies
WO2014030750A1 (en) 2012-08-24 2014-02-27 中外製薬株式会社 MOUSE FcγRII-SPECIFIC Fc ANTIBODY
WO2014030728A1 (en) 2012-08-24 2014-02-27 中外製薬株式会社 Fcγriib-specific fc region variant
KR20190121874A (en) 2012-08-29 2019-10-28 에프. 호프만-라 로슈 아게 Blood brain barrier shuttle
JOP20200308A1 (en) 2012-09-07 2017-06-16 Novartis Ag IL-18 binding molecules
PE20150650A1 (en) 2012-09-12 2015-05-26 Genzyme Corp POLYPEPTIDES CONTAINING HR WITH ALTERED GLYCOSILATION AND REDUCED EFFECTIVE FUNCTION
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
AU2013329311A1 (en) 2012-10-09 2015-04-30 Igenica Biotherapeutics, Inc. Anti-C16orf54 antibodies and methods of use thereof
WO2014071074A2 (en) 2012-11-01 2014-05-08 Abbvie Inc. Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
EP2914621B1 (en) 2012-11-05 2023-06-07 Foundation Medicine, Inc. Novel ntrk1 fusion molecules and uses thereof
EP2914622B1 (en) 2012-11-05 2023-06-07 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
KR20150064205A (en) 2012-11-08 2015-06-10 에프. 호프만-라 로슈 아게 Her3 antigen binding proteins binding to the beta-hairpin of her3
EP2917237A1 (en) 2012-11-09 2015-09-16 Pfizer Inc. Platelet-derived growth factor b specific antibodies and compositions and uses thereof
PH12019501031A1 (en) 2012-11-13 2022-11-14 Genentech Inc Anti-hemagglutinin antibodies and methods of use
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the preparation of immunoconjugates and uses thereof
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
WO2014083379A1 (en) 2012-11-30 2014-06-05 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
HUE053669T2 (en) 2012-12-05 2021-07-28 Novartis Ag Compositions and methods for antibodies targeting epo
KR20150094658A (en) 2012-12-10 2015-08-19 바이오젠 엠에이 인코포레이티드 Anti-blood dendritic cell antigen 2 antibodies and uses thereof
CA2894689A1 (en) 2012-12-19 2014-06-26 Amplimmune, Inc. Anti-human b7-h4 antibodies and their uses
TWI693073B (en) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 Therapeutic agent for GPC3 target is the effective therapeutic agent for GPC3 target administered to patients
EP3557260B1 (en) 2012-12-21 2022-05-18 Chugai Seiyaku Kabushiki Kaisha Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy
ES2700984T3 (en) 2012-12-21 2019-02-20 Hoffmann La Roche Multifunctional proteins comprising MHC class I multivalent disulfide-linked
US9790277B2 (en) 2012-12-21 2017-10-17 The Johns Hopkins University Anti-H7CR antibodies
US10766960B2 (en) 2012-12-27 2020-09-08 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
CA2896723C (en) 2012-12-28 2024-02-13 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
ES2689080T3 (en) 2013-01-02 2018-11-08 Glenmark Pharmaceuticals S.A. Antibodies that bind to TL1A and its uses
WO2014107739A1 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Antibodies against pcsk9
JP6377635B2 (en) 2013-01-10 2018-08-22 ゲンマブ ビー．ブイ． Human IgG1 Fc region variants and uses thereof
AU2014207342C1 (en) 2013-01-18 2019-04-04 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
WO2014116749A1 (en) 2013-01-23 2014-07-31 Genentech, Inc. Anti-hcv antibodies and methods of using thereof
EP2948473A1 (en) 2013-01-24 2015-12-02 GlaxoSmithKline Intellectual Property Development Limited Tnf-alpha antigen-binding proteins
TWI682941B (en) 2013-02-01 2020-01-21 美商再生元醫藥公司 Antibodies comprising chimeric constant domains
ES2829499T3 (en) 2013-02-05 2021-06-01 Engmab Sarl Method for the selection of antibodies against BCMA
EP2762496A1 (en) 2013-02-05 2014-08-06 EngMab AG Method for the selection of antibodies against BCMA
BR112015017338B1 (en) 2013-02-08 2022-11-29 Novartis Ag ISOLATED THERAPEUTIC HUMAN ANTIBODY OR ANTIGEN-BINDING PORTION THEREOF, ITS USE AND PRODUCTION PROCESS, PHARMACEUTICAL COMPOSITION, ISOLATED NUCLEIC ACID MOLECULE, CLONING OR EXPRESSION VECTOR AND TRANSGENIC MICRO-ORGANISM
WO2014124258A2 (en) 2013-02-08 2014-08-14 Irm Llc Specific sites for modifying antibodies to make immunoconjugates
SG10201706468RA (en) 2013-02-08 2017-09-28 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates
ES2870802T3 (en) 2013-02-12 2021-10-27 Bristol Myers Squibb Co High pH Protein Refolding Methods
EP2956468B1 (en) 2013-02-12 2020-06-10 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
EP3255062B1 (en) 2013-02-14 2019-07-03 Innate Pharma Anti-nkp46 antibody for diganosis of a non-cutaneous peripheral t-cell lymphoma (ptcl)
FI2956477T4 (en) 2013-02-15 2024-04-24 Bioverativ Therapeutics Inc Optimized factor viii gene
DK3521312T3 (en) 2013-02-20 2021-06-28 Innate Pharma COMPOUND BINDING SPECIFICALLY TO KIR3DL2, FOR USE IN THE TREATMENT OF PERIFF T-CELL LYMPHOM
WO2014128235A1 (en) 2013-02-22 2014-08-28 F. Hoffmann-La Roche Ag Methods of treating cancer and preventing drug resistance
WO2014130879A2 (en) 2013-02-22 2014-08-28 Stem Centrx, Inc. Novel antibody conjugates and uses thereof
CA2901126C (en) 2013-02-25 2022-01-25 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
CA2896259A1 (en) 2013-02-26 2014-09-04 Roche Glycart Ag Anti-mcsp antibodies
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
JP2016510751A (en) 2013-03-06 2016-04-11 ジェネンテック， インコーポレイテッド Methods of treating and preventing anticancer drug resistance
KR102494631B1 (en) 2013-03-11 2023-02-06 젠자임 코포레이션 Site-specific antibody-drug conjugation through glycoengineering
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
MX2015012404A (en) 2013-03-13 2016-02-03 Eleven Biotherapeutics Inc Chimeric cytokine formulations for ocular delivery.
BR112015022576A2 (en) 2013-03-14 2017-10-24 Genentech Inc pharmaceutical product and its use, kit and method for treating hyperproliferative dysfunction
KR20150127216A (en) 2013-03-14 2015-11-16 제넨테크, 인크. Methods of treating cancer and preventing cancer drug resistance
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
BR112015022019A2 (en) 2013-03-14 2017-08-29 Genentech Inc ISOLATED ANTIBODIES, NUCLEIC ACID, HOST CELL, METHOD OF PRODUCING ANTIBODIES, IMMUNOCONJUGATE, PHARMACEUTICAL FORMULATION, METHODS FOR TREATMENT OF INDIVIDUALS, INHIBITION OF CELL PROLIFERATION, DETECTION OF HUMAN B7-H4 AND CANCER DETECTION
RS62304B1 (en) 2013-03-14 2021-09-30 Macrogenics Inc BISPECIFIC MOLECULES WHICH ARE IMMUNOREACTIVE WITH IMMUNE EFFECTIVE CELLS EXPRESSING AN ACTIVATING RECEPTOR
EP3611189A1 (en) 2013-03-14 2020-02-19 Novartis AG Antibodies against notch 3
TW201512219A (en) 2013-03-15 2015-04-01 Abbvie Inc Dual specific binding proteins directed against IL-1[beta] and/or IL-17
JP6387392B2 (en) 2013-03-15 2018-09-05 バイオベラティブ セラピューティクス インコーポレイテッド Factor IX polypeptide preparation
CA2902765A1 (en) 2013-03-15 2014-09-25 Genentech, Inc. Compositions and methods for diagnosis and treatment of hepatic cancers
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
FR3003171B1 (en) * 2013-03-15 2015-04-10 Lab Francais Du Fractionnement NOVEL MEDICAMENTS COMPRISING AN ENHANCED ANTIBODY COMPOSITION IN MAJORITY LOAD ENFORCEMENT
SG11201507429TA (en) 2013-03-15 2015-10-29 Genentech Inc Il-22 polypeptides and il-22 fc fusion proteins and methods of use
US11220556B2 (en) 2013-03-15 2022-01-11 Biomolecular Holdings Llc Hybrid immunoglobulin containing non-peptidyl linkage
BR112015021576A2 (en) 2013-03-15 2017-10-10 Dana Farber Cancer Inst Inc therapeutic peptides
CN105339001A (en) 2013-03-15 2016-02-17 基因泰克公司 Methods of treating cancer and preventing cancer drug resistance
US20160009824A1 (en) 2013-03-15 2016-01-14 Merck Patent Gmbh Tetravalent bispecific antibodies
KR20230070054A (en) 2013-03-15 2023-05-19 제넨테크, 인크. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
CN105143265A (en) 2013-03-15 2015-12-09 豪夫迈·罗氏有限公司 Anti-crth2 antibodies and their use
CN105451767B (en) 2013-03-15 2019-10-18 泽恩格尼亚股份有限公司 Multivalence and monovalent polyspecific compound and application thereof
AU2014233436B2 (en) 2013-03-15 2019-12-05 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
US9598485B2 (en) 2013-03-15 2017-03-21 Ac Immune S.A. Anti-tau antibodies and methods of use
MA38498B1 (en) 2013-03-15 2018-11-30 Glaxosmithkline Ip Dev Ltd Anti-lag-3 binding proteins
CN105007950B (en) 2013-03-15 2019-01-15 诺华股份有限公司 Antibody Drug Conjugates
AU2014236986A1 (en) 2013-03-15 2015-09-03 Biogen Ma Inc. Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies
WO2014160753A1 (en) 2013-03-27 2014-10-02 Genentech, Inc. Use of biomarkers for assessing treatment of gastrointestinal inflammatory disorders with beta7 integrin antagonists
CA2908350C (en) 2013-04-02 2023-08-08 Futa Mimoto Fc region variant
KR20150144804A (en) 2013-04-22 2015-12-28 글리코토페 게엠베하 Anti-cancer treatments with anti-egfr antibodies having a low fucosylation
WO2014177460A1 (en) 2013-04-29 2014-11-06 F. Hoffmann-La Roche Ag Human fcrn-binding modified antibodies and methods of use
PT2992013T (en) 2013-04-29 2020-03-05 Teva Pharmaceuticals Australia Pty Ltd Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
PL2992010T3 (en) 2013-04-29 2021-08-23 F.Hoffmann-La Roche Ag Fc-receptor binding modified asymmetric antibodies and methods of use
PE20151926A1 (en) 2013-05-20 2016-01-07 Genentech Inc ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
WO2014186877A1 (en) 2013-05-24 2014-11-27 Uger Marni Diane FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
SG11201509618QA (en) 2013-05-24 2015-12-30 Medimmune Llc Anti-b7-h5 antibodies and their uses
BR112015029788B1 (en) 2013-05-31 2024-01-02 Zymeworks Inc HETERO-MULTIMER, USE AND METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND METHOD FOR REDUCING EFFECTOR FUNCTION OF AN IgG FC CONSTRUCT
AR096601A1 (en) 2013-06-21 2016-01-20 Novartis Ag ANTIBODIES OF LEXINED OXIDATED LDL RECEIVER 1 AND METHODS OF USE
US9562101B2 (en) 2013-06-21 2017-02-07 Novartis Ag Lectin-like oxidized LDL receptor 1 antibodies and methods of use
TW201542591A (en) 2013-06-24 2015-11-16 Chugai Pharmaceutical Co Ltd Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
WO2015017146A2 (en) 2013-07-18 2015-02-05 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
CN105814074B (en) 2013-07-18 2020-04-21 图鲁斯生物科学有限责任公司 Humanized antibodies with ultralong complementarity determining regions
US10947269B2 (en) 2013-08-08 2021-03-16 Bioverativ Therapeutics Inc. Purification of chimeric FVIII molecules
US11384149B2 (en) 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
UA116479C2 (en) 2013-08-09 2018-03-26 Макродженікс, Інк. SPECIFIC MONOVALENT Fc-DIATELY CONNECTING BACKGROUND OF THE CD32B AND CD79b AND ITS APPLICATION
KR20160042438A (en) 2013-08-12 2016-04-19 제넨테크, 인크. Compositions and method for treating complement-associated conditions
TW201722994A (en) 2013-08-13 2017-07-01 賽諾菲公司 Antibodies to Plasminogen Activator Inhibitor-1 (PAI-1) and uses thereof
PE20160244A1 (en) 2013-08-13 2016-05-10 Sanofi Sa ANTIBODIES AGAINST PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 (PAI-1) AND USES OF THE SAME
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
MX2016001969A (en) 2013-08-14 2016-06-02 Novartis Ag Methods of treating sporadic inclusion body myositis.
EP2840091A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
EP2839842A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
US20150093399A1 (en) 2013-08-28 2015-04-02 Bioasis Technologies, Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
CA2922547C (en) 2013-08-28 2020-03-10 Stemcentrx, Inc. Site-specific antibody conjugation methods and compositions
JP2016538318A (en) 2013-08-28 2016-12-08 ステムセントリックス， インコーポレイテッド New SEZ6 modulator and method of use
BR112016005408B1 (en) 2013-09-13 2023-03-21 Beigene Switzerland Gmbh ANTI-PD1, F(AB) OR F(AB)2 ANTIBODIES AND REFERRED USE ANTIBODY FOR TREATMENT OF CANCER OR VIRAL INFECTION
HK1218124A1 (en) 2013-09-17 2017-02-03 豪夫迈．罗氏有限公司 Methods of using anti-lgr5 antibodies
WO2015048330A2 (en) 2013-09-25 2015-04-02 Biogen Idec Ma Inc. On-column viral inactivation methods
KR102441231B1 (en) 2013-09-27 2022-09-06 추가이 세이야쿠 가부시키가이샤 Method for preparing polypeptide heteromultimers
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
JP6535675B2 (en) 2013-10-02 2019-06-26 メディミューン，エルエルシー Neutralization of anti-influenza A antibody and use thereof
CN105814078A (en) 2013-10-11 2016-07-27 豪夫迈·罗氏有限公司 Nsp4 inhibitors and methods of use
EP3055329B1 (en) 2013-10-11 2018-06-13 F. Hoffmann-La Roche AG Multispecific domain exchanged common variable light chain antibodies
CN105744954B (en) 2013-10-18 2021-03-05 豪夫迈·罗氏有限公司 anti-RSPO 2 and/or anti-RSPO 3 antibodies and uses thereof
JP6715767B2 (en) 2013-10-23 2020-07-01 ジェネンテック， インコーポレイテッド Method for diagnosing and treating eosinophilic disease
PL3063275T3 (en) 2013-10-31 2020-03-31 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
MX2016005763A (en) 2013-11-06 2016-08-19 Stemcentrx Inc Novel anti-claudin antibodies and methods of use.
CN104623637A (en) 2013-11-07 2015-05-20 健能隆医药技术（上海）有限公司 Application of IL-22 dimer in preparation of intravenous injection drugs
CA2929386C (en) 2013-11-07 2023-01-03 Inserm (Institut National De La Sante Et De La Recherche Medicale) Neuregulin allosteric anti-her3 antibody
US10584147B2 (en) 2013-11-08 2020-03-10 Biovertiv Therapeutics Inc. Procoagulant fusion compound
WO2015068847A1 (en) 2013-11-11 2015-05-14 中外製薬株式会社 Antigen-binding molecule containing modified antibody variable region
PE20161092A1 (en) 2013-11-13 2016-10-28 Pfizer SPECIFIC ANTIBODIES FOR LIGAND 1A TYPE FACTOR OF TUMOR NECROSIS AND COMPOSITIONS AND USE OF THEM
LT3071597T (en) 2013-11-21 2020-10-12 F. Hoffmann-La Roche Ag ANTIBODIES TO ALPHA-SUNUCLEIN AND THEIR USES
JP7060317B2 (en) 2013-12-04 2022-04-26 中外製薬株式会社 Antigen-binding molecule and its library whose antigen-binding ability changes according to the concentration of the compound
EA201691078A1 (en) 2013-12-06 2017-01-30 Дана-Фарбер Кэнсер Инститьют, Инк. THERAPEUTIC PEPTIDES
WO2015089117A1 (en) 2013-12-09 2015-06-18 Allakos Inc. Anti-siglec-8 antibodies and methods of use thereof
JP6502942B2 (en) 2013-12-13 2019-04-17 ジェネンテック， インコーポレイテッド Anti-CD33 antibody and immunoconjugate
CN106030310B (en) 2013-12-13 2019-01-04 通用医疗公司 Soluble high-molecular amount (HMW) TAU type and its application
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
AU2014364601A1 (en) 2013-12-17 2016-07-07 Genentech, Inc. Methods of treating HER2-positive cancers using PD-1 axis binding antagonists and anti-HER2 antibodies
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
RU2016128726A (en) 2013-12-17 2018-01-23 Дженентек, Инк. METHODS FOR TREATING MALIGNANT TUMORS USING PD-1 BINDING ANTAGONISTS AND ANTIBODIES AGAINST CD20
RS60443B1 (en) 2013-12-17 2020-07-31 Genentech Inc Anti-cd3 antibodies and methods of use
KR20160099092A (en) 2013-12-17 2016-08-19 제넨테크, 인크. Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
LT3083680T (en) 2013-12-20 2020-04-10 F. Hoffmann-La Roche Ag HUMANIZED ANTI-Tau(pS422) ANTIBODIES AND METHODS OF USE
TWI670283B (en) 2013-12-23 2019-09-01 美商建南德克公司 Antibodies and methods of use
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
SG10201805933TA (en) 2013-12-24 2018-08-30 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
PT3087095T (en) 2013-12-24 2019-10-09 Argenx Bvba Fcrn antagonists and methods of use
JP6476194B2 (en) 2014-01-03 2019-02-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Bispecific anti-hapten / anti-blood brain barrier receptor antibodies, complexes thereof, and their use as blood brain barrier shuttles
WO2015101587A1 (en) 2014-01-03 2015-07-09 F. Hoffmann-La Roche Ag Covalently linked helicar-anti-helicar antibody conjugates and uses thereof
MX373017B (en) 2014-01-03 2020-04-28 Hoffmann La Roche COVALENTLY LINKED POLYPEPTIDE TOXIN-ANTIBODY CONJUGATES.
