IL302529B2 - AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS - Google Patents

AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS

Info

Publication number
IL302529B2
IL302529B2 IL302529A IL30252923A IL302529B2 IL 302529 B2 IL302529 B2 IL 302529B2 IL 302529 A IL302529 A IL 302529A IL 30252923 A IL30252923 A IL 30252923A IL 302529 B2 IL302529 B2 IL 302529B2
Authority
IL
Israel
Prior art keywords
alkyl
cycloalkyl
independently selected
aryl
membered heteroaryl
Prior art date
Application number
IL302529A
Other languages
English (en)
Hebrew (he)
Other versions
IL302529B1 (en
IL302529A (en
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of IL302529A publication Critical patent/IL302529A/en
Publication of IL302529B1 publication Critical patent/IL302529B1/en
Publication of IL302529B2 publication Critical patent/IL302529B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL302529A 2018-03-08 2019-03-07 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS IL302529B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862640276P 2018-03-08 2018-03-08
US201862702230P 2018-07-23 2018-07-23
US201862745873P 2018-10-15 2018-10-15
PCT/US2019/021186 WO2019226213A2 (en) 2018-03-08 2019-03-07 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS

Publications (3)

Publication Number Publication Date
IL302529A IL302529A (en) 2023-07-01
IL302529B1 IL302529B1 (en) 2024-11-01
IL302529B2 true IL302529B2 (en) 2025-03-01

Family

ID=67844335

Family Applications (2)

Application Number Title Priority Date Filing Date
IL302529A IL302529B2 (en) 2018-03-08 2019-03-07 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS
IL277071A IL277071B2 (en) 2018-03-08 2019-03-07 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL277071A IL277071B2 (en) 2018-03-08 2019-03-07 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS

Country Status (33)

Country Link
US (5) US10669262B2 (enExample)
EP (2) EP3762368B1 (enExample)
JP (2) JP7268049B2 (enExample)
KR (1) KR102828717B1 (enExample)
CN (2) CN118290402A (enExample)
AU (2) AU2019272342B2 (enExample)
BR (1) BR112020018094A2 (enExample)
CA (1) CA3093445A1 (enExample)
CL (1) CL2020002275A1 (enExample)
CO (1) CO2020012169A2 (enExample)
CR (2) CR20240101A (enExample)
CY (1) CY1125169T1 (enExample)
DK (1) DK3762368T3 (enExample)
EC (1) ECSP20061378A (enExample)
ES (1) ES2910071T3 (enExample)
HR (1) HRP20220331T1 (enExample)
HU (1) HUE057970T2 (enExample)
IL (2) IL302529B2 (enExample)
LT (1) LT3762368T (enExample)
MA (1) MA54133B1 (enExample)
MD (1) MD3762368T2 (enExample)
MX (2) MX2020009228A (enExample)
PE (2) PE20210641A1 (enExample)
PH (1) PH12020551390A1 (enExample)
PL (1) PL3762368T3 (enExample)
PT (1) PT3762368T (enExample)
RS (1) RS63124B1 (enExample)
SG (1) SG11202008560VA (enExample)
SI (1) SI3762368T1 (enExample)
SM (1) SMT202200134T1 (enExample)
TW (2) TWI827583B (enExample)
UA (1) UA128288C2 (enExample)
WO (1) WO2019226213A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
SG11202012425QA (en) 2018-07-13 2021-01-28 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2021219418A1 (en) * 2020-04-29 2021-11-04 Basf Se Preparation of aromatic carboxyamides by palladium-catalyzed carbonylation reaction
CN112341437A (zh) * 2020-12-21 2021-02-09 李寒 一种取代的吡嗪衍生物及其应用
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂

Family Cites Families (818)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2190837B1 (enExample) 1972-06-29 1974-12-27 Rhone Progil
US4705853A (en) 1982-09-30 1987-11-10 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
US5025096A (en) 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
US4861884A (en) 1985-10-15 1989-08-29 The Dow Chemical Company Compositions prepared from amino substituted pyrazines and carboxylic acids, carboxylic acid anhydrides, carboxylic acid esters or carboxylic acid halides
US4735321A (en) 1986-05-02 1988-04-05 The Coca-Cola Company Mobile extra display module
GB8718445D0 (en) 1987-08-04 1987-09-09 Wyeth John & Brother Ltd Pyridyl-ethers
JP2691986B2 (ja) 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
JPH0782249B2 (ja) 1989-11-09 1995-09-06 キヤノン株式会社 トナー
JPH061776Y2 (ja) 1990-02-14 1994-01-19 関東自動車工業株式会社 樹脂成形用型締装置の上型回転装置
NL9001162A (nl) 1990-05-18 1991-12-16 Stamicarbon Werkwijze ter bereiding van 2-n-acylaminopyridines en 2-aminopyridines uit 5-oxoalkaannitriloximmen alsmede deze 5-oxoalkaannitriloximmen, 2-n-acylaminopyridines en 2-aminopyridines.
US5155117A (en) 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
JPH0558997A (ja) 1991-09-04 1993-03-09 Mitsubishi Kasei Corp チオカルバモイルアセトニトリル誘導体
EP0553009B1 (fr) 1992-01-23 1997-06-04 Institut Francais Du Petrole Catalyseur d'alkylation de paraffines
US5315043A (en) 1992-02-05 1994-05-24 E. I. Du Pont De Nemours And Company Aromatic nucleophilic fluorination
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5252737A (en) 1992-05-22 1993-10-12 Monsanto Company Process for preparing N-aliphatic substituted p-phenylenediamines
JPH061776A (ja) 1992-06-18 1994-01-11 Nippon Soda Co Ltd 置換ピラジンカルボニトリルの製造方法
US5232945A (en) 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
JPH06256327A (ja) 1993-03-03 1994-09-13 Nippon Soda Co Ltd ４−置換アゼチジノン誘導体の製造方法
JP4327911B2 (ja) 1993-03-03 2009-09-09 日本曹達株式会社 イミド化合物の製造方法
ZA942125B (en) 1993-03-26 1994-11-10 Shell Res Ltd Herbicidal heterocyclic compounds.
US5436134A (en) 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
US5534416A (en) 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5545535A (en) 1993-04-13 1996-08-13 Molecular Probes, Inc. Fluorescent assay for bacterial gram reaction
US5451702A (en) 1993-04-26 1995-09-19 Monsanto Company Process for preparing substituted aromatic amines
TW266206B (enExample) 1993-04-28 1995-12-21 Takeda Pharm Industry Co Ltd
JPH0782249A (ja) 1993-06-30 1995-03-28 Nippon Soda Co Ltd ４−置換アゼチジノン誘導体の製造法
US5602156A (en) 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
US5744492A (en) 1993-09-17 1998-04-28 United States Of America Method for inhibiting angiogenesis
US5393860A (en) 1994-02-04 1995-02-28 Hoechst Celanese Corporation Polymer compositions containing substituted pyrazines
US5430123A (en) 1994-02-04 1995-07-04 Hoechst Celanese Corporation Polymer compositions containing substituted pyrazines
US5459266A (en) 1994-02-04 1995-10-17 Hoechst Celanese Corporation Substituted pyrazines
US5863903A (en) 1994-03-09 1999-01-26 Novo Nordisk A/S Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
ATE243196T1 (de) 1994-03-09 2003-07-15 Novo Nordisk As Piperidine und pyrrolidine
DE19509353A1 (de) 1994-03-31 1995-10-05 Basf Ag 4-Aminopiperidine
SE9401353D0 (sv) 1994-04-21 1994-04-21 Pharmacia Ab Novel antitumour compounds with antimitotic activity
DE4417746A1 (de) 1994-05-20 1995-11-23 Bayer Ag Neue Farbstoffe zum Massefärben von Kunststoffen
KR0151819B1 (ko) 1994-06-11 1998-10-15 강박광 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법
GB9412522D0 (en) 1994-06-22 1994-08-10 Ici Plc Optical recording media
DE4427529A1 (de) 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von 1,2,4-Triazin-3,5-dionen
FR2725718B1 (fr) 1994-10-14 1997-01-24 Virbac Lab Bis-2-aminopyridines, leur procede de preparation et leurs applications
US5883106A (en) 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
SK281577B6 (sk) 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
JPH08175994A (ja) 1994-10-27 1996-07-09 Takeda Chem Ind Ltd 脂質代謝改善剤
DE122007000005I2 (de) 1994-10-27 2008-04-24 Janssen Pharmaceutica Nv Apolipoprotein-b syntheseinhibitoren
US5677459A (en) 1994-11-10 1997-10-14 Sibia Neurosciences, Inc. Methods for the preparation of modulators of acetylcholine receptors
US5705512A (en) 1994-11-10 1998-01-06 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5703100A (en) 1994-11-10 1997-12-30 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5723477A (en) 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6057346A (en) 1994-12-12 2000-05-02 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of retroviral LTR promoters by calcium response modifiers
US5521056A (en) 1995-01-10 1996-05-28 Eastman Kodak Company Photographic peracid bleaching composition and processing method using ternary iron carboxylate complexes as catalysts in peracid bleaching solutions
US5639776A (en) 1995-01-12 1997-06-17 Otsuka Kagaku Kabushiki Kaisha 4, 5-dihydropyrazole-5-thione derivatives and miticides comprising the same
US5656449A (en) 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
JPH08337583A (ja) 1995-04-13 1996-12-24 Takeda Chem Ind Ltd 複素環化合物およびその製造法
GB9520355D0 (en) 1995-10-05 1995-12-06 Zeneca Ltd Chemical process
ATE208766T1 (de) 1995-05-23 2001-11-15 Janssen Pharmaceutica Nv (2-morpholinylmethyl)benzamid-derivate
WO1997001538A1 (en) 1995-06-28 1997-01-16 Zeneca Limited Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl)phenylacetate
WO1997011943A1 (en) 1995-09-26 1997-04-03 Nippon Soda Co., Ltd. Pyrazole compounds, process for preparing the same, and agrohorticultural bactericide
AU7528696A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Muscarine antagonists
WO1997016187A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine antagonists
US5756508A (en) 1995-10-31 1998-05-26 Merck & Co., Inc. Muscarine antagonists
GB9525296D0 (en) 1995-12-11 1996-02-07 Merck Sharp & Dohme Therapeutic agents
MY117098A (en) 1996-01-15 2004-05-31 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
GB9605331D0 (en) 1996-03-13 1996-05-15 Glaxo Group Ltd Chemical compounds
US5880137A (en) 1996-04-19 1999-03-09 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
EP0914318A1 (en) 1996-05-11 1999-05-12 Kings College London Pyrazines
DE19620508A1 (de) 1996-05-22 1997-11-27 Hoechst Ag Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
US5672592A (en) 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
FR2751969B1 (fr) 1996-08-01 1998-12-04 Centre Nat Rech Scient Composes activateurs du canal cftr, et compositions pharmaceutiques les contenant
US6340682B1 (en) 1996-08-23 2002-01-22 Kowa Co., Ltd. Diamide compound and drugs containing the same
TW382127B (en) 1996-08-30 2000-02-11 Sony Corp Magnetic recording medium and cleaning tape
US6294504B1 (en) 1996-09-26 2001-09-25 Syngenta Crop Protection, Inc. Herbicidal composition
ES2203790T3 (es) 1996-10-02 2004-04-16 Bristol-Myers Squibb Pharma Company 1,4-dihidro-2h-3,1-benzoxacin-2-onas 4,4-disustituidas utiles como inhibidores de la transcriptasa reversa del hiv e intermedios y procedimientos para su preparacion.
US5869487A (en) 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
ATE234091T1 (de) 1996-10-24 2003-03-15 Merck & Co Inc Thrombin inhibitoren
US20020115678A1 (en) 1996-10-28 2002-08-22 Ellis William Y. Compounds, compositions and methods for treating antibiotic-resistant infections
US5965572A (en) 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
US6274598B1 (en) 1996-10-28 2001-08-14 The United States Of America As Represented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
US6147080A (en) 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
JPH10188264A (ja) 1996-12-24 1998-07-21 Sony Corp 磁気記録媒体及びその製造方法
WO1998029114A1 (en) 1996-12-30 1998-07-09 Bar-Ilan University Tricarboxylic acid-containing oxyalkyl esters and uses thereof
AU6161198A (en) 1997-02-18 1998-09-08 E.I. Du Pont De Nemours And Company Herbicidal tetrazolinones
JPH10324687A (ja) 1997-02-19 1998-12-08 Nippon Soda Co Ltd ピロール化合物、製法および農園芸用殺菌剤
US5811442A (en) 1997-02-21 1998-09-22 Bencherif; Merouane Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow
DE19718742A1 (de) 1997-05-02 1998-11-05 Hoechst Ag Verfahren zur Herstellung von aromatischen Aldehyden durch katalytische Gasphasenhydrierung der Carbonsäuren
FR2763334A1 (fr) 1997-05-13 1998-11-20 Lipha Derives anthraniliques
FR2763588B1 (fr) 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
GB9711753D0 (en) 1997-06-06 1997-08-06 Merck Sharp & Dohme Therapeutic agents
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6172084B1 (en) 1997-06-19 2001-01-09 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
WO1999001453A1 (en) 1997-07-02 1999-01-14 F. Hoffmann-La Roche Ag A process for the manufacture of optically active chromanylpyridine derivatives
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
AU740447B2 (en) 1997-09-23 2001-11-01 Merck & Co., Inc. Thrombin inhibitors
EP1039907A4 (en) 1997-12-01 2001-09-19 Merck & Co Inc THROMBIN HEMMER
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
IL136768A0 (en) 1997-12-22 2001-06-14 Bayer Ag INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
PT1056725E (pt) 1997-12-22 2006-09-29 Bayer Pharmaceuticals Corp Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo
AU1685999A (en) 1997-12-24 1999-07-19 Ihara Chemical Industry Co. Ltd. Pyridyloxy(thio)alkanoic acid amide derivatives and agricultural/horticultural bactericides
EP0930302B1 (en) 1998-01-16 2003-04-02 F.Hoffmann-La Roche Ag Benzosulfone derivatives
ID24959A (id) 1998-01-28 2000-08-31 Shionogi & Co Senyawa-senyawa trisiklik yang baru
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
JPH11292883A (ja) 1998-04-07 1999-10-26 Yoshitomi Fine Chemical Kk トリフェニルボロンアミン付加化合物の製造方法
PL358909A1 (en) 1998-04-27 2004-08-23 Janssen Pharmaceutica N.V. Pellets having a core coated with a lipid lowering agent and a polymer
DE69921994T2 (de) 1998-05-02 2005-12-01 Astrazeneca Ab Heterozyklische verbindungen mit faktor xa hemmender wirkung
EP1085879A2 (en) 1998-06-08 2001-03-28 Advanced Medicine, Inc. Multibinding agents that modulate the 5-ht transporter
US6197798B1 (en) 1998-07-21 2001-03-06 Novartis Ag Amino-benzocycloalkane derivatives
CO5090829A1 (es) 1998-07-21 2001-10-30 Novartis Ag Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b.
TR200100431T2 (tr) 1998-08-10 2001-06-21 Partnership Of Michael E. Garst, George Sachs & Jai Moo Proton pompalama önleyici ilaçlar
PT1107964E (pt) 1998-08-11 2010-06-11 Novartis Ag Derivados de isoquinolina com actividade inibidora da angiogénese
JP2000073094A (ja) 1998-08-28 2000-03-07 Lion Corp カビ取り剤組成物
JP2000076640A (ja) 1998-08-31 2000-03-14 Sony Corp 磁気記録再生装置
JP2000076642A (ja) 1998-08-31 2000-03-14 Sony Corp 磁気記録再生装置
JP2000076643A (ja) 1998-08-31 2000-03-14 Sony Corp 磁気ディスク装置
EP1114030B1 (en) 1998-09-15 2005-06-01 Syngenta Participations AG Pyridine ketones useful as herbicides
JP2002528723A (ja) 1998-10-27 2002-09-03 モレキュラー・プロウブズ・インコーポレーテッド 遷移金属錯体を含有する発光タンパク質染色剤
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
CA2350888A1 (en) 1998-12-04 2000-06-15 John Anthony Butera 4-3-substituted-amino-cyclobut-3-ene-1,2-diones and use for influencing smooth muscle contraction
HK1044154A1 (zh) 1998-12-04 2002-10-11 藤泽药品工业株式会社 磺酰胺化合物及其药物用途
US20020103141A1 (en) 1998-12-23 2002-08-01 Mckearn John P. Antiangiogenic combination therapy for the treatment of cancer
AR023071A1 (es) 1998-12-23 2002-09-04 Syngenta Participations Ag Compuestos de piridincetona, compuestos intermediarios, composicion herbicida e inhibidora del crecimiento de plantas, metodo para controlar la vegetacion indeseada, metodo para inhibir el crecimiento de las plantas, y uso de la composicion para controlar el crecimiento indeseado de plantas.
GB9901253D0 (en) 1999-01-20 1999-03-10 Isis Innovation Bis-terpyridine-platinum(II) complexes
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
DE19932571A1 (de) 1999-07-13 2001-01-18 Clariant Gmbh Verfahren zur Herstellung von Biarylen unter Palladophosphacyclobutan-Katalyse
AU6371900A (en) 1999-07-26 2001-02-13 Du Pont Pharmaceuticals Company Lactam inhibitors of hepatitis c virus ns3 protease
US7122627B2 (en) 1999-07-26 2006-10-17 Bristol-Myers Squibb Company Lactam inhibitors of Hepatitis C virus NS3 protease
JP2003508391A (ja) 1999-08-31 2003-03-04 マキシア・ファーマシューティカルズ・インコーポレイテッド ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用
JP2001072660A (ja) 1999-09-08 2001-03-21 Welfide Corp ＴＮＦ−α産生抑制剤および／またはＩＬ−１０産生促進剤
JP4523093B2 (ja) 1999-09-20 2010-08-11 広栄化学工業株式会社 ２−アミノ−ブロモピラジン類の製造方法
AU1053501A (en) 1999-11-02 2001-05-14 Ajinomoto Co., Inc. Polyazanaphthalene compound and medicinal use thereof
KR20020058023A (ko) 1999-11-18 2002-07-12 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 살충성 아미노헤테로시클릴아미드 화합물
US6664272B2 (en) 1999-12-03 2003-12-16 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
JP4388189B2 (ja) 2000-03-08 2009-12-24 独立行政法人科学技術振興機構 ピリジン誘導体及びその製造方法
JP2003531200A (ja) 2000-04-24 2003-10-21 アリックス セラピューティクス 糖尿病、高脂血症、高コレステロール血症、およびアテローム性動脈硬化症の治療のための材料と方法
US6768008B2 (en) 2000-04-24 2004-07-27 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
WO2001087853A1 (en) 2000-05-17 2001-11-22 Universite Catholique De Louvain Aryl-substituted n,n-heterocyclic compounds, method for their preparation and their use in therapeutics and diagnostics
KR100786927B1 (ko) 2000-06-28 2007-12-17 스미스클라인비이참피이엘시이 습식 분쇄방법
WO2002000648A1 (en) 2000-06-28 2002-01-03 Ssp Co., Ltd. Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts
MXPA03000504A (es) 2000-07-19 2003-06-24 Hoffmann La Roche Derivados de pirimidina.
US6541639B2 (en) 2000-07-26 2003-04-01 Bristol-Myers Squibb Pharma Company Efficient ligand-mediated Ullmann coupling of anilines and azoles
