BR112021020447A2 - Methods and uses of variant icos ligand fusion proteins (icosl) - Google Patents

Methods and uses of variant icos ligand fusion proteins (icosl)

Info

Publication number
BR112021020447A2
BR112021020447A2 BR112021020447A BR112021020447A BR112021020447A2 BR 112021020447 A2 BR112021020447 A2 BR 112021020447A2 BR 112021020447 A BR112021020447 A BR 112021020447A BR 112021020447 A BR112021020447 A BR 112021020447A BR 112021020447 A2 BR112021020447 A2 BR 112021020447A2
Authority
BR
Brazil
Prior art keywords
methods
icosl
fusion proteins
proteins
icos ligand
Prior art date
Application number
BR112021020447A
Other languages
Portuguese (pt)
Inventor
Jan Hillson
Jing Yang
Ryan Swanson
Stanford Peng
Original Assignee
Alpine Immune Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpine Immune Sciences Inc filed Critical Alpine Immune Sciences Inc
Publication of BR112021020447A2 publication Critical patent/BR112021020447A2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

métodos e usos de proteínas de fusão de ligante icos variante (icosl). a presente invenção refere-se a proteínas imunomoduladoras que compreendem variantes de icosl e ácidos nucleicos que codificam tais proteínas. as proteínas imunomoduladoras fornecem utilidade terapêutica para uma variedade de condições imunológicas e oncológicas. composições e métodos para fazer e usar tais proteínas são fornecidos.methods and uses of variant icos ligand (icosl) fusion proteins. the present invention relates to immunomodulatory proteins comprising icosl variants and nucleic acids encoding such proteins. immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. compositions and methods for making and using such proteins are provided.

BR112021020447A 2019-04-17 2020-04-16 Methods and uses of variant icos ligand fusion proteins (icosl) BR112021020447A2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962835488P 2019-04-17 2019-04-17
US201962855830P 2019-05-31 2019-05-31
US201962931212P 2019-11-05 2019-11-05
US201962945071P 2019-12-06 2019-12-06
US202062962832P 2020-01-17 2020-01-17
US202062987854P 2020-03-10 2020-03-10
PCT/US2020/028601 WO2020214867A1 (en) 2019-04-17 2020-04-16 Methods and uses of variant icos ligand (icosl) fusion proteins

Publications (1)

Publication Number Publication Date
BR112021020447A2 true BR112021020447A2 (en) 2022-05-17

Family

ID=70554252

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021020447A BR112021020447A2 (en) 2019-04-17 2020-04-16 Methods and uses of variant icos ligand fusion proteins (icosl)

Country Status (12)

Country Link
US (1) US20220218785A1 (en)
EP (2) EP3955953A1 (en)
JP (1) JP2022529059A (en)
KR (1) KR20220035032A (en)
CN (1) CN114302736A (en)
AU (1) AU2020257238A1 (en)
BR (1) BR112021020447A2 (en)
CA (1) CA3136816A1 (en)
IL (1) IL287290A (en)
MX (1) MX2021012607A (en)
SG (1) SG11202111033VA (en)
WO (1) WO2020214867A1 (en)

Families Citing this family (5)

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KR20230051602A (en) 2016-04-15 2023-04-18 알파인 이뮨 사이언시즈, 인코포레이티드 Icos ligand variant immunomodulatory proteins and uses thereof
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MX2022013998A (en) 2020-05-08 2023-02-16 Alpine Immune Sciences Inc April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof.
WO2022103797A1 (en) * 2020-11-10 2022-05-19 Massachusetts Institute Of Technology Engineered protein for rapid, efficient capture of pathogen-specific antibodies
KR20230155960A (en) * 2022-05-03 2023-11-13 고려대학교 산학협력단 ICOS-L variants with enhanced binding to ICOS

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Also Published As

Publication number Publication date
AU2020257238A1 (en) 2021-12-02
KR20220035032A (en) 2022-03-21
CN114302736A (en) 2022-04-08
SG11202111033VA (en) 2021-11-29
CA3136816A1 (en) 2020-10-22
EP3955953A1 (en) 2022-02-23
JP2022529059A (en) 2022-06-16
US20220218785A1 (en) 2022-07-14
WO2020214867A1 (en) 2020-10-22
EP4438054A2 (en) 2024-10-02
IL287290A (en) 2021-12-01
MX2021012607A (en) 2022-03-11

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