ES2864160T3 (en) 2014-01-06 2021-10-13 Hoffmann La Roche Monovalent Blood Brain Barrier Shuttle Modules
HRP20240640T1 (en) 2014-01-10 2024-08-02 Bioverativ Therapeutics Inc. Factor viii chimeric proteins and uses thereof
CA2931986A1 (en) 2014-01-15 2015-07-23 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn- and maintained protein a-binding properties
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
EP3097122B9 (en) 2014-01-24 2020-11-11 NGM Biopharmaceuticals, Inc. Antibodies binding beta klotho domain 2 and methods of use thereof
BR112016015693A2 (en) 2014-01-24 2017-10-24 Genentech Inc Method To Treat Prostate Cancer And Antibody
US20170044232A1 (en) 2014-02-04 2017-02-16 Genentech, Inc. Mutant smoothened and methods of using the same
US20150246963A1 (en) 2014-02-08 2015-09-03 Genentech, Inc. Methods of treating alzheimer's disease
CA2938731A1 (en) 2014-02-08 2015-08-13 Genentech, Inc. Methods of treating alzheimer's disease
ES2685424T3 (en) 2014-02-12 2018-10-09 F. Hoffmann-La Roche Ag Anti-Jagged1 antibodies and procedures for use
BR112016018754A2 (en) 2014-02-14 2017-10-10 S Chi Andrew method of treating a cancer with vascularization
CR20160379A (en) 2014-02-21 2016-10-07 Genentech Inc BISPECIFIC ANTIBODIES ANTI-IL 13 / IL-17 AND ITS USES
JP6825909B2 (en) 2014-02-28 2021-02-03 アラコス インコーポレイテッド Methods and Compositions for Treating SIGLEC-8 Related Diseases
US9732154B2 (en) * 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
NZ631007A (en) 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
EP3960767A3 (en) 2014-03-12 2022-06-01 Novartis AG Specific sites for modifying antibodies to make immunoconjugates
CA2941687A1 (en) 2014-03-14 2015-09-17 Genentech, Inc. Methods and compositions for secretion of heterologous polypeptides
KR102587838B1 (en) 2014-03-14 2023-10-12 바이오몰레큘러 홀딩스 엘엘씨 Hybrid immunoglobulin containing non-peptidyl linkage
DK3116908T3 (en) 2014-03-14 2019-10-07 Innate Pharma HUMANIZED KIR3DL2 ANTIBODIES
EP3116903A2 (en) 2014-03-14 2017-01-18 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
AU2015231307B2 (en) 2014-03-19 2021-01-28 Genzyme Corporation Site-specific glycoengineering of targeting moieties
TWI754319B (en) 2014-03-19 2022-02-01 美商再生元醫藥公司 Methods and antibody compositions for tumor treatment
RU2723940C2 (en) 2014-03-21 2020-06-18 Экс-Боди, Инк. Bispecific antigen-binding polypeptides
US20170107294A1 (en) 2014-03-21 2017-04-20 Nordlandssykehuset Hf Anti-cd14 antibodies and uses thereof
CA2943329A1 (en) 2014-03-24 2015-10-01 Genentech, Inc. Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
KR20220065091A (en) 2014-03-27 2022-05-19 제넨테크, 인크. Methods for diagnosing and treating inflammatory bowel disease
LT3126394T (en) 2014-03-31 2020-01-27 F. Hoffmann-La Roche Ag Anti-ox40 antibodies and methods of use
CA2943834A1 (en) 2014-03-31 2015-10-08 Genentech, Inc. Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
CA2944649C (en) 2014-04-04 2022-06-21 Bionomics, Inc. Humanized antibodies that bind lgr5
ES2900898T3 (en) 2014-04-07 2022-03-18 Chugai Pharmaceutical Co Ltd Bispecific immunoactivating antibodies
EP3129055B1 (en) 2014-04-11 2020-07-01 MedImmune, LLC Bispecific her2 antibodies
JP2017518737A (en) 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Anti-pSYK antibody molecules and their use for SYK targeted therapeutics
TW201622746A (en) 2014-04-24 2016-07-01 諾華公司 Methods of improving or accelerating physical recovery after surgery for hip fracture
WO2015164615A1 (en) 2014-04-24 2015-10-29 University Of Oslo Anti-gluten antibodies and uses thereof
MA39934A (en) 2014-05-01 2017-03-08 Hoffmann La Roche Anti-factor d antibody variants and uses thereof
UA119352C2 (en) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд COMBINATION OF LENALIDOMIDE OR POMALIDOMIDE AND STRUCTURES OF ANTI-CD38 ANTIBODY-ATHENED INTERPHERONE ALPHA-2B AND METHOD OF TREATMENT38
CN106459959A (en) 2014-05-08 2017-02-22 中外制药株式会社 GPC3-Targeting Therapeutics Administered to Patients Responding to GPC3-Targeting Therapeutics Therapeutics
JP6894702B2 (en) * 2014-05-13 2021-06-30 中外製薬株式会社 T cell redirection antigen-binding molecule for cells with immunosuppressive function
EP3702369A1 (en) 2014-05-16 2020-09-02 Ablynx NV Immunoglobulin variable domains
CA2946662A1 (en) 2014-05-22 2015-11-26 Genentech, Inc. Anti-gpc3 antibodies and immunoconjugates
CA2944717A1 (en) 2014-05-23 2015-11-26 Genentech, Inc. Mit biomarkers and methods using the same
SMT202100116T1 (en) 2014-05-28 2021-05-07 Agenus Inc Anti-gitr antibodies and methods of use thereof
ES2890079T3 (en) 2014-05-29 2022-01-17 Macrogenics Inc Trispecific binding molecules and methods of using same
SMT201900745T1 (en) 2014-05-30 2020-01-14 Henlix Biotech Co Ltd Anti-epidermal growth factor receptor (egfr) antibodies
EP3151921B1 (en) 2014-06-06 2019-08-28 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
WO2015191715A1 (en) 2014-06-11 2015-12-17 Genentech, Inc. Anti-lgr5 antibodies and uses thereof
CN107073109B (en) 2014-06-11 2021-08-06 凯西·A·格林 Use of VISTA agonists and antagonists to inhibit or enhance humoral immunity
US20230190750A1 (en) 2014-06-13 2023-06-22 Genentech, Inc. Methods of treating and preventing cancer drug resistance
EP3161001A2 (en) 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
AR100978A1 (en) 2014-06-26 2016-11-16 Hoffmann La Roche ANTI-Tau HUMANIZED ANTIBODY BRAIN LAUNCHERS (pS422) AND USES OF THE SAME
WO2015197736A1 (en) 2014-06-26 2015-12-30 F. Hoffmann-La Roche Ag Anti-brdu antibodies and methods of use
DK3160994T3 (en) 2014-06-27 2025-05-05 Innate Pharma MULTISPECIFIC ANTIGEN-BINDING PROTEINS
JP6822849B2 (en) 2014-06-27 2021-01-27 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． Multispecific NKp46 binding protein
WO2016004113A1 (en) 2014-06-30 2016-01-07 Biogen Ma Inc. Optimized factor ix gene
KR102130600B1 (en) 2014-07-03 2020-07-08 베이진 엘티디 Anti-PD-L1 Antibodies and Their Use as Therapeutics and Diagnostics
KR102360693B1 (en) 2014-07-11 2022-02-08 벤타나 메디컬 시스템즈, 인코포레이티드 Anti-pd-l1 antibodies and diagnostic uses thereof
CN106488775A (en) 2014-07-11 2017-03-08 基因泰克公司 NOTCH approach suppresses
NZ728688A (en) 2014-07-22 2023-06-30 Cb Therapeutics Inc Anti-pd-1 antibodies
EP3177649B1 (en) 2014-08-05 2024-02-28 Apollomics Inc. Anti-pd-l1 antibodies
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
NZ728425A (en) 2014-08-07 2022-05-27 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
TW201613977A (en) 2014-08-07 2016-04-16 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
CA2954599A1 (en) 2014-08-12 2016-02-18 Novartis Ag Anti-cdh6 antibody drug conjugates
MD4733C1 (en) 2014-08-19 2021-07-31 Merck Sharp & Dohme Corp Anti-TIGIT antibodies
JO3663B1 (en) 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
WO2016030488A1 (en) 2014-08-27 2016-03-03 Innate Pharma Treatment of celiac disease
MX2017002605A (en) 2014-08-28 2017-05-19 Bioatla Llc Conditionally active chimeric antigen receptors for modified t-cells.
TW201617368A (en) 2014-09-05 2016-05-16 史坦森特瑞斯公司 Novel anti-MFI2 antibodies and methods of use
FR3025515B1 (en) 2014-09-05 2016-09-09 Lab Francais Du Fractionnement PROCESS FOR PURIFYING MONOCLONAL ANTIBODY
AU2015314954B2 (en) 2014-09-12 2021-05-13 Genentech, Inc. Anti-HER2 antibodies and immunoconjugates
CN106804108B (en) 2014-09-12 2021-08-10 基因泰克公司 anti-B7-H4 antibodies and immunoconjugates
BR112017003236A2 (en) 2014-09-12 2017-11-28 Genentech Inc cysteine engineered antibodies, drug conjugates and antibodies, drug and antibody conjugate preparation method and pharmaceutical composition
CR20170095A (en) 2014-09-12 2017-07-19 Genentech Inc ANTI-CLL-1 ANTIBODIES AND IMMUNOCATE PLAYERS RECIPROCAL REFERENCES WITH RELATED APPLICATIONS
EP3197500A1 (en) 2014-09-17 2017-08-02 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
RS60349B8 (en) 2014-09-23 2022-10-31 Hoffmann La Roche Method of using anti-cd79b immunoconjugates
SG11201701803XA (en) 2014-09-26 2017-04-27 Bayer Pharma AG Stabilized adrenomedullin derivatives and use thereof
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
BR112017006515A8 (en) 2014-09-29 2018-02-27 Univ Duke bispecific molecules, compositions, method for treating or preventing HIV-1 infection in an individual with this need, and vector
WO2016056812A1 (en) * 2014-10-06 2016-04-14 Genexine, Inc. Human igg4 fc polypeptide variant
MA41044A (en) 2014-10-08 2017-08-15 Novartis Ag COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
PT3204425T (en) 2014-10-09 2020-12-18 Genzyme Corp Glycoengineered antibody drug conjugates
CA3203273A1 (en) 2014-10-14 2016-04-21 Halozyme, Inc. Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
WO2016061389A2 (en) 2014-10-16 2016-04-21 Genentech, Inc. Anti-alpha-synuclein antibodies and methods of use
MA41480A (en) 2014-10-17 2017-12-19 Glenmark Pharmaceuticals Sa ANTIBODIES BOUND TO CCR6 AND THEIR USES
EP3209687A1 (en) 2014-10-23 2017-08-30 Innate Pharma Treatment of cancers using anti-nkg2a agents
IL251822B2 (en) 2014-10-29 2023-03-01 Teva Pharmaceuticals Australia Pty Ltd Interferon alpha2b variants
EP3215850B1 (en) 2014-11-03 2019-07-03 F. Hoffmann-La Roche AG Assays for detecting t cell immune subsets and methods of use thereof
KR20170074246A (en) 2014-11-03 2017-06-29 제넨테크, 인크. Methods and biomarkers for predicting efficacy and evaluation of an 0x40 agonist treatment
RU2705274C2 (en) 2014-11-05 2019-11-06 Дженентек, Инк. Methods for producing double-stranded proteins in bacteria
HRP20201351T1 (en) 2014-11-05 2020-11-27 Genentech, Inc. PROCEDURES FOR THE PRODUCTION OF TWO - CHAIN PROTEINS IN BACTERIA
RU2017119185A (en) 2014-11-05 2018-12-05 Дженентек, Инк. ANTIBODIES AGAINST FGFR2 / 3 AND WAYS OF THEIR APPLICATION
AR102522A1 (en) 2014-11-06 2017-03-08 Hoffmann La Roche FC REGION VARIATIONS WITH MODIFIED PROPERTIES OF UNION TO FCRN AND PROTEIN A
CN107108720A (en) 2014-11-06 2017-08-29 豪夫迈·罗氏有限公司 Fc region variants and its application method that FCRN with change is combined
WO2016073157A1 (en) 2014-11-06 2016-05-12 Genentech, Inc. Anti-ang2 antibodies and methods of use thereof
KR20170072343A (en) 2014-11-06 2017-06-26 제넨테크, 인크. Combination therapy comprising ox40 binding agonists and tigit inhibitors
JP2018500882A (en) 2014-11-10 2018-01-18 ジェネンテック， インコーポレイテッド Animal model of nephropathy and drug for treating it
KR20170080604A (en) 2014-11-10 2017-07-10 제넨테크, 인크. Anti-interleukin-33 antibodies and uses thereof
CN107001472B (en) 2014-11-10 2020-12-11 免疫医疗有限公司 Binding molecules specific for CD73 and uses thereof
GB2538120A (en) 2014-11-11 2016-11-09 Medimmune Ltd Therapeutic combinations comprising anti-CD73 antibodies and uses thereof
TWI831044B (en) 2014-11-11 2024-02-01 日商中外製藥股份有限公司 Antigen-binding molecules, pharmaceutical compositions containing antigen-binding molecules, and methods of manufacturing and selecting antigen-binding molecules
ES2987508T3 (en) 2014-11-14 2024-11-15 Novartis Ag Antibody-drug conjugates
SI3699198T1 (en) 2014-11-17 2025-06-30 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using cd3xcd20 bispecific antibody
CA2967368A1 (en) 2014-11-17 2016-05-26 Genentech, Inc. Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
WO2016081639A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Antibodies against bace1 and use thereof for neural disease immunotherapy
CN107001473B (en) 2014-11-19 2021-07-09 豪夫迈·罗氏有限公司 Anti-transferrin receptor antibodies and methods of use
WO2016079597A1 (en) 2014-11-19 2016-05-26 Axon Neuroscience Se Humanized tau antibodies in alzheimer's disease
CN107250158B (en) 2014-11-19 2022-03-25 基因泰克公司 Anti-transferrin receptor/anti-BACE 1 multispecific antibodies and methods of use
CN107250157B (en) 2014-11-21 2021-06-29 百时美施贵宝公司 Antibodies comprising modified heavy chain constant regions
CA2968357A1 (en) 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Antibodies against cd73 and uses thereof
US9382321B2 (en) * 2014-11-26 2016-07-05 Adventis Health System/Sunbelt, Inc. Effector-deficient anti-CD32A antibodies
JP6721590B2 (en) 2014-12-03 2020-07-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Multispecific antibody
HRP20191584T1 (en) 2014-12-05 2019-11-29 Hoffmann La Roche ANTI-CD79B ANTIBODIES AND METHODS OF ADMINISTRATION
MX2017007136A (en) 2014-12-05 2017-12-04 Immunext Inc Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators.
US10398774B2 (en) 2014-12-09 2019-09-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies against AXL
KR20170085595A (en) 2014-12-10 2017-07-24 제넨테크, 인크. Blood brain barrier receptor antibodies and methods of use
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
MX2017007209A (en) 2014-12-18 2017-08-28 Hoffmann La Roche Assay and method for determining cdc eliciting antibodies.
EP3981794A1 (en) 2014-12-19 2022-04-13 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use
UY36449A (en) 2014-12-19 2016-07-29 Novartis Ag COMPOSITIONS AND METHODS FOR ANTIBODIES DIRECTED TO BMP6
PE20221834A1 (en) 2014-12-19 2022-11-29 Chugai Pharmaceutical Co Ltd ANTIMYOSTATIN ANTIBODIES
CN107278206B (en) 2014-12-19 2021-04-02 雷根尼桑斯公司 Antibodies that bind to human C6 and uses thereof
KR102644115B1 (en) 2014-12-23 2024-03-05 브리스톨-마이어스 스큅 컴퍼니 Antibodies to tigit
SG10201906471PA (en) 2015-01-14 2019-09-27 Brigham & Womens Hospital Inc Treatment of cancer with anti-lap monoclonal antibodies
CN113956354A (en) 2015-01-22 2022-01-21 中外制药株式会社 Combinations and methods of use of two or more anti-C5 antibodies
US10501552B2 (en) 2015-01-26 2019-12-10 Macrogenics, Inc. Multivalent molecules comprising DR5-binding domains
EP3250927B1 (en) 2015-01-28 2020-02-19 H. Hoffnabb-La Roche Ag Gene expression markers and treatment of multiple sclerosis
HK1244512A1 (en) 2015-02-04 2018-08-10 健泰科生物技术公司 Mutant smoothened and methods of using the same
TWI844507B (en) 2015-02-05 2024-06-11 日商中外製藥股份有限公司 Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, and uses therof
US10457737B2 (en) 2015-02-09 2019-10-29 Research Development Foundation Engineered immunoglobulin Fc polypeptides displaying improved complement activation
CN115350275A (en) 2015-02-19 2022-11-18 康姆普根有限公司 anti-PVRIG antibodies and methods of use
EP3259597B1 (en) 2015-02-19 2022-04-06 Compugen Ltd. Pvrig polypeptides and methods of treatment
CN113209289A (en) 2015-02-26 2021-08-06 豪夫迈·罗氏有限公司 Integrin beta 7 antagonists and methods for treating Crohn's disease
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
AU2016230827B2 (en) 2015-03-09 2021-10-28 argenx BV Methods of reducing serum levels of fc-containing agents using fcrn antagonists
HK1247287A1 (en) 2015-03-16 2018-09-21 F. Hoffmann-La Roche Ag Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases
WO2016146833A1 (en) 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
EP3277725B1 (en) 2015-03-30 2020-11-25 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to fc gamma receptors
FR3034420A1 (en) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement ANTI-CD303 MONOCLONAL ANTIBODIES
AR104368A1 (en) 2015-04-03 2017-07-19 Lilly Co Eli ANTI-CD20- / ANTI-BAFF BIESPECTIFIC ANTIBODIES
KR102721595B1 (en) 2015-04-03 2024-10-23 유레카 쎄라퓨틱스, 인코포레이티드 Constructs targeting AFP peptide/MHC complexes and uses thereof
CA2981183A1 (en) * 2015-04-07 2016-10-13 Greg Lazar Antigen binding complex having agonistic activity and methods of use
PL3283508T3 (en) 2015-04-17 2021-10-11 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
HRP20211159T1 (en) 2015-04-24 2021-10-29 F. Hoffmann - La Roche Ag Methods of identifying bacteria comprising binding polypeptides
HK1252158A1 (en) 2015-05-01 2019-05-17 Genentech, Inc. Masked anti-cd3 antibodies and methods of use
EP3292152A1 (en) 2015-05-07 2018-03-14 Agenus Inc. Anti-ox40 antibodies and methods of use thereof
JP6963508B2 (en) 2015-05-11 2021-11-10 ジェネンテック， インコーポレイテッド Compositions and Methods for Treating Lupus Nephritis
CA2983282A1 (en) 2015-05-12 2016-11-17 Genentech, Inc. Therapeutic and diagnostic methods for cancer
EP3297673A4 (en) 2015-05-22 2019-05-08 Memorial Sloan-Kettering Cancer Center ANTIBODIES SIMILAR TO SPECIFIC T CELL RECEPTORS FOR PRAME PEPTIDE
US10526415B2 (en) 2015-05-22 2020-01-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies fragments inhibiting both the Cath-D catalytic activity and its binding to the LRP1 receptor
EP4335931A3 (en) 2015-05-29 2024-06-19 F. Hoffmann-La Roche AG Therapeutic and diagnostic methods for cancer
TN2019000101A1 (en) 2015-05-29 2020-07-15 Bristol Myers Squibb Co Antibodies against ox40 and uses thereof.
WO2016196381A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Pd-l1 promoter methylation in cancer
JP2018520658A (en) 2015-05-29 2018-08-02 ジェネンテック， インコーポレイテッド Humanized anti-Ebola virus glycoprotein antibodies and uses thereof
DK3303373T3 (en) 2015-05-30 2020-06-02 Molecular Templates Inc De-immunized Shiga toxin A subunit scaffolds and cell-targeted molecules comprising the same
CN107810012A (en) 2015-06-02 2018-03-16 豪夫迈·罗氏有限公司 Use the composition and method of the anti-Antybody therapy sacred diseases of IL 34
EP3303386B1 (en) 2015-06-05 2024-08-28 Genentech, Inc. Anti-tau antibodies and methods of use
US10047155B2 (en) 2015-06-05 2018-08-14 Novartis Ag Antibodies targeting bone morphogenetic protein 9 (BMP9) and methods therefor
AU2016274584A1 (en) 2015-06-08 2018-01-04 Genentech, Inc. Methods of treating cancer using anti-OX40 antibodies and PD-1 axis binding antagonists
TWI773646B (en) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 Lag-3-binding molecules and methods of use thereof
AU2016274585A1 (en) 2015-06-08 2017-12-14 Genentech, Inc. Methods of treating cancer using anti-OX40 antibodies
TW201710286A (en) 2015-06-15 2017-03-16 艾伯維有限公司 Binding proteins against VEGF, PDGF, and/or their receptors
CN108064246A (en) 2015-06-15 2018-05-22 基因泰克公司 Antibody and immune conjugate
EP3310814B1 (en) 2015-06-16 2023-08-02 F. Hoffmann-La Roche AG Humanized and affinity matured antibodies to fcrh5 and methods of use
JP2018526972A (en) 2015-06-16 2018-09-20 ジェネンテック， インコーポレイテッド Anti-CD3 antibody and method of use
EP3310378B1 (en) 2015-06-16 2024-01-24 F. Hoffmann-La Roche AG Anti-cll-1 antibodies and methods of use
WO2016203432A1 (en) 2015-06-17 2016-12-22 Novartis Ag Antibody drug conjugates
DK3310812T3 (en) 2015-06-17 2025-09-29 Hoffmann La Roche Anti-HER2 antibodies and methods of use
HK1254432A1 (en) 2015-06-17 2019-07-19 Allakos Inc. Methods and compositions for treating fibrotic diseases
CN116327953A (en) 2015-06-17 2023-06-27 豪夫迈·罗氏有限公司 Methods of treating locally advanced or metastatic breast cancer using PD-1 axis binding antagonists and taxanes
EP3313881A1 (en) 2015-06-23 2018-05-02 Innate Pharma Multispecific nk engager proteins
JP6840682B2 (en) 2015-06-23 2021-03-10 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． Multispecific antigen binding protein
WO2016207245A1 (en) 2015-06-24 2016-12-29 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
WO2016207717A1 (en) 2015-06-24 2016-12-29 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
CN107810199B (en) 2015-06-24 2021-11-09 豪夫迈·罗氏有限公司 Anti-transferrin receptor antibodies with tailored affinity
JOP20200312A1 (en) 2015-06-26 2017-06-16 Novartis Ag Factor xi antibodies and methods of use
CN108026172B (en) 2015-06-26 2022-04-29 赛诺菲生物技术公司 Monoclonal anti-IL-1RCP antibody
BR112017027736A2 (en) 2015-06-29 2018-10-09 Genentech Inc anti-cd20 type ii antibody for use in organ transplantation
CA3162816A1 (en) 2015-06-29 2017-01-05 Ventana Medical Systems, Inc. Materials and methods for performing histochemical assays for human pro-epiregulin and amphiregulin
EP3971211A1 (en) 2015-07-13 2022-03-23 Compugen Ltd. Hide1 compositions and methods
US11230605B2 (en) * 2015-07-22 2022-01-25 Inatherys Anti-TfR antibodies and their use in treating proliferative and inflammatory disorders
EP3325010B1 (en) 2015-07-23 2023-06-21 The Regents of The University of California Antibodies to coagulation factor xia and uses thereof
WO2017019729A1 (en) 2015-07-27 2017-02-02 The General Hospital Corporation Antibody derivatives with conditionally enabled effector function
TWI762879B (en) 2015-07-30 2022-05-01 美商宏觀基因股份有限公司 Pd-1-binding molecules and methods of use thereof
EP3328994A4 (en) 2015-07-31 2019-04-17 Memorial Sloan-Kettering Cancer Center CD56 TARGETING ANTIGEN BINDING PROTEINS AND USES THEREOF
MX377710B (en) 2015-08-03 2025-03-11 Bristol Myers Squibb Co MONOCLONAL ANTIBODIES AGAINST BCMA.
