DE2051580C3 - Für die parenterale Verabreichung geeignete wirkstoffhaltige pharmazeutische Zubereitungen - Google Patents

Für die parenterale Verabreichung geeignete wirkstoffhaltige pharmazeutische Zubereitungen

Info

Publication number
DE2051580C3
DE2051580C3 DE2051580A DE2051580A DE2051580C3 DE 2051580 C3 DE2051580 C3 DE 2051580C3 DE 2051580 A DE2051580 A DE 2051580A DE 2051580 A DE2051580 A DE 2051580A DE 2051580 C3 DE2051580 C3 DE 2051580C3
Authority
DE
Germany
Prior art keywords
active ingredient
polymer
polylactide
drug
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2051580A
Other languages
German (de)
English (en)
Other versions
DE2051580A1 (de
DE2051580B2 (de
Inventor
Richard Merrill Wilmington Del. Scribner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of DE2051580A1 publication Critical patent/DE2051580A1/de
Publication of DE2051580B2 publication Critical patent/DE2051580B2/de
Application granted granted Critical
Publication of DE2051580C3 publication Critical patent/DE2051580C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2051580A 1969-10-23 1970-10-21 Für die parenterale Verabreichung geeignete wirkstoffhaltige pharmazeutische Zubereitungen Expired DE2051580C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86889969A 1969-10-23 1969-10-23
US7930970A 1970-10-08 1970-10-08

Publications (3)

Publication Number Publication Date
DE2051580A1 DE2051580A1 (de) 1971-05-06
DE2051580B2 DE2051580B2 (de) 1980-07-10
DE2051580C3 true DE2051580C3 (de) 1981-04-02

Family

ID=26761845

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2051580A Expired DE2051580C3 (de) 1969-10-23 1970-10-21 Für die parenterale Verabreichung geeignete wirkstoffhaltige pharmazeutische Zubereitungen

Country Status (6)

Country Link
US (1) US3773919A (https=)
JP (1) JPS5017525B1 (https=)
CA (1) CA982479A (https=)
DE (1) DE2051580C3 (https=)
FR (1) FR2070153B1 (https=)
GB (1) GB1325209A (https=)

Families Citing this family (2629)

* Cited by examiner, † Cited by third party
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FR2070153B1 (https=) 1975-01-10
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GB1325209A (en) 1973-08-01
DE2051580B2 (de) 1980-07-10
CA982479A (en) 1976-01-27
FR2070153A1 (https=) 1971-09-10

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