ATE338566T1 (de) 2000-07-27 2006-09-15 Pharmacia Corp Aldosteronantagonist und cyclooxygenase-2 hemmer- kombinationstherapie zur verhinderung oder behandlung von entzündungsverwandten kardiovaskulären krankheiten
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
WO2002024689A1 (en) 2000-09-21 2002-03-28 Aryx Therapeutics Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis
EP1334139A2 (en) 2000-11-07 2003-08-13 Symyx Technologies, Inc. Substituted pyridyl amine ligands, complexes and catalysts therefrom. processes for producing polyolefins therewith
MXPA03004458A (es) 2000-11-20 2005-01-25 Pharmacia Corp Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion.
FR2816942B1 (fr) 2000-11-23 2003-05-09 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
DE10060807A1 (de) 2000-12-07 2002-06-20 Aventis Pharma Gmbh Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
KR100844062B1 (ko) 2001-02-21 2008-07-07 미쓰이 가가쿠 가부시키가이샤 올레핀 중합용 촉매 및 이 촉매를 사용하는 올레핀중합체의 제조방법
DE60210058T2 (de) 2001-03-02 2006-11-09 F. Hoffmann-La Roche Ag Alkoxycarbonylamino-heteroaryl-carbonsäurederivate als ip-antagonisten
FR2821718B1 (fr) 2001-03-08 2003-06-13 Aventis Cropscience Sa Nouvelles compositions fongicides a base de derives de pyridylmethylbenzamide et d'imidazoline ou d'oxazolidine
JP2004523571A (ja) 2001-03-08 2004-08-05 マキシア・ファーマシューティカルズ・インコーポレイテッド Ｒｘｒ活性化分子
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
IL157009A0 (en) 2001-03-28 2004-02-08 Pfizer N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad
ATE409181T1 (de) 2001-05-08 2008-10-15 Univ Yale Proteomimetische verbindungen und verfahren
JP2002338537A (ja) 2001-05-16 2002-11-27 Mitsubishi Pharma Corp アミド化合物およびその医薬用途
JP2002338837A (ja) 2001-05-16 2002-11-27 Fuji Photo Film Co Ltd 新規化合物、色素、インク組成物、インクジェット用インク、インクジェット記録方法、及び熱転写色素
JP4026768B2 (ja) 2001-06-08 2007-12-26 日本たばこ産業株式会社 流動体の塗布装置及びその塗布ノズル
JP4180254B2 (ja) 2001-06-29 2008-11-12 独立行政法人科学技術振興機構 窒素含有６員環の製造方法
SE0102438D0 (sv) 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
JP4340404B2 (ja) 2001-07-23 2009-10-07 独立行政法人科学技術振興機構 不飽和６員環の製造方法
EP2168576A3 (en) 2001-09-14 2010-05-26 Shionogi & Co., Ltd. Tricyclic compounds for treating dyslipidemia and arteriosclerotic diseases
JP4339881B2 (ja) 2001-09-19 2009-10-07 ソフトバンクモバイル株式会社 ベアラ選択方法および移動通信端末
BR0212760A (pt) 2001-09-19 2004-12-07 Aventis Pharma Sa Compostos quìmicos
FR2830194B1 (fr) 2001-09-28 2003-12-19 Oreal Composition contenant un derive de pyrazine et utilisation pour la teinture directe ou d'oxydation et/ou l'eclaircissement optique des fibres keratiniques
FR2831022B1 (fr) 2001-10-23 2004-01-23 Aventis Cropscience Sa Composition fongicide a base d'au moins un derive de pyridylmethylbenzamide et d'au moins un derive dithiocarbamate
DE60213842T2 (de) 2001-10-30 2007-09-06 Novartis Ag Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung
US7166368B2 (en) 2001-11-07 2007-01-23 E. I. Du Pont De Nemours And Company Electroluminescent platinum compounds and devices made with such compounds
US7361671B2 (en) 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
JP4416998B2 (ja) 2001-11-19 2010-02-17 日本エンバイロケミカルズ株式会社 微生物防除剤
DE10238113A1 (de) 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
US7091357B2 (en) 2001-12-26 2006-08-15 University Of Kentucky Research Foundation Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
JP2005162612A (ja) 2002-01-09 2005-06-23 Ajinomoto Co Inc アシルスルホンアミド誘導体
CA2471566A1 (en) 2002-01-10 2003-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Combination of mtp inhibitors or apob-secretion inhibitors with fibrates for use as pharmaceuticals
AU2002357084A1 (en) 2002-01-11 2003-07-30 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
EP1470108B1 (en) 2002-01-18 2016-08-24 Vittal Mallya Scientific Research Foundation 1,4-dihydropyridine and pyridine compounds as calcium channel blockers
EP1467981A1 (en) 2002-01-25 2004-10-20 Kylix Pharmaceuticals B.V. 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
JP4467307B2 (ja) 2002-02-22 2010-05-26 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ５−ｈｔ受容体アンタゴニストとしてのピリジルスルホン誘導体
AU2003213642A1 (en) 2002-02-28 2003-09-16 Rensselaer Polytechnic Institute High-affinity, low-molecular-mass displacers for ion-exchange chromatography
US20050069551A1 (en) 2002-03-08 2005-03-31 Emory University Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis
US20040127719A1 (en) 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same
US20090011991A1 (en) 2002-03-08 2009-01-08 Emory University Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis
CN1374306A (zh) 2002-03-27 2002-10-16 江苏省农药研究所 改良的杀虫剂中间体制备方法
JP2005320249A (ja) 2002-05-01 2005-11-17 Banyu Pharmaceut Co Ltd ２−アミノピラジン誘導体の製造方法
US20060089400A1 (en) 2002-05-03 2006-04-27 The Vernalis Group Of Companies Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases
US6806265B2 (en) 2002-05-16 2004-10-19 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
PE20040522A1 (es) 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
AU2003218176A1 (en) 2002-06-11 2003-12-22 Bristol-Myers Squibb Company Asymetric synthesis of amino-pyrrolidinones
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP4178008B2 (ja) 2002-08-02 2008-11-12 日本エンバイロケミカルズ株式会社 藻類防除剤および藻類防除方法
BR0313204A (pt) 2002-08-02 2005-06-28 Pharmacia Corp Métodos para tratamento e prevenção de condições gastrointestinais
JP2003292408A (ja) 2002-08-13 2003-10-15 Takeda Chem Ind Ltd 微生物防除剤
SE0202429D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel Compounds
EP1542948A4 (en) 2002-08-23 2008-12-17 Univ Connecticut NEW BIPHENYL AND BIPHENYLENE CANNABINOIDS
EP1551369A4 (en) 2002-08-28 2007-05-09 Intermune Inc COMBINATION THERAPY FOR THE TREATMENT OF FIBROTIC DISEASES
WO2004020413A1 (ja) 2002-08-29 2004-03-11 Zeon Corporation 遷移金属化合物、共役ジエン重合用触媒、共役ジエン重合体の製造方法、ならびにポリイソプレンとその環化物およびそれらの製造方法
JP2004123617A (ja) 2002-10-03 2004-04-22 Japan Enviro Chemicals Ltd 微生物防除剤
JP4566540B2 (ja) 2002-10-03 2010-10-20 日本エンバイロケミカルズ株式会社 工業用殺菌剤、塗料、インク、樹脂エマルション、金属加工油剤、湿し水
CN1720243A (zh) 2002-10-07 2006-01-11 瓦卡尔治疗公司 具有同时阻滞l－型钙通道和抑制3型磷酸二酯酶活性能力的二氢吡啶化合物
US20070066619A1 (en) 2002-10-07 2007-03-22 Artesian Therapeutics, Inc. Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
JP3587839B2 (ja) 2002-10-23 2004-11-10 日本エンバイロケミカルズ株式会社 ビス四級アンモニウム塩化合物の安定化方法
US20040082641A1 (en) 2002-10-28 2004-04-29 Rytved Klaus Asger Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
FR2846657B1 (fr) 2002-11-05 2004-12-24 Servier Lab Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ITMI20022389A1 (it) 2002-11-12 2004-05-13 Nicox Sa Farmaci per le disfunzioni sessuali.
TWI335913B (en) 2002-11-15 2011-01-11 Vertex Pharma Diaminotriazoles useful as inhibitors of protein kinases
DE10254596A1 (de) 2002-11-22 2004-06-03 Merck Patent Gmbh Indolderivate
AU2003294442A1 (en) 2002-11-22 2004-06-18 Bristol-Myers Squibb Company 3-heterocyclic benzylamide derivatives as potassium channel openers
EP1575951B1 (en) 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
US20040127519A1 (en) 2002-12-12 2004-07-01 Pharmacia Corporation Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
MXPA05006367A (es) 2002-12-12 2005-08-29 Pharmacia Corp Metodo de uso de compuestos de aminocianopiridina como inhibidores de cinasa-2 de proteina activada de cinasa de proteina activada por mitogeno.
US20040142978A1 (en) 2002-12-12 2004-07-22 Pharmacia Corporation Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
JP4473503B2 (ja) 2002-12-16 2010-06-02 日本エンバイロケミカルズ株式会社 微生物防除剤
SE0203752D0 (sv) 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
JP3502629B1 (ja) 2002-12-26 2004-03-02 日本エンバイロケミカルズ株式会社 微生物防除剤および安定化方法
GB0300783D0 (en) 2003-01-14 2003-02-12 Btg Int Ltd Treatment of neurodegenerative conditions
GB0301350D0 (en) 2003-01-21 2003-02-19 Merck Sharp & Dohme Therapeutic agents
TW200418791A (en) 2003-01-23 2004-10-01 Bristol Myers Squibb Co Pharmaceutical compositions for inhibiting proteasome
WO2004069160A2 (en) 2003-01-28 2004-08-19 Smithkline Beecham Corporation Chemical compounds
PE20040945A1 (es) 2003-02-05 2004-12-14 Warner Lambert Co Preparacion de quinazolinas substituidas
US20060160864A1 (en) 2003-02-07 2006-07-20 Mitsuru Shiraishi Acrylamide derivative, process for producing the same, and use
CA2515235A1 (en) 2003-02-10 2004-08-19 Bayer Healthcare Ag Bis(hetero)aryl carboxamide derivatives for use as pgi2 antagonists
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
DE10315573A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
US7129264B2 (en) 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
CA2464604A1 (en) 2003-04-17 2004-10-17 Queen's University At Kingston Organic luminescent compounds and methods of making and using same
DE10318611A1 (de) 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318610A1 (de) 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
DE10318609A1 (de) 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
EP1837330B1 (en) 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
GB0311081D0 (en) 2003-05-14 2003-06-18 Btg Internat Limted Treatment of neurodegenerative conditions
US7507782B2 (en) 2003-05-21 2009-03-24 Basell Polyolefine Gmbh Transition-metal complexes with tridentate, nitrogen-containing ligands
AU2003902860A0 (en) 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
CA2526506A1 (en) 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
WO2004113258A1 (ja) 2003-06-20 2004-12-29 Shionogi & Co., Ltd. 炭素−炭素結合生成反応
EP1644325A2 (en) 2003-06-23 2006-04-12 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
WO2005005382A2 (en) 2003-07-02 2005-01-20 Cytokinetics, Inc. Compounds, compositions and methods
JP4363098B2 (ja) 2003-07-11 2009-11-11 三菱化学株式会社 ビスイミダゾピラジノン誘導体及びビスアミノピラジン誘導体
WO2005025623A2 (en) 2003-07-28 2005-03-24 Emory University Ef-24-factor vii conjugates
JP2005058997A (ja) 2003-07-30 2005-03-10 Mitsubishi Motors Corp 排気浄化触媒装置
JP2007500178A (ja) 2003-07-30 2007-01-11 サイクラセル・リミテッド プロテインキナーゼ阻害剤としてのピリジニルアミノ−ピリミジン誘導体
US7198730B2 (en) 2003-08-28 2007-04-03 E. I. Du Pont De Nemours And Company Phosphorescent material
US7504401B2 (en) 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
WO2005026166A1 (en) 2003-09-16 2005-03-24 'chemical Diversity Research Institute', Ltd. Physiologically active composition, pharmaceutical composition, substituted 1,2-dihydro[2,7] naphthyridines, method for the production and use thereof
PL1664041T3 (pl) 2003-09-22 2008-12-31 Euro Celtique Sa Przydatne do leczenia bólu związki fenylowo-karboksyamidowe
AR045944A1 (es) 2003-09-24 2005-11-16 Novartis Ag Derivados de isoquinolina 1.4-disustituidas
JP2005126586A (ja) 2003-10-24 2005-05-19 Konica Minolta Holdings Inc ポリメチン色素、光電変換材料用半導体、光電変換素子及び太陽電池
AU2004289652B8 (en) 2003-11-07 2011-01-20 Taisho Pharmaceutical Co., Ltd. Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto
FR2862304A1 (fr) 2003-11-14 2005-05-20 Centre Nat Rech Scient Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
US20080194574A1 (en) 2003-12-16 2008-08-14 Axxima Pharmaceuticals Ag Pyrazine Derivatives As Effective Compounds Against Infectious Diseases
WO2005066162A1 (en) 2003-12-23 2005-07-21 Human Biomolecular Research Institute Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer
CA2554050A1 (en) 2004-02-04 2005-08-18 Neurosearch A/S Diazabicyclic aryl derivatives as cholinergic receptor modulators
DE102004005785A1 (de) 2004-02-06 2005-08-25 Bayer Cropscience Ag 2-Halogenfuryl/thienyl-3-carboxamide
CA2555402A1 (en) 2004-02-12 2005-09-01 Celine Bonnefous Bipyridyl amides as modulators of metabotropic glutamate receptor-5
CA2557794A1 (en) 2004-03-15 2005-10-06 Eli Lilly And Company Opioid receptor antagonists
US7596407B2 (en) 2004-03-26 2009-09-29 Solvay Pharmaceuticals, B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
EP1732541A4 (en) 2004-04-07 2008-03-05 Takeda Pharmaceutical CYCLIC COMPOUNDS
US20050239826A1 (en) 2004-04-14 2005-10-27 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
TWI326282B (en) 2004-04-28 2010-06-21 Mitsubishi Tanabe Pharma Corp Heterocyclic compound
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
RU2401265C2 (ru) 2004-06-10 2010-10-10 Айрм Ллк Соединения и композиции в качестве ингибиторов протеинкиназы
RU2006144075A (ru) 2004-06-16 2008-07-27 Вайет (Us) ДИФЕНИЛИМИДАЗОПИРИМИДИН И -ИМИДАЗОЛАМИНЫ КАК ИНГИБИТОРЫ β-СЕКРЕТАЗЫ
BRPI0512213A (pt) 2004-06-16 2008-02-19 Wyeth Corp método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto
JP4413087B2 (ja) 2004-06-16 2010-02-10 新日本製鐵株式会社 スラグ砕石の製造方法
EP1841460A2 (en) 2004-06-18 2007-10-10 Neurochem (International) Limited Therapeutic formulations for the treatment of beta-amyloid related diseases
DE102004032651A1 (de) 2004-07-06 2006-02-16 Bayer Healthcare Ag Verwendung von substituierten 2-Thio-3,5-dicyano-4-phenyl-6-aminopyriden bei der Behandlung von Übelkeit und Erbrechen
JP5050312B2 (ja) 2004-07-23 2012-10-17 コニカミノルタホールディングス株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
EP1789041B1 (en) 2004-07-28 2008-07-09 F. Hoffmann-Roche AG Aryl-pyridine derivatives as 11-beta-hsd1 inhibitors
EP1798224A1 (en) 2004-10-05 2007-06-20 Shionogi Co., Ltd. Biaryl derivative
CA2584794A1 (en) 2004-10-26 2006-05-04 Third-Order Nanotechnologies, Inc. Tricyclic spacer systems for nonlinear optical devices
CA2585172C (en) 2004-10-29 2014-08-12 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
WO2006051704A1 (ja) 2004-11-15 2006-05-18 Taisho Pharmaceutical Co., Ltd. イミン化合物
JPWO2006051937A1 (ja) 2004-11-15 2008-05-29 塩野義製薬株式会社 ヘテロ５員環誘導体
JP2008520693A (ja) 2004-11-18 2008-06-19 ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー プロテインチロシンホスファターゼ阻害剤としての置換アミノ酸
JP2008520645A (ja) 2004-11-23 2008-06-19 ファイザー・プロダクツ・インク ジベンジルアミン化合物および誘導体