CA2994516A1 (en) 2015-08-03 2017-02-09 Novartis Ag Methods of treating fgf21-associated disorders
CA2994547A1 (en) 2015-08-03 2017-02-09 Bioverativ Therapeutics Inc. Factor ix fusion proteins and methods of making and using same
CN105384825B (en) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
WO2017040342A1 (en) 2015-08-28 2017-03-09 Genentech, Inc. Anti-hypusine antibodies and uses thereof
EP3344656A1 (en) 2015-09-01 2018-07-11 Agenus Inc. Anti-pd-1 antibodies and methods of use thereof
CN117510633A (en) 2015-09-02 2024-02-06 伊缪泰普有限公司 anti-LAG-3 antibodies
EP3842457A1 (en) 2015-09-09 2021-06-30 Novartis AG Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
AU2016320748B2 (en) 2015-09-09 2019-05-02 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies
WO2017046746A1 (en) 2015-09-15 2017-03-23 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
US9862760B2 (en) 2015-09-16 2018-01-09 Novartis Ag Polyomavirus neutralizing antibodies
BR112018002432A2 (en) 2015-09-18 2018-09-18 Chugai Pharmaceutical Co Ltd il-8 binding antibodies and uses thereof
TWI703158B (en) 2015-09-18 2020-09-01 美商希佛隆公司 Antibodies that specifically bind to tl1a
CA2999138C (en) 2015-09-21 2024-05-21 Aptevo Research And Development Llc Cd3 binding polypeptides
CA2999369C (en) 2015-09-22 2023-11-07 Spring Bioscience Corporation Anti-ox40 antibodies and diagnostic uses thereof
CN108137681B (en) 2015-09-23 2024-06-18 豪夫迈·罗氏有限公司 Optimized variants of anti-VEGF antibodies
KR20180083313A (en) 2015-09-24 2018-07-20 에이비비트로, 엘엘씨 HIV antibody compositions and methods of use
TWI811892B (en) 2015-09-25 2023-08-11 美商建南德克公司 Anti-tigit antibodies and methods of use
JP6843868B2 (en) 2015-09-29 2021-03-17 セルジーン コーポレイション PD-1 binding protein and its usage
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
EP3150636A1 (en) 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Tetravalent multispecific antibodies
CR20180161A (en) 2015-10-02 2018-05-25 Hoffmann La Roche Bispecific Antibodies for PD1 and TIM3
CN114057884A (en) 2015-10-02 2022-02-18 豪夫迈·罗氏有限公司 Bispecific anti-human CD20/human transferrin receptor antibody and methods of use
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
CN108602887B (en) 2015-10-02 2022-06-21 豪夫迈·罗氏有限公司 Bispecific antibodies specific for costimulatory TNF receptors
AR106189A1 (en) 2015-10-02 2017-12-20 Hoffmann La Roche BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE
MY190297A (en) 2015-10-02 2022-04-12 Hoffmann La Roche Anti-pd1 antibodies and methods of use
WO2017062682A2 (en) 2015-10-06 2017-04-13 Genentech, Inc. Method for treating multiple sclerosis
US20170247467A1 (en) 2015-10-07 2017-08-31 Hoffmann-La Roche Inc. Bispecific antibodies with tetravalency for a costimulatory tnf receptor
WO2017066714A1 (en) 2015-10-16 2017-04-20 Compugen Ltd. Anti-vsig1 antibodies and drug conjugates
MA43354A (en) 2015-10-16 2018-08-22 Genentech Inc CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE
MA45326A (en) 2015-10-20 2018-08-29 Genentech Inc CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
US10604577B2 (en) 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
CA2946113A1 (en) 2015-10-23 2017-04-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
EP3184547A1 (en) 2015-10-29 2017-06-28 F. Hoffmann-La Roche AG Anti-tpbg antibodies and methods of use
MA44334A (en) 2015-10-29 2018-09-05 Novartis Ag ANTIBODY CONJUGATES INCLUDING A TOLL-TYPE RECEPTOR AGONIST
WO2017072210A1 (en) 2015-10-29 2017-05-04 F. Hoffmann-La Roche Ag Anti-variant fc-region antibodies and methods of use
JO3555B1 (en) 2015-10-29 2020-07-05 Merck Sharp & Dohme An antibody that inactivates the human pneumonia virus
JP6920292B2 (en) 2015-10-30 2021-08-18 ジェネンテック， インコーポレイテッド Hinge-modified antibody fragment and preparation method
CN108472382A (en) 2015-10-30 2018-08-31 豪夫迈·罗氏有限公司 Anti- factor D antibody variants conjugate and application thereof
TW201730211A (en) 2015-10-30 2017-09-01 建南德克公司 Anti-Factor D antibodies and conjugates
DK3368578T3 (en) 2015-10-30 2021-05-25 Hoffmann La Roche Anti-HtrA1 Antibodies and Methods of Using Them
CN108602884B (en) 2015-11-08 2024-06-25 豪夫迈·罗氏有限公司 Method for screening multispecific antibodies
EP3378488A4 (en) 2015-11-18 2019-10-30 Chugai Seiyaku Kabushiki Kaisha METHOD FOR ENHANCING THE HUMORAL IMMUNE RESPONSE
JP6931329B2 (en) 2015-11-18 2021-09-01 中外製薬株式会社 Combination therapy using T cell redirection antigen-binding molecule for cells with immunosuppressive function
AU2016356780A1 (en) 2015-11-19 2018-06-28 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
CN108602885B (en) 2015-11-30 2022-05-24 百时美施贵宝公司 Anti-human IP-10 antibodies and uses thereof
ES2861449T3 (en) 2015-12-02 2021-10-06 Stcube & Co Inc Antibodies and Molecules that Immunospecifically Bind to BTN1A1 and Their Therapeutic Uses
CN116063542A (en) 2015-12-02 2023-05-05 阿吉纳斯公司 Antibodies and methods of use thereof
JP7227007B2 (en) 2015-12-02 2023-02-21 ストサイエンシス， インコーポレイテッド Antibodies specific for glycosylated BTLA (B- and T-lymphocyte-attenuating factor)
EA201891341A1 (en) 2015-12-04 2018-11-30 Новартис Аг ANTIQUE-CYTOKINE PRIMED COMPOSITIONS AND METHODS OF APPLICATION FOR IMMUNOREGULATION
EP3389714A4 (en) 2015-12-14 2019-11-13 MacroGenics, Inc. BISPECIFIC MOLECULES HAVING IMMUNOREACTIVITY TO PD-1 AND CTLA-4 AND METHODS OF USE
RU2018123481A (en) 2015-12-16 2020-01-20 Мерк Шарп И Доум Корп. ANTI-LAG3 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS
EA201891420A1 (en) 2015-12-18 2019-02-28 Чугаи Сейяку Кабусики Кайся ANTIBODIES TO MYOSTATIN, POLYPEPTIDES, CONTAINING OPTIONS OF FC-REGIONS, AND METHODS OF THEIR APPLICATION
PT3390442T (en) 2015-12-18 2024-01-08 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
KR20180089510A (en) 2015-12-18 2018-08-08 노파르티스 아게 Antibodies targeting CD32b and methods of using the same
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
BR112018009312A8 (en) 2015-12-28 2019-02-26 Chugai Pharmaceutical Co Ltd method for promoting purification efficiency of fc region-containing polypeptide
BR112018011029A2 (en) 2016-01-08 2018-11-21 Hoffmann La Roche methods for treating or delaying cancer progression and improving immune function in a cancer individual, uses of a binding antagonist and a bispecific antibody, compositions and kits
WO2017124001A2 (en) 2016-01-14 2017-07-20 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for foxp3-derived peptides
CN108602883A (en) 2016-01-20 2018-09-28 基因泰克公司 High-dose treatment for Alzheimer's disease
SI3411478T1 (en) 2016-02-01 2022-10-28 Bioverativ Therapeutics Inc. Optimized factor VIII genes
CA3019952A1 (en) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened and methods of using the same
MX2018009800A (en) 2016-02-12 2018-11-09 Janssen Pharmaceutica Nv Anti-vista (b7h5) antibodies.
CU20180088A7 (en) 2016-02-17 2019-05-03 Novartis Ag ANTIBODIES ANTI TGFBETA 2
AU2017225854B2 (en) 2016-02-29 2020-11-19 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
IL295230A (en) 2016-03-04 2022-10-01 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
SG11201807936VA (en) 2016-03-14 2018-10-30 Chugai Pharmaceutical Co Ltd Cell injury inducing therapeutic drug for use in cancer therapy
EP3430039A1 (en) * 2016-03-14 2019-01-23 Universitetet I Oslo Engineered immunoglobulins with altered fcrn binding
US20170267764A1 (en) 2016-03-15 2017-09-21 Innate Pharma Anti-mica antibodies
US11767362B1 (en) 2016-03-15 2023-09-26 Chugai Seiyaku Kabushiki Kaisha Methods of treating cancers using PD-1 axis binding antagonists and anti-GPC3 antibodies
EP3430034A1 (en) 2016-03-16 2019-01-23 Merrimack Pharmaceuticals, Inc. Engineered trail for cancer therapy
KR20220004226A (en) 2016-03-22 2022-01-11 바이오노믹스 리미티드 Administration of an anti-lgr5 monoclonal antibody
CN114907483B (en) 2016-03-22 2024-07-26 国家医疗保健研究所 Humanized anti-claudin-1 antibody and its use
US20170315132A1 (en) 2016-03-25 2017-11-02 Genentech, Inc. Multiplexed total antibody and antibody-conjugated drug quantification assay
EA201892190A1 (en) 2016-03-29 2019-04-30 Янссен Байотек, Инк. TREATMENT OF PSORIASIS WITH ANTI-BODY TO IL-12 AND / OR IL-23 WITH THE GROWTH OF THE INTERVAL BETWEEN THE INTRODUCTION OF DOSE
US20170319688A1 (en) 2016-04-14 2017-11-09 Genentech, Inc. Anti-rspo3 antibodies and methods of use
CN109328069B (en) 2016-04-15 2023-09-01 亿一生物医药开发(上海)有限公司 Use of IL-22 in the treatment of necrotizing enterocolitis
US11525000B2 (en) 2016-04-15 2022-12-13 Immunext, Inc. Anti-human VISTA antibodies and use thereof
MA43552A (en) 2016-04-15 2018-11-07 Alpine Immune Sciences Inc CD80 VARIANT IMMUNOMODULATOR PROTEINS AND THEIR USES
MX2018012493A (en) 2016-04-15 2019-06-06 Genentech Inc Methods for monitoring and treating cancer.
SG11201808994YA (en) 2016-04-15 2018-11-29 Bioatla Llc Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof
ES2850428T3 (en) 2016-04-15 2021-08-30 Hoffmann La Roche Cancer monitoring and treatment procedures
WO2017180813A1 (en) 2016-04-15 2017-10-19 Macrogenics, Inc. Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof
KR20250095754A (en) 2016-04-15 2025-06-26 알파인 이뮨 사이언시즈, 인코포레이티드 Icos ligand variant immunomodulatory proteins and uses thereof
CA3019588A1 (en) 2016-04-20 2017-10-26 Merck Sharp & Dohme Corp. Cmv neutralizing antigen binding proteins
TW201805309A (en) 2016-04-21 2018-02-16 艾伯維史坦森特瑞斯有限責任公司 Novel anti-BMPR1B antibodies and methods of use
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
CN109071647B (en) 2016-04-27 2022-11-22 诺华股份有限公司 Antibody against growth differentiation factor 15 and use thereof
JP6675017B2 (en) 2016-05-02 2020-04-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Contrast body-single chain target binding substance
IL321475A (en) 2016-05-06 2025-08-01 Medimmune Llc Bispecific binding proteins and uses thereof
EP3455256A1 (en) 2016-05-09 2019-03-20 Bristol-Myers Squibb Company Tl1a antibodies and uses thereof
EP3455252B1 (en) 2016-05-11 2022-02-23 F. Hoffmann-La Roche AG Modified anti-tenascin antibodies and methods of use
HUE060072T2 (en) 2016-05-13 2023-01-28 Bioatla Inc Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
TW201802121A (en) 2016-05-25 2018-01-16 諾華公司 Reversal binding agent against factor XI/XIa antibody and use thereof
BR112018074463A2 (en) 2016-05-27 2019-03-06 Agenus Inc. anti-tim-3 antibodies and methods of use.
JP7022080B2 (en) 2016-05-27 2022-02-17 ジェネンテック， インコーポレイテッド Biochemical analytical methods for the characterization of site-specific antibody-drug conjugates
CN109476648B (en) 2016-06-06 2022-09-13 豪夫迈·罗氏有限公司 Sevelamer antibody-drug conjugates and methods of use
JP7148504B2 (en) 2016-06-08 2022-10-05 ゼンコー，インコーポレイティド Treatment of IgG4-related diseases with anti-CD19 antibodies cross-linked to CD32B
US11434269B2 (en) 2016-06-15 2022-09-06 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)
KR102306744B1 (en) 2016-06-17 2021-09-28 추가이 세이야쿠 가부시키가이샤 Anti-myostatin antibodies and methods of use
JP7133477B2 (en) 2016-06-24 2022-09-08 ジェネンテック， インコーポレイテッド Anti-polyubiquitin multispecific antibody
CN119120423A (en) 2016-07-01 2024-12-13 分解治疗有限责任公司 Optimized dinuclease fusions and methods
JP6983824B2 (en) 2016-07-04 2021-12-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft New antibody format
US10864203B2 (en) 2016-07-05 2020-12-15 Beigene, Ltd. Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer
MY200602A (en) 2016-07-14 2024-01-04 Bristol Myers Squibb Co Antibodies against tim3 and uses thereof
CA3030926A1 (en) 2016-07-19 2018-01-25 Teva Pharmaceuticals Australia Pty Ltd. Anti-cd47 combination therapy
WO2018014260A1 (en) 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
US20200148750A1 (en) 2016-07-21 2020-05-14 Emory University Ebola Virus Antibodies and Binding Agents Derived Therefrom
US20190330318A1 (en) 2016-07-25 2019-10-31 Biogen Ma Inc. Anti-hspa5 (grp78) antibodies and uses thereof
EP3491013A1 (en) 2016-07-28 2019-06-05 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
EP3491022B1 (en) 2016-07-29 2025-09-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Antibodies targeting tumor associated macrophages and uses thereof
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
US20190185578A1 (en) 2016-07-29 2019-06-20 Chugai Seiyaku Kabushiki Kaisha Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity
NL2017270B1 (en) 2016-08-02 2018-02-09 Aduro Biotech Holdings Europe B V New anti-hCTLA-4 antibodies
JP7464389B2 (en) 2016-08-02 2024-04-09 ビステラ， インコーポレイテッド Engineered Polypeptides and Uses Thereof
EP3494141A4 (en) 2016-08-03 2020-04-08 Bio-Techne Corporation IDENTIFICATION OF VSIG3 / VISTA AS A NEW IMMUNE CONTROL POINT AND ITS USE IN IMMUNOTHERAPY
CN109790223A (en) 2016-08-05 2019-05-21 阿拉科斯有限责任公司 Anti- SIGLEC-7 antibody for treating cancer
US11053308B2 (en) 2016-08-05 2021-07-06 Chugai Seiyaku Kabushiki Kaisha Method for treating IL-8-related diseases
SG11201900027XA (en) 2016-08-05 2019-02-27 Medimmune Llc Anti-o2 antibodies and uses thereof
CN109476748B (en) 2016-08-08 2023-05-23 豪夫迈·罗氏有限公司 Methods for the treatment and diagnosis of cancer
EP3496763A1 (en) 2016-08-11 2019-06-19 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
CA3033661A1 (en) * 2016-08-12 2018-02-15 Janssen Biotech, Inc. Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions
DK3347379T5 (en) 2016-08-17 2020-06-15 Compugen Ltd ANTI-TIGIT ANTIBODIES, ANTI-ENVIRONMENTAL ANTIBODIES AND COMBINATIONS THEREOF
HUE065528T2 (en) 2016-08-19 2024-06-28 Beigene Switzerland Gmbh Combination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer
US10981976B2 (en) 2016-08-31 2021-04-20 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof
WO2018045379A1 (en) 2016-09-02 2018-03-08 Dana-Farber Cancer Institute, Inc. Composition and methods of treating b cell disorders
EP3512883A1 (en) 2016-09-13 2019-07-24 Humanigen, Inc. Epha3 antibodies for the treatment of pulmonary fibrosis
JP7072576B2 (en) 2016-09-16 2022-05-20 シャンハイ・ヘンリウス・バイオテック・インコーポレイテッド Anti-PD-1 antibody
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CA3036701A1 (en) 2016-09-19 2018-03-22 Celgene Corporation Methods of treating immune disorders using pd-1 binding proteins
EP3515932B1 (en) 2016-09-19 2023-11-22 F. Hoffmann-La Roche AG Complement factor based affinity chromatography
EP3515943A4 (en) 2016-09-19 2020-05-06 Celgene Corporation Methods of treating vitiligo using pd-1 binding proteins
EP4360714A3 (en) 2016-09-21 2024-07-24 Nextcure, Inc. Antibodies for siglec-15 and methods of use thereof
KR102644544B1 (en) 2016-09-21 2024-03-11 넥스트큐어 인코포레이티드 Antibodies for SIGLEC-15 and methods of using the same
IL265473B2 (en) 2016-09-23 2024-01-01 Genentech Inc Uses of il-13 antagonists for treating atopic dermatitis
JOP20190055A1 (en) 2016-09-26 2019-03-24 Merck Sharp & Dohme Anti-cd27 antibodies
KR20190059305A (en) 2016-09-30 2019-05-30 얀센 바이오테크 인코포레이티드 A safe and effective way to treat psoriasis with anti-IL23-specific antibodies
JP7050770B2 (en) 2016-10-05 2022-04-08 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Method for preparing antibody drug conjugate
AU2017339517B2 (en) 2016-10-06 2024-03-14 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
JP7066696B2 (en) 2016-10-11 2022-05-13 アジェナス インコーポレイテッド Anti-LAG-3 antibody and its usage
KR20190064636A (en) 2016-10-19 2019-06-10 메디뮨 엘엘씨 Anti-O1 antibodies and uses thereof
US11286295B2 (en) 2016-10-20 2022-03-29 Sanofi Anti-CHIKV monoclonal antibodies directed against the E2 structural protein
MX2019004691A (en) 2016-10-20 2019-12-09 I Mab Biopharma Us Ltd Novel cd47 monoclonal antibodies and uses thereof.
KR20230173745A (en) 2016-10-21 2023-12-27 이나뜨 파르마 에스.에이. Treatment with anti-kir3dl2 agents
CN110267678A (en) 2016-10-29 2019-09-20 霍夫曼-拉罗奇有限公司 Anti-MIC antibodies and methods of use
TWI788307B (en) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
EA201990787A1 (en) 2016-11-02 2019-12-30 Энгмаб Сарл SPECIFIC ANTIBODY TO BCMA AND CD3 AND IMMUNOLOGICAL MEDICINE FOR COMBINED USE IN TREATMENT OF MULTIPLE MYELOMA
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
WO2018089695A1 (en) 2016-11-11 2018-05-17 Dynavax Technologies Corporation Toll-like receptor antagonist compounds and methods of use
CN109996809A (en) 2016-11-14 2019-07-09 诺华股份有限公司 Composition relevant to fusogenic protein MINION, method and therapeutical uses
TWI791471B (en) 2016-11-15 2023-02-11 美商建南德克公司 Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
WO2018093841A1 (en) 2016-11-16 2018-05-24 Janssen Biotech, Inc. Method of treating psoriasis with anti-il-23 specific antibody
TW201829463A (en) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 anti-HLA-G antibody and use thereof
JOP20190100A1 (en) 2016-11-19 2019-05-01 Potenza Therapeutics Inc Anti-gitr antigen-binding proteins and methods of use thereof
CN110023334B (en) 2016-11-21 2023-11-14 科雅博有限责任公司 anti-GP 73 antibodies and immunoconjugates
KR20190080949A (en) 2016-11-23 2019-07-08 바이오버라티브 테라퓨틱스 인크. A bispecific antibody that binds to coagulation factor IX and coagulation factor X
BR112019011115A2 (en) 2016-12-02 2019-10-01 Bioverativ Therapeutics Inc methods for treating hemophilic arthropathy using chimeric clotting factors
CA3044838A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
WO2018104893A1 (en) 2016-12-06 2018-06-14 Glaxosmithkline Intellectual Property Development Limited Alpha4-beta7 antibodies with incrased fcrn binding and/or half-life
MD3551660T2 (en) 2016-12-07 2024-03-31 Agenus Inc Anti-CTLA-4 antibodies and methods of use thereof
EP3551655A2 (en) 2016-12-07 2019-10-16 Genentech, Inc. Anti-tau antibodies and methods of their use
AU2017373945B2 (en) 2016-12-07 2025-01-23 Agenus Inc. Antibodies and methods of use thereof
TW202328181A (en) 2016-12-07 2023-07-16 美商建南德克公司 Anti-tau antibodies and methods of use
MX2019006331A (en) 2016-12-12 2019-07-12 Genentech Inc Methods of treating cancer using anti-pd-l1 antibodies and antiandrogens.
BR112019012691A2 (en) 2016-12-19 2019-11-19 Fundacio Privada Inst Catalana De Recerca I Estudis Avancats antibodies against lif and its uses
US10583191B2 (en) 2016-12-19 2020-03-10 Mosaic Biomedicals Slu Antibodies against LIF and uses thereof
EP3559034B1 (en) 2016-12-20 2020-12-02 H. Hoffnabb-La Roche Ag Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists
MA47130B1 (en) 2016-12-21 2025-05-30 Cephalon, Inc. ANTIBODIES SPECIFICALLY BINDING TO HUMAN IL-15 AND THEIR USES
JOP20190134A1 (en) 2016-12-23 2019-06-02 Potenza Therapeutics Inc Anti-neuropilin antigen-binding proteins and methods of use thereof
CN110325550B (en) 2016-12-23 2024-03-08 诺华股份有限公司 Factor XI antibodies and methods of use
EP3559032A1 (en) 2016-12-23 2019-10-30 Innate Pharma Heterodimeric antigen binding proteins
CR20190309A (en) 2017-01-03 2019-08-21 Hoffmann La Roche BI-SPECIFIC ANTIGEN BINDING MOLECULES INCLUDING CLONE 20H4.9 ANTI-4-1BB
WO2018129029A1 (en) 2017-01-04 2018-07-12 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
WO2018129332A1 (en) 2017-01-06 2018-07-12 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists
CA3049165A1 (en) 2017-01-06 2018-07-12 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
EP3568468A4 (en) 2017-01-12 2020-12-30 Eureka Therapeutics, Inc. AGAINST HISTONE H3 PEPTIDE / MHC COMPLEX CONSTRUCTS AND USES THEREOF
EP3573989A4 (en) 2017-01-25 2020-11-18 Beigene, Ltd. CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF
IL268327B2 (en) 2017-01-31 2025-09-01 Chugai Pharmaceutical Co Ltd A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease
EP3580237B1 (en) 2017-02-08 2025-05-14 Novartis AG Fgf21 mimetic antibodies and uses thereof
CN110945021B (en) * 2017-02-10 2025-09-12 根马布私人有限公司 Polypeptide variants and their uses
CR20190387A (en) 2017-02-10 2019-09-25 Genentech Inc ANTIBODIES AGAINST TRYPTASE, COMPOSITIONS OF THESE AND USES OF THEM
JP2020508049A (en) 2017-02-17 2020-03-19 デナリ セラピューティクス インコーポレイテッドＤｅｎａｌｉ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Engineered transferrin receptor binding polypeptide
CA3051839A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
CN110352074B (en) 2017-02-28 2024-07-16 思进股份有限公司 Cysteine mutant antibodies for conjugation
EP3596122A1 (en) 2017-02-28 2020-01-22 Bristol-Myers Squibb Company Use of anti-ctla-4 antibodies with enhanced adcc to enhance immune response to a vaccine
WO2018160841A1 (en) 2017-03-01 2018-09-07 Genentech, Inc. Diagnostic and therapeutic methods for cancer
US11274160B2 (en) 2017-03-02 2022-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale Antibodies having specificity to Nectin-4 and uses thereof
HRP20231382T1 (en) 2017-03-16 2024-02-16 Alpine Immune Sciences, Inc. PD-L1 VARIANT OF IMMUNOMODULATING PROTEINS AND THEIR USE
MX2019010887A (en) 2017-03-16 2019-10-15 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof.
