TR201908138T4 - Bir anti-her2 antikoru ilaç konjügatı ve bir bcl-2 inhibitörü ile kombinasyon terapisi. - Google Patents
Bir anti-her2 antikoru ilaç konjügatı ve bir bcl-2 inhibitörü ile kombinasyon terapisi. Download PDFInfo
- Publication number
- TR201908138T4 TR201908138T4 TR2019/08138T TR201908138T TR201908138T4 TR 201908138 T4 TR201908138 T4 TR 201908138T4 TR 2019/08138 T TR2019/08138 T TR 2019/08138T TR 201908138 T TR201908138 T TR 201908138T TR 201908138 T4 TR201908138 T4 TR 201908138T4
- Authority
- TR
- Turkey
- Prior art keywords
- inhibitor
- combination therapy
- drug conjugate
- bcl
- her2 antibody
- Prior art date
Links
- 239000012664 BCL-2-inhibitor Substances 0.000 title abstract 2
- 229940123711 Bcl2 inhibitor Drugs 0.000 title abstract 2
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 2
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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Abstract
Mevcut buluş, kanserden muzdarip bir hastanın, özellikle bir HER2 eksprese edici kanseri olan bir hastanın tedavisi için bir anti-HER2 antikor-ilaç konjugatını ve seçici bir Bcl-2 inhibitörünü içeren bir kombinasyon terapisine yöneliktir,
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562189610P | 2015-07-07 | 2015-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201908138T4 true TR201908138T4 (tr) | 2019-06-21 |
Family
ID=56464320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/08138T TR201908138T4 (tr) | 2015-07-07 | 2016-07-06 | Bir anti-her2 antikoru ilaç konjügatı ve bir bcl-2 inhibitörü ile kombinasyon terapisi. |
Country Status (21)
Country | Link |
---|---|
US (3) | US10898570B2 (tr) |
EP (1) | EP3319995B1 (tr) |
JP (2) | JP6910339B2 (tr) |
KR (2) | KR20240129101A (tr) |
CN (2) | CN113607945A (tr) |
AU (1) | AU2016290065B2 (tr) |
BR (1) | BR112017028012A2 (tr) |
CA (1) | CA2990465A1 (tr) |
DK (1) | DK3319995T3 (tr) |
ES (1) | ES2731377T3 (tr) |
HR (1) | HRP20191019T1 (tr) |
HU (1) | HUE044139T2 (tr) |
IL (1) | IL256451B (tr) |
LT (1) | LT3319995T (tr) |
MX (1) | MX2018000135A (tr) |
PL (1) | PL3319995T3 (tr) |
PT (1) | PT3319995T (tr) |
RS (1) | RS58823B1 (tr) |
SI (1) | SI3319995T1 (tr) |
TR (1) | TR201908138T4 (tr) |
WO (1) | WO2017007846A1 (tr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190096384A (ko) | 2017-03-02 | 2019-08-19 | 제넨테크, 인크. | Her2-양성 유방암 어쥬번트 치료 |
CN107349426B (zh) * | 2017-07-12 | 2018-03-23 | 马骥 | 阿司匹林与曲妥珠单抗联合或协同在肿瘤治疗中的应用 |
CN114206392A (zh) * | 2019-06-10 | 2022-03-18 | 苏特罗生物制药公司 | 免疫调节剂抗体药物偶联物及其用途 |
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KR101689946B1 (ko) * | 2012-06-08 | 2016-12-26 | 에프. 호프만-라 로슈 아게 | 암의 치료를 위한 포스포이노시타이드 3 키나제 억제제 화합물 및 화학치료제의 돌연변이체 선택성 및 조합물 |
WO2014039855A1 (en) * | 2012-09-07 | 2014-03-13 | Genentech, Inc. | Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor |
CN104370905B (zh) * | 2014-10-22 | 2016-06-01 | 南京友杰医药科技有限公司 | Bcl-2抑制剂ABT-199的合成 |
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2016
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- 2016-07-06 CN CN201680040184.1A patent/CN107922504B/zh active Active
- 2016-07-06 KR KR1020247027710A patent/KR20240129101A/ko active Search and Examination
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- 2016-07-06 WO PCT/US2016/041184 patent/WO2017007846A1/en active Application Filing
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DK3319995T3 (da) | 2019-06-24 |
HUE044139T2 (hu) | 2019-09-30 |
KR20180021060A (ko) | 2018-02-28 |
US10898570B2 (en) | 2021-01-26 |
PL3319995T3 (pl) | 2019-09-30 |
US20180140700A1 (en) | 2018-05-24 |
MX2018000135A (es) | 2018-03-23 |
KR102697939B1 (ko) | 2024-08-26 |
RS58823B1 (sr) | 2019-07-31 |
AU2016290065A1 (en) | 2018-01-18 |
CN107922504A (zh) | 2018-04-17 |
EP3319995A1 (en) | 2018-05-16 |
WO2017007846A1 (en) | 2017-01-12 |
ES2731377T3 (es) | 2019-11-15 |
JP2018521064A (ja) | 2018-08-02 |
BR112017028012A2 (pt) | 2018-08-28 |
US20240277838A1 (en) | 2024-08-22 |
CN113607945A (zh) | 2021-11-05 |
IL256451A (en) | 2018-02-28 |
KR20240129101A (ko) | 2024-08-27 |
PT3319995T (pt) | 2019-06-14 |
CA2990465A1 (en) | 2017-01-12 |
AU2016290065B2 (en) | 2022-08-11 |
EP3319995B1 (en) | 2019-04-17 |
IL256451B (en) | 2021-12-01 |
JP2021178825A (ja) | 2021-11-18 |
LT3319995T (lt) | 2019-07-10 |
JP6910339B2 (ja) | 2021-07-28 |
SI3319995T1 (sl) | 2019-07-31 |
CN107922504B (zh) | 2021-07-30 |
US20210213130A1 (en) | 2021-07-15 |
HRP20191019T1 (hr) | 2019-09-06 |
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