AU2005309019A1 (en) 2004-11-24 2006-06-01 Novartis Ag Combinations of JAK inhibitors and at least one of Bcr-Abl, Flt-3, FAK or RAF kinase inhibitors
US20080015223A1 (en) 2004-12-03 2008-01-17 Arena Pharmaceuticals, Inc. Pyrazole Derivatives as Modulators of the 5-Ht2a Serotonin Receptor Useful for the Treatment of Disorders Related Thereto
CA2591738A1 (en) 2004-12-22 2006-06-29 Merck & Co., Inc. Process for making substituted piperidines
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
MX2007008008A (es) 2004-12-30 2007-11-12 Astex Therapeutics Ltd Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora.
WO2006080884A1 (en) 2005-01-27 2006-08-03 Astrazeneca Ab Novel biaromatic compounds, inhibitors of the p2x7-receptor
DE602006010665D1 (en) 2005-02-07 2010-01-07 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1
JP2008530048A (ja) 2005-02-11 2008-08-07 バイエル・クロツプサイエンス・エス・アー ピリジルメチルベンズアミド誘導体及びチアゾールカルボキサミド誘導体を含んでいる殺菌剤組成物
MX2007010068A (es) 2005-02-16 2007-10-10 Schering Corp Piperazino-piperidinas con actividad antagonista de cxcr3.
WO2006103254A1 (en) 2005-04-01 2006-10-05 Clariant International Ltd Betaines of squaric acid for use in optical layers for optical data recording
US7820699B2 (en) 2005-04-27 2010-10-26 Hoffmann-La Roche Inc. Cyclic amines
WO2006124874A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Inhibitors of b-raf kinase
DE102005025315A1 (de) 2005-06-02 2006-12-14 Merck Patent Gmbh Ionische Flüssigkeiten mit niedriger Viskosität
US7312331B2 (en) 2005-06-17 2007-12-25 The Regents Of The University Of California Stable cyclic (alkyl)(amino) carbenes as ligands for transition metal catalysts
DE102005030400A1 (de) 2005-06-27 2006-12-28 Archimica Gmbh Verfahren zur Herstellung von Arylaminen, Arylethern und Arylthioethern
DE102005032332A1 (de) 2005-07-08 2007-01-11 Merck Patent Gmbh Metallkomplexe
WO2007009083A2 (en) 2005-07-12 2007-01-18 Acadia Pharmaceuticals Inc. Compounds with activity at retinoic acid receptors
WO2007011721A1 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
CN100562514C (zh) 2005-07-22 2009-11-25 中国科学院上海药物研究所 一类取代丙酰胺衍生物、其制备方法和用途
AU2006275403A1 (en) 2005-08-02 2007-02-08 Lexicon Pharmaceuticals, Inc. 2-aminoaryl pyridines as protein kinases inhibitors
JP4799073B2 (ja) 2005-08-04 2011-10-19 日本エンバイロケミカルズ株式会社 微生物防除剤
KR100696636B1 (ko) 2005-08-18 2007-03-19 삼성에스디아이 주식회사 염료감응 태양 전지용 염료 및 이로부터 제조된 염료감응태양 전지
JP2009506068A (ja) 2005-08-25 2009-02-12 エモリー・ユニバーシティ Ｈｉｆ阻害剤
US8071597B2 (en) 2005-08-26 2011-12-06 Merck Serono Sa Pyrazine compounds and uses as PI3K inhibitors
US8044173B2 (en) 2005-09-13 2011-10-25 University Of Reading Asymmetric synthesis of peptides
US20090215857A1 (en) 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
WO2007033196A1 (en) 2005-09-14 2007-03-22 Bristol-Myers Squibb Company Met kinase inhibitors
DE102005045132A1 (de) 2005-09-22 2007-03-29 Archimica Gmbh Verfahren zur Herstellung von 2-Arylcarbonylverbindungen, 2-Arylestern und 2-Arylnitrilen sowie ihrer heteroaromatischen Analoga
US20080255149A1 (en) 2005-09-27 2008-10-16 Novartis Ag Carboxyamine Compounds and Methods of Use Thereof
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2007145819A (ja) 2005-10-28 2007-06-14 Tanabe Seiyaku Co Ltd 医薬組成物
TW200732320A (en) 2005-10-31 2007-09-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
TW200734304A (en) 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
US7531008B2 (en) 2005-11-30 2009-05-12 L'oreal S.A. Use of at least one cationic cyanin derivative for dyeing the hair, composition containing it, process for treating keratin fibers using the composition, and device therefor
AR057959A1 (es) 2005-12-01 2007-12-26 Elan Pharm Inc 5-pirazolpiperidinas-(sustituidas)
WO2007063935A1 (ja) 2005-12-02 2007-06-07 Mitsubishi Tanabe Pharma Corporation 芳香族化合物
JP2007161674A (ja) 2005-12-16 2007-06-28 Tanabe Seiyaku Co Ltd ピペリジン化合物およびその製法
WO2007073855A1 (en) 2005-12-23 2007-07-05 Bayer Healthcare Ag Use of adenosine a1 receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases
US7855291B2 (en) 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
US8399442B2 (en) 2005-12-30 2013-03-19 Astex Therapeutics Limited Pharmaceutical compounds
DE102006000649A1 (de) 2006-01-03 2007-07-05 Degussa Gmbh Universell einsetzbare Zusammensetzungen
DE102006000651A1 (de) 2006-01-03 2007-07-12 Degussa Gmbh Präparation aus Ionischen Flüssigkeiten und Harzen
FR2896798A1 (fr) 2006-01-27 2007-08-03 Sanofi Aventis Sa Derives de sulfonamides, leur preparation et leur application en therapeutique
HUP0600101A2 (en) 2006-02-09 2007-09-28 Univ Szegedi Resolution process for the preparation of cyclic beta-amino acids esters there of
US8227093B2 (en) 2006-02-11 2012-07-24 Samsung Mobile Display Co., Ltd. Cyclometalated transition metal complex and organic electroluminescence device using the same
CN101384586A (zh) * 2006-02-14 2009-03-11 诺华公司 Pi-3激酶抑制剂及其应用方法
DE102006009813A1 (de) 2006-03-01 2007-09-06 Bayer Healthcare Ag Verwendung von A2b/A1 Rezeptor Agonisten zur Modulation der Lipidspiegel
CN101460482B (zh) 2006-03-21 2013-03-27 默沙东公司 具有cxcr3拮抗剂活性的杂环取代的吡啶化合物
JP2009533327A (ja) 2006-03-22 2009-09-17 バーテックス ファーマシューティカルズ インコーポレイテッド 増殖性疾患を処置するためのｃ−ＭＥＴキナーゼ阻害剤
US8232298B2 (en) 2006-03-22 2012-07-31 Janssen Pharmaceutica N.V. Inhibitors of the interaction between MDM2 and P53
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2007113258A1 (en) 2006-04-03 2007-10-11 Glaxo Group Limited Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
CN101466698A (zh) 2006-04-14 2009-06-24 默克公司 作为缩胆囊素-1受体调节剂的取代的咪唑4-甲酰胺类化合物
WO2007120718A2 (en) 2006-04-14 2007-10-25 Merck & Co., Inc. Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators
CN101058577A (zh) 2006-04-18 2007-10-24 中国科学院化学研究所 1,4－二氢吡啶类化合物及其制备方法
WO2007125061A1 (en) 2006-04-27 2007-11-08 Glaxo Group Limited Spirocompounds useful as modulators for dopamine d3 receptors
BRPI0710946A2 (pt) 2006-04-27 2012-03-06 Sanofi-Aventis Deutschland Gmbh inibidores dos canais de Íon task-1 e task-3
WO2007129664A1 (ja) 2006-05-02 2007-11-15 National University Corporation Nagoya University 不斉触媒作用用キラル四座配位子並びにその使用
ITMI20060895A1 (it) 2006-05-08 2007-11-09 Kemon S P A Intermedi primari per la colorazione ossidativa dei capelli
DE102006025316A1 (de) 2006-05-31 2007-12-06 Bayer Healthcare Ag Isoindolin-1-on-, Isoindolin-3-on- und Isoindolin-1,3-dion-Derivate und ihre Verwendung
US20080039450A1 (en) 2006-06-22 2008-02-14 Jensen Annika J Compounds
EP2038261A2 (en) 2006-06-22 2009-03-25 Mallinckrodt Inc. Pyrazine derivatives with extended conjugation and uses thereof
US20080280891A1 (en) 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
JP5564251B2 (ja) 2006-06-29 2014-07-30 キネックス ファーマシューティカルズ， エルエルシー キナーゼカスケードを調節するためのビアリール組成物および方法
ES2500165T3 (es) 2006-06-29 2014-09-30 Kinex Pharmaceuticals, Llc Composiciones de biarilo y métodos para modular una cascada de quinasas
WO2008005937A2 (en) 2006-06-30 2008-01-10 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases through inhibiton of hsp90
US20080032992A1 (en) 2006-07-04 2008-02-07 Astrazeneca Ab New Pyridine Analogues V
JP5054770B2 (ja) 2006-07-11 2012-10-24 デウン ファーマシューティカル カンパニー リミテッド 新規のビアリールベンゾイミダゾール誘導体及びこれを含む医薬組成物
ITMI20061368A1 (it) 2006-07-14 2008-01-15 Acraf Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
MX2009000577A (es) 2006-07-14 2009-03-09 Schering Corp Compuestos de piperazina sustituida heterociclica con actividad antagonista de cxcr3.
KR101403887B1 (ko) 2006-08-03 2014-06-20 트러스티즈 오브 터프츠 칼리지 홍조화를 유발하지 않는 니아신 유사체, 및 이의 사용 방법
EP1900727A1 (en) 2006-08-30 2008-03-19 Cellzome Ag Aminopyridine derivatives as kinase inhibitors
CA2662359A1 (en) 2006-09-21 2008-03-27 Novartis Ag Pyrrole derivatives useful for the treatment of cytokine-mediated diseases
KR100932093B1 (ko) 2006-09-27 2009-12-16 주식회사종근당 미세소관 형성 저해제로서 유용한 벤조페논 유도체
GB0619342D0 (en) 2006-09-30 2006-11-08 Vernalis R&D Ltd New chemical compounds
JPWO2008044713A1 (ja) 2006-10-10 2010-02-18 日本農薬株式会社 置換ピリジンカルボン酸アニリド誘導体又はその塩類、及び農園芸用薬剤並びにその使用方法
DE102006048042A1 (de) 2006-10-11 2008-04-17 Bayer Healthcare Ag Acylaminoimidazole und Acylaminothiazole
DE102006048924A1 (de) 2006-10-17 2008-04-24 Bayer Healthcare Ag Acylaminopyrazole
US7820605B2 (en) 2006-10-27 2010-10-26 Chevron Oronite Company Llc Lubricating oil additive composition and method of making the same
MX2009004623A (es) 2006-10-30 2009-05-15 Novartis Ag Imidazopiridazinas como inhibidores de la lipido cinasa pi3k.
KR101146875B1 (ko) 2006-11-01 2012-05-16 에스케이이노베이션 주식회사 전이금속 촉매계 및 이를 이용한 에틸렌 단독중합체 또는에틸렌과 올레핀의 공중합체 제조방법
JP2009023986A (ja) 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
WO2008073480A1 (en) 2006-12-11 2008-06-19 Irm Llc Compounds and compositions as kinase inhibitors
GB0624689D0 (en) 2006-12-11 2007-01-17 Glaxo Group Ltd Novel fluorescent kinase ligands and methods employing the same
US8466163B2 (en) 2006-12-11 2013-06-18 Bionomics Limited Furo[2,3-d]pyrimidines and related compounds and methods for treating disease states by inhibiting tubulin polymerization
UA99270C2 (en) 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
FR2910298A1 (fr) 2006-12-20 2008-06-27 Oreal Composition tinctoriale contenant une silicone reactive, un colorant fluorescent ou azurant optique, procede de coloration utilisant la composition
GB0625659D0 (en) 2006-12-21 2007-01-31 Cancer Rec Tech Ltd Therapeutic compounds and their use
TW200840566A (en) 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
EP1938686A1 (de) 2006-12-29 2008-07-02 Bayer CropScience AG Substituierte 1-(3-Pyridinyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
FR2911876B1 (fr) 2007-01-29 2009-03-06 Rhodia Recherches & Tech Nouveaux complexes organometalliques mixtes a base de carbenes a motif alkyllaminocyclique.
AU2008210455A1 (en) 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
US20080269241A1 (en) 2007-02-15 2008-10-30 Darin Allen Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
EP1975159A1 (en) 2007-03-27 2008-10-01 Bayer Schering Pharma Aktiengesellschaft 2,3,4,9-Tetrahydro-1H-carbazoles
EP1974729A1 (en) 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
WO2008124092A2 (en) 2007-04-03 2008-10-16 E. I. Du Pont De Nemours And Company Substituted benzene fungicides
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
US7482492B2 (en) 2007-04-12 2009-01-27 Xerox Corporation Cost effective method for synthesis of triarylamine compounds
WO2008127727A1 (en) 2007-04-13 2008-10-23 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
EP1985445B1 (en) 2007-04-27 2011-07-20 Agfa Graphics N.V. A lithographic printing plate precursor
EP2146702A2 (en) 2007-05-03 2010-01-27 NorthEastern University Methods of treating fungal infections
US8263585B2 (en) 2007-05-04 2012-09-11 Novartis Ag Organic compounds
CN101679150B (zh) 2007-05-17 2013-05-15 Lg化学株式会社 蒽衍生物和使用该蒽衍生物的有机电子器件
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
EP1997493A1 (en) 2007-05-28 2008-12-03 Laboratorios del Dr. Esteve S.A. Combination of a 5-HT7 receptor ligand and an opioid receptor ligand
TW200846319A (en) 2007-05-28 2008-12-01 China Petrochemical Dev Corp Method for preparing carbonate diester
WO2008150899A1 (en) 2007-05-29 2008-12-11 Emory University Combination therapies for treatment of cancer and inflammatory diseases
US20100176380A1 (en) 2007-05-30 2010-07-15 Ho Kuk Jung Organic photoelectric device and material used therein
JP2009007342A (ja) 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
AU2008259804B2 (en) 2007-06-05 2013-04-18 Sanofi-Aventis Substituted benzoylamino-indan-2-carboxylic acids and related compounds
JP5104060B2 (ja) 2007-06-25 2012-12-19 コニカミノルタホールディングス株式会社 有機エレクトロルミネッセンス素子材料、有機エレクトロルミネッセンス素子、表示装置及び照明装置
EP2170335A1 (en) 2007-06-26 2010-04-07 Lexicon Pharmaceuticals, Inc. Compositions comprising tryptophan hydroxylase inhibitors
GB0713259D0 (en) 2007-07-09 2007-08-15 Astrazeneca Ab Pyrazine derivatives 954
MY150032A (en) 2007-07-19 2013-11-29 Merck Sharp & Dohme Heterocyclic amide compounds as protein kinase inhibitors
BRPI0813629A2 (pt) 2007-07-26 2018-07-10 Novartis Ag derivados de pirimidina úteis no tratamento de condições inflamatórias ou alérgicas
TWI388566B (zh) 2007-08-29 2013-03-11 Nat Univ Tsing Hua 含有碳烯配位基之過渡金屬錯合物及其在有機電激發光元件之應用
WO2009039181A2 (en) 2007-09-17 2009-03-26 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of Or. State Univ. Sulfonamide-based organocatalysts and method for their use
WO2009051705A1 (en) 2007-10-18 2009-04-23 Merck & Co., Inc. Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
FR2922550B1 (fr) 2007-10-19 2009-11-27 Sanofi Aventis Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
EP2211620B1 (en) 2007-10-25 2013-12-25 Merck Sharp & Dohme Corp. 3-PYRAZIN SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AS JANUS KINASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES
KR100957620B1 (ko) 2007-11-01 2010-05-13 제일모직주식회사 유기광전소자용 재료, 및 이를 이용한 유기광전소자
US7960547B2 (en) 2007-12-03 2011-06-14 Chien-Hong Cheng Transition metal complexes with carbene ligands and their application
CN101450939B (zh) 2007-12-05 2013-06-19 沈阳药科大学 新型苯并咪唑类化合物
WO2009073246A1 (en) 2007-12-06 2009-06-11 Universal Display Corporation Method for the synthesis of iridium (iii) complexes with sterically demanding ligands
CA2707989A1 (en) 2007-12-07 2009-06-11 Novartis Ag Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases
JP2009185020A (ja) 2008-01-11 2009-08-20 Ishihara Sangyo Kaisha Ltd ピリジルアミジン誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤
GB0801199D0 (en) 2008-01-23 2008-02-27 Acal Energy Ltd Fuel cells
US20100311582A1 (en) 2008-01-25 2010-12-09 Syngenta Crop Protection, Inc. Chemical compounds
CA2714181C (en) 2008-02-04 2013-12-24 Mercury Therapeutics, Inc. Ampk modulators
AU2009215033A1 (en) 2008-02-15 2009-08-20 Merck Sharp & Dohme Corp. Fused pyridone M1 receptor positive allosteric modulators