KR20190141146A (en) 2017-03-16 2019-12-23 알파인 이뮨 사이언시즈, 인코포레이티드 PD-L2 variant immunomodulatory protein and uses thereof
KR20190138636A (en) 2017-03-22 2019-12-13 제넨테크, 인크. Optimized Antibody Compositions for the Treatment of Eye Disorders
CN119971025A (en) 2017-03-24 2025-05-13 诺华股份有限公司 Methods for preventing and treating heart disease
CN110494446A (en) 2017-03-28 2019-11-22 基因泰克公司 The method for treating neurodegenerative disease
EP3601345A1 (en) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
EP3601346A1 (en) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
JOP20190203A1 (en) 2017-03-30 2019-09-03 Potenza Therapeutics Inc Anti-tigit antigen-binding proteins and methods of use thereof
WO2018185618A1 (en) 2017-04-03 2018-10-11 Novartis Ag Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
WO2018185045A1 (en) 2017-04-04 2018-10-11 F. Hoffmann-La Roche Ag Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap
AU2018247797B2 (en) 2017-04-05 2024-10-10 F. Hoffmann-La Roche Ag Anti-LAG3 antibodies
SG11201909154SA (en) 2017-04-05 2019-10-30 Hoffmann La Roche Bispecific antibodies specifically binding to pd1 and lag3
TWI796329B (en) 2017-04-07 2023-03-21 美商默沙東有限責任公司 Anti-ilt4 antibodies and antigen-binding fragments
MA50956A (en) 2017-04-13 2020-10-14 Agenus Inc ANTI-CD137 ANTIBODIES AND RELATED METHODS OF USE
MX2019012192A (en) 2017-04-14 2020-01-21 Genentech Inc Diagnostic and therapeutic methods for cancer.
BR112019021495A8 (en) 2017-04-14 2023-05-02 Inst Curie AMHRII-BINDING COMPOUNDS FOR THE PREVENTION OR TREATMENT OF LUNG CANCER
CA3058282A1 (en) 2017-04-14 2018-10-18 Gamamabs Pharma Amhrii-binding compounds for preventing or treating cancers
EP3612215B1 (en) 2017-04-20 2024-08-28 aTyr Pharma, Inc. Compositions for treating lung inflammation
PE20200150A1 (en) 2017-04-21 2020-01-17 Genentech Inc USE OF KLK5 ANTAGONISTS FOR THE TREATMENT OF A DISEASE
JP7295030B2 (en) 2017-04-26 2023-06-20 ユーリカ セラピューティックス， インコーポレイテッド Construct that specifically recognizes glypican 3 and use thereof
SG10201913677SA (en) 2017-04-27 2020-03-30 Tesaro Inc Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
AR111651A1 (en) 2017-04-28 2019-08-07 Novartis Ag CONJUGATES OF ANTIBODIES THAT INCLUDE TOLL TYPE RECEIVER AGONISTS AND COMBINATION THERAPIES
DK3618863T3 (en) 2017-05-01 2023-08-21 Agenus Inc ANTI-TIGIT ANTIBODIES AND METHODS OF USING THEREOF
BR112019022912A2 (en) 2017-05-05 2020-05-26 Allakos Inc. METHODS AND COMPOSITIONS TO TREAT ALLERGIC EYE DISEASES
AU2018266202C1 (en) 2017-05-10 2025-05-08 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
WO2019103857A1 (en) 2017-11-22 2019-05-31 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
US11168129B2 (en) 2017-05-15 2021-11-09 University Of Rochester Broadly neutralizing anti-influenza human monoclonal antibody and uses thereof
JOP20190271A1 (en) 2017-05-24 2019-11-21 Novartis Ag Antibody-cytokine engrafted proteins and methods of use for immune related disorders
MY206158A (en) 2017-05-24 2024-12-02 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
US20200362058A1 (en) 2017-05-24 2020-11-19 Novartis Ag Antibody-cytokine engrafted proteins and methods of use
WO2018215937A1 (en) 2017-05-24 2018-11-29 Novartis Ag Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer
EP4098662A1 (en) 2017-05-25 2022-12-07 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
EP3630834A1 (en) 2017-05-31 2020-04-08 STCube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1
KR20250036941A (en) 2017-05-31 2025-03-14 주식회사 에스티큐브앤컴퍼니 Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
SG10202111336RA (en) 2017-06-01 2021-11-29 Compugen Ltd Triple combination antibody therapies
KR20250097991A (en) 2017-06-06 2025-06-30 주식회사 에스티큐브앤컴퍼니 Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands
UY37758A (en) 2017-06-12 2019-01-31 Novartis Ag METHOD OF MANUFACTURING OF BIESPECTIFIC ANTIBODIES, BISPECTIFIC ANTIBODIES AND THERAPEUTIC USE OF SUCH ANTIBODIES
WO2018229706A1 (en) 2017-06-16 2018-12-20 Novartis Ag Combination therapy for the treatment of cancer
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
CA3062194A1 (en) 2017-06-20 2018-12-27 Amgen Inc. Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
MX2019015057A (en) 2017-06-23 2020-08-03 Velosbio Inc Ror1 antibody immunoconjugates.
KR102757960B1 (en) 2017-06-26 2025-01-22 베이진 엘티디 Immunotherapy for hepatocellular carcinoma (HCC)
EP3645564A1 (en) 2017-06-28 2020-05-06 Novartis AG Methods for preventing and treating urinary incontinence
MX2020000604A (en) 2017-07-21 2020-09-10 Genentech Inc Therapeutic and diagnostic methods for cancer.
CN107748258A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of Fc γ RII acceptors
CN107748262A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of Fc γ RIIIA acceptors
US10961318B2 (en) 2017-07-26 2021-03-30 Forty Seven, Inc. Anti-SIRP-α antibodies and related methods
CN107748259A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of FcRn acceptors
CN107748253A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of Fc γ RI acceptors
KR20230066126A (en) 2017-07-27 2023-05-12 알렉시온 파마슈티칼스, 인코포레이티드 High concentration anti-c5 antibody formulations
MX2020001593A (en) 2017-08-09 2020-07-13 Bioverativ Therapeutics Inc NUCLEIC ACID MOLECULES AND USES THEREOF.
KR102713874B1 (en) 2017-08-11 2024-10-10 제넨테크, 인크. Anti-CD8 antibodies and uses thereof
KR102777015B1 (en) 2017-08-22 2025-03-10 사나바이오, 엘엘씨 Availability of interferon receptors and their uses
KR20240138135A (en) 2017-08-25 2024-09-20 파이브 프라임 테라퓨틱스, 인크. B7-h4 antibodies and methods of use thereof
HUE054261T2 (en) 2017-09-19 2021-08-30 Tillotts Pharma Ag Antibody variants
EP3456737B1 (en) 2017-09-19 2024-02-14 Tillotts Pharma Ag Antibody variants
WO2019059411A1 (en) 2017-09-20 2019-03-28 Chugai Seiyaku Kabushiki Kaisha Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent
TW201922780A (en) 2017-09-25 2019-06-16 美商健生生物科技公司 Safe and effective method for treating lupus with anti-IL12/IL23 antibody
JP6496095B1 (en) 2017-09-29 2019-04-03 中外製薬株式会社 Multispecific antigen-binding molecule having blood coagulation factor VIII (FVIII) cofactor function alternative activity and pharmaceutical preparation containing the molecule as an active ingredient
CN111801347A (en) 2017-10-10 2020-10-20 高山免疫科学股份有限公司 CTLA-4 variant immunomodulatory proteins and uses thereof
WO2019075090A1 (en) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
EP3694890A4 (en) 2017-10-12 2021-11-03 Immunowake Inc. LIGHT CHAIN ANTIBODY FUSION PROTEIN WITH VEGFR
AU2018347607B2 (en) 2017-10-14 2025-08-21 Cytomx Therapeutics, Inc. Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
TW202500579A (en) 2017-10-18 2025-01-01 美商艾爾潘免疫科學有限公司 Variant icos ligand immunomodulatory proteins and related compositions and methods
CN111246885B (en) 2017-10-20 2024-06-11 豪夫迈·罗氏有限公司 Methods for generating multispecific antibodies from monospecific antibodies
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag Antibodies targeting cd32b and methods of use thereof
CN118512588A (en) 2017-10-26 2024-08-20 亚力兄制药公司 Dosage and administration of anti-C5 antibodies for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (AHUS)
JP7438942B2 (en) 2017-10-30 2024-02-27 エフ． ホフマン－ラ ロシュ アーゲー Methods for in vivo generation of multispecific antibodies from monospecific antibodies
ES2984919T3 (en) 2017-11-06 2024-10-31 Hoffmann La Roche Diagnostic and therapeutic procedures for cancer
MA50580A (en) 2017-11-06 2020-09-16 Janssen Biotech Inc SAFE AND EFFECTIVE METHOD OF TREATING PSORIASIC ARTHRITIS WITH A SPECIFIC ANTIBODY ANTI-IL23
JP7311425B2 (en) 2017-11-08 2023-07-19 協和キリン株式会社 Bispecific antibodies that bind to CD40 and EpCAM
JP7731196B2 (en) 2017-11-14 2025-08-29 中外製薬株式会社 Anti-C1s Antibodies and Methods of Use
EP3713959A1 (en) 2017-11-21 2020-09-30 Innate Pharma Multispecific antigen binding proteins
US20200308301A1 (en) 2017-11-22 2020-10-01 Novartis Ag Reversal binding agents for anti-factor xi/xia antibodies and uses thereof
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
WO2019106578A2 (en) 2017-12-01 2019-06-06 Novartis Ag Polyomavirus neutralizing antibodies
EP3720963A4 (en) 2017-12-05 2021-12-08 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region binding cd3 and cd137
JP7422659B2 (en) 2017-12-08 2024-01-26 アルジェニクス ビーブイ Use of FcRn antagonists for the treatment of generalized myasthenia gravis
JP7565795B2 (en) 2017-12-15 2024-10-11 アイオバンス バイオセラピューティクス，インコーポレイテッド System and method for determining beneficial administration of tumor infiltrating lymphocytes and methods of use thereof, and beneficial administration of tumor infiltrating lymphocytes and methods of use thereof
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
US11802154B2 (en) 2017-12-20 2023-10-31 Alexion Pharmaceuticals, Inc. Humanized anti-CD200 antibodies and uses thereof
US12139533B2 (en) 2017-12-20 2024-11-12 Alexion Pharmaceuticals, Inc. Liquid formulations of anti-CD200 antibodies
EP3502140A1 (en) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules
US20190211098A1 (en) 2017-12-22 2019-07-11 Genentech, Inc. Use of pilra binding agents for treatment of a disease
TWI817974B (en) 2017-12-28 2023-10-11 日商中外製藥股份有限公司 Cytotoxicity-inducing therapeutic agent
JP7369127B2 (en) 2017-12-28 2023-10-25 ナンジン レジェンド バイオテック カンパニー，リミテッド Single domain antibodies against TIGIT and variants thereof
TW201930350A (en) 2017-12-28 2019-08-01 大陸商南京傳奇生物科技有限公司 Antibodies and variants thereof against PD-L1
FR3076294B1 (en) 2017-12-29 2022-01-28 Lab Francais Du Fractionnement METHOD FOR PURIFYING ANTIBODIES FROM RAW MILK
EP3731864A1 (en) 2017-12-29 2020-11-04 F. Hoffmann-La Roche SA Anti-vegf antibodies and methods of use
EP3735417A1 (en) 2018-01-03 2020-11-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
IL315325B1 (en) 2018-01-04 2025-07-01 Iconic Therapeutics Inc Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
US11466077B2 (en) 2018-01-05 2022-10-11 Ac Immune Sa Misfolded TDP-43 binding molecules
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
US12129297B2 (en) 2018-01-12 2024-10-29 Bristol-Myers Squibb Company Antibodies against TIM3 and uses thereof
EP3740507A4 (en) 2018-01-15 2022-08-24 Nanjing Legend Biotech Co., Ltd. SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST PD-1
EP3740505A1 (en) 2018-01-16 2020-11-25 Lakepharma Inc. Bispecific antibody that binds cd3 and another target
SG11202006259SA (en) 2018-01-26 2020-08-28 Genentech Inc Il-22 fc fusion proteins and methods of use
JP7345479B2 (en) 2018-01-26 2023-09-15 ジェネンテック， インコーポレイテッド Composition and method of use
IL276286B2 (en) * 2018-01-26 2025-07-01 Genzyme Corp Fc variants with enhanced binding to fcrn and prolonged half-life
WO2019148410A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1 antibodies
CN111918674A (en) 2018-02-01 2020-11-10 比奥维拉迪维治疗股份有限公司 Use of Lentiviral Vectors Expressing Factor VIII
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
CN111868082A (en) 2018-02-02 2020-10-30 博奥泰克尼公司 Compounds that modulate the interaction of VISTA and VSIG3 and methods of making and using the same
CA3089287A1 (en) 2018-02-08 2019-08-15 Genentech, Inc. Bispecific antigen-binding molecules and methods of use
AU2019218128A1 (en) 2018-02-09 2020-09-17 Genentech, Inc. Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
CA3090795A1 (en) 2018-02-13 2019-08-22 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists
JP7350756B2 (en) 2018-02-14 2023-09-26 アバ セラピューティクス アーゲー Anti-human PD-L2 antibody
CA3091174A1 (en) 2018-02-21 2019-08-29 Five Prime Therapeutics, Inc. B7-h4 antibody formulations
EP3755364A1 (en) 2018-02-21 2020-12-30 F. Hoffmann-La Roche AG Dosing for treatment with il-22 fc fusion proteins
US20200399376A1 (en) 2018-02-26 2020-12-24 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2019169229A1 (en) 2018-03-01 2019-09-06 Nextcure, Inc. Klrg1 binding compositions and methods of use thereof
MA52416A (en) 2018-03-02 2021-04-21 Five Prime Therapeutics Inc B7-H4 ANTIBODIES AND PROCESSES FOR USE
NL2020520B1 (en) 2018-03-02 2019-09-12 Labo Bio Medical Invest B V Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
MX2020009265A (en) 2018-03-05 2020-10-01 Janssen Biotech Inc Methods of treating crohn's disease with anti-il23 specific antibody.
CN119074915A (en) 2018-03-13 2024-12-06 豪夫迈·罗氏有限公司 Therapeutic combinations of 4-1BB agonists and anti-CD20 antibodies
CA3087423A1 (en) 2018-03-14 2019-09-19 Beijing Xuanyi Pharmasciences Co., Ltd. Anti-claudin 18.2 antibodies
EP3765517A1 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
CN116327926A (en) 2018-03-15 2023-06-27 中外制药株式会社 Anti-dengue virus antibodies with cross-reactivity to Zika virus and methods of use
WO2019183362A1 (en) * 2018-03-21 2019-09-26 Dana-Farber Cancer Institute, Inc. Fc variant compositions and methods of use thereof
EP3768716A1 (en) 2018-03-21 2021-01-27 Five Prime Therapeutics, Inc. Antibodies binding to vista at acidic ph
WO2019183551A1 (en) 2018-03-23 2019-09-26 Bristol-Myers Squibb Company Antibodies against mica and/or micb and uses thereof
EP3774861A1 (en) 2018-03-28 2021-02-17 Bristol-Myers Squibb Company Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
KR20200135510A (en) 2018-03-29 2020-12-02 제넨테크, 인크. Regulation of lactation stimulating activity in mammalian cells
JP7346790B2 (en) 2018-03-30 2023-09-20 ナンジン レジェンド バイオテック カンパニー，リミテッド Single domain antibodies against LAG-3 and their uses
MY206833A (en) 2018-04-02 2025-01-09 Bristol Myers Squibb Co Anti-trem-1 antibodies and uses thereof
TW202011029A (en) 2018-04-04 2020-03-16 美商建南德克公司 Methods for detecting and quantifying FGF21
EP3552631A1 (en) 2018-04-10 2019-10-16 Inatherys Antibody-drug conjugates and their uses for the treatment of cancer
EP3774895A1 (en) 2018-04-12 2021-02-17 MedImmune Limited Combination of lif inhibitors and pd-1 axis inhibitors for use in treating cancer
PE20201503A1 (en) 2018-04-13 2020-12-29 Genentech Inc STABLE ANTI-CD79B IMMUNOCONJUGATE FORMULATIONS
AR114789A1 (en) 2018-04-18 2020-10-14 Hoffmann La Roche ANTI-HLA-G ANTIBODIES AND THE USE OF THEM
AR115052A1 (en) 2018-04-18 2020-11-25 Hoffmann La Roche MULTI-SPECIFIC ANTIBODIES AND THE USE OF THEM
US11958895B2 (en) 2018-05-03 2024-04-16 University Of Rochester Anti-influenza neuraminidase monoclonal antibodies and uses thereof
EP3790587A4 (en) 2018-05-11 2022-01-26 Janssen Biotech, Inc. METHOD OF TREATMENT OF DEPRESSION USING IL-23 ANTIBODIES
CN110464842B (en) 2018-05-11 2022-10-14 信达生物制药(苏州)有限公司 Formulations comprising anti-PCSK 9 antibodies and uses thereof
AU2019269131B2 (en) 2018-05-14 2024-02-22 Fundació Privada Institució Catalana De Recerca I Estudis Avançats Antibodies against LIF and dosage forms thereof
SI3793586T1 (en) 2018-05-16 2024-07-31 Csl Limited VARIANTS OF THE SOLUBLE COMPLEMENT TYPE 1 RECEPTOR AND THEIR USES
DK3793588T3 (en) 2018-05-18 2025-06-16 Bioverativ Therapeutics Inc METHODS FOR TREATING HEMOPHILIA A
WO2019226658A1 (en) 2018-05-21 2019-11-28 Compass Therapeutics Llc Multispecific antigen-binding compositions and methods of use
CN112566935B (en) 2018-05-23 2024-12-13 百济神州有限公司 Anti-OX40 antibodies and methods of use
TWI869346B (en) 2018-05-30 2025-01-11 瑞士商諾華公司 Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
ES2996257T3 (en) 2018-05-31 2025-02-12 Alexion Pharma Inc Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients
US11932681B2 (en) 2018-05-31 2024-03-19 Novartis Ag Hepatitis B antibodies
US11492409B2 (en) 2018-06-01 2022-11-08 Novartis Ag Binding molecules against BCMA and uses thereof
BR112020024249A2 (en) 2018-06-01 2021-03-02 Compugen Ltd. bispecific anti-pvrig / anti-tigit antibody, composition, nucleic acid composition, expression vector composition, host cell, methods for producing a bispecific anti-pvrig / anti-tigit antibody, for activation of a patient's t cells, for activation of a patient's cytotoxic t cells, for activation of a patient's nk cells, for activation of a patient's delta gamma t cells, for activation of a patient's th1 cells, to decrease or eliminate the number of cells and / or the activity of at least one of the regulatory t cells in a patient, to increase the production of interferon-gamma and / or the secretion of pro-inflammatory cytokines in a patient and to treat cancer in a patient, anti-pvrig antibody, anti antibody -tigit, and, expression vector.
CN112867394B9 (en) 2018-06-04 2024-12-06 马萨诸塞州渤健公司 Anti-VLA-4 antibodies with reduced effector function
US20210238308A1 (en) 2018-06-04 2021-08-05 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule showing changed half-life in cytoplasm
CA3099757A1 (en) 2018-06-05 2019-12-12 Amgen Inc. Modulating antibody dependent cellular phagocytosis
TWI851577B (en) 2018-06-07 2024-08-11 美商思進公司 Camptothecin conjugates
JP7486437B2 (en) 2018-06-08 2024-05-17 アルジェニクス ビーブイ Compositions and methods for treating immune thrombocytopenia
TWI848953B (en) 2018-06-09 2024-07-21 德商百靈佳殷格翰國際股份有限公司 Multi-specific binding proteins for cancer treatment
WO2019241758A1 (en) 2018-06-15 2019-12-19 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
MA52300A (en) 2018-06-18 2021-04-21 Fundacio Privada Inst Dinvestigacio Oncològica De Vall Hebron COMBINATION OF LIF INHIBITORS AND PLATINUM-BASED ANTI-NEOPLASICS AGENTS FOR USE IN THE TREATMENT OF CANCER
SG11202012342WA (en) 2018-06-18 2021-01-28 Eureka Therapeutics Inc Constructs targeting prostate-specific membrane antigen (psma) and uses thereof
EP3810185A4 (en) 2018-06-22 2022-03-23 Cugene Inc. Interleukin-2 variants and methods of uses thereof
SG11202012446UA (en) 2018-06-23 2021-01-28 Genentech Inc Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
US12312394B2 (en) 2018-06-28 2025-05-27 Alexion Pharmaceuticals, Inc. Methods of producing anti-C5 antibodies
EP3817720A2 (en) 2018-07-03 2021-05-12 Bristol-Myers Squibb Company Fgf21 formulations
WO2020010250A2 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
EP3818082A1 (en) 2018-07-04 2021-05-12 F. Hoffmann-La Roche AG Novel bispecific agonistic 4-1bb antigen binding molecules
JP7411627B2 (en) 2018-07-09 2024-01-11 ファイヴ プライム セラピューティクス インク Antibody that binds to ILT4
WO2020014306A1 (en) 2018-07-10 2020-01-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
US12091462B2 (en) 2018-07-11 2024-09-17 Five Prime Therapeutics, Inc. Antibodies binding to vista at acidic pH
AU2019305637A1 (en) 2018-07-18 2021-03-11 Genentech, Inc. Methods of treating lung cancer with a PD-1 axis binding antagonist, an antimetabolite, and a platinum agent
US20200025776A1 (en) 2018-07-18 2020-01-23 Janssen Biotech, Inc. Sustained Response Predictors After Treatment With Anti-IL23 Specific Antibody
HUE067057T2 (en) 2018-08-01 2024-09-28 Chugai Pharmaceutical Co Ltd Medicinal product for use in the treatment or prevention of C5-related disease
WO2020027330A1 (en) 2018-08-03 2020-02-06 中外製薬株式会社 Antigen-binding molecule containing two antigen-binding domains that are linked to each other
MX2021001599A (en) 2018-08-09 2021-07-02 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof for non-viral gene therapy.
