SG11201808994YA - Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof - Google Patents
Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereofInfo
- Publication number
- SG11201808994YA SG11201808994YA SG11201808994YA SG11201808994YA SG11201808994YA SG 11201808994Y A SG11201808994Y A SG 11201808994YA SG 11201808994Y A SG11201808994Y A SG 11201808994YA SG 11201808994Y A SG11201808994Y A SG 11201808994YA SG 11201808994Y A SG11201808994Y A SG 11201808994YA
- Authority
- SG
- Singapore
- Prior art keywords
- flag
- international
- antibodies
- chain variable
- axl
- Prior art date
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title abstract 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title abstract 4
- 229940127121 immunoconjugate Drugs 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 241001556567 Acanthamoeba polyphaga mimivirus Species 0.000 abstract 1
- 101100022187 Caenorhabditis elegans mab-10 gene Proteins 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111111011111111011111011111101111011111 International Bureau ... .1 j ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/180842 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07K 16/28 (2006.01) G01N 33/68 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 47/50 (2017.01) A61K 39/00 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2017/027372 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 13 April 2017 (13.04.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/323,036 15 April 2016 (15.04.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: BIOATLA, LLC [US/US]; 11011 Torreyana TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Road, San Diego, CA 92121 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: SHORT, Jay M.; 12985 Via Esperia, Del mar, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, California 92014 (US). CHANG, Hwai Wen; 1318 Shad- ow Hills Drive, San Marcos, California 92069 (US). GW, KM, ML, MR, NE, SN, TD, TG). FREY, Gerhard; 13768 Via Cima Bella, San Diego, Cali- Declarations under Rule 4.17: _ fornia 92129 (US). — of inventorship (Rule 4.17(N)) (74) Agent: DUNLEAVY, Kevin J.; MENDELSOHN DUN- Published: = LEAVY, P.C., 1500 John F. Kennedy Blvd., Suite 312, = Philadelphia, Pennsylvania 19102 (US). — with international search report (Art. 21(3)) (81) Designated States (unless otherwise indicated, for every — with sequence listing part of description (Rule 5.2(a)) = kind of national protection available): AE, AG, AL, AM, = = (54) Title: ANTI-AXL ANTIBODIES, OF = 3 ng 75 inAb = 1.5 = = t a. 11 .4 ei 71' __ ot b ANTIBODY FRAGMENTS AND THEIR IMMUNOCONJUGATES 75 fig rrAbIlh 0 ill_ ! = 60 °C 10 ng mAb 10 ng mAbilh il 1 MIMI 0 _214 et74 = ' —PAL-_ AND USES THERE- 60 °C !Mut $ GC © QC There are 11 antibodies tester under each condition (i.e., 11 bars in each set of bars). The 11 bars under each condition from left to right represent respectively clones BAP063 10F10, BAP063.9-13-1-FIAG, BAP063.9-29-2-FLAG, BAPC63.9-45-2-FIAG, BAN/63.9-13-3- FLAG, BAP063 21 3 FLAG, BAP063.9-21-4-FLAG, BAP063.9-29-4-FLAG, BAP063.9-48-3-FLAG. non-specific rhAh, no mAh 11 FIG. 5 N 11 0 (57) : A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to Axl \" protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable re - Cgion that bind to Axl protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody frag- ments containing the polypeptide are also provided.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662323036P | 2016-04-15 | 2016-04-15 | |
PCT/US2017/027372 WO2017180842A1 (en) | 2016-04-15 | 2017-04-13 | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808994YA true SG11201808994YA (en) | 2018-11-29 |
Family
ID=60042774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808994YA SG11201808994YA (en) | 2016-04-15 | 2017-04-13 | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
Country Status (12)
Country | Link |
---|---|
US (2) | US11149088B2 (en) |
EP (1) | EP3443012A4 (en) |
JP (3) | JP6735355B2 (en) |
KR (5) | KR20230162730A (en) |
CN (1) | CN109563164A (en) |
AU (3) | AU2017248644B2 (en) |
CA (1) | CA3021086C (en) |
IL (1) | IL262173B (en) |
MX (3) | MX2018012418A (en) |
SG (1) | SG11201808994YA (en) |
TW (2) | TW202246348A (en) |
WO (1) | WO2017180842A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11542332B2 (en) * | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
EP3443001A4 (en) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
CA3021086C (en) * | 2016-04-15 | 2023-10-17 | Bioatla, Llc | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
HRP20221298T1 (en) | 2016-05-13 | 2022-12-23 | Bioatla, Inc. | Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof |
JP2019528323A (en) | 2016-08-31 | 2019-10-10 | バイオアトラ、エルエルシー | Conditionally active polypeptide and method for producing the same |
JP7280827B2 (en) * | 2017-01-18 | 2023-05-24 | エクスマ バイオテック コーポレイション | Chimeric antigen receptor for AXL or ROR2 and methods of use thereof |
CN107759691B (en) * | 2017-12-04 | 2018-09-25 | 杭州尚健生物技术有限公司 | A kind of monoclonal antibody of specific binding AXL |
CN110483639A (en) | 2018-05-15 | 2019-11-22 | 复旦大学 | Target antibody and the antibody-drug conjugates and its preparation method and application of AXL |
CN110540592B (en) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | Antibodies that bind to AXL protein and uses thereof |
EP3807318A4 (en) * | 2018-06-14 | 2022-03-02 | BioAtla, Inc. | Multi-specific antibody constructs |
WO2020050993A2 (en) | 2018-09-07 | 2020-03-12 | Bioatla, Llc | Conditionally active chimeric antigen receptors for modified t-cells |
EP3946453A4 (en) * | 2019-03-29 | 2022-12-07 | Celldex Therapeutics, Inc. | Anti-axl antibodies and methods of use thereof |
WO2021013746A1 (en) | 2019-07-19 | 2021-01-28 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
JP2023550043A (en) * | 2020-11-12 | 2023-11-30 | バイオアトラ インコーポレイテッド | Method for treating Axl-expressing cancer using anti-Axl antibodies, antibody fragments, and immunoconjugates thereof |
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