JP2011513233A (ja) 2008-02-22 2011-04-28 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｇｐｒ１１９活性モジュレーターとしての化合物および組成物
GB0804067D0 (en) 2008-03-04 2008-04-09 Syngenta Participations Ag Chemical compounds
CA2718241A1 (en) 2008-03-11 2009-09-17 Neurosearch A/S Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors
GB0804702D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
GB0804701D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
JP5509104B2 (ja) 2008-03-14 2014-06-04 エグゼリクシス， インコーポレイテッド １１β−ＨＳＤ１モジュレータとしてのアザビシクロ［３．２．１］オクチル誘導体
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
FR2928922B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
US8236446B2 (en) 2008-03-26 2012-08-07 Ada Technologies, Inc. High performance batteries with carbon nanomaterials and ionic liquids
EP2272822A4 (en) 2008-03-31 2012-01-18 Renascience Co Ltd PLASMINOG ACTIVATOR-1 HEMMER
GB2472554B (en) 2008-05-05 2012-12-05 Ada Technologies Inc High performance carbon nanocomposites for ultracapacitors
PT2303270T (pt) 2008-05-05 2017-08-25 Sanofi Sa Derivados fundidos do ácido ciclopentanocarboxílico substituídos por acilamino e sua utilização como produtos farmacêuticos
FR2930939B1 (fr) 2008-05-09 2010-07-30 Sanofi Aventis Derives de pyrrole, leur preparation et leur application en therapeutique
AU2009252615B2 (en) 2008-05-29 2013-08-15 Kowa Company, Ltd. Substituted carbinol compound having cyclic linker
CN101591332B (zh) 2008-05-30 2014-04-16 莱西肯医药有限公司 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法
CN102056897B (zh) 2008-06-05 2014-05-07 旭化成制药株式会社 磺酰胺化合物及其用途
ES2383246T3 (es) 2008-06-05 2012-06-19 Glaxo Group Limited 4-amino-indazoles
JP2011526294A (ja) 2008-06-25 2011-10-06 エンビボ ファーマシューティカルズ インコーポレイテッド ホスホジエステラーゼ１０阻害剤としての二置換フェニル化合物
KR101015858B1 (ko) 2008-06-26 2011-02-23 제일모직주식회사 유기 화합물, 및 이를 포함하는 유기 광전 소자
TW201002202A (en) 2008-06-27 2010-01-16 Du Pont Fungicidal pyridines
CN101619056B (zh) 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
TWI436973B (zh) 2008-08-07 2014-05-11 China Petrochemical Dev Corp 碳氫化合物之液相氧化方法
JP2012500223A (ja) 2008-08-15 2012-01-05 ローカス ファーマスーティカルズ，インコーポレイテッド Ｍａｐキナーゼインヒビターとしての尿素誘導体
PL2344474T3 (pl) 2008-09-02 2016-03-31 Novartis Ag Pochodne pikolinamidu jako inhibitory kinaz
WO2010027583A1 (en) 2008-09-03 2010-03-11 Universal Display Corporation Phosphorescent materials
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
WO2010029300A1 (en) 2008-09-12 2010-03-18 Biolipox Ab Bis aromatic compounds for use in the treatment of inflammation
JP5608655B2 (ja) 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
EP2168965A1 (en) 2008-09-25 2010-03-31 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine, imidazopyrazine, imidazopyridazine and imidazopyrimidine derivatives as melanocortin-4 receptor antagonists
WO2010042500A2 (en) 2008-10-06 2010-04-15 Emory University Heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
EP2344636B1 (en) 2008-10-09 2017-12-06 Howard Hughes Medical Institute Novel chimeric ligand-gated ion channels and methods of use thereof
US8435911B2 (en) 2008-10-16 2013-05-07 Basell Polyolefine Gmbh Hybrid catalyst composition for polymerization of olefins
FR2937262B1 (fr) 2008-10-17 2010-11-05 Inst Francais Du Petrole Procede de preparation d'une composition catalytique pour la dimerisation, la co-dimerisation et l'oligomerisation des olefines.
JP2012506381A (ja) 2008-10-21 2012-03-15 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−ＭＥＴタンパク質キナーゼ阻害剤
AU2008363274A1 (en) 2008-10-24 2010-04-29 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
CA2743134A1 (en) 2008-11-10 2010-05-14 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2010056992A1 (en) 2008-11-13 2010-05-20 The Trustees Of Columbia University In The City Of New York Methods of preventing and treating low bone mass diseases
WO2010061903A1 (ja) * 2008-11-27 2010-06-03 塩野義製薬株式会社 Pi3k阻害活性を有するピリミジン誘導体およびピリジン誘導体
WO2010065333A1 (en) 2008-12-01 2010-06-10 Lexicon Pharmaceuticals, Inc. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis
JP2010143829A (ja) 2008-12-16 2010-07-01 Dainippon Sumitomo Pharma Co Ltd 新規なイミダゾキノリン誘導体
KR20110099740A (ko) 2008-12-18 2011-09-08 이 아이 듀폰 디 네모아 앤드 캄파니 글루타로니트릴로부터 다이아미노피리딘의 합성을 위한 연속 액체상 방법
DE102009055828A1 (de) 2008-12-19 2010-07-01 Merck Patent Gmbh Verfahren zur Herstellung metallbeschichteter Partikel
ES2921576T3 (es) 2008-12-19 2022-08-29 Vertex Pharma Compuestos útiles como inhibidores de la quinasa ATR
TW201024259A (en) 2008-12-24 2010-07-01 China Petrochemical Dev Corp Method for preparing organic carboxylic acid ester
CN101781200B (zh) 2009-01-20 2013-04-03 中国石油化学工业开发股份有限公司 有机羧酸酯的制造方法
WO2010091384A2 (en) 2009-02-09 2010-08-12 Georgetown University Cadherin-11 inhibitors and methods of use thereof
SI2396307T1 (sl) 2009-02-11 2015-02-27 Merck Patent Gmbh Novi amino azaheterockliäśni karboksamidi
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
CN101513584B (zh) 2009-03-04 2011-11-09 中国科学院过程工程研究所 一种基于碱性离子液体催化剂的氧化脱硫方法
WO2010111573A1 (en) 2009-03-27 2010-09-30 Abbott Laboratories Compounds as cannabinoid receptor ligands
BRPI1014572B8 (pt) * 2009-04-16 2022-07-19 Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii Imidazopirazinas para uso como inibidores de cinase
UY32582A (es) * 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
JP2012162460A (ja) 2009-05-27 2012-08-30 Nippon Soda Co Ltd 含窒素ヘテロアリール誘導体および農園芸用殺菌剤
WO2010138901A1 (en) 2009-05-29 2010-12-02 Biogen Idec Ma Inc Carboxylic acid-containing compounds, derivatives thereof, and related methods of use
WO2010148351A1 (en) 2009-06-18 2010-12-23 Cylene Pharmaceuticals, Inc. Rhodanines and related heterocycles as kinase inhibitors
EP2445879A1 (en) 2009-06-25 2012-05-02 Institut Univ. de Ciència i Tecnologia, S.A. N-(2-oxo-1-phenylpiperidin-3-yl) sulfonamides for the identification of biological and pharmacological activity
ES2354550B1 (es) 2009-06-26 2011-11-15 Institut Univ. De Ciència I Tecnologia, S.A. Biblioteca de n-(1-fenil-2-oxo-3-piperidil)sulfonamidas para el descubrimiento de fármacos.
ES2354551B1 (es) 2009-07-01 2011-11-15 Institut Univ. De Ciencia I Tecnologia S.A. Bibliotecas de n-(1-fenil-2-oxo-3-piperidil)sulfonamidas para la identificación de actividad biológica y farmacológica.
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US20140004565A1 (en) 2009-07-06 2014-01-02 Alnylam Pharmaceuticals, Inc. Cell-based bioprocessing
JP2014501097A (ja) 2009-07-06 2014-01-20 アルナイラム ファーマシューティカルズ， インコーポレイテッド 生物由来物質の産生を高めるための組成物及び方法
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2011005842A1 (en) 2009-07-09 2011-01-13 Gilead Sciences, Inc. Anti-rsv compounds
JP4590020B1 (ja) 2009-07-31 2010-12-01 富士フイルム株式会社 電荷輸送材料及び有機電界発光素子
JP4599469B1 (ja) 2009-08-31 2010-12-15 富士フイルム株式会社 有機電界発光素子用材料及び有機電界発光素子
FR2949465B1 (fr) 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
EP2473041B1 (en) 2009-09-04 2018-03-07 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
WO2011032034A2 (en) 2009-09-10 2011-03-17 University Of Idaho Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
US20110230465A1 (en) 2009-09-18 2011-09-22 Boehringer Ingleheim International Gmbh Viral polymerase inhibitors
US20130029967A1 (en) 2009-09-24 2013-01-31 Centro Nacional De Investigaciones Oncologicas (Cnio) Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
CN102639495A (zh) 2009-10-06 2012-08-15 百时美施贵宝公司 吡咯烷gpr40调节剂
WO2011050323A1 (en) 2009-10-22 2011-04-28 The Washington University Compounds and methods for treating bacterial infections
WO2011049150A1 (en) 2009-10-22 2011-04-28 Sumitomo Chemical Company, Limited Pyrone compound and its use for pest control
CN101712809A (zh) 2009-10-30 2010-05-26 上海拓引数码技术有限公司 一种有机染料、其制备方法及含该有机染料的可录式光学信息记录介质
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
EP3296398A1 (en) 2009-12-07 2018-03-21 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
WO2011072064A1 (en) 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
JPWO2011071109A1 (ja) 2009-12-11 2013-04-22 塩野義製薬株式会社 アミノ基を有する縮合ヘテロ環化合物
WO2011081945A2 (en) 2009-12-14 2011-07-07 Cornell University Activation and activators of sirt6
MX2012006776A (es) 2009-12-14 2012-10-05 Merck Patent Gmbh Inhibidores de la esfingosina quinasa.
WO2011081937A1 (en) 2009-12-15 2011-07-07 Gilead Sciences, Inc. Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
US20110190267A1 (en) 2010-01-05 2011-08-04 Shire Pharmaceuticals, Inc. Prodrugs of opioids and uses thereof
US20130109758A1 (en) 2010-01-06 2013-05-02 The University Of British Columbia Bisphenol derivative therapeutics and methods for their use
JP5735986B2 (ja) 2010-01-18 2015-06-17 エムエムヴィ メディシンズ フォア マラリア ヴェンチャーＭｍｖ Ｍｅｄｉｃｉｎｅｓ Ｆｏｒ Ｍａｌａｒｉａ Ｖｅｎｔｕｒｅ 新規抗マラリア剤
GEP20146177B (en) 2010-01-27 2014-10-10 Boehringer Ingelheim Int Pyrazole compounds as crth2 antagonists
BR112012018954A2 (pt) 2010-02-05 2016-04-12 Merck Patent Gmbh derivados de hetaril-[1,8]naftiridina
MX2012010035A (es) 2010-03-16 2012-10-01 Aventis Pharma Inc Pirimidinas sustituidas como antagonistas del receptor de la prostaglandina d2.
JP6161537B2 (ja) 2010-04-07 2017-07-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物及び使用の方法
WO2011129936A2 (en) 2010-04-16 2011-10-20 Kinex Pharmaceuticals, Llc Compositions and methods for the prevention and treatment of cancer
EP2568984A1 (en) 2010-05-12 2013-03-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
FR2959944B1 (fr) 2010-05-12 2012-06-08 Inst Francais Du Petrole Solution absorbante contenant un inhibiteur de degradation derive de la pyridine et procede d'absorption de composes acides contenus dans un effluent gazeux.
CA2798760A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as inhibitors of atr kinase
WO2011143365A1 (en) 2010-05-13 2011-11-17 Amgen Inc. Nitrogen heterocyclic compounds useful as pde10 inhibitors
TWI428343B (zh) 2010-05-14 2014-03-01 Nat Univ Tsing Hua 無硫氰酸根配基的光敏錯合物及敏化染料太陽能電池
CA2836175A1 (en) 2010-05-28 2011-12-01 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
ES2539379T3 (es) 2010-06-22 2015-06-30 Basf Se Procedimiento de preparación de 4-hidroxipiridinas
UY33469A (es) 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
US8846931B2 (en) 2010-07-05 2014-09-30 Merck Patent Gmbh Bipyridyl derivatives
JP2013531030A (ja) 2010-07-12 2013-08-01 ファイザー・リミテッド 電位開口型ナトリウムチャネルの阻害剤としてのｎ−スルホニルベンズアミド
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
ES2550939T3 (es) 2010-07-16 2015-11-13 Nivalis Therapeutics, Inc. Nuevos compuestos de dihidropiridin-2-(1H)-ona como inhibidores de la S-nitrosoglutatión reductasa y antagonistas del receptor de la neurocinina-3
JP5587701B2 (ja) 2010-08-06 2014-09-10 日本エンバイロケミカルズ株式会社 実験用水循環／収容装置用微生物防除剤、および実験用水循環／収容装置の微生物防除方法
US9326987B2 (en) 2010-09-08 2016-05-03 Glaxo Group Limited Indazole derivatives for use in the treatment of influenza virus infection
WO2012036278A1 (ja) 2010-09-17 2012-03-22 大正製薬株式会社 グリシントランスポーター阻害物質
ES2379919B1 (es) 2010-10-06 2013-03-19 Consejo Superior De Investigaciones Científicas (Csic) SÍNTESIS DE PIRIDONAS BICÍCLICAS QUE CONTIENEN EL SISTEMA HETEROCÍCLICO DE IMIDAZOL(1,2-a)PIRIDINA, A PARTIR DE 2-AMINO-6-(PROP-2-IN-1-IL AMINO) PIRIDINAS.
JP2013544827A (ja) 2010-11-24 2013-12-19 エクセリクシス， インク． ＰＩ３Ｋ／ｍＴＯＲの阻害剤としてのベンゾオキサゼピン類ならびにそれらの使用法および製造法
GB201020161D0 (en) 2010-11-26 2011-01-12 Almac Discovery Ltd Pharmaceutical compounds
IT1402842B1 (it) 2010-11-30 2013-09-27 Annunziato 7-nitro-5-fenil-1(pirrolidin-1-ilmetil)-1h-benzo[e][1,4] diazepin-2(3h)-one ed altri composti derivati delle benzodiazepine.
KR101728898B1 (ko) 2010-12-07 2017-04-21 광주과학기술원 신규한 하이드라진 유도체 및 이의 용도
DE102010054892A1 (de) 2010-12-17 2012-06-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung eines Polyesters sowie Zusammensetzung und Formkörper umfassend einen derartigen Polyester
CN102125875B (zh) 2011-01-20 2012-09-05 郑州大学 二茂铁亚胺环钯-膦加合物在不对称联芳化合物合成中的应用
US20130306962A1 (en) 2011-02-11 2013-11-21 Universal Display Corporation Organic light emitting device and materials for use in same
IT1404379B1 (it) 2011-02-11 2013-11-22 Lembo Eterocicli ad attivita' antiipertensiva
JP5964328B2 (ja) 2011-02-11 2016-08-03 ユニバーサル ディスプレイ コーポレイション 有機発光素子及び該有機発光素子に使用されるための材料
WO2012112958A2 (en) 2011-02-19 2012-08-23 The Broad Institute, Inc High-throughput assays to probe leukemia within the stromal niche
US20140171525A1 (en) 2011-02-21 2014-06-19 Honeywell International Inc. Polyurethane foam premixes containing halogenated olefin blowing agents and foams made from same
US11179500B2 (en) 2011-02-24 2021-11-23 Emory University JAB1 inhibitory compositions for ossification and methods related thereto
US8962623B2 (en) 2011-03-04 2015-02-24 Locus Pharmaceuticals, Inc. Aminopyrazine compounds
US9108984B2 (en) * 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012136111A1 (zh) 2011-04-02 2012-10-11 中国人民解放军军事医学科学院毒物药物研究所 苯丙酸化合物、其制备方法及其医药用途
MX2013011450A (es) 2011-04-05 2014-02-03 Vertex Pharma Compuestos de aminopirazina utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr).
HRP20170422T1 (hr) 2011-04-12 2017-06-16 Chong Kun Dang Pharmaceutical Corp. 3-(2-aril-cikloalkenilmetil)-oksazolidin-2-on derivati kao inhibitori transportnog proteina estera kolesterola (cetp)
CA2834928C (en) 2011-05-03 2017-10-17 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US20120289481A1 (en) 2011-05-13 2012-11-15 O'neil Jennifer Compositions and methods for treating cancer
EP2524918A1 (en) 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
AR086539A1 (es) 2011-05-24 2014-01-08 Bristol Myers Squibb Co COMPUESTOS PARA LA REDUCCION DE LA PRODUCCION DE b-AMILOIDE
EP2714698B1 (en) 2011-05-31 2016-11-09 Merck Patent GmbH Compounds containing hydrido-tricyano-borate anions
AR086653A1 (es) 2011-06-03 2014-01-15 Bristol Myers Squibb Co COMPUESTOS PARA LA REDUCCION DE PRODUCCION DE b-AMILOIDE
CN102260218B (zh) 2011-06-07 2013-05-08 北京理工大学 一种胺基吡嗪香料的合成方法