US12172106B2 (en) 2018-08-09 2024-12-24 Regeneron Pharmaceuticals, Inc. Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor
UA128584C2 (en) 2018-08-10 2024-08-21 Чугаі Сейяку Кабусікі Кайся Anti-cd137 antigen-binding molecule and utilization thereof
WO2020037258A1 (en) 2018-08-17 2020-02-20 Ab Studio Inc. Catabodies and methods of use thereof
ES3009025T3 (en) 2018-08-31 2025-03-25 Regeneron Pharma Dosing strategy that mitigates cytokine release syndrome for cd3/cd20 bispecific antibodies
TW202031273A (en) 2018-08-31 2020-09-01 美商艾歐凡斯生物治療公司 Treatment of nsclc patients refractory for anti-pd-1 antibody
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
WO2020053742A2 (en) 2018-09-10 2020-03-19 Novartis Ag Anti-hla-hbv peptide antibodies
CN112673022B (en) 2018-09-10 2024-07-09 南京传奇生物科技有限公司 Single domain antibodies to CD33 and constructs thereof
WO2020055900A1 (en) 2018-09-11 2020-03-19 Amgen Inc. Methods of modulating antibody-dependent cell-mediated cytotoxicity
KR20210061341A (en) 2018-09-13 2021-05-27 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Novel LILRB4 antibodies and uses thereof
AU2019342017A1 (en) 2018-09-18 2021-05-13 Merrimack Pharmaceuticals, Inc. Anti-TNFR2 antibodies and uses thereof
US20220177587A1 (en) 2018-09-19 2022-06-09 Alpine Immune Sciences, Inc. Methods and uses of variant cd80 fusion proteins and related constructs
EP3853611A1 (en) 2018-09-19 2021-07-28 F. Hoffmann-La Roche AG Therapeutic and diagnostic methods for bladder cancer
CA3111809A1 (en) 2018-09-21 2020-03-26 Genentech, Inc. Diagnostic methods for triple-negative breast cancer
BR112021005467A2 (en) 2018-09-24 2021-06-22 Janssen Biotech, Inc. safe and effective method to treat ulcerative colitis with anti-il12/il23 antibody
EP3856787A4 (en) 2018-09-27 2022-06-29 Celgene Corporation SIRPalpha BINDING PROTEINS AND METHODS OF USE THEREOF
US11591390B2 (en) 2018-09-27 2023-02-28 Celgene Corporation SIRP-α binding proteins and methods of use thereof
KR20210087027A (en) 2018-09-27 2021-07-09 실리오 디벨럽먼트, 인크. Masked cytokine polypeptide
TW202028238A (en) 2018-09-28 2020-08-01 日商中外製藥股份有限公司 Antigen-binding molecules capable of binding cd3 and cd137 but not simultaneously
KR20210068061A (en) 2018-09-28 2021-06-08 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule comprising a modified antibody variable region
CN112654641A (en) 2018-10-01 2021-04-13 豪夫迈·罗氏有限公司 Bispecific antigen binding molecules with trivalent binding to CD40
AU2019355252A1 (en) 2018-10-01 2021-04-01 F. Hoffmann-La Roche Ag Bispecific antigen binding molecules comprising anti-FAP clone 212
US11130802B2 (en) 2018-10-10 2021-09-28 Tilos Therapeutics, Inc. Anti-lap antibody variants
UY38407A (en) 2018-10-15 2020-05-29 Novartis Ag TREM2 STABILIZING ANTIBODIES
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
MX2021004348A (en) 2018-10-18 2021-05-28 Genentech Inc DIAGNOSTIC AND THERAPEUTIC PROCEDURES FOR SARCOMATOID KIDNEY CANCER.
CN119405797A (en) 2018-10-30 2025-02-11 亚力兄制药公司 Subcutaneous dosing and administration of anti-C5 antibodies for the treatment of paroxysmal nocturnal hemoglobinuria (PNH)
WO2020089437A1 (en) 2018-10-31 2020-05-07 Engmab Sàrl Combination therapy
US20230053449A1 (en) 2018-10-31 2023-02-23 Novartis Ag Dc-sign antibody drug conjugates
EP4219550A1 (en) 2018-11-02 2023-08-02 Oklahoma Medical Research Foundation Monoclonal antibodies to eltd1 and uses thereof
EP3877407A1 (en) 2018-11-05 2021-09-15 F. Hoffmann-La Roche AG Methods of producing two chain proteins in prokaryotic host cells
CA3118634A1 (en) 2018-11-05 2020-05-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients refractory for anti-pd-1 antibody
MX2021005751A (en) 2018-11-16 2021-10-01 Memorial Sloan Kettering Cancer Center ANTIBODIES AGAINST MUCIN 16 AND METHODS OF USE THEREOF.
AR117091A1 (en) 2018-11-19 2021-07-07 Bristol Myers Squibb Co MONOCLONAL ANTIBODIES ANTAGONISTS AGAINST CD40 AND THEIR USES
AU2019383017A1 (en) 2018-11-20 2021-06-03 Janssen Biotech, Inc. Safe and effective method of treating psoriasis with anti-IL-23 specific antibody
US20220364171A1 (en) 2018-11-23 2022-11-17 Katholieke Universiteit Leuven Predicting a treatment response in inflammatory bowel disease
TWI779253B (en) 2018-11-27 2022-10-01 大陸商信達生物製藥（蘇州）有限公司 ANTI-IL-23p19 ANTIBODY AND USE THEREOF
JP2022513653A (en) 2018-11-28 2022-02-09 ブリストル－マイヤーズ スクイブ カンパニー Antibodies containing modified heavy chain constant regions
JP7713886B2 (en) 2018-11-30 2025-07-28 アルパイン イミューン サイエンシズ インコーポレイテッド CD86 variant immunomodulatory proteins and uses thereof
JP2022513708A (en) 2018-12-05 2022-02-09 モルフォシス・アーゲー Multispecific antigen-binding molecule
KR20210100656A (en) 2018-12-05 2021-08-17 제넨테크, 인크. Diagnostic methods and compositions for cancer immunotherapy
EP3892632A4 (en) 2018-12-05 2022-08-17 Bica Therapeutics Inc. Modified product of fc domain of antibody
MX2021006573A (en) 2018-12-06 2021-07-15 Genentech Inc Combination therapy of diffuse large b-cell lymphoma comprising an anti-cd79b immunoconjugates, an alkylating agent and an anti-cd20 antibody.
US12428484B2 (en) 2018-12-06 2025-09-30 Alexion Pharmaceuticals, Inc. Anti-ALK2 antibodies and uses thereof
CN113227119A (en) 2018-12-10 2021-08-06 基因泰克公司 Photocrosslinked peptides for site-specific conjugation to Fc-containing proteins
WO2020121059A1 (en) 2018-12-14 2020-06-18 Northern Biologics Inc. Anti-periostin antibodies and uses thereof
WO2020128638A1 (en) 2018-12-18 2020-06-25 Northern Biologics Inc. Flt3 agonist antibodies and uses thereof
KR20210132644A (en) 2018-12-18 2021-11-04 캐터펄트 테라퓨틱스 비.브이. Use of an anti-CCR7 mAb for the prevention or treatment of graft versus host disease (GvHD)
WO2020128864A1 (en) 2018-12-18 2020-06-25 Janssen Biotech, Inc. Safe and effective method of treating lupus with anti-il12/il23 antibody
WO2020128863A1 (en) 2018-12-19 2020-06-25 Novartis Ag Anti-tnf-alpha antibodies
EP3898667A2 (en) 2018-12-20 2021-10-27 F. Hoffmann-La Roche AG Modified antibody fcs and methods of use
AU2019403313A1 (en) 2018-12-21 2021-07-15 Genentech, Inc. Methods of producing polypeptides using a cell line resistant to apoptosis
CR20210332A (en) 2018-12-21 2021-09-09 Hoffmann La Roche Antibody that binds to vegf and il-1beta and methods of use
CN113490688B (en) 2018-12-26 2025-07-29 希望之城公司 Activatable masked anti-CTLA 4 binding proteins
WO2020139956A1 (en) 2018-12-28 2020-07-02 Sparx Therapeutics Inc. Binding molecules specific for claudin 18.2, compositons and methods thereof, for treatment of cancer and other diseases
BR112021012569A2 (en) 2018-12-28 2021-09-14 Kyowa Kirin Co., Ltd. B-SPECIFIC TFR-BINDING ANTIBODY
WO2020141145A1 (en) 2018-12-30 2020-07-09 F. Hoffmann-La Roche Ag Anti-rabbit cd19 antibodies and methods of use
CN113597319A (en) 2019-01-04 2021-11-02 分解治疗有限责任公司 Treatment of xerosis with nuclease fusion proteins
WO2020148207A1 (en) 2019-01-14 2020-07-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies binding to hla-a2
CA3124837A1 (en) 2019-01-14 2020-07-23 Genentech, Inc. Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine
PH12021551783A1 (en) 2019-01-22 2022-05-30 Bristol Myers Squibb Co Antibodies against il-7r alpha subunit and uses thereof
AU2020211974A1 (en) 2019-01-22 2021-08-05 Genentech, Inc. Immunoglobulin a antibodies and methods of production and use
EP3914620A1 (en) 2019-01-22 2021-12-01 Innate Pharma Treatment of t cell lymphoma
KR102794884B1 (en) 2019-01-23 2025-04-15 제넨테크, 인크. Method for producing multimeric proteins in eukaryotic host cells
CN113614107A (en) 2019-01-23 2021-11-05 Encefa公司 CD31 competitors and uses thereof
US11414496B2 (en) 2019-01-23 2022-08-16 Takeda Pharmaceutical Company Limited Anti-CD38 binding domains
US20220089770A1 (en) 2019-01-24 2022-03-24 Chugai Seiyaku Kabushiki Kaisha Novel cancer antigens and antibodies of said antigens
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
SG11202109061YA (en) 2019-02-21 2021-09-29 Marengo Therapeutics Inc Multifunctional molecules that bind to t cell related cancer cells and uses thereof
SG11202108955QA (en) 2019-02-21 2021-09-29 Marengo Therapeutics Inc Antibody molecules that bind to nkp30 and uses thereof
CN113874051A (en) 2019-02-27 2021-12-31 安吉克公司 Antibody-drug conjugates comprising anti-TM4SF1 antibodies and methods of using the same
BR112021016923A2 (en) 2019-02-27 2021-11-03 Genentech Inc Methods for treating a patient with hematologic cancer, methods for treating a patient with relapsed or refractory mm, methods for treating a patient having a relapsed or refractory lnh, and kits
CA3131305A1 (en) 2019-03-01 2020-09-10 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
CA3131953A1 (en) 2019-03-01 2020-09-10 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
BR112021017144A2 (en) 2019-03-08 2021-11-09 Genentech Inc Assay to detect a membrane-associated protein, methods to quantify the concentration of circulating protein, to determine whether a patient with b-cell lymphoma is likely to exhibit a response to an anti-cd20 therapy, to determine the affinity of an anti-cd20 antibody cd20, to determine the activation of t cells and method of treating a tumor
MX2021010996A (en) 2019-03-14 2021-11-04 Genentech Inc Treatment of cancer with her2xcd3 bispecific antibodies in combination with anti-her2 mab.
KR20210141990A (en) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 Methods of Preparation for Generating Anti-IL12/IL23 Antibody Compositions
AU2020243588A1 (en) 2019-03-18 2021-10-07 Janssen Biotech, Inc. Method of treating psoriasis in pediatric subjects with anti-IL12/IL23 antibody
JP7601758B2 (en) 2019-03-19 2024-12-17 中外製薬株式会社 Antigen-binding molecule containing an antigen-binding domain whose antigen-binding activity changes in an MTA-dependent manner, and library for obtaining said antigen-binding domain
US20220177558A1 (en) 2019-03-25 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment of taupathy disorders by targeting new tau species
MA55529A (en) 2019-04-03 2022-02-09 Genzyme Corp REDUCED FRAGMENTATION ANTI-ALPHA BETA TCR BINDING POLYPEPTIDES
KR20220005471A (en) 2019-04-08 2022-01-13 바이오젠 엠에이 인코포레이티드 Anti-integrin antibodies and uses thereof
GB2589049C (en) 2019-04-11 2024-02-21 argenx BV Anti-IgE antibodies
US12006511B2 (en) 2019-04-15 2024-06-11 The Medical College Of Wisconsin, Inc. Recombinant PD-L1 peptides and methods of use
BR112021020447A2 (en) 2019-04-17 2022-05-17 Alpine Immune Sciences Inc Methods and uses of variant icos ligand fusion proteins (icosl)
MX2021012608A (en) 2019-04-18 2021-11-12 Ac Immune Sa Novel molecules for therapy and diagnosis.
EP3955960B1 (en) 2019-04-18 2025-01-15 Bristol-Myers Squibb Company Ipilimumab variants with enhanced specificity for binding at low ph
JP7593939B2 (en) 2019-04-19 2024-12-03 ジェネンテック， インコーポレイテッド Anti-MERTK antibodies and methods of use thereof
AU2020257748A1 (en) 2019-04-19 2021-11-18 Chugai Seiyaku Kabushiki Kaisha Chimeric receptor recognizing modification site of antibody
CN114269376A (en) 2019-05-03 2022-04-01 豪夫迈·罗氏有限公司 Methods of treating cancer with anti-PD-L1 antibodies
BR112021022815A2 (en) 2019-05-14 2021-12-28 Genentech Inc Methods to treat follicular lymphoma, kits, immunoconjugates and polatuzumab vedotin
EP3970743A4 (en) 2019-05-15 2023-02-15 Kyowa Kirin Co., Ltd. Bispecific antibody binding to cd40 and fap
EP3971293A4 (en) 2019-05-15 2023-02-08 Kyowa Kirin Co., Ltd. BISPECIFIC ANTIBODIES CAPABLE OF BINDING TO CD40 AND GPC3
CN119613486A (en) 2019-05-20 2025-03-14 诺华股份有限公司 Antibody drug conjugates with linkers comprising hydrophilic groups
WO2020236797A1 (en) 2019-05-21 2020-11-26 Novartis Ag Variant cd58 domains and uses thereof
EP3972634A2 (en) 2019-05-21 2022-03-30 Novartis AG Trispecific binding molecules against bcma and uses thereof
BR112021023048A2 (en) 2019-05-21 2022-04-19 Novartis Ag cd19 binding molecules and uses thereof
TW202110879A (en) 2019-05-23 2021-03-16 瑞士商Ａｃ 免疫有限公司 Anti-tdp-43 binding molecules and uses thereof
CN113905757A (en) 2019-06-05 2022-01-07 中外制药株式会社 Antibody cleavage site binding molecule
AU2020286968A1 (en) 2019-06-07 2021-11-25 argenx BV Pharmaceutical formulations of FcRn inhibitors suitable for subcutaneous administration
CA3140537A1 (en) 2019-06-10 2020-12-17 Takahiro Ishiguro Anti-t cell antigen-binding molecule to be used in combination with cytokine inhibitor
WO2020251834A1 (en) * 2019-06-11 2020-12-17 The Rockefeller University Antibodies and methods for treatment of viral infections
CN114531878A (en) 2019-06-27 2022-05-24 豪夫迈·罗氏有限公司 Novel ICOS antibodies and tumor-targeted antigen-binding molecules comprising same
TW202116805A (en) 2019-07-10 2021-05-01 日商中外製藥股份有限公司 Claudin-6 binding molecules and uses thereof
WO2021005232A1 (en) 2019-07-11 2021-01-14 Umc Utrecht Holding B.V. Intranasal administration of neutralising antiviral antibodies
CN114341187A (en) 2019-07-12 2022-04-12 中外制药株式会社 Anti-mutant FGFR3 antibodies and uses thereof
CN114174536A (en) 2019-07-15 2022-03-11 百时美施贵宝公司 anti-TREM-1 antibodies and uses thereof
CN114144435B (en) 2019-07-15 2024-06-25 百时美施贵宝公司 Antibodies against human TREM-1 and uses thereof
WO2021009263A1 (en) 2019-07-16 2021-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity for cd38 and uses thereof
EP4004044A1 (en) 2019-07-24 2022-06-01 H. Lundbeck A/S Anti-mglur5 antibodies and uses thereof
EP4004037A1 (en) 2019-07-26 2022-06-01 Vanderbilt University Human monoclonal antibodies to enterovirus d68
CN112300279A (en) 2019-07-26 2021-02-02 上海复宏汉霖生物技术股份有限公司 Methods and compositions directed to anti-CD 73 antibodies and variants
CN114615993A (en) 2019-07-29 2022-06-10 康姆普根有限公司 Anti-PVRIG antibody preparation and use thereof
CN115068604A (en) 2019-07-31 2022-09-20 豪夫迈·罗氏有限公司 Dosage and administration regimen for treating or preventing C5-related diseases by using anti-C5 antibody covalenzumab
KR102618269B1 (en) 2019-07-31 2023-12-27 에프. 호프만-라 로슈 아게 Dosage and administration regimen for treatment or prevention of C5-related diseases by use of anti-C5 antibody crovalimab
TWI832183B (en) 2019-08-06 2024-02-11 香港商新旭生技股份有限公司 Antibodies that bind to pathological tau species and uses thereof
MX2022001626A (en) 2019-08-06 2022-03-02 Glaxosmithkline Ip Dev Ltd BIOPHARMACEUTICAL COMPOSITIONS AND RELATED PROCEDURES.
BR112022002761A2 (en) 2019-08-12 2022-08-09 Aptevo Res & Development Llc 4-1BB AND OX40 BINDING PROTEINS AND RELATED COMPOSITIONS AND METHODS, 4-1BB ANTIBODIES, OX40 ANTIBODIES
EP4013774A1 (en) 2019-08-13 2022-06-22 Elpis Biopharmaceuticals Engineered interleukin-2 receptor beta agonists
PE20221151A1 (en) 2019-08-30 2022-07-18 Agenus Inc ANTI-CD96 ANTIBODIES AND THEIR METHODS OF USE
EP4438057A3 (en) 2019-09-12 2025-01-01 F. Hoffmann-La Roche AG Compositions and methods of treating lupus nephritis
US12312414B2 (en) 2019-09-18 2025-05-27 Genentech, Inc. Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use
WO2021053559A1 (en) 2019-09-18 2021-03-25 Novartis Ag Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
TW202124446A (en) 2019-09-18 2021-07-01 瑞士商諾華公司 Combination therapies with entpd2 antibodies
BR112022004831A2 (en) 2019-09-19 2022-06-07 Bristol Myers Squibb Co Antibodies that bind to seen at acidic pH
TW202126699A (en) 2019-09-20 2021-07-16 美商建南德克公司 Dosing for anti-tryptase antibodies
EP4041767A1 (en) 2019-09-26 2022-08-17 StCube & Co. Antibodies specific to glycosylated ctla-4 and methods of use thereof
WO2021058729A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance type i receptor antibodies and uses thereof
JP2022550067A (en) 2019-09-27 2022-11-30 ヤンセン バイオテツク，インコーポレーテツド Anti-CEACAM antibody and use thereof
WO2021058763A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance antibodies and uses thereof
JP2022548978A (en) 2019-09-27 2022-11-22 ジェネンテック， インコーポレイテッド Dosing for Treatment with Drugs Anti-TIGIT and Anti-PD-L1 Antagonist Antibodies
EP4038182A1 (en) 2019-09-30 2022-08-10 Bioverativ Therapeutics Inc. Lentiviral vector formulations
BR112022006620A2 (en) 2019-10-08 2022-08-30 Nectin Therapeutics Ltd ANTIBODIES AGAINST POLYOVIRUS RECEPTOR (PVR) AND THEIR USES
CN114829404B (en) 2019-10-09 2025-09-09 斯特库比公司 Antibodies specific for glycosylated LAG3 and methods of use thereof
KR20220086618A (en) 2019-10-18 2022-06-23 제넨테크, 인크. Methods of Use of Anti-CD79b Immunoconjugates to Treat Diffuse Large B-Cell Lymphoma
WO2021091605A1 (en) 2019-11-04 2021-05-14 Compugen Ltd. Combination therapy with anti-pvrig antibodies formulations and anti-pd-1 antibodies
US20220389103A1 (en) 2019-11-06 2022-12-08 Genentech, Inc. Diagnostic and therapeutic methods for treatment of hematologic cancers
WO2021096888A1 (en) 2019-11-12 2021-05-20 Foundation Medicine, Inc. Methods of detecting a fusion gene encoding a neoantigen
CN114929741A (en) 2019-12-04 2022-08-19 免疫医疗有限公司 Antibodies against LIF and uses thereof
EP4069734A1 (en) 2019-12-04 2022-10-12 AC Immune SA Novel molecules for therapy and diagnosis
US20230057899A1 (en) 2019-12-05 2023-02-23 Compugen Ltd. Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing
EP4072682A1 (en) 2019-12-09 2022-10-19 Institut National de la Santé et de la Recherche Médicale (INSERM) Antibodies having specificity to her4 and uses thereof
WO2021119429A1 (en) 2019-12-13 2021-06-17 Cugene Inc. Novel interleukin-15 (il-15) fusion proteins and uses thereof
WO2021119505A1 (en) 2019-12-13 2021-06-17 Genentech, Inc. Anti-ly6g6d antibodies and methods of use
CN113045655A (en) 2019-12-27 2021-06-29 高诚生物医药(香港)有限公司 anti-OX 40 antibodies and uses thereof
CA3162444C (en) 2019-12-27 2024-04-30 Hitoshi KATADA Anti-ctla-4 antibody and use thereof
IL294330B1 (en) 2020-01-06 2025-07-01 Vaccinex Inc Anti-CCR8 antibodies and their uses
WO2021140202A1 (en) 2020-01-08 2021-07-15 argenx BV Methods for treating pemphigus disorders
CN110818795B (en) 2020-01-10 2020-04-24 上海复宏汉霖生物技术股份有限公司 anti-TIGIT antibodies and methods of use
WO2022050954A1 (en) 2020-09-04 2022-03-10 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2021194481A1 (en) 2020-03-24 2021-09-30 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
MX2022009391A (en) 2020-01-31 2022-09-26 Genentech Inc Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine.
