AU2006244885B2 - Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics - Google Patents

Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics Download PDF

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AU2006244885B2
AU2006244885B2 AU2006244885A AU2006244885A AU2006244885B2 AU 2006244885 B2 AU2006244885 B2 AU 2006244885B2 AU 2006244885 A AU2006244885 A AU 2006244885A AU 2006244885 A AU2006244885 A AU 2006244885A AU 2006244885 B2 AU2006244885 B2 AU 2006244885B2
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antibody
cancer
seq
human
antigen
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AU2006244885A1 (en
Inventor
Josephine M. Cardarelli
Bing Chen
Alan J. Korman
Mark J. Selby
Mohan Srinivasan
Changyu Wang
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Ono Pharmaceutical Co Ltd
ER Squibb and Sons LLC
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Ono Pharmaceutical Co Ltd
ER Squibb and Sons LLC
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Assigned to MEDAREX, L.L.C., ONO PHARMACEUTICAL CO., LTD. reassignment MEDAREX, L.L.C. Request to Amend Deed and Register Assignors: MEDAREX, INC., ONO PHARMACEUTICAL CO., LTD.
Assigned to ONO PHARMACEUTICAL CO., LTD., E. R. SQUIBB & SONS, L.L.C. reassignment ONO PHARMACEUTICAL CO., LTD. Request to Amend Deed and Register Assignors: MEDAREX, L.L.C., ONO PHARMACEUTICAL CO., LTD.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K51/04—Organic compounds
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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AU2006244885A 2005-05-09 2006-05-02 Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics Active 2031-01-11 AU2006244885B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011203119A AU2011203119C1 (en) 2005-05-09 2011-06-27 Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US67946605P 2005-05-09 2005-05-09
US60/679,466 2005-05-09
US73843405P 2005-11-21 2005-11-21
US60/738,434 2005-11-21
US74891905P 2005-12-08 2005-12-08
US60/748,919 2005-12-08
PCT/JP2006/309606 WO2006121168A1 (en) 2005-05-09 2006-05-02 Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics

Related Child Applications (1)

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AU2011203119A Division AU2011203119C1 (en) 2005-05-09 2011-06-27 Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics

Publications (2)

Publication Number Publication Date
AU2006244885A1 AU2006244885A1 (en) 2006-11-16
AU2006244885B2 true AU2006244885B2 (en) 2011-03-31

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AU2006244885A Active 2031-01-11 AU2006244885B2 (en) 2005-05-09 2006-05-02 Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics

Country Status (27)

Country Link
US (10) US8008449B2 (en:Method)
EP (6) EP2418278A3 (en:Method)
JP (9) JP4361545B2 (en:Method)
KR (3) KR101318469B1 (en:Method)
CN (5) CN103059138B (en:Method)
AU (1) AU2006244885B2 (en:Method)
BE (1) BE2015C074I2 (en:Method)
BR (1) BRPI0610235B8 (en:Method)
CA (3) CA2970873C (en:Method)
CY (2) CY2015057I1 (en:Method)
DK (2) DK2439273T3 (en:Method)
ES (2) ES2427646T5 (en:Method)
FR (1) FR15C0087I2 (en:Method)
HU (2) HUE044719T2 (en:Method)
IL (2) IL187108A (en:Method)
LT (2) LT2439273T (en:Method)
LU (1) LU92904I2 (en:Method)
MX (1) MX2007013978A (en:Method)
NL (1) NL300782I2 (en:Method)
NO (6) NO341219B1 (en:Method)
NZ (1) NZ563193A (en:Method)
PL (2) PL2439273T3 (en:Method)
PT (2) PT2161336E (en:Method)
RU (4) RU2494107C2 (en:Method)
SI (2) SI2161336T1 (en:Method)
TW (1) TWI379898B (en:Method)
WO (1) WO2006121168A1 (en:Method)

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JP5401001B2 (ja) 2002-09-11 2014-01-29 ジェネンテック， インコーポレイテッド 免疫関連疾患の治療のための新規組成物と方法
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DE102005046490A1 (de) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
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