ITMI20110208U1 (it) 2011-06-17 2012-12-18 Masterlab S R L Unipersonale Dispositivo per il collegamento a un profilato per telai di serramenti con canale aperto di una piastra di copertura di detto canale e kit di copertura di un canale aperto di un profilato per telai di serramenti
US9309250B2 (en) 2011-06-22 2016-04-12 Vertex Pharmaceuticals Incorporated Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
WO2012177639A2 (en) 2011-06-22 2012-12-27 Alnylam Pharmaceuticals, Inc. Bioprocessing and bioproduction using avian cell lines
US8822469B2 (en) 2011-06-22 2014-09-02 Vertex Pharmaceuticals Incorporated Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
KR101502500B1 (ko) 2011-07-01 2015-03-16 주식회사 엘지화학 비수 전해액 및 이를 이용한 리튬 이차전지
CN102850328B (zh) 2011-07-01 2014-12-24 苏州东南药业股份有限公司 吡啶类化合物、其制备方法、包含该化合物的药物组合物及其用途
EP2543673A1 (de) 2011-07-08 2013-01-09 cynora GmbH Kupfer(I)komplexe für opto-elektronische Vorrichtungen
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
AU2012293417A1 (en) 2011-08-10 2013-05-02 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
JP2014522873A (ja) 2011-08-12 2014-09-08 ビーエーエスエフ ソシエタス・ヨーロピア アントラニルアミド化合物および殺虫剤としてのその使用
WO2013024003A1 (en) 2011-08-12 2013-02-21 Basf Se N-thio-anthranilamide compounds and their use as pesticides
SI2744330T1 (sl) 2011-08-15 2020-11-30 University Of Utah Research Foundation Substituirani (E)-N'-(1-feniletiliden) benzohidrazidni analogi kot inhibitorji histon-demetilaze
US20140243196A1 (en) 2011-08-18 2014-08-28 Basf Se Carbamoylmethoxy- and Carbamoylmethylthio- and Carbamoylmethylamino Benzamides for Combating Invertebrate Pests
CL2014000498A1 (es) 2011-08-29 2014-12-19 Infinity Pharmaceuticals Inc Compuestos heterociclicos, inhibidores selectivos de isoformas de pi3k de clase i; composicion farmaceutica que los comprende; y metodo para tratar un trastorno selccionado de cancer, una enfermedad antiinflamaoria o una enfermedad autoinmune.
PT3513793T (pt) 2011-09-02 2021-05-10 Incyte Holdings Corp Heterociclilaminas como inibidores de pi3k
US9518217B2 (en) 2011-09-06 2016-12-13 E Ink Holdings Inc. Transition metal carbene complexes and the electroluminescent application thereof
WO2013040276A1 (en) 2011-09-13 2013-03-21 California Institute Of Technology Multi-metallic organometallic complexes, and related polymers, compositions, methods and systems
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
CN104024267A (zh) 2011-09-20 2014-09-03 道康宁公司 含铁硅氢加成催化剂及含有该催化剂的组合物
WO2013043846A1 (en) 2011-09-20 2013-03-28 Dow Corning Corporation Metal containing hydrosilylation catalysts and compositions containing the catalysts
US20140182483A1 (en) 2011-09-20 2014-07-03 Dow Corning Corporation Titanium Containing Hydrosilylation Catalysts And Compositions Containing The Catalysts
US20140228573A1 (en) 2011-09-20 2014-08-14 Dow Corning Corporation Zirconium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts
WO2013043765A2 (en) 2011-09-20 2013-03-28 Dow Corning Corporation Hafnium containing hydrosilylation catalysts and compositions containing the catalysts
CN103857685A (zh) 2011-09-20 2014-06-11 道康宁公司 含钒硅氢加成催化剂及含有该催化剂的组合物
CN103814037A (zh) 2011-09-20 2014-05-21 道康宁公司 含锰硅氢加成催化剂及含有该催化剂的组合物
US20140225027A1 (en) 2011-09-20 2014-08-14 Dow Corning Corporation Silver Containing Hydrosilylation Catalysts And Compositions Containing The Catalysts
WO2013043767A2 (en) 2011-09-20 2013-03-28 Dow Corning Corporation Rhenium containing hydrosilylation catalysts and compositions containing the catalysts
CN106496173A (zh) 2011-09-30 2017-03-15 沃泰克斯药物股份有限公司 用于制备可用作atr激酶抑制剂的化合物的方法
WO2013052391A1 (en) 2011-10-05 2013-04-11 Merck Sharp & Dohme Corp. PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
US9123897B2 (en) 2011-10-14 2015-09-01 Hodogaya Chemical Co., Ltd. Benzotriazole derivatives and organic electroluminescent devices using the derivatives
JP6177246B2 (ja) 2011-10-17 2017-08-09 ザ・ジョンズ・ホプキンス・ユニバーシティ ヒドロキシルアミンで置換された、ｈｎｏ供与体としてのメルドラム酸、バルビツール酸、及びピラゾロンの誘導体
SG11201401856VA (en) 2011-10-26 2014-05-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
US9586964B2 (en) 2011-10-28 2017-03-07 Vanderbilt University Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
CN103087050A (zh) 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 芳基激酶抑制剂
JPWO2013069242A1 (ja) 2011-11-07 2015-04-02 出光興産株式会社 有機エレクトロルミネッセンス素子用材料及びそれを用いた有機エレクトロルミネッセンス素子
US8841337B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US8846918B2 (en) 2011-11-09 2014-09-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US8846917B2 (en) 2011-11-09 2014-09-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US8841450B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US9133131B2 (en) 2011-11-15 2015-09-15 Purdue Pharma L.P. Pyrimidine diol amides as sodium channel blockers
ES2565821T3 (es) 2011-11-21 2016-04-07 Basf Se Proceso para preparar compuestos 1H-pirazol-5-carboxilato N-sustituidos y derivados de los mismos
JP2013129653A (ja) 2011-11-22 2013-07-04 Nissan Chem Ind Ltd トリアゾ−ル誘導体および有害生物防除剤
JP2013129651A (ja) 2011-11-22 2013-07-04 Nissan Chem Ind Ltd チアゾール誘導体および有害生物防除剤
EP2790705B1 (en) 2011-12-15 2017-12-06 Novartis AG Use of inhibitors of the activity or function of pi3k
WO2013088315A1 (en) 2011-12-15 2013-06-20 Pfizer Limited Sulfonamide derivatives
US8859584B2 (en) 2011-12-19 2014-10-14 Abbvie, Inc. TRPV1 antagonists
US8969325B2 (en) 2011-12-19 2015-03-03 Abbvie Inc. TRPV1 antagonists
CN103159738B (zh) 2011-12-19 2016-09-07 上海泓博智源医药股份有限公司 炔基桥连的杂芳香化合物及其应用
WO2013092936A2 (en) 2011-12-20 2013-06-27 Galderma Research & Development Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne
US20130190356A1 (en) 2011-12-22 2013-07-25 Genentech, Inc. Benzyl sulfonamide derivatives as rorc modulators
JP2014015447A (ja) 2011-12-22 2014-01-30 Nissan Chem Ind Ltd ピラゾール誘導体および有害生物防除剤
US20150001516A1 (en) 2011-12-27 2015-01-01 Konica Minolta, Inc. Transparent electrode, electronic device, organic electroluminescence element, and method for manufacturing organic electroluminescence elements
US20150291514A1 (en) 2012-01-04 2015-10-15 Pfizer Limted N-Aminosulfonyl Benzamides
IN2012DE00110A (enExample) 2012-01-11 2015-05-08 Syngenta Ltd
DK2810937T3 (en) 2012-01-31 2017-03-13 Daiichi Sankyo Co Ltd PYRIDONE DERIVATIVES
WO2013117649A1 (en) 2012-02-10 2013-08-15 Galapagos Nv Imidazo [4, 5 -c] pyridine derivatives useful for the treatment of degenerative and inflammatory diseases
US9138492B2 (en) 2012-02-23 2015-09-22 Canon Kabushiki Kaisha Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle
US9340549B2 (en) 2012-03-05 2016-05-17 Amgen Inc. Oxazolidinone compounds and derivatives thereof
US20150119394A1 (en) 2012-03-28 2015-04-30 Merck Sharp & Dohme Corp. Insulin-Like Growth Factor-1 Receptor Inhibitors
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
DE102012006896A1 (de) 2012-04-05 2013-10-10 Merck Patent Gmbh Silikate mit organischen Kationen
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR101749611B1 (ko) 2012-04-12 2017-06-21 벌시테크 리미티드 유기발광다이오드용 백금(ⅱ) 착화합물
WO2013161929A1 (ja) 2012-04-26 2013-10-31 塩野義製薬株式会社 ピリジニルモルホリノン誘導体およびそれらを含有する医薬組成物
WO2013162061A1 (ja) 2012-04-26 2013-10-31 第一三共株式会社 二環性ピリミジン化合物
KR101383239B1 (ko) 2012-04-30 2014-04-10 한국화학연구원 베타-세크리테아제 활성을 억제하는 4-(벤즈이미다졸-2-일아미노)피롤리딘 유도체 및 이를 유효성분으로 함유하는 약제학적 조성물
CA2871270A1 (en) 2012-05-02 2013-11-07 Lupin Limited Substituted pyridine compounds as crac modulators
JP2014001205A (ja) 2012-05-22 2014-01-09 Nissan Chem Ind Ltd 動物の寄生虫防除剤
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds
US20150150935A1 (en) 2012-06-05 2015-06-04 Cara Therapeutics, Inc. Peripheral kappa receptor agonists for reducing pain and inflammation
EP2676947A1 (de) 2012-06-18 2013-12-25 LANXESS Deutschland GmbH Verfahren zur Isomerisierung von subsituierten Aromaten unter Verwendung einer Salzschmelze
CN103524372B (zh) 2012-07-03 2015-06-10 南京圣和药业股份有限公司 一种组蛋白去乙酰化酶抑制剂
JP2014111559A (ja) 2012-07-04 2014-06-19 Nissan Chem Ind Ltd ピラゾール誘導体および有害生物防除剤
WO2014007395A1 (ja) 2012-07-06 2014-01-09 日産化学工業株式会社 ピラゾール若しくはチアゾール誘導体又はその塩及び有害生物防除剤
JP2015003895A (ja) 2012-07-06 2015-01-08 日産化学工業株式会社 チアゾール誘導体および有害生物防除剤
WO2014011768A1 (en) 2012-07-10 2014-01-16 Adispell, Inc. Anti-anxiety treatment
WO2014018741A1 (en) 2012-07-27 2014-01-30 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
JP2015524483A (ja) 2012-08-09 2015-08-24 ニューロポア セラピーズ，インコーポレイティド Ｐｉ３−キナーゼシグナリング経路の調節因子としてのアリール及びヘテロアリールで置換されたベンゼン誘導体
JP2014037382A (ja) 2012-08-17 2014-02-27 Nissan Chem Ind Ltd 殺虫、殺ダニ、殺線虫、殺軟体動物、殺菌又は殺バクテリア剤組成物及び病害虫の防除方法
WO2014033631A1 (en) 2012-08-31 2014-03-06 Novartis Ag N-(3-pyridyl) biarylamides as kinase inhibitors
EP2892534B8 (en) 2012-09-06 2021-09-15 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN103664878A (zh) 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 杂芳环及其衍生物类酪氨酸激酶抑制剂
AU2013322736A1 (en) 2012-09-26 2015-02-26 F. Hoffmann-La Roche Ag Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
JP6127436B2 (ja) 2012-10-10 2017-05-17 コニカミノルタ株式会社 白色エレクトロルミネッセンスデバイス及び白色エレクトロルミネッセンスデバイスの製造方法
JP5994551B2 (ja) 2012-10-10 2016-09-21 コニカミノルタ株式会社 エレクトロルミネッセンスデバイス
TWI598325B (zh) 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類
JP6015765B2 (ja) 2012-10-22 2016-10-26 コニカミノルタ株式会社 透明電極、電子デバイスおよび有機エレクトロルミネッセンス素子
WO2014065236A1 (ja) 2012-10-22 2014-05-01 コニカミノルタ株式会社 透明電極、電子デバイスおよび有機エレクトロルミネッセンス素子
WO2014065209A1 (ja) 2012-10-23 2014-05-01 日本曹達株式会社 ピリジン化合物またはその塩、有害生物防除剤、殺虫剤または殺ダニ剤、および外部寄生虫防除剤
KR102000211B1 (ko) 2012-10-29 2019-09-30 삼성디스플레이 주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
UA117359C2 (uk) 2012-11-14 2018-07-25 Тейдзін Фарма Лімітед Похідне піридину
WO2014079805A1 (en) 2012-11-23 2014-05-30 Boehringer Ingelheim International Gmbh Pyrazole compounds for treating hairloss
WO2014090147A1 (zh) 2012-12-14 2014-06-19 上海恒瑞医药有限公司 嘧啶类衍生物及其可药用盐、其制备方法及其在医药上的应用
US9475784B2 (en) 2012-12-19 2016-10-25 Bristol-Myers Squibb Company 4,6-diarylaminothiazines as BACE1 inhibitors and their use for the reduction of beta-amyloid production
EP2934518B1 (en) 2012-12-19 2020-02-19 Merck Sharp & Dohme Corp. Spirocyclic cetp inhibitors
WO2014099834A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
KR20140083620A (ko) 2012-12-26 2014-07-04 제일모직주식회사 차광층용 감광성 수지 조성물 및 이를 이용한 차광층
JP5911419B2 (ja) 2012-12-27 2016-04-27 キヤノン株式会社 有機発光素子及び表示装置
CN103896946B (zh) 2012-12-28 2018-04-03 浙江导明医药科技有限公司 用于预防及治疗多种自身免疫疾病的新化合物
WO2013171729A2 (en) 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
TW201443037A (zh) 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
CN103694236B (zh) 2013-01-15 2017-05-31 苏州开拓药业股份有限公司 一种嘧啶骨架具有刺猬通路拮抗剂活性的抗肿瘤化合物
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
RU2671212C2 (ru) 2013-02-02 2018-10-30 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд Замещенный 2-аминопиридин в качестве ингибитора протеинкиназы
US9840471B2 (en) 2013-02-19 2017-12-12 Senomyx, Inc. Compounds useful as modulators of TRPM8
GEP201606600B (en) 2013-02-22 2017-01-10 Pfizer Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)
CN103923085B (zh) 2013-02-25 2016-08-24 苏州云轩医药科技有限公司 具有刺猬通路拮抗剂活性的吡啶杂环化合物及其用途
TWI687220B (zh) 2013-03-01 2020-03-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
EP2774919A1 (en) 2013-03-06 2014-09-10 Pharmeste S.R.L. In Liquidazione Novel sulfonamide TRPA1 receptor antagonists
JP6279358B2 (ja) 2013-03-12 2018-02-14 花王株式会社 酸化性組成物
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
JP6362367B2 (ja) 2013-03-12 2018-07-25 花王株式会社 酸化性組成物
JP2014198841A (ja) 2013-03-12 2014-10-23 花王株式会社 酸化性組成物
WO2014164543A1 (en) 2013-03-13 2014-10-09 The Regents Of The University Of Michigan Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
WO2014160185A2 (en) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
US9346802B2 (en) 2013-03-15 2016-05-24 Epizyme, Inc. CARM1 inhibitors and uses thereof
CA2904393A1 (en) 2013-03-15 2014-09-25 Araxes Pharma Llc Covalent inhibitors of kras g12c
JP2016519674A (ja) 2013-03-20 2016-07-07 バイエル・ファルマ・アクティエンゲゼルシャフト 過剰増殖障害を治療または予防するための３−アセチルアミノ−１−（フェニル−ヘテロアリール−アミノカルボニルまたはフェニル−ヘテロアリール−カルボニルアミノ）ベンゼン誘導体
KR101599009B1 (ko) 2013-03-29 2016-03-14 동아에스티 주식회사 Cetp 억제 활성을 갖는 신규한 옥사졸리디논 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물
AR096022A1 (es) 2013-04-11 2015-12-02 Basf Se Compuestos de pirimidinio sustituido, útiles para combatir plagas de animales
CN103193702B (zh) 2013-04-18 2014-12-24 陕西师范大学 含氮杂环化合物官能团化的方法
ITMI20130647A1 (it) 2013-04-19 2014-10-20 Univ Bologna Alma Mater Composti con attività inibente sulle sirtuine
US9783550B2 (en) 2013-05-14 2017-10-10 The Board Of Regents Of The University Of Texas System Highly potent inhibitors of porcupine
WO2014184343A1 (en) 2013-05-17 2014-11-20 Basf Se Process for preparing n-substituted 1h-pyrazole-5-carboxylic acid compounds and derivatives thereof
JP6375697B2 (ja) 2013-05-31 2018-08-22 コニカミノルタ株式会社 透明電極、電子デバイス及び有機エレクトロルミネッセンス素子
US9193736B2 (en) 2013-06-11 2015-11-24 Janssen Pharmaceutica, Nv PDE 10a inhibitors for the treatment of type II diabetes
JP6184830B2 (ja) 2013-06-14 2017-08-23 花王株式会社 漂白洗浄剤組成物
EP3013796B9 (en) 2013-06-27 2020-07-01 LG Chem, Ltd. Biaryl derivatives as gpr120 agonists
WO2015004029A1 (en) 2013-07-08 2015-01-15 Technische Universität München 18f-labeling of aromatic and heteroaromatic molecules with unprotected carboxylic acid groups
WO2015014900A1 (en) 2013-07-31 2015-02-05 Minoryx Therapeutics S.L. Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof
JPWO2015015993A1 (ja) 2013-08-01 2017-03-02 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子
WO2015023664A2 (en) 2013-08-12 2015-02-19 Adispell, Inc. Therapeutic treatment for drug poisoning and addiction
WO2015025172A1 (en) 2013-08-22 2015-02-26 Mark David Charles 5-aryl-thiazol-2-yl-amine compounds and their therapeutic use
WO2015025962A1 (ja) 2013-08-23 2015-02-26 富山化学工業株式会社 アミジン化合物またはその塩