KR20220139915A (en) 2020-02-06 2022-10-17 브리스톨-마이어스 스큅 컴퍼니 IL-10 and its uses
EP4103602A1 (en) 2020-02-11 2022-12-21 Vanderbilt University Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov- 2)
IL295382A (en) 2020-02-12 2022-10-01 Chugai Pharmaceutical Co Ltd An anti-cd137 antigen-binding molecule for use in cancer therapy
TWI888487B (en) 2020-02-14 2025-07-01 日商協和麒麟股份有限公司 Bispecific antibodies that bind to CD3
WO2021173844A1 (en) 2020-02-26 2021-09-02 Biograph 55, Inc. C19 c38 bispecific antibodies
CN115066440A (en) 2020-02-28 2022-09-16 上海复宏汉霖生物技术股份有限公司 anti-CD 137 constructs and uses thereof
EP4110826A4 (en) 2020-02-28 2024-08-14 Shanghai Henlius Biotech, Inc. Anti-cd137 constructs, multispecific antibody and uses thereof
BR112022016999A2 (en) 2020-02-28 2022-10-25 Genzyme Corp MODIFIED BINDING POLYPEPTIDES FOR OPTIMIZED DRUG CONJUGATION
IL295979A (en) 2020-03-06 2022-10-01 Ona Therapeutics S L Anti-cd36 antibodies and their use to treat cancer
KR20220152316A (en) 2020-03-12 2022-11-15 이뮨-온크 테라퓨틱스, 인코포레이티드 Novel anti-LILRB4 antibody and derivative products
EP4118114A1 (en) 2020-03-13 2023-01-18 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
US20240043530A1 (en) 2020-03-13 2024-02-08 Jiangsu Hengrui Pharmaceuticals Co., Ltd. PVRIG Binding Protein And Its Medical Uses
EP4121163A1 (en) 2020-03-19 2023-01-25 Genentech, Inc. Isoform-selective anti-tgf-beta antibodies and methods of use
US11365239B2 (en) 2020-03-20 2022-06-21 Tsb Therapeutics (Beijing) Co., Ltd. Anti-SARS-COV-2 antibodies and uses thereof
EP4107185A1 (en) 2020-03-23 2022-12-28 Genentech, Inc. Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia
JP2023518812A (en) 2020-03-23 2023-05-08 ジェネンテック， インコーポレイテッド Combination of tocilizumab and remdesivir to treat COVID19 pneumonia
US20240025991A1 (en) 2020-03-23 2024-01-25 Genentech, Inc. Method for treating pneumonia, including covid-19 pneumonia, with an il6 antagonist
EP4126949A1 (en) 2020-03-24 2023-02-08 Genentech, Inc. Tie2-binding agents and methods of use
WO2021195385A1 (en) 2020-03-26 2021-09-30 Vanderbilt University HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-GoV-2)
SMT202400070T1 (en) 2020-03-26 2024-03-13 Univ Vanderbilt Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
EP4127153A2 (en) 2020-03-26 2023-02-08 Genentech, Inc. Modified mammalian cells having reduced host cell proteins
US20230128499A1 (en) 2020-03-27 2023-04-27 Novartis Ag Bispecific combination therapy for treating proliferative diseases and autoimmune diseases
CN115397850A (en) 2020-03-30 2022-11-25 豪夫迈·罗氏有限公司 Antibodies that bind to VEGF and PDGF-B and methods of use thereof
TWI799824B (en) 2020-03-31 2023-04-21 日商中外製藥股份有限公司 Dll3-targeting multispecific antigen-binding molecules and uses thereof
IL296802A (en) 2020-03-31 2022-11-01 Chugai Pharmaceutical Co Ltd A method for the production of multispecific antigen binding molecules
WO2021202235A1 (en) 2020-04-01 2021-10-07 University Of Rochester Monoclonal antibodies against the hemagglutinin (ha) and neuraminidase (na) of influenza h3n2 viruses
AR121706A1 (en) 2020-04-01 2022-06-29 Hoffmann La Roche OX40 AND FAP-TARGETED BSPECIFIC ANTIGEN-BINDING MOLECULES
WO2021202959A1 (en) 2020-04-03 2021-10-07 Genentech, Inc. Therapeutic and diagnostic methods for cancer
US20230272056A1 (en) 2020-04-09 2023-08-31 Merck Sharp & Dohme Llc Affinity matured anti-lap antibodies and uses thereof
CN113874507A (en) 2020-04-09 2021-12-31 苏州艾博生物科技有限公司 Nucleic acid vaccine for coronavirus
WO2021207662A1 (en) 2020-04-10 2021-10-14 Genentech, Inc. Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome
PE20230255A1 (en) 2020-04-17 2023-02-07 Hutchison Medipharma Ltd ANTI-OX40 ANTIBODY AND USES THEREOF
AU2021259861A1 (en) 2020-04-24 2022-11-17 Genentech, Inc. Methods of using anti-CD79b immunoconjugates
KR20230005172A (en) 2020-04-24 2023-01-09 에프. 호프만-라 로슈 아게 Modulation of enzymes and pathways using sulfhydryl compounds and their derivatives
AU2021262744A1 (en) 2020-04-27 2022-10-06 The Regents Of The University Of California Isoform-independent antibodies to lipoprotein(a)
EP4143345A1 (en) 2020-04-28 2023-03-08 Genentech, Inc. Methods and compositions for non-small cell lung cancer immunotherapy
MX2021015024A (en) 2020-04-28 2022-01-18 Univ Rockefeller Neutralizing anti-sars-cov-2 antibodies and methods of use thereof.
KR20230087414A (en) 2020-05-03 2023-06-16 레베나 (쑤저우) 바이오파마 컴퍼니 리미티드 Antibody-drug conjugates (ADCS) comprising an anti-Trop-2 antibody, compositions comprising the ADCS, and methods of making and using the same
US20210347880A1 (en) 2020-05-05 2021-11-11 Janssen Biotech, Inc. Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody
IL297980A (en) 2020-05-08 2023-01-01 Alpine Immune Sciences Inc April and baff inhibitory immunomodulatory proteins and methods of use thereof
EP4149558A1 (en) 2020-05-12 2023-03-22 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to treat cutaneous t-cell lymphomas and tfh derived lymphomas
BR112022022986A2 (en) 2020-05-13 2023-01-17 Disc Medicine Inc ANTI-HEMOJUVELIN (HJV) ANTIBODIES TO TREAT MYELOFIBROSIS
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
KR20230010749A (en) 2020-05-17 2023-01-19 아스트라제네카 유케이 리미티드 SARS-COV-2 antibodies and methods for selecting and using them
GB2595299B (en) 2020-05-21 2022-08-03 Mabsolve Ltd Modified immunoglobulin FC regions
AU2021275499A1 (en) 2020-05-22 2022-11-24 Formycon Ag Ace2-fc fusion proteins and uses thereof
CN113993900B (en) 2020-05-27 2023-08-04 舒泰神（北京）生物制药股份有限公司 Antibody specifically recognizing nerve growth factor and use thereof
EP4157462A1 (en) 2020-06-02 2023-04-05 Dynamicure Biotechnology LLC Anti-cd93 constructs and uses thereof
CN116529260A (en) 2020-06-02 2023-08-01 当康生物技术有限责任公司 anti-CD 93 constructs and uses thereof
JP2023527918A (en) 2020-06-08 2023-06-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Anti-HBV antibody and method of use
JPWO2021251438A1 (en) 2020-06-10 2021-12-16
WO2021252977A1 (en) 2020-06-12 2021-12-16 Genentech, Inc. Methods and compositions for cancer immunotherapy
MX2022015877A (en) 2020-06-16 2023-01-24 Genentech Inc Methods and compositions for treating triple-negative breast cancer.
KR20230024368A (en) 2020-06-18 2023-02-20 제넨테크, 인크. Treatment with anti-TIGIT antibodies and PD-1 axis binding antagonists
CN115768478A (en) 2020-06-19 2023-03-07 中外制药株式会社 anti-T cell antigen binding molecules for use in combination with angiogenesis inhibitors
CN115734972A (en) 2020-06-22 2023-03-03 信达生物制药(苏州)有限公司 anti-CD 73 antibodies and uses thereof
KR20230074703A (en) 2020-06-24 2023-05-31 바이오버라티브 테라퓨틱스 인크. Method for removing free factor VIII from preparations of lentiviral vectors modified to express the protein
EP4172192A1 (en) 2020-06-24 2023-05-03 Genentech, Inc. Apoptosis resistant cell lines
MX2022016322A (en) 2020-06-25 2023-01-24 Merck Sharp & Dohme Llc High affinity antibodies targeting tau phosphorylated at serine 413.
CN115884986A (en) 2020-06-29 2023-03-31 Inserm(法国国家健康医学研究院) Anti-protein S single domain antibody and polypeptide comprising same
EP4171614A1 (en) 2020-06-29 2023-05-03 Resolve Therapeutics, LLC Treatment of sjogren's syndrome with nuclease fusion proteins
WO2022013745A1 (en) 2020-07-13 2022-01-20 Janssen Biotech, Inc. Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
TW202216780A (en) 2020-07-17 2022-05-01 美商建南德克公司 Anti-notch2 antibodies and methods of use
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
US20230322935A1 (en) 2020-07-29 2023-10-12 Dynamicure Biotechnology Llc Anti-cd93 constructs and uses thereof
US20220073603A1 (en) 2020-07-30 2022-03-10 Janssen Biotech, Inc. Method of Treating Psoriasis in Pediatric Subjects with Anti-IL12/IL23 Antibody
IL300225A (en) 2020-07-31 2023-03-01 Chugai Pharmaceutical Co Ltd Pharmaceutical composition including cell expressing chimeric receptor
WO2022031749A1 (en) 2020-08-03 2022-02-10 Genentech, Inc. Diagnostic and therapeutic methods for lymphoma
JP2023536904A (en) 2020-08-06 2023-08-30 バイオベラティブ・ユーエスエイ・インコーポレイテッド Inflammatory Cytokines and Fatigue in Subjects With Complement-Mediated Disease
AU2021325339A1 (en) 2020-08-10 2023-04-06 Astrazeneca Uk Limited SARS-CoV-2 antibodies for treatment and prevention of COVID-19
JP2023537761A (en) 2020-08-14 2023-09-05 エイシー イミューン ソシエテ アノニム Humanized anti-TDP-43 binding molecules and uses thereof
SMT202500106T1 (en) 2020-08-18 2025-05-12 Cephalon Llc Anti-par-2 antibodies and methods of use thereof
KR20250137202A (en) 2020-08-20 2025-09-17 에이투 바이오쎄라퓨틱스, 인크. Compositions and methods for treating ceacam positive cancers
WO2022040470A1 (en) * 2020-08-20 2022-02-24 A2 Biotherapeutics, Inc. Compositions and methods for treating ceacam positive cancers
KR20250140123A (en) 2020-08-20 2025-09-24 에이투 바이오쎄라퓨틱스, 인크. Compositions and methods for treating mesothelin positive cancers
WO2022043517A2 (en) 2020-08-27 2022-03-03 Cureab Gmbh Anti-golph2 antibodies for macrophage and dendritic cell differentiation
US20230416371A1 (en) 2020-08-28 2023-12-28 Chugai Seiyaku Kabushiki Kaisha Heterodimer fc polypeptide
KR20230056766A (en) 2020-08-28 2023-04-27 제넨테크, 인크. CRISPR/Cas9 multiple knockout of host cell proteins
JP2023540705A (en) 2020-08-28 2023-09-26 サナ バイオテクノロジー，インコーポレイテッド Modified antiviral binding agents
JP7158626B1 (en) 2020-09-04 2022-10-21 エフ．ホフマン－ラ ロシュ アーゲー Antibodies that bind to VEGF-A and ANG2 and methods of use
CN116685351A (en) 2020-09-17 2023-09-01 基因泰克公司 Results of EMPACTA: random, double-blind, placebo-controlled, multicenter study for assessing the efficacy and safety of tobrazumab in hospitalized patients with covd-19 pneumonia
IL301763A (en) 2020-09-28 2023-05-01 Angitia Biomedicines Ltd Antisclerostin structures and their uses
EP4222172A1 (en) 2020-09-30 2023-08-09 Compugen Ltd. Combination therapy with anti-pvrig antibodies formulations, anti-tigit antibodies, and anti-pd-1 antibodies
TW202446417A (en) 2020-10-05 2024-12-01 美商建南德克公司 Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2022076606A1 (en) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
JP2023546359A (en) 2020-10-06 2023-11-02 アイオバンス バイオセラピューティクス，インコーポレイテッド Treatment of NSCLC patients with tumor-infiltrating lymphocyte therapy
WO2022079297A1 (en) 2020-10-16 2022-04-21 Ac Immune Sa Antibodies binding to alpha-synuclein for therapy and diagnosis
WO2022084400A1 (en) 2020-10-20 2022-04-28 Kantonsspital St. Gallen Antibodies or antigen-binding fragments specifically binding to gremlin-1 and uses thereof
KR20230110523A (en) 2020-10-22 2023-07-24 얀센 바이오테크 인코포레이티드 Proteins Comprising a Delta-Like Ligand 3 (DLL3) Antigen Binding Region and Uses Thereof
WO2022090801A2 (en) 2020-10-26 2022-05-05 Compugen Ltd. Pvrl2 and/or pvrig as biomarkers for treatment
WO2022093981A1 (en) 2020-10-28 2022-05-05 Genentech, Inc. Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists
WO2022090469A2 (en) 2020-10-29 2022-05-05 Formycon Ag Ace2 fusion proteins and uses thereof
AR123997A1 (en) 2020-11-04 2023-02-01 Univ Rockefeller NEUTRALIZING ANTIBODIES AGAINST SARS-CoV-2
IL302217A (en) 2020-11-04 2023-06-01 Genentech Inc Dosage for treatment with bispecific anti-CD20/anti-CD3 antibodies and anti-CD79B drug antibody conjugates
US12351643B2 (en) 2020-11-04 2025-07-08 Genentech, Inc. Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
WO2022098628A2 (en) 2020-11-04 2022-05-12 Genentech, Inc. Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies
AU2021374083A1 (en) 2020-11-06 2023-06-01 Novartis Ag Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
KR20230104651A (en) 2020-11-06 2023-07-10 노파르티스 아게 CD19 Binding Molecules and Uses Thereof
WO2022115865A2 (en) 2020-11-25 2022-06-02 Xilio Development, Inc. Tumor-specific cleavable linkers
AU2021390501A1 (en) 2020-12-01 2023-06-29 Aptevo Research And Development Llc Heterodimeric psma and cd3-binding bispecific antibodies
EP4255451A4 (en) 2020-12-03 2025-01-01 The Board Of Regents Of The University Of Texas System METHODS FOR IDENTIFICATION OF LILRB BLOCKING ANTIBODIES
TW202237639A (en) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof
TW202237638A (en) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof
WO2022125941A1 (en) 2020-12-11 2022-06-16 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
WO2022130182A1 (en) 2020-12-14 2022-06-23 Novartis Ag Reversal binding agents for anti-natriuretic peptide receptor 1 (npr1) antibodies and uses thereof
IL303656A (en) 2020-12-17 2023-08-01 Hoffmann La Roche ANTI-HLA-G antibodies and their use
US20240299539A1 (en) 2020-12-17 2024-09-12 Iovance Biotherapeutics, Inc. Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
CA3202473A1 (en) 2020-12-17 2022-06-23 Friedrich Graf Finckenstein Treatment of cancers with tumor infiltrating lymphocytes
WO2022140797A1 (en) 2020-12-23 2022-06-30 Immunowake Inc. Immunocytokines and uses thereof
CN117098548A (en) 2020-12-23 2023-11-21 信达生物制药(苏州)有限公司 anti-B7-H3 antibodies and uses thereof
US20240110152A1 (en) 2020-12-31 2024-04-04 Iovance Biotherapeutics, Inc. Devices and processes for automated production of tumor infiltrating lymphocytes
EP4274658A1 (en) 2021-01-06 2023-11-15 F. Hoffmann-La Roche AG Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody
WO2022155324A1 (en) 2021-01-15 2022-07-21 The Rockefeller University Neutralizing anti-sars-cov-2 antibodies
CA3205670A1 (en) 2021-01-22 2022-07-28 Kehao Zhao Anti-pd-l1 monoclonal antibodies and fusion proteins with interleukin-15 (il-15), interleukin-15 receptor 15 alpha or interleukin-2
US20240076373A1 (en) 2021-01-28 2024-03-07 Compugen Ltd. Combination therapy with anti-pvrig antibodies formulations and anti-pd-1 antibodies
CN117120084A (en) 2021-01-28 2023-11-24 维肯芬特有限责任公司 Methods and means for modulating B cell mediated immune responses
AU2022212599A1 (en) 2021-01-28 2023-08-17 Universität Ulm Method and means for modulating b-cell mediated immune responses
WO2022162203A1 (en) 2021-01-28 2022-08-04 Vaccinvent Gmbh Method and means for modulating b-cell mediated immune responses
US20240082397A1 (en) 2021-01-28 2024-03-14 Compugen Ltd. Anti-pvrig antibodies formulations and uses thereof
EP4284919A1 (en) 2021-01-29 2023-12-06 Iovance Biotherapeutics, Inc. Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
WO2022169872A1 (en) 2021-02-03 2022-08-11 Genentech, Inc. Multispecific binding protein degrader platform and methods of use
US20240226295A9 (en) 2021-02-15 2024-07-11 Takeda Pharmaceutical Company Limited Cell therapy compositions and methods for modulating tgf-b signaling
US20240254246A1 (en) 2021-02-17 2024-08-01 Prometheus Biosciences, Inc. Anti-cd30l antibodies and uses thereof
WO2022187270A1 (en) 2021-03-01 2022-09-09 Xilio Development, Inc. Combination of ctla4 and pd1/pdl1 antibodies for treating cancer
JP2024508488A (en) 2021-03-01 2024-02-27 エクシリオ デベロップメント， インコーポレイテッド Combination of masked CTLA4 and PD1/PD-L1 antibodies to treat cancer
JP2024509543A (en) 2021-03-03 2024-03-04 フォーマイコン アーゲー Formulation of ACE2 Fc fusion protein
EP4301418A1 (en) 2021-03-03 2024-01-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates comprising an anti-bcma antibody
JP2024509184A (en) 2021-03-05 2024-02-29 アイオバンス バイオセラピューティクス，インコーポレイテッド Tumor preservation and cell culture composition
EP4301472A1 (en) 2021-03-05 2024-01-10 Dynamicure Biotechnology LLC Anti-vista constructs and uses thereof
KR20230148226A (en) 2021-03-10 2023-10-24 이뮤노웨이크 인크. Immunomodulatory Molecules and Their Uses
MX2023010705A (en) 2021-03-12 2023-11-22 Janssen Biotech Inc Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody.
JP2024512377A (en) 2021-03-12 2024-03-19 ジェネンテック， インコーポレイテッド Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use
JP2024510588A (en) 2021-03-12 2024-03-08 ヤンセン バイオテツク，インコーポレーテツド Method of treating psoriatic arthritis patients with inadequate response to TNF therapy with anti-IL23-specific antibodies
JP2024511970A (en) 2021-03-15 2024-03-18 ジェネンテック， インコーポレイテッド Compositions and methods for the treatment of lupus nephritis
WO2022197877A1 (en) 2021-03-19 2022-09-22 Genentech, Inc. Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents
EP4308691A1 (en) 2021-03-19 2024-01-24 Iovance Biotherapeutics, Inc. Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
WO2022204155A1 (en) 2021-03-23 2022-09-29 Iovance Biotherapeutics, Inc. Cish gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2022204564A2 (en) 2021-03-25 2022-09-29 Iovance Biotherapeutics, Inc. Methods and compositions for t-cell coculture potency assays and use with cell therapy products
TW202300648A (en) 2021-03-25 2023-01-01 美商當康生物科技有限公司 Anti-igfbp7 constructs and uses thereof
KR20230162793A (en) 2021-03-26 2023-11-28 얀센 바이오테크 인코포레이티드 Humanized antibodies against paired helical filament tau and uses thereof
IL305847A (en) 2021-03-26 2023-11-01 Innate Pharma Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging
EP4313296A1 (en) 2021-03-31 2024-02-07 Bioverativ USA Inc. Reducing surgery-associated hemolysis in cold agglutinin disease patients
JP2024514530A (en) 2021-04-02 2024-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Antibodies against truncated CDCP1 and uses thereof
KR20230173164A (en) 2021-04-19 2023-12-26 제넨테크, 인크. modified mammalian cells
EP4326287A2 (en) 2021-04-19 2024-02-28 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
EP4334343A2 (en) 2021-05-06 2024-03-13 The Rockefeller University Neutralizing anti-sars- cov-2 antibodies and methods of use thereof
CA3216795A1 (en) 2021-05-07 2022-11-10 Alpine Immune Sciences, Inc. Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein
WO2022241446A1 (en) 2021-05-12 2022-11-17 Genentech, Inc. Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
BR112023023777A2 (en) 2021-05-14 2024-01-30 Genentech Inc ISOLATED ANTIBODIES, PHARMACEUTICAL COMPOSITION, ISOLATED NUCLEIC ACID, ISOLATED VECTOR, ISOLATED HOST CELL, METHOD FOR PRODUCING AN ANTIBODY, METHOD FOR TREATING A CONDITION ASSOCIATED WITH LOSS OF TREM2 FUNCTION, METHOD FOR REDUCING STREM2 LEVELS AND USE OF AN ANTIBODY
WO2022241235A1 (en) 2021-05-14 2022-11-17 Genentech, Inc. Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
WO2022245859A1 (en) 2021-05-17 2022-11-24 Curia Ip Holdings, Llc Sars-cov-2 spike protein antibodies
WO2022245877A1 (en) 2021-05-17 2022-11-24 Curia Ip Holdings, Llc Sars-cov-2 spike protein antibodies
CA3219148A1 (en) 2021-05-17 2022-11-24 Frederick G. Vogt Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2022243261A1 (en) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Agonistic cd40 antigen binding molecules targeting cea
EP4341385A1 (en) 2021-05-21 2024-03-27 Genentech, Inc. Modified cells for the production of a recombinant product of interest
BR112023024804A2 (en) 2021-05-28 2024-02-15 Glaxosmithkline Ip Dev Ltd COMBINATION THERAPIES TO TREAT CANCER
EP4347647A1 (en) 2021-06-01 2024-04-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of b cell depleting agents for the treatment of rheumatic heart disease
TW202306994A (en) 2021-06-04 2023-02-16 日商中外製藥股份有限公司 Anti-ddr2 antibodies and uses thereof
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
MX2023014647A (en) 2021-06-09 2024-01-31 Innate Pharma MULTI-SPECIFIC NKP46 BINDING PROTEINS.