US9359330B2 (en) 2013-08-26 2016-06-07 Purdue Pharma L.P. Substituted piperidines as sodium channel blockers
WO2015031561A1 (en) 2013-08-30 2015-03-05 Bp Corporation North America Inc. Catalytic conversion of alcohols
JP2016540725A (ja) 2013-10-04 2016-12-28 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 炭化水素の酸化を触媒することのできる分子触媒および炭化水素を酸化する方法
DE102013016324A1 (de) 2013-10-04 2015-04-09 Merck Patent Gmbh Perfluoralkylfluor- oder Perfluoralkylchlorgermanate
AP2016009099A0 (en) 2013-11-01 2016-03-31 Novartis Ag Aminoheteroaryl benzamides as kinase inhibitors
WO2015066697A1 (en) 2013-11-04 2015-05-07 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US10033000B2 (en) 2013-11-15 2018-07-24 Universal Display Corporation Organic electroluminescent materials and devices
US9340504B2 (en) 2013-11-21 2016-05-17 Purdue Pharma L.P. Pyridine and piperidine derivatives as novel sodium channel blockers
US9708278B2 (en) 2013-11-27 2017-07-18 Vanderbilt University Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1
EP3076968B1 (en) 2013-12-02 2019-04-17 ChemoCentryx, Inc. Ccr6 compounds
US10355227B2 (en) 2013-12-16 2019-07-16 Universal Display Corporation Metal complex for phosphorescent OLED
GB201322334D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
MX2016008130A (es) 2013-12-20 2016-10-13 Esteve Labor Dr Derivados de piperidina con actividad multimodal contra el dolor.
EP3082805B1 (en) 2013-12-20 2020-02-05 Institute for Drug Discovery, LLC Substituted amino triazoles, and methods using same
JP6340788B2 (ja) 2013-12-25 2018-06-13 コニカミノルタ株式会社 透明電極及び電子デバイス
JP2015125845A (ja) 2013-12-26 2015-07-06 コニカミノルタ株式会社 透明電極及び電子デバイス
CA2935683A1 (en) 2013-12-30 2015-07-09 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
ES2699351T3 (es) 2014-01-17 2019-02-08 Novartis Ag Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
CN103848838A (zh) 2014-01-23 2014-06-11 中国药科大学 一类c-Met与VEGFR-2双重拮抗剂、其制备方法及其医疗用途
JP2015141806A (ja) 2014-01-28 2015-08-03 出光興産株式会社 有機エレクトロルミネッセンス素子の製造方法、組成物、有機エレクトロルミネッセンス素子、および電子機器
CN103804312B (zh) 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
US9673407B2 (en) 2014-02-28 2017-06-06 Universal Display Corporation Organic electroluminescent materials and devices
WO2015138273A1 (en) 2014-03-13 2015-09-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
WO2015142903A2 (en) 2014-03-17 2015-09-24 Genentech, Inc. Method of controlling lactate production with piperdine-dione derivatives
MA39749A (fr) 2014-03-17 2017-01-25 Hoffmann La Roche Dérivés de pipéridine-dione
WO2015139621A1 (zh) 2014-03-18 2015-09-24 北京韩美药品有限公司 4-杂芳基取代的苯甲酸或苯甲酰胺类化合物
AU2015231239B2 (en) 2014-03-19 2018-11-29 Amydis, Inc. Amyloid targeting agents and methods of using the same
CN104926801B (zh) 2014-03-22 2019-06-04 浙江大学 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用
JP6269260B2 (ja) 2014-03-31 2018-01-31 宇部興産株式会社 ビアリール化合物の製造方法
EP2933849A1 (de) 2014-04-15 2015-10-21 cynora GmbH Hostmaterialien für OLEDs
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
US9862711B2 (en) * 2014-04-24 2018-01-09 Novartis Ag Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
CA2945212A1 (en) * 2014-04-24 2015-10-29 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
EP3137124B1 (en) 2014-04-29 2019-01-09 Microvention, Inc. Polymers including active agents
WO2015179563A2 (en) 2014-05-22 2015-11-26 Abide Therapeutics, Inc. N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
CN105461738B (zh) 2014-06-03 2019-03-08 中国人民解放军军事医学科学院毒物药物研究所 一种雷帕霉素衍生物、其制备方法、其药物组合物及用途
CN104004026A (zh) 2014-06-09 2014-08-27 江西冠能光电材料有限公司 一种电负性磷光材料
SG11201610500WA (en) 2014-06-17 2017-01-27 Vertex Pharma Method for treating cancer using a combination of chk1 and atr inhibitors
US20170121322A1 (en) 2014-06-18 2017-05-04 Bayer Pharma Aktiengesellschaft Bet-protein inhibiting 3,4-dihydropyrido[2,3-b]pyrazinones with meta-substituted aromatic amino- or ether groups
GB201411236D0 (en) 2014-06-25 2014-08-06 Takeda Pharmaceutical Novel compounds
GB201411239D0 (en) 2014-06-25 2014-08-06 Takeda Pharmaceutical Novel compounds
CN106463273B (zh) 2014-07-07 2019-01-15 富士胶片株式会社 光电转换元件、色素增感太阳能电池、金属络合物色素、色素溶液、以及三联吡啶化合物或其酯化物
WO2016006512A1 (ja) 2014-07-07 2016-01-14 富士フイルム株式会社 光電変換素子、色素増感太陽電池、金属錯体色素、色素溶液、およびターピリジン化合物またはそのエステル化物
JP6362235B2 (ja) 2014-07-14 2018-07-25 ツーセン ファーマシューティカル カンパニー リミテッド ピリジン誘導体およびその抗マイコバクテリウムにおける使用
CN105315199B (zh) 2014-07-14 2020-11-20 湖南化工研究院有限公司 N-吡啶芳氧苯氧羧酸衍生物及其制备方法与应用
CA2954328A1 (en) 2014-07-23 2016-01-28 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
AU2015293541B2 (en) 2014-07-25 2019-11-21 Piramal Enterprises Limited Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
PE20170673A1 (es) 2014-08-05 2017-05-22 Alios Biopharma Inc Terapia de combinacion para tratar una paramixovirus
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
KR101887213B1 (ko) 2014-08-12 2018-08-09 삼성에스디아이 주식회사 화합물, 이를 포함하는 유기 광전자 소자 및 표시장치
CA2958193C (en) 2014-08-18 2024-02-27 Hudson Biopharma Inc. Spiropyrrolidines as mdm2 inhibitors
US20170290806A1 (en) 2014-09-08 2017-10-12 Temple University-Of The Commonwealth System Of Higher Education PCSK9 Inhibitors and Methods of Use Thereof
US10669635B2 (en) 2014-09-18 2020-06-02 Baker Hughes, A Ge Company, Llc Methods of coating substrates with composite coatings of diamond nanoparticles and metal
WO2016049565A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions and methods for inhibition of ras
JP2017528498A (ja) 2014-09-25 2017-09-28 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
JP2017536411A (ja) 2014-10-01 2017-12-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Ｂｍｐ阻害用組成物及びｂｍｐ阻害方法
JP6100745B2 (ja) 2014-10-01 2017-03-22 ユー・ディー・シー アイルランド リミテッド 有機電界発光素子
KR102525131B1 (ko) 2014-10-08 2023-04-24 레드엑스 파마 피엘씨 Wnt 신호 경로의 억제제로서의 N-피리디닐 아세트아미드 유도체
PT3204381T (pt) 2014-10-08 2022-07-18 Redx Pharma Plc Derivados de n-piridinil acetamida como inibidores da via de sinalização wnt
US10174012B2 (en) 2014-11-04 2019-01-08 The University Of Kansas LKB1-AMPK activators for therapeutic use in polycystic kidney disease
WO2016073623A2 (en) 2014-11-04 2016-05-12 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
WO2016074757A1 (de) 2014-11-11 2016-05-19 Merck Patent Gmbh Verfahren zur herstellung von mono- und bis(perfluoralkyl)fluorophosphatsalzen und deren säuren
WO2016088354A1 (ja) 2014-12-05 2016-06-09 出光興産株式会社 金属錯体化合物、有機エレクトロルミネッセンス素子用材料、組成物、有機エレクトロルミネッセンス素子及び電子機器
JP6621477B2 (ja) 2014-12-18 2019-12-18 ファイザー・インク ピリミジンおよびトリアジン誘導体ならびにａｘｌ阻害薬としてのそれらの使用
CN104557863B (zh) 2014-12-18 2017-03-15 中国科学院广州生物医药与健康研究院 一种新型烟酰胺磷酸核糖转移酶抑制剂及其合成方法与应用
TWI703133B (zh) 2014-12-23 2020-09-01 美商艾克斯基製藥公司 ３,５-二胺基吡唑激酶抑制劑
JP6502091B2 (ja) 2014-12-26 2019-04-17 国立研究開発法人産業技術総合研究所 高圧水素製造法および製造システム
WO2016116517A1 (de) 2015-01-20 2016-07-28 Cynora Gmbh Pyridine und deren derivate als bausteine zur verwendung in optoelektronischen bauelementen
US10230053B2 (en) 2015-01-30 2019-03-12 Samsung Display Co., Ltd. Organic light-emitting device
CN107207958B (zh) 2015-02-03 2018-11-16 住友化学株式会社 组合物和使用该组合物的发光元件
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
CN104744348B (zh) 2015-02-13 2018-01-09 华侨大学 多取代吡啶衍生物及其制备方法
US9701671B2 (en) 2015-02-20 2017-07-11 Canon Kabushiki Kaisha Organic compound, electrochromic element containing the same, optical filter, lens unit, imaging device, and window component
SG10201907576SA (en) 2015-02-27 2019-09-27 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
US10577349B2 (en) 2015-03-02 2020-03-03 Sanford Burnham Prebys Medical Discovery Institute Quinolinones as inhibitors of translation initiation complex
EP3265445B1 (en) 2015-03-06 2021-05-05 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
WO2016161145A1 (en) 2015-03-31 2016-10-06 Dana-Farber Cancer Institute, Inc. Stk4 inhibitors for treatment of hematologic malignancies
EP3283479B1 (en) 2015-04-01 2022-12-14 Rigel Pharmaceuticals, Inc. Tgf-beta inhibitors
UA120389C2 (uk) 2015-04-08 2019-11-25 Торрент Фармасьютікалз Лімітед Нові сполуки піридинію
KR101953175B1 (ko) 2015-04-24 2019-02-28 주식회사 엘지화학 함질소 다환 화합물 및 이를 이용하는 유기 발광 소자
WO2016173557A1 (zh) 2015-04-30 2016-11-03 中国科学院上海药物研究所 一类具有激酶抑制活性的化合物、制备方法和用途
EP3288943B1 (en) 2015-05-01 2022-09-28 Pfizer Inc. Pyrrolo[2,3-b]pyrazinyl acrylamides and epoxides thereof as inhibitors of janus kinase
GB201507753D0 (en) 2015-05-06 2015-06-17 Biolipox Ab New compounds and uses
WO2016181772A1 (ja) 2015-05-08 2016-11-17 コニカミノルタ株式会社 π共役系化合物、有機エレクトロルミネッセンス素子材料、発光性薄膜、有機エレクトロルミネッセンス素子、表示装置及び照明装置
US20160340311A1 (en) 2015-05-22 2016-11-24 Dow Agrosciences Llc Recovery and/or reuse of palladium catalyst after a suzuki coupling
US11925102B2 (en) 2015-06-04 2024-03-05 Universal Display Corporation Organic electroluminescent materials and devices
CN104927742B (zh) 2015-06-23 2017-05-17 上海东和胶粘剂有限公司 聚氨酯木结构胶及其制备方法
JP2017019789A (ja) 2015-07-13 2017-01-26 大阪ガスケミカル株式会社 微生物防除剤
WO2017011279A1 (en) 2015-07-13 2017-01-19 Merck Sharp & Dohme Corp. Bicyclic heterocycles as inhibitors of cholesterol ester transfer protein
CN105175202B (zh) 2015-07-14 2018-09-07 绍兴文理学院 由芳香肼制备联芳烃的方法
TWI608132B (zh) 2015-08-06 2017-12-11 羅門哈斯電子材料有限公司 自含有吡啶基烷基胺及雙環氧化物之反應產物的銅電鍍覆浴液電鍍覆光阻劑限定之特徵的方法
KR101735687B1 (ko) 2015-09-23 2017-05-15 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계 및 이를 이용한 올레핀 올리고머화 방법
KR101832448B1 (ko) 2015-09-24 2018-02-26 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계, 및 이를 이용한 올레핀 올리고머화 방법
US20170092880A1 (en) 2015-09-25 2017-03-30 Universal Display Corporation Organic electroluminescent materials and devices
WO2017058728A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356347A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
WO2017059434A1 (en) 2015-10-02 2017-04-06 Esanex, Inc. Use of tetrahydroindazolylbenzamide and tetrahydroindolylbenzamide derivatives for the treatment of cancer
US9890149B2 (en) 2015-10-07 2018-02-13 NuBridge BioSciences Isothiazole derivatives as CFTR modulators
US9981945B2 (en) 2015-10-07 2018-05-29 NuBridge BioSciences Pyrimidine derivatives as CFTR modulators
US10174002B2 (en) 2015-10-07 2019-01-08 NuBridge BioSciences Pyridine derivatives as CFTR modulators
WO2017061581A1 (ja) 2015-10-08 2017-04-13 株式会社神鋼環境ソリューション ビピリジン化合物の合成方法およびピリジン化合物の製造方法
BR112018007068B1 (pt) 2015-10-09 2024-01-02 Janssen Pharmaceutica N.V. Derivados de quinoxalina e piridopirazina como inibidores de pi3kbeta, seu uso e composição farmacêutica que os compreende
WO2017070003A1 (en) 2015-10-20 2017-04-27 Kiacta Sárl Use of prodrugs of 1,3-propanedisulfonic acid or pharmaceutically acceptable salts thereof for the treatment of sarcoidosis
BR112018008630A2 (pt) 2015-11-06 2018-10-30 Neurocrine Biosciences Inc derivados de n-[2-(1-benzilpiperidin-4-il)etil]-4-(pirazin-2-il)-piperazina-1-carboxamida, seus usos, composição farmacêutica
CN120204220A (zh) 2015-11-17 2025-06-27 博蔚医药生物科技股份有限公司 治疗及/或预防纤维性疾病的胺基萘醌化合物
EP3388428B1 (en) 2015-12-07 2021-08-04 Suzhou Sinovent Pharmaceuticals Company Five-membered heterocyclic amides wnt pathway inhibitor
AU2016366523A1 (en) 2015-12-09 2018-07-05 Case Western Reserve University Method of modulating ribonucleotide reductase
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
KR102419178B1 (ko) 2015-12-29 2022-07-11 삼성디스플레이 주식회사 유기 발광 소자
KR102396293B1 (ko) 2015-12-29 2022-05-11 삼성디스플레이 주식회사 유기 발광 소자
US20170190689A1 (en) 2016-01-05 2017-07-06 Incyte Corporation Pyridine and pyridimine compounds as pi3k-gamma inhibitors
WO2017118734A1 (en) 2016-01-08 2017-07-13 The Institute Of Cancer Research: Royal Cancer Hospital Inhibitors of ataxia-telangiectasia mutated and rad3-related protein kinase (atr) for use in methods of treating cancer
KR102813707B1 (ko) 2016-01-22 2025-05-28 셰브런 오로나이트 컴퍼니 엘엘씨 올레핀 공중합체 분산제-유형 점도 향상제 및 아민 화합물의 혼합물을 함유하는 시너지 윤활유 조성물
EP3410828B1 (en) 2016-01-28 2021-02-24 Sumitomo Chemical Company Limited Method for producing film
KR20170093273A (ko) 2016-02-03 2017-08-16 주식회사 동진쎄미켐 유기발광소자
WO2017170765A1 (ja) 2016-03-30 2017-10-05 田辺三菱製薬株式会社 新規含窒素複素環化合物
US10236456B2 (en) 2016-04-11 2019-03-19 Universal Display Corporation Organic electroluminescent materials and devices
US10865205B2 (en) 2016-04-22 2020-12-15 Dana-Farber Cancer Institute, Inc. Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of CDK8 inhibitors with E3 ligase ligand and methods of use
US20170305861A1 (en) 2016-04-25 2017-10-26 Immunomet Therapeutics, Inc Heteroaryl compounds comprising nitrogen and use thereof
WO2017189569A1 (en) 2016-04-25 2017-11-02 Trustees Of Tufts College Multimediator dpp4 and fap inhibitors, and uses related thereto
AR108396A1 (es) 2016-05-06 2018-08-15 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
US10138248B2 (en) 2016-06-24 2018-11-27 Incyte Corporation Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors
KR102482673B1 (ko) 2016-07-05 2022-12-30 광저우 맥시노벨 파마수티컬스 씨오., 엘티디. 방향족 아세틸렌 또는 방향족 에틸렌계 화합물, 그의 중간체, 제조 방법, 약물 조성물 및 용도
CN107759614B (zh) 2016-08-16 2023-01-24 中国科学院上海药物研究所 一类噁唑并吡啶季铵盐类化合物、其制备方法及用途
CN109863142B (zh) 2016-08-24 2022-06-10 豪夫迈·罗氏有限公司 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法
SMT202000554T1 (it) 2016-09-02 2020-11-10 Suven Life Sciences Ltd Modulatori allosterici positivi del recettore muscarinico m1
WO2018056644A1 (ko) 2016-09-21 2018-03-29 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계 및 이를 이용한 올레핀 올리고머 제조방법
WO2018056643A1 (ko) 2016-09-21 2018-03-29 롯데케미칼 주식회사 올레핀 올리고머화용 촉매계 및 이를 이용한 올레핀 올리고머 제조방법
JP6812542B2 (ja) 2016-09-28 2021-01-13 ドン−ア エスティ カンパニー リミテッド テトラヒドロピリジン誘導体および抗菌剤としてのその使用
TWI734861B (zh) 2016-12-19 2021-08-01 瑞典商指紋卡公司 包括顯示功能之電容式指紋感測裝置
CN106831735B (zh) 2017-01-23 2019-10-11 牡丹江医学院 一种治疗骨质疏松的杂环化合物及其制备方法和用途
CN106905299B (zh) 2017-02-28 2019-04-02 牡丹江医学院 一种治疗胰腺炎的药物及其制备方法
KR102717072B1 (ko) 2017-10-18 2024-10-15 인사이트 코포레이션 Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Also Published As

Publication number Publication date
US20220213065A1 (en) 2022-07-07
IL277071A (en) 2020-10-29
IL277071B2 (en) 2024-07-01
PH12020551390A1 (en) 2021-11-22
US20250313550A1 (en) 2025-10-09
SI3762368T1 (sl) 2022-06-30
AU2019272342B2 (en) 2024-03-07
MA54133A (fr) 2021-01-13
CN112074505A (zh) 2020-12-11
EP3762368A2 (en) 2021-01-13
HRP20220331T1 (hr) 2022-05-13
UA128288C2 (uk) 2024-05-29
CR20240101A (es) 2024-05-24
AU2024203916A1 (en) 2024-06-27
MX2023000100A (es) 2023-02-09
ES2910071T3 (es) 2022-05-11
BR112020018094A2 (pt) 2020-12-22
HUE057970T2 (hu) 2022-06-28
US20200339542A1 (en) 2020-10-29
LT3762368T (lt) 2022-06-10
WO2019226213A2 (en) 2019-11-28
MX2020009228A (es) 2021-01-08
JP7268049B2 (ja) 2023-05-02
IL302529B1 (en) 2024-11-01
US12365668B2 (en) 2025-07-22
DK3762368T3 (da) 2022-03-28
SG11202008560VA (en) 2020-10-29
PT3762368T (pt) 2022-05-06
CR20200464A (es) 2021-04-14
AU2019272342A1 (en) 2020-09-24
RS63124B1 (sr) 2022-05-31
SMT202200134T1 (it) 2022-05-12
KR20200142508A (ko) 2020-12-22
JP7558334B2 (ja) 2024-09-30
EP3762368B1 (en) 2022-01-26
TW202413336A (zh) 2024-04-01
KR20250103804A (ko) 2025-07-07
MA54133B1 (fr) 2022-01-31
IL302529A (en) 2023-07-01
MD3762368T2 (ro) 2022-07-31
JP2023099049A (ja) 2023-07-11
ECSP20061378A (es) 2021-04-29
PE20210641A1 (es) 2021-03-23
CY1125169T1 (el) 2024-02-16
PL3762368T3 (pl) 2022-06-06
JP2021515773A (ja) 2021-06-24
CL2020002275A1 (es) 2021-02-19
CN112074505B (zh) 2024-04-05
WO2019226213A3 (en) 2020-01-02
US20240400541A1 (en) 2024-12-05
CN118290402A (zh) 2024-07-05
TWI827583B (zh) 2024-01-01
IL277071B1 (en) 2024-03-01
US20190276435A1 (en) 2019-09-12
TW201938542A (zh) 2019-10-01
TWI903299B (zh) 2025-11-01
US11926616B2 (en) 2024-03-12
PE20251292A1 (es) 2025-05-14
KR102828717B1 (ko) 2025-07-07
CO2020012169A2 (es) 2020-12-21
US10669262B2 (en) 2020-06-02
CA3093445A1 (en) 2019-11-28
EP4056560A1 (en) 2022-09-14

Similar Documents

Publication Publication Date Title
JP7558334B2 (ja) ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物
US12516065B2 (en) Tertiary alcohols as PI3K-γ inhibitors
US20220411383A1 (en) AMINOPYRAZINE DERIVATIVES AS PI3K-y INHIBITORS
HK40080900A (en) Aminopyrazine diol compounds as pi3k-y inhibitors
HK40044960A (en) Aminopyrazine diol compounds as pi3k-y inhibitors
HK40044960B (en) Aminopyrazine diol compounds as pi3k-y inhibitors
BR122025015788A2 (pt) Compostos de aminopirazina diol, seus usos como inibidores de pi3k- gama e composição farmacêutica dos mesmos
EA045434B1 (ru) СОЕДИНЕНИЯ АМИНОПИРАЗИНДИОЛА КАК ИНГИБИТОРЫ PI3Kγ
EA043981B1 (ru) ТРЕТИЧНЫЕ СПИРТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-γ