CN117529504A (en) 2021-06-09 2024-02-06 先天制药公司 Multispecific antibodies that bind to CD20, NKP46, CD16 and are conjugated to IL-2
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
KR20240019831A (en) 2021-06-11 2024-02-14 제넨테크, 인크. How to treat chronic obstructive pulmonary disease using ST2 antagonists
WO2022263357A1 (en) 2021-06-14 2022-12-22 Argenx Iip Bv Anti-il-9 antibodies and methods of use thereof
WO2022266660A1 (en) 2021-06-17 2022-12-22 Amberstone Biosciences, Inc. Anti-cd3 constructs and uses thereof
CA3219360A1 (en) 2021-06-22 2022-12-29 Novartis Ag Bispecific antibodies for use in treatment of hidradenitis suppurativa
US20240002510A2 (en) 2021-06-25 2024-01-04 Chugai Seiyaku Kabushiki Kaisha Anti-ctla-4 antibody and use thereof
CA3220353A1 (en) 2021-06-25 2022-12-29 Chugai Seiyaku Kabushiki Kaisha Use of anti-ctla-4 antibody
PE20242297A1 (en) 2021-06-25 2024-12-11 Chugai Pharmaceutical Co Ltd ANTI-CTLA-4 ANTIBODY
EP4588524A3 (en) 2021-07-01 2025-09-03 Compugen Ltd. Anti-tigit and anti-pvrig in monotherapy and combination treatments
MX2023015416A (en) 2021-07-02 2024-04-30 Genentech Inc Methods and compositions for treating cancer.
WO2023283611A1 (en) 2021-07-08 2023-01-12 Staidson Biopharma Inc. Antibodies specifically recognizing tnfr2 and uses thereof
CN117916260A (en) 2021-07-09 2024-04-19 詹森生物科技公司 Method for preparing anti-IL12/IL23 antibody composition
EP4370545A1 (en) 2021-07-12 2024-05-22 Genentech, Inc. Structures for reducing antibody-lipase binding
EP4371572A4 (en) 2021-07-14 2025-08-06 Staidson Beijing Biopharmaceuticals Co Ltd ANTIBODIES WITH SPECIFIC RECOGNITION OF CD40 AND APPLICATION THEREOF
WO2023288241A1 (en) 2021-07-14 2023-01-19 Genentech, Inc. Anti-c-c motif chemokine receptor 8 (ccr8) antibodies and methods of use
WO2023004386A1 (en) 2021-07-22 2023-01-26 Genentech, Inc. Brain targeting compositions and methods of use thereof
KR20240036570A (en) 2021-07-22 2024-03-20 에프. 호프만-라 로슈 아게 Heterodimeric Fc domain antibodies
CA3226111A1 (en) 2021-07-22 2023-01-26 Iovance Biotherapeutics, Inc. Method for cryopreservation of solid tumor fragments
WO2023010060A2 (en) 2021-07-27 2023-02-02 Novab, Inc. Engineered vlrb antibodies with immune effector functions
IL309120A (en) 2021-07-28 2024-02-01 Hoffmann La Roche Methods and compositions for treating cancer
WO2023009716A1 (en) 2021-07-28 2023-02-02 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
IL309934A (en) 2021-07-30 2024-03-01 Ona Therapeutics S L Anti-CD36 antibodies and their use for cancer treatment
US20240343799A1 (en) 2021-08-02 2024-10-17 Innovent Biologics (Suzhou) Co., Ltd. ANTI-CD79BxCD3 BISPECIFIC ANTIBODY AND USE THEREOF
EP4380980A1 (en) 2021-08-03 2024-06-12 F. Hoffmann-La Roche AG Bispecific antibodies and methods of use
WO2023012669A2 (en) 2021-08-03 2023-02-09 Glaxosmithkline Intellectual Property Development Limited Biopharmaceutical compositions and stable isotope labeling peptide mapping method
US20240336697A1 (en) 2021-08-07 2024-10-10 Genentech, Inc. Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
WO2023019239A1 (en) 2021-08-13 2023-02-16 Genentech, Inc. Dosing for anti-tryptase antibodies
JP2024534067A (en) 2021-08-19 2024-09-18 エフ． ホフマン－ラ ロシュ アーゲー Multivalent anti-variant fc region antibodies and methods of use
CA3229748A1 (en) 2021-08-26 2023-03-02 Akifumi Kato Bispecific antibody that binds to cd116 and cd131
KR20240049296A (en) 2021-08-27 2024-04-16 제넨테크, 인크. How to Treat Tauopathy
WO2023034750A1 (en) 2021-08-30 2023-03-09 Genentech, Inc. Anti-polyubiquitin multispecific antibodies
AU2022339767A1 (en) 2021-08-30 2024-04-11 Lassen Therapeutics, Inc. Anti-il-11rα antibodies
JP2024535002A (en) 2021-09-09 2024-09-26 アイオバンス バイオセラピューティクス，インコーポレイテッド Process for generating TIL products using PD-1 TALEN knockdown
EP4403576A1 (en) * 2021-09-17 2024-07-24 Korea University Research and Business Foundation Glycosylated fc variants with improved selective binding affinity to fc gamma riiia
WO2023043124A1 (en) * 2021-09-17 2023-03-23 고려대학교 산학협력단 GLYCATED FC VARIANTS WITH IMPROVED BINDING AFFINITY FOR FCγRIIIA
JP2024534581A (en) 2021-09-24 2024-09-20 アイオバンス バイオセラピューティクス，インコーポレイテッド Expansion process and agents for tumor-infiltrating lymphocytes
JPWO2023053282A1 (en) 2021-09-29 2023-04-06
AU2022358522A1 (en) 2021-09-30 2024-03-28 Seagen Inc. B7-h4 antibody-drug conjugates for the treatment of cancer
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2023056403A1 (en) 2021-09-30 2023-04-06 Genentech, Inc. Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
CA3233953A1 (en) 2021-10-05 2023-04-13 Matthew Bruce Combination therapies for treating cancer
AU2022361184A1 (en) 2021-10-08 2024-05-09 Chugai Seiyaku Kabushiki Kaisha Method for preparing prefilled syringe formulation
CN116064598B (en) 2021-10-08 2024-03-12 苏州艾博生物科技有限公司 Nucleic acid vaccine for coronavirus
WO2023064958A1 (en) 2021-10-15 2023-04-20 Compugen Ltd. Combination therapy with anti-pvrig antibodies formulations, anti-tigit antibodies, and anti-pd-1 antibodies
CA3235824A1 (en) 2021-10-27 2023-05-04 Frederick G. Vogt Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
JP2024541946A (en) 2021-10-29 2024-11-13 ヤンセン バイオテツク，インコーポレーテツド Methods of treating Crohn's disease with anti-IL23 specific antibodies
TW202342095A (en) 2021-11-05 2023-11-01 英商阿斯特捷利康英國股份有限公司 Composition for treatment and prevention of covid-19
AU2022379952A1 (en) 2021-11-05 2024-05-16 Mab Biotec, Inc. Monoclonal antibodies against carcinoembryonic antigens, and their uses
WO2023086803A1 (en) 2021-11-10 2023-05-19 Iovance Biotherapeutics, Inc. Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
EP4430072A1 (en) 2021-11-10 2024-09-18 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
EP4433501A1 (en) 2021-11-15 2024-09-25 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
KR20240102971A (en) 2021-11-16 2024-07-03 제넨테크, 인크. Method and composition for treating systemic lupus erythematosus (SLE) using mosunetuzumab
EP4433167A1 (en) 2021-11-16 2024-09-25 AC Immune SA Novel molecules for therapy and diagnosis
CA3235096A1 (en) 2021-11-17 2023-05-25 Disc Medicine, Inc. Methods for treating anemia of kidney disease
EP4436997A1 (en) 2021-11-23 2024-10-02 Janssen Biotech, Inc. Method of treating ulcerative colitis with anti-il23 specific antibody
EP4437112A1 (en) 2021-11-24 2024-10-02 Formycon AG Improved ace2 fusion proteins
WO2023094571A1 (en) 2021-11-25 2023-06-01 Formycon Ag Stabilization of ace2 fusion proteins
EP4445911A1 (en) 2021-12-06 2024-10-16 Beijing SoloBio Genetechnology Co., Ltd. Bispecific antibody that specifically binds to klebsiella pneumoniae o2 and o1 antigens, and composition
TW202330582A (en) 2021-12-15 2023-08-01 美商建南德克公司 Stabilized il-18 polypeptides and uses thereof
EP4448579A1 (en) 2021-12-17 2024-10-23 Shanghai Henlius Biotech, Inc. Anti-ox40 antibodies and methods of use
CA3240585A1 (en) 2021-12-17 2023-06-22 Wenfeng Xu Anti-ox40 antibodies, multispecific antibodies and methods of use
CA3241017A1 (en) 2021-12-17 2023-06-22 Robert Ferris Combination therapies for hiv infections and uses thereof
CR20240246A (en) 2021-12-20 2024-07-19 Hoffmann La Roche AGONIST ANTI-LTBR ANTIBODIES AND BISPECIFIC ANTIBODIES THAT INCLUDE THEM
CN118974083A (en) 2022-01-07 2024-11-15 强生企业创新公司 Materials and Methods for IL-1β Binding Protein
IL314367A (en) 2022-01-18 2024-09-01 argenx BV Galectin-10 antibodies
US20230322958A1 (en) 2022-01-19 2023-10-12 Genentech, Inc. Anti-Notch2 Antibodies and Conjugates and Methods of Use
EP4469159A1 (en) 2022-01-27 2024-12-04 The Rockefeller University Broadly neutralizing anti-sars-cov-2 antibodies targeting the n-terminal domain of the spike protein and methods of use thereof
US20250099588A1 (en) 2022-01-28 2025-03-27 Iovance Biotherapeutics, Inc. Cytokine associated tumor infiltrating lymphocytes compositions and methods
WO2023147486A1 (en) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Tumor infiltrating lymphocytes engineered to express payloads
IL315043A (en) 2022-02-16 2024-10-01 Ac Immune Sa Humanized molecules that bind TDP-43 and uses thereof
TW202342510A (en) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 Antibodies
AU2023228912A1 (en) 2022-03-03 2024-09-19 Yale University Humanized 3e10 antibodies, variants, and antigen binding fragments thereof
EP4490173A1 (en) 2022-03-07 2025-01-15 Alpine Immune Sciences, Inc. Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses
WO2023173026A1 (en) 2022-03-10 2023-09-14 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
CN119173530A (en) 2022-03-11 2024-12-20 詹森药业有限公司 Multispecific antibodies and their uses
IL315541A (en) 2022-03-11 2024-11-01 Janssen Pharmaceutica Nv Multispecific antibodies and uses thereof
WO2023170290A1 (en) 2022-03-11 2023-09-14 Janssen Pharmaceutica Nv Multispecific antibodies and uses thereof
KR20240144422A (en) 2022-03-15 2024-10-02 컴퓨젠 엘티디. IL-18BP antagonist antibodies and their uses in monotherapy and combination therapy for cancer treatment
WO2023178357A1 (en) 2022-03-18 2023-09-21 Evolveimmune Therapeutics, Inc. Bispecific antibody fusion molecules and methods of use thereof
EP4245374A3 (en) 2022-03-18 2024-07-10 Compugen Ltd. Pvrl2 and/or pvrig as biomarkers for treatment
WO2023179740A1 (en) 2022-03-25 2023-09-28 Shanghai Henlius Biotech , Inc. Anti-msln antibodies and methods of use
WO2023186756A1 (en) 2022-03-28 2023-10-05 F. Hoffmann-La Roche Ag Interferon gamma variants and antigen binding molecules comprising these
WO2023187657A1 (en) 2022-03-30 2023-10-05 Novartis Ag Methods of treating disorders using anti-natriuretic peptide receptor 1 (npr1) antibodies
CN119698430A (en) 2022-03-30 2025-03-25 詹森生物科技公司 Methods for treating mild to moderate psoriasis with IL-23 specific antibodies
GB202204813D0 (en) 2022-04-01 2022-05-18 Bradcode Ltd Human monoclonal antibodies and methods of use thereof
WO2023191816A1 (en) 2022-04-01 2023-10-05 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
JP2025512313A (en) 2022-04-06 2025-04-17 アイオバンス バイオセラピューティクス，インコーポレイテッド Treatment of NSCLC patients with tumor-infiltrating lymphocyte therapy
AU2023250038A1 (en) 2022-04-08 2024-11-14 Ac Immune Sa Anti-tdp-43 binding molecules
US20230406930A1 (en) 2022-04-13 2023-12-21 Genentech, Inc. Pharmaceutical compositions of therapeutic proteins and methods of use
EP4507704A1 (en) 2022-04-15 2025-02-19 Iovance Biotherapeutics, Inc. Til expansion processes using specific cytokine combinations and/or akti treatment
WO2023203177A1 (en) 2022-04-20 2023-10-26 Kantonsspital St. Gallen Antibodies or antigen-binding fragments pan-specifically binding to gremlin-1 and gremlin-2 and uses thereof
EP4514842A1 (en) 2022-04-29 2025-03-05 AstraZeneca UK Limited Sars-cov-2 antibodies and methods of using the same
WO2023212304A1 (en) 2022-04-29 2023-11-02 23Andme, Inc. Antigen binding proteins
TW202406934A (en) 2022-05-03 2024-02-16 美商建南德克公司 Anti-ly6e antibodies, immunoconjugates, and uses thereof
EP4524158A1 (en) 2022-05-09 2025-03-19 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibody that specifically recognizes gdf15 and use thereof
JP2025516551A (en) 2022-05-10 2025-05-30 アイオバンス バイオセラピューティクス，インコーポレイテッド Treatment of cancer patients with tumor-infiltrating lymphocyte therapy in combination with IL-15R agonists
CN119731199A (en) 2022-05-10 2025-03-28 艾佩斯瑞生物制药公司 Engineered interleukin-2 receptor beta-reducing binding agonists
IL316738A (en) 2022-05-11 2024-12-01 Genentech Inc Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
AR129268A1 (en) 2022-05-11 2024-08-07 Hoffmann La Roche ANTIBODY THAT BINDS TO VEGF-A AND IL6 AND METHODS OF USE
US20230374122A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Method for Evaluating and Treating Psoriatic Arthritis with IL23 Antibody
CN119233996B (en) 2022-05-31 2025-08-26 明济生物制药（北京）有限公司 Anti-CD40 antibodies and anti-PD-L1×CD40 bispecific antibodies and their applications
KR20250022049A (en) 2022-06-07 2025-02-14 제넨테크, 인크. Method for determining the efficacy of a treatment for lung cancer comprising an anti-PD-L1 antagonist and an anti-TIGIT antagonist antibody
WO2023237706A2 (en) 2022-06-08 2023-12-14 Institute For Research In Biomedicine (Irb) Cross-specific antibodies, uses and methods for discovery thereof
WO2023239803A1 (en) 2022-06-08 2023-12-14 Angiex, Inc. Anti-tm4sf1 antibody-drug conjugates comprising cleavable linkers and methods of using same
WO2023237928A2 (en) 2022-06-10 2023-12-14 Horizon Therapeutics Ireland Dac Igf1r antibodies
JP2025520431A (en) 2022-06-15 2025-07-03 アルジェニクス ビーブイ FCRN/antigen binding molecules and methods of use
AU2023293090A1 (en) 2022-06-15 2025-01-30 Bioverativ Usa Inc. Anti-complement c1s antibody formulation
WO2023250507A1 (en) 2022-06-24 2023-12-28 Bioverativ Usa Inc. Methods for treating complement-mediated diseases
WO2024011114A1 (en) 2022-07-06 2024-01-11 Iovance Biotherapeutics, Inc. Devices and processes for automated production of tumor infiltrating lymphocytes
AU2023305619A1 (en) 2022-07-13 2025-01-23 F. Hoffmann-La Roche Ag Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
CN120322455A (en) 2022-07-19 2025-07-15 舒泰神(加州)生物科技有限公司 Antibodies specifically recognizing B and T lymphocyte attenuator (BTLA) and their applications
EP4558524A1 (en) 2022-07-19 2025-05-28 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
CN119604537A (en) 2022-07-22 2025-03-11 百时美施贵宝公司 Antibodies that bind to human PAD4 and their uses
TW202417504A (en) 2022-07-22 2024-05-01 美商建南德克公司 Anti-steap1 antigen-binding molecules and uses thereof
AR130041A1 (en) 2022-07-27 2024-10-30 Cephalon Llc ANTI-TL1A ANTIBODIES FORMULATIONS
MA71621A (en) 2022-07-27 2025-05-30 Cephalon Llc ANTI-TL1A ANTIBODIES FOR THE TREATMENT OF ULCERATIVE COLITIS AND CROHN'S DISEASE
WO2024026496A1 (en) 2022-07-28 2024-02-01 Compugen Ltd. Combination therapy with anti-pvrig antibodies formulations and anti-pd-1 antibodies
EP4565683A1 (en) 2022-08-01 2025-06-11 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
JP2025525969A (en) 2022-08-05 2025-08-07 ヤンセン バイオテツク，インコーポレーテツド CD98-binding constructs for treating brain tumors
MA71684A (en) 2022-08-05 2025-05-30 Janssen Biotech, Inc. TRANSFERRIN RECEPTOR-BINDING PROTEINS FOR THE TREATMENT OF BRAIN TUMORS
AU2023325906A1 (en) 2022-08-19 2025-02-13 Evive Biotechnology (Shanghai) Ltd Formulations comprising g-csf and uses thereof
KR20250071294A (en) 2022-08-22 2025-05-21 압데라 테라퓨틱스 인크. DLL3 binding molecules and uses thereof
EP4577569A1 (en) 2022-08-25 2025-07-02 GlaxoSmithKline Intellectual Property Development Ltd Antigen binding proteins and uses thereof
WO2024044675A1 (en) 2022-08-25 2024-02-29 Beigene, Ltd. Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies
CN119744182A (en) 2022-08-29 2025-04-01 第一三共株式会社 Antibody drug conjugates comprising a mutant Fc region
JP2025529210A (en) 2022-09-01 2025-09-04 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド Compositions and methods for channeling apolipoprotein L1 to induce mammalian cell death - Patents.com
WO2024049949A1 (en) 2022-09-01 2024-03-07 Genentech, Inc. Therapeutic and diagnostic methods for bladder cancer
CN120077071A (en) 2022-09-07 2025-05-30 当康生物技术有限责任公司 Anti-VISTA constructs and uses thereof
WO2024052503A1 (en) 2022-09-08 2024-03-14 Institut National de la Santé et de la Recherche Médicale Antibodies having specificity to ltbp2 and uses thereof
EP4587473A1 (en) 2022-09-12 2025-07-23 Institut National de la Santé et de la Recherche Médicale New anti-itgb8 antibodies and its uses thereof
CN120225564A (en) 2022-09-21 2025-06-27 赛诺菲生物技术公司 Humanized anti-IL-1R 3 antibodies and methods of use thereof
WO2024061930A1 (en) 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale New method to treat and diagnose peripheral t-cell lymphoma (ptcl)
EP4596580A1 (en) 2022-09-27 2025-08-06 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibody for specifically recognizing light and use thereof
KR20250099778A (en) 2022-10-04 2025-07-02 알파인 이뮨 사이언시즈, 인코포레이티드 Mutated TACI-FC fusion proteins for use in the treatment of autoantibody-mediated diseases
TW202421664A (en) 2022-10-07 2024-06-01 美商建南德克公司 Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies
AU2023365967A1 (en) 2022-10-20 2025-06-05 Beijing Solobio Genetechnology Co., Ltd. Antibody combination specifically binding to trail or fasl, and bispecific antibody
KR20250113537A (en) 2022-10-25 2025-07-25 아블렉시스, 엘엘씨 anti-CD3 antibody
WO2024091991A1 (en) 2022-10-25 2024-05-02 Genentech, Inc. Therapeutic and diagnostic methods for multiple myeloma
US20240166750A1 (en) 2022-10-25 2024-05-23 Ablynx N.V. GLYCOENGINEERED Fc VARIANT POLYPEPTIDES WITH ENHANCED EFFECTOR FUNCTION
WO2024094741A1 (en) 2022-11-03 2024-05-10 F. Hoffmann-La Roche Ag Combination therapy with anti-cd19/anti-cd28 bispecific antibody
WO2024098024A1 (en) 2022-11-04 2024-05-10 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
EP4612277A1 (en) 2022-11-04 2025-09-10 Iovance Biotherapeutics, Inc. Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
AU2023375342A1 (en) 2022-11-08 2025-04-24 F. Hoffmann-La Roche Ag Compositions and methods of treating childhood onset idiopathic nephrotic syndrome
WO2024107731A2 (en) 2022-11-14 2024-05-23 Ablexis, Llc Anti-pd-l1 antibodies
US20240190978A1 (en) 2022-11-15 2024-06-13 CSBioAsset LLC Compositions and methods for immunomodulatory bifunctional fusion molecules
WO2024108053A1 (en) 2022-11-17 2024-05-23 Sanofi Ceacam5 antibody-drug conjugates and methods of use thereof
EP4623073A2 (en) 2022-11-21 2025-10-01 Iovance Biotherapeutics, Inc. Methods for assessing proliferation potency of gene-edited t cells
CN120584182A (en) 2022-11-21 2025-09-02 艾欧凡斯生物治疗公司 Two-dimensional process of tumor-infiltrating lymphocyte expansion and its therapy
CN120569403A (en) 2022-11-22 2025-08-29 詹森生物科技公司 Method for treating ulcerative colitis with anti-IL23 specific antibodies
CN120187458A (en) 2022-11-24 2025-06-20 广州百济神州生物制药有限公司 Anti-CEA antibody drug conjugates and methods of use
AR131163A1 (en) 2022-11-25 2025-02-19 Chugai Pharmaceutical Co Ltd METHODS FOR PRODUCING PROTEINS
EP4382120A1 (en) 2022-12-05 2024-06-12 Institut Regional du Cancer de Montpellier Anti-slc1a4 monoclonal antibodies and uses thereof
EP4631974A1 (en) 2022-12-08 2025-10-15 Nanjing Vazyme Biotech Co., Ltd. Antibody specifically binding to rsv
EP4386084A1 (en) 2022-12-14 2024-06-19 Formycon AG Improved ace2 fusion proteins
CN120476149A (en) 2022-12-23 2025-08-12 成都恩沐生物科技有限公司 Multispecific peptide complex targeting GPRC5D
AU2023412611A1 (en) 2022-12-23 2025-07-10 Chimagen Biosciences, Ltd Novel anti-gprc5d antibody
KR20250137203A (en) 2022-12-27 2025-09-17 예일 유니버시티 antibody drug conjugates
AU2024206846A1 (en) 2023-01-06 2025-08-21 Lassen Therapeutics, Inc. ANTI-IL-11Rα ANTIBODIES FOR TREATING THYROID EYE DISEASE
IL321948A (en) 2023-01-06 2025-09-01 Lassen Therapeutics Inc Anti-il-18bp antibodies
TW202430560A (en) 2023-01-06 2024-08-01 美商拉森醫療公司 Anti-il-18bp antibodies
WO2024150074A2 (en) 2023-01-13 2024-07-18 Takeda Pharmaceutical Company Limited Coronavirus antibodies and therapeutic uses thereof
WO2024151885A1 (en) 2023-01-13 2024-07-18 Iovance Biotherapeutics, Inc. Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
TW202432607A (en) 2023-01-18 2024-08-16 美商建南德克公司 Multispecific antibodies and uses thereof
AR131637A1 (en) 2023-01-19 2025-04-16 Beigene Ltd ANTI-cMET ANTIBODIES AND METHODS OF USE
WO2024158824A1 (en) 2023-01-23 2024-08-02 Yale University Antibody oligonucleotide conjugates
WO2024163494A1 (en) 2023-01-31 2024-08-08 F. Hoffmann-La Roche Ag Methods and compositions for treating non-small cell lung cancer and triple-negative breast cancer
WO2024163009A1 (en) 2023-01-31 2024-08-08 Genentech, Inc. Methods and compositions for treating urothelial bladder cancer
WO2024170543A1 (en) 2023-02-14 2024-08-22 Institut National de la Santé et de la Recherche Médicale Anti-cd44 antibodies and uses thereof
WO2024173607A2 (en) 2023-02-14 2024-08-22 Evolveimmune Therapeutics, Inc. Combination of bispecific antibodies and chimeric antigen receptor t cells for treatment
WO2024182443A2 (en) 2023-02-27 2024-09-06 Compugen Ltd. Triple combination therapy with anti-pvrig antibodies, anti-tigit antibodies, and pembrolizumab
WO2024182714A1 (en) 2023-03-02 2024-09-06 Alloy Therapeutics, Inc. Anti-cd22 antibodies and uses thereof
TW202436344A (en) 2023-03-03 2024-09-16 瑞士商百濟神州瑞士有限責任公司 Cd16a antibodies and methods of use
AR132040A1 (en) 2023-03-03 2025-05-21 Beigene Switzerland Gmbh MUC1 AND CD16A ANTIBODIES AND METHODS OF USE
AR132043A1 (en) 2023-03-03 2025-05-21 Beigene Switzerland Gmbh MUC1 ANTIBODIES AND METHODS OF USE
WO2024186635A2 (en) 2023-03-03 2024-09-12 Celldex Therapeutics, Inc. Anti-stem cell factor (scf) and anti-thymic stromal lymphopoietin (tslp) antibodies and bispecific constructs
WO2024184810A1 (en) 2023-03-06 2024-09-12 Beigene Switzerland Gmbh Anti-cldn6 and anti-cd3 multispecific antibodies and methods of use
AR132064A1 (en) 2023-03-06 2025-05-21 Beigene Switzerland Gmbh ANTI-CLDN6 ANTIBODIES AND METHODS OF USE
TW202436345A (en) 2023-03-06 2024-09-16 瑞士商百濟神州瑞士有限責任公司 Anti-cd3 multispecific antibodies and methods of use
WO2024184494A1 (en) 2023-03-08 2024-09-12 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
WO2024191785A1 (en) 2023-03-10 2024-09-19 Genentech, Inc. Fusions with proteases and uses thereof
WO2024188965A1 (en) 2023-03-13 2024-09-19 F. Hoffmann-La Roche Ag Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody
WO2024194686A2 (en) 2023-03-17 2024-09-26 Oxitope Pharma B.V. Anti-phosphocholine antibodies and methods of use thereof
WO2024194685A2 (en) 2023-03-17 2024-09-26 Oxitope Pharma B.V. Anti-phosphocholine antibodies and methods of use thereof
AU2024239150A1 (en) 2023-03-21 2025-10-02 Biograph 55, Inc. Cd19/cd38 multispecific antibodies
WO2024197302A1 (en) 2023-03-23 2024-09-26 Yale University Compositions and methods for delivering antibody oligonucleotide conjugates for exon skipping
WO2024200846A1 (en) 2023-03-30 2024-10-03 272BIO Limited Gnrh-binding polypeptides and uses thereof
WO2024206738A1 (en) 2023-03-31 2024-10-03 Immunai Inc. Humanized anti-trem2 antibodies
US20240327522A1 (en) 2023-03-31 2024-10-03 Genentech, Inc. Anti-alpha v beta 8 integrin antibodies and methods of use
WO2024211235A1 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
WO2024211234A1 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
WO2024211236A2 (en) 2023-04-05 2024-10-10 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
WO2024212827A1 (en) 2023-04-12 2024-10-17 Shanghai Kangabio Co., Limited Multifunctional molecules comprising masked interleukin 12 and methods of use
WO2024220546A2 (en) 2023-04-17 2024-10-24 Peak Bio, Inc. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates
WO2024226829A2 (en) 2023-04-26 2024-10-31 Yale University Enpp3-binding molecules, compositions formed therefrom, and methods of use thereof for the treatment of cancer
WO2024233341A1 (en) 2023-05-05 2024-11-14 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2024231320A1 (en) 2023-05-08 2024-11-14 F. Hoffmann-La Roche Ag Targeted interferon alpha fusion proteins and methods of use
WO2024233646A1 (en) 2023-05-10 2024-11-14 Genentech, Inc. Methods and compositions for treating cancer
TW202509065A (en) 2023-05-16 2025-03-01 瑞士商赫孚孟拉羅股份公司 Pd-1-regulated il-2 immunoconjugates and uses thereof
WO2024236156A1 (en) 2023-05-17 2024-11-21 Institut National de la Santé et de la Recherche Médicale Anti-cathepsin-d antibodies
WO2024254455A1 (en) 2023-06-08 2024-12-12 Genentech, Inc. Macrophage signatures for diagnostic and therapeutic methods for lymphoma
WO2024251884A1 (en) 2023-06-09 2024-12-12 Innate Pharma Nk cell engager proteins comprising anti-cd20 and ant-nkp46 antibody, linked to il-2 in treatment of r/r b-nhl
EP4477236A1 (en) 2023-06-14 2024-12-18 Inatherys Combination therapy for treating a tumor using adc comprising anti-cd71 antibodies and bh3 mimetics
TW202504929A (en) 2023-06-22 2025-02-01 美商建南德克公司 Methods and compositions for cancer treatment
WO2024263761A1 (en) 2023-06-22 2024-12-26 Genentech, Inc. Antibodies and uses thereof
WO2024263195A1 (en) 2023-06-23 2024-12-26 Genentech, Inc. Methods for treatment of liver cancer
WO2024263904A1 (en) 2023-06-23 2024-12-26 Genentech, Inc. Methods for treatment of liver cancer
TW202515608A (en) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
WO2025002410A1 (en) 2023-06-30 2025-01-02 Evive Biotechnology (Shanghai) Ltd G-csf dimer for use in the treatment or prevention of chemotherapy or radiotherapy induced neutropenia
WO2025015318A2 (en) 2023-07-13 2025-01-16 Iovance Biotherapeutics, Inc. Cytokine encoding lentiviral vectors and uses thereof for making tumor infiltrating lymphocytes
WO2025012417A1 (en) 2023-07-13 2025-01-16 Institut National de la Santé et de la Recherche Médicale Anti-neurotensin long fragment and anti-neuromedin n long fragment antibodies and uses thereof
WO2025019790A1 (en) 2023-07-19 2025-01-23 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with trop-2 targeting adc
WO2025024265A1 (en) 2023-07-21 2025-01-30 Bristol-Myers Squibb Company Methods of assessing citrullination and activity of pad4 modulators
WO2025022280A1 (en) 2023-07-21 2025-01-30 Astrazeneca Ab Treatment of neurodegenerative diseases
WO2025021790A2 (en) 2023-07-24 2025-01-30 F. Hoffmann-La Roche Ag Multispecific antibodies
WO2025034806A1 (en) 2023-08-08 2025-02-13 Wisconsin Alumni Research Foundation Single-domain antibodies and variants thereof against fibroblast activation protein
WO2025032071A1 (en) 2023-08-09 2025-02-13 F. Hoffmann-La Roche Ag Mono and multispecific anti-trem2 antibodies, methods and uses thereof
WO2025032069A1 (en) 2023-08-09 2025-02-13 F. Hoffmann-La Roche Ag Mono and multispecific anti-trem2 antibodies, methods and uses thereof
WO2025032070A1 (en) 2023-08-09 2025-02-13 F. Hoffmann-La Roche Ag Anti-a-beta protein antibodies, methods and uses thereof
TW202525845A (en) 2023-08-23 2025-07-01 法商賽諾菲公司 Ctla-4-based lysosomal degraders and uses thereof
WO2025046298A2 (en) 2023-09-01 2025-03-06 iTeos Belgium SA Anti-trem2 antibodies and methods of use
WO2025049905A1 (en) 2023-09-01 2025-03-06 Gennao Bio, Inc. Dnase co-expression in host cells
WO2025045251A2 (en) 2023-09-03 2025-03-06 Kira Pharmaceuticals (Us) Llc Multispecific constructs comprising anti-factor d moiety
WO2025059037A1 (en) 2023-09-11 2025-03-20 Evolveimmune Therapeutics, Inc. Bispecific antibody fusion molecules targeting b7-h4 and cd3 and methods of use thereof
WO2025064890A1 (en) 2023-09-20 2025-03-27 Evolveimmune Therapeutics, Inc. Bispecific antibody fusion molecules targeting cd180 and cd3 and methods of use thereof
WO2025064885A1 (en) 2023-09-20 2025-03-27 Evolveimmune Therapeutics, Inc. Multispecific antibodies that bind cd3 and cd2 and methods of use thereof
TW202517673A (en) 2023-09-25 2025-05-01 瑞士商赫孚孟拉羅股份公司 Antibody that binds to c3bbb
WO2025072888A2 (en) 2023-09-28 2025-04-03 Novavax, Inc. Anti-sars-cov-2 spike (s) antibodies and their use in treating covid-19
WO2025068957A1 (en) 2023-09-29 2025-04-03 Novartis Ag Bispecific antibodies for use in lowering the risk of cardiovascular disease events in subjects known to be a carrier of clonal expansion of hematopoietic cell lines with somatic mutations
WO2025076081A1 (en) 2023-10-03 2025-04-10 Absci Corporation Tl1a associated antibody compositions and methods of use
WO2025076389A1 (en) 2023-10-06 2025-04-10 Seagen Inc. Methods of treating advanced solid tumors with b7-h4 antibody-drug conjugates
WO2025085489A1 (en) 2023-10-17 2025-04-24 Bristol-Myers Squibb Company Gspt1-degrading compounds, anti-cd33 antibodies and antibody-drug conjugates and uses thereof
WO2025101484A1 (en) 2023-11-06 2025-05-15 Iovance Biotherapeutics, Inc. Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
WO2025099120A1 (en) 2023-11-09 2025-05-15 F. Hoffmann-La Roche Ag Multispecific antibodies with conditional activity
WO2025106474A1 (en) 2023-11-14 2025-05-22 Genentech, Inc. Therapeutic and diagnostic methods for treating cancer with anti-fcrh5/anti-cd3 bispecific antibodies
WO2025114862A1 (en) 2023-11-27 2025-06-05 Glaxosmithkline Intellectual Property Development Limited Il-33 binding antibodies
WO2025120015A1 (en) 2023-12-06 2025-06-12 Institut National de la Santé et de la Recherche Médicale Cd5 targeting antibodies with depleting and t or b-cell activation effects
WO2025122885A1 (en) 2023-12-08 2025-06-12 Absci Corporation Anti-her2 associated antibody compositions designed by artificial intelligence and methods of use
US20250197511A1 (en) 2023-12-13 2025-06-19 Horizon Therapeutics Ireland Dac Methods for the treatment of thyroid eye disease
WO2025133707A1 (en) 2023-12-19 2025-06-26 Vectory Therapeutics B.V. Anti-tdp-43 antibodies and uses thereof
GB202319605D0 (en) 2023-12-20 2024-01-31 argenx BV Monovalent binding molecules and methods of use
WO2025132503A1 (en) 2023-12-20 2025-06-26 F. Hoffmann-La Roche Ag Antibodies binding to ceacam5
WO2025133694A1 (en) 2023-12-20 2025-06-26 argenx BV Fcrn/hsa-binding molecules and methods of use
WO2025133042A2 (en) 2023-12-22 2025-06-26 F. Hoffmann-La Roche Ag Activatable fusion proteins and methods of use
WO2025147696A1 (en) 2024-01-05 2025-07-10 Resolve Therapeutics, Llc Treatment of symptoms associated with sars-cov viral infection or a prior sars-cov viral infection with nuclease agents
WO2025146131A1 (en) 2024-01-05 2025-07-10 Beigene, Ltd. ANTI-FGFR2b ANTIBODIES, CONJUGATES AND METHODS OF USE
WO2025149947A1 (en) 2024-01-12 2025-07-17 Seagen Inc. Antibody-drug conjugates
WO2025149633A1 (en) 2024-01-12 2025-07-17 Laigo Bio B.V. Bispecific antigen binding proteins
WO2025155877A2 (en) 2024-01-18 2025-07-24 The Regents Of The University Of California Antibodies binding to pad4 and uses thereof
US12319742B1 (en) 2024-01-24 2025-06-03 Shattuck Labs, Inc. Antibodies that bind TNFRSF25
WO2025160331A1 (en) 2024-01-26 2025-07-31 Futuregen Biopharmaceutical (Beijing) Co., Ltd. Antibodies capable of specifically binding tl1a and use thereof
WO2025171182A1 (en) 2024-02-08 2025-08-14 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with cancer vaccine
WO2025174974A1 (en) 2024-02-14 2025-08-21 Bristol-Myers Squibb Company Anti-cd33 antibodies and uses thereof
WO2025172924A1 (en) 2024-02-15 2025-08-21 Janssen Biotech, Inc. Anti-transferrin receptor compositions and methods thereof
WO2025184208A1 (en) 2024-02-27 2025-09-04 Bristol-Myers Squibb Company Anti-ceacam5 antibodies and uses thereof
US20250269052A1 (en) 2024-02-27 2025-08-28 Bristol-Myers Squibb Company Anti-ceacam5 antibody drug conjugates
WO2025186332A1 (en) 2024-03-05 2025-09-12 Ac Immune Sa Vectorized anti-tdp-43 antibodies
WO2025196691A1 (en) 2024-03-20 2025-09-25 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
WO2025196639A1 (en) 2024-03-21 2025-09-25 Seagen Inc. Cd25 antibodies, antibody-drug conjugates, and uses thereof
CN119552212B (en) * 2025-01-26 2025-04-25 杭州康源食品科技有限公司 A tripeptide LFP with uric acid-lowering activity and its application

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (en) 1978-01-06 1979-08-03 David Bernard DRYER FOR SCREEN-PRINTED SHEETS
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4490473A (en) * 1983-03-28 1984-12-25 Panab Labeled antibodies and methods
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (en) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Process for the biotechnical production of alkaline phosphatase
US4752601A (en) * 1983-08-12 1988-06-21 Immunetech Pharmaceuticals Method of blocking immune complex binding to immunoglobulin FC receptors
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5985599A (en) * 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
EP0307434B2 (en) * 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5204244A (en) * 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5576184A (en) * 1988-09-06 1996-11-19 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
EP0435911B1 (en) 1988-09-23 1996-03-13 Cetus Oncology Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
ATE144793T1 (en) 1989-06-29 1996-11-15 Medarex Inc BISPECIFIC REAGENTS FOR AIDS THERAPY
GB8916400D0 (en) * 1989-07-18 1989-09-06 Dynal As Modified igg3
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5364930A (en) * 1990-10-16 1994-11-15 Northwestern University Synthetic C1q peptide fragments
US5419904A (en) * 1990-11-05 1995-05-30 The Regents Of The University Of California Human B-lymphoblastoid cell line secreting anti-ganglioside antibody
JPH06507398A (en) 1991-05-14 1994-08-25 リプリジェン　コーポレーション Heterogeneous conjugate antibody for treatment of HIV infection
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
GB9206422D0 (en) * 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
EP0640094A1 (en) * 1992-04-24 1995-03-01 The Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
CA2140280A1 (en) 1992-08-17 1994-03-03 Avi J. Ashkenazi Bispecific immunoadhesins
EP0752248B1 (en) 1992-11-13 2000-09-27 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5885573A (en) * 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
US6491916B1 (en) * 1994-06-01 2002-12-10 Tolerance Therapeutics, Inc. Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
JPH08511420A (en) * 1993-06-16 1996-12-03 セルテック・セラピューテイクス・リミテッド Body
US5731168A (en) * 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5730977A (en) * 1995-08-21 1998-03-24 Mitsui Toatsu Chemicals, Inc. Anti-VEGF human monoclonal antibody
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US5834597A (en) * 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
WO1998023289A1 (en) * 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
US6277375B1 (en) * 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
DE19721700C1 (en) 1997-05-23 1998-11-19 Deutsches Krebsforsch Mutant OKT3 antibody
WO1998058964A1 (en) * 1997-06-24 1998-12-30 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
CN1204147C (en) 1998-02-25 2005-06-01 利思进药品公司 Methods of increasing the circulating half-life of antibody-based fusion proteins
ES2292236T3 (en) 1998-04-02 2008-03-01 Genentech, Inc. VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS.
US6528624B1 (en) * 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6242195B1 (en) * 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
US6194551B1 (en) * 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
EP1105427A2 (en) 1998-08-17 2001-06-13 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
US7183387B1 (en) * 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6676927B1 (en) * 1999-01-20 2004-01-13 The Rockefeller University Animal model and methods for its use in the selection of cytotoxic antibodies
DE60122286T2 (en) 2000-02-11 2007-08-02 Merck Patent Gmbh INCREASING THE CIRCULATORY HALF-TIME OF ANTIBODY-BASED FUSION PROTEINS
CA2399940A1 (en) * 2000-04-13 2001-10-25 The Rockefeller University Enhancement of antibody-mediated immune responses
ES2727425T3 (en) * 2000-12-12 2019-10-16 Medimmune Llc Molecules with prolonged half-lives, compositions and uses thereof
US20040002587A1 (en) * 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20060062727A1 (en) 2002-07-09 2006-03-23 Philips Heidi S Compositions and methods for the diagnosis and treatment of tumor
CN101987871A (en) 2002-09-27 2011-03-23 赞科股份有限公司 Optimized fc variants and methods for their generation
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
ATE480562T1 (en) 2002-10-15 2010-09-15 Facet Biotech Corp CHANGE IN FCRN BINDING AFFINITIES OR SERUM HALF-LIFE TIMES OF ANTIBODIES USING MUtagenesis
US7608260B2 (en) * 2003-01-06 2009-10-27 Medimmune, Llc Stabilized immunoglobulins
JP2006524039A (en) 2003-01-09 2006-10-26 マクロジェニクス，インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
JP2007531707A (en) 2003-10-15 2007-11-08 ピーディーエル バイオファーマ， インコーポレイテッド Modification of Fc fusion protein serum half-life by mutagenesis of heavy chain constant region positions 250, 314 and / or 428 of IG
ZA200701715B (en) * 2004-08-19 2008-07-30 Genentech Inc Polypeptide variants with altered effector function
DOP2006000029A (en) * 2005-02-07 2006-08-15 Genentech Inc ANTIBODY VARIANTS AND USES THEREOF. (VARIATIONS OF AN ANTIBODY AND USES OF THE